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The animal trypanosomiases and their chemotherapy: a review

  • FEDERICA GIORDANI (a1), LIAM J. MORRISON (a2), TIM G. ROWAN (a3), HARRY P. DE KONING (a1) and MICHAEL P. BARRETT (a1)...

Summary

Pathogenic animal trypanosomes affecting livestock have represented a major constraint to agricultural development in Africa for centuries, and their negative economic impact is increasing in South America and Asia. Chemotherapy and chemoprophylaxis represent the main means of control. However, research into new trypanocides has remained inadequate for decades, leading to a situation where the few compounds available are losing efficacy due to the emergence of drug-resistant parasites. In this review, we provide a comprehensive overview of the current options available for the treatment and prophylaxis of the animal trypanosomiases, with a special focus on the problem of resistance. The key issues surrounding the main economically important animal trypanosome species and the diseases they cause are also presented. As new investment becomes available to develop improved tools to control the animal trypanosomiases, we stress that efforts should be directed towards a better understanding of the biology of the relevant parasite species and strains, to identify new drug targets and interrogate resistance mechanisms.

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This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.

Corresponding author

*Corresponding author: Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, Sir Graeme Davies Building, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK. E-mail: michael.barrett@glasgow.ac.uk

References

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Afewerk, Y., Clausen, P. H., Abebe, G., Tilahun, G. and Mehlitz, D. (2000). Multiple-drug resistant Trypanosoma congolense populations in village cattle of Metekel district, north-west Ethiopia. Acta Tropica 76, 231238.
Agosin, M. and von Brand, T. (1954). Studies on the carbohydrate metabolism of Trypanosoma congolense . Experimental Parasitology 3, 517524.
Ahmed, S. K., Rahman, A. H., Hassan, M. A., Salih, S. E., Paone, M. and Cecchi, G. (2016). An atlas of tsetse and bovine trypanosomosis in Sudan. Parasites & Vectors 9, 194.
Ainanshe, O. A., Jennings, F. W. and Holmes, P. H. (1992). Isolation of drug-resistant strains of Trypanosoma congolense from the lower Shabelle region of southern Somalia. Tropical Animal Health and Production 24, 6573.
Alirol, E., Schrumpf, D., Amici Heradi, J., Riedel, A., de Patoul, C., Quere, M. and Chappuis, F. (2013). Nifurtimox-eflornithine combination therapy for second-stage gambiense human African trypanosomiasis: medecins Sans Frontieres experience in the Democratic Republic of the Congo. Clinical Infectious Diseases 56, 195203.
Alkhaldi, A. A., Martinek, J., Panicucci, B., Dardonville, C., Zikova, A. and de Koning, H. P. (2016). Trypanocidal action of bisphosphonium salts through a mitochondrial target in bloodstream form Trypanosoma brucei . International Journal for Parasitology: Drugs and Drug Resistance 6, 2334.
Alsford, S., Eckert, S., Baker, N., Glover, L., Sanchez-Flores, A., Leung, K. F., Turner, D. J., Field, M. C., Berriman, M. and Horn, D. (2012). High-throughput decoding of antitrypanosomal drug efficacy and resistance. Nature 482, 232236.
Apted, F. I. (1970). Treatment of human trypanosomiasis. In The African Trypanosomiases (ed. Mulligan, H. W.), pp. 684710. George Allen and Unwin Ltd., London, UK.
Auty, H., Mundy, A., Fyumagwa, R. D., Picozzi, K., Welburn, S. and Hoare, R. (2008). Health management of horses under high challenge from trypanosomes: a case study from Serengeti, Tanzania. Veterinary Parasitology 154, 233241.
Auty, H., Anderson, N. E., Picozzi, K., Lembo, T., Mubanga, J., Hoare, R., Fyumagwa, R. D., Mable, B., Hamill, L., Cleaveland, S. and Welburn, S. C. (2012). Trypanosome diversity in wildlife species from the serengeti and Luangwa Valley ecosystems. PLoS Neglected Tropical Diseases 6, e1828.
Auty, H., Torr, S. J., Michoel, T., Jayaraman, S. and Morrison, L. J. (2015). Cattle trypanosomosis: the diversity of trypanosomes and implications for disease epidemiology and control. Revue Scientifique et Technique de l'OIE 34, 587598.
Baker, N., Glover, L., Munday, J. C., Aguinaga, A. D., Barrett, M. P., de Koning, H. P. and Horn, D. (2012). Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes. Proceedings of the National Academy of Sciences of the United States of America 109, 1099611001.
Baker, N., de Koning, H. P., Maser, P. and Horn, D. (2013). Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story. Trends in Parasitology 29, 110118.
Baker, N., Hamilton, G., Wilkes, J. M., Hutchinson, S., Barrett, M. P. and Horn, D. (2015). Vacuolar ATPase depletion affects mitochondrial ATPase function, kinetoplast dependency, and drug sensitivity in trypanosomes. Proceedings of the National Academy of Sciences of the United States of America 112, 91129117.
Baltz, T., Baltz, D., Giroud, C. and Crockett, J. (1985). Cultivation in a semi-defined medium of animal infective forms of Trypanosoma brucei, T. equiperdum, T. evansi, T. rhodesiense and T. gambiense . EMBO Journal 4, 12731277.
Banks, K. L. (1979). In vitro binding of Trypanosoma congolense to erythrocytes. Journal of Protozoology 26, 103108.
Banks, K. L. (1980). Injury induced by Trypanosoma congolense adhesion to cell membranes. Journal of Parasitology 66, 3437.
Barrett, M. P. and Fairlamb, A. H. (1999). The biochemical basis of arsenical-diamidine crossresistance in African trypanosomes. Parasitology Today 15, 136140.
Barrett, M. P., Zhang, Z. Q., Denise, H., Giroud, C. and Baltz, T. (1995). A diamidine-resistant Trypanosoma equiperdum clone contains a P2 purine transporter with reduced substrate affinity. Molecular and Biochemical Parasitology 73, 223229.
Barrett, M. P., Burchmore, R. J., Stich, A., Lazzari, J. O., Frasch, A. C., Cazzulo, J. J. and Krishna, S. (2003). The trypanosomiases. Lancet 362, 14691480.
Barrett, M. P., Boykin, D. W., Brun, R. and Tidwell, R. R. (2007). Human African trypanosomiasis: pharmacological re-engagement with a neglected disease. British Journal of Pharmacology 152, 11551171.
Batista, J. S., Riet-Correa, F., Teixeira, M. M., Madruga, C. R., Simoes, S. D. and Maia, T. F. (2007). Trypanosomiasis by Trypanosoma vivax in cattle in the Brazilian semiarid: description of an outbreak and lesions in the nervous system. Veterinary Parasitology 143, 174181.
Batista, J. S., Oliveira, A. F., Rodrigues, C. M., Damasceno, C. A., Oliveira, I. R., Alves, H. M., Paiva, E. S., Brito, P. D., Medeiros, J. M., Rodrigues, A. C. and Teixeira, M. M. (2009). Infection by Trypanosoma vivax in goats and sheep in the Brazilian semiarid region: from acute disease outbreak to chronic cryptic infection. Veterinary Parasitology 165, 131135.
Batista, J. S., Rodrigues, C. M., Olinda, R. G., Silva, T. M., Vale, R. G., Camara, A. C., Reboucas, R. E., Bezerra, F. S., Garcia, H. A. and Teixeira, M. M. (2012). Highly debilitating natural Trypanosoma vivax infections in Brazilian calves: epidemiology, pathology, and probable transplacental transmission. Parasitology Research 110, 7380.
Bengaly, Z., Sidibe, I., Boly, H., Sawadogo, L. and Desquesnes, M. (2002 a). Comparative pathogenicity of three genetically distinct Trypanosoma congolense-types in inbred Balb/c mice. Veterinary Parasitology 105, 111118.
Bengaly, Z., Sidibe, I., Ganaba, R., Desquesnes, M., Boly, H. and Sawadogo, L. (2002 b). Comparative pathogenicity of three genetically distinct types of Trypanosoma congolense in cattle: clinical observations and haematological changes. Veterinary Parasitology 108, 119.
Bennett, S. C. J. (1930). Camel trypanosomiasis in the Sudan. In Proceedings of the 1929 Pan African Veterinary Conference, Pretoria, South Africa, pp. 1015.
Bennett, S. C. J. (1936). The treatment of equine Trypanosoma congolense infections with Surfen C (Bayer). Journal of Comparative Pathology and Therapeutics 49, 151159.
Berger, B. J. and Fairlamb, A. H. (1994). Properties of melarsamine hydrochloride (Cymelarsan) in aqueous solution. Antimicrobial Agents and Chemotherapy 38, 12981302.
Berlin, D., Nasereddin, A., Azmi, K., Ereqat, S., Abdeen, Z. and Baneth, G. (2010). Longitudinal study of an outbreak of Trypanosoma evansi infection in equids and dromedary camels in Israel. Veterinary Parasitology 174, 317322.
Berriman, M., Ghedin, E., Hertz-Fowler, C., Blandin, G., Renauld, H., Bartholomeu, D. C., Lennard, N. J., Caler, E., Hamlin, N. E., Haas, B., Bohme, U., Hannick, L., Aslett, M. A., Shallom, J., Marcello, L., Hou, L., Wickstead, B., Alsmark, U. C., Arrowsmith, C., Atkin, R. J., Barron, A. J., Bringaud, F., Brooks, K., Carrington, M., Cherevach, I., Chillingworth, T. J., Churcher, C., Clark, L. N., Corton, C. H., Cronin, A. et al. (2005). The genome of the African trypanosome Trypanosoma brucei . Science 309, 416422.
Biryomumaisho, S., Rwakishaya, E. K., Melville, S. E., Cailleau, A. and Lubega, G. W. (2013). Livestock trypanosomosis in Uganda: parasite heterogeneity and anaemia status of naturally infected cattle, goats and pigs. Parasitology Research 112, 14431450.
Biteau, N., Asencio, C., Izotte, J., Rousseau, B., Fevre, M., Pillay, D. and Baltz, T. (2016). Trypanosoma brucei gambiense infections in mice lead to tropism to the reproductive organs, and horizontal and vertical transmission. PLoS Neglected Tropical Diseases 10, e0004350.
Blum, J., Nkunku, S. and Burri, C. (2001). Clinical description of encephalopathic syndromes and risk factors for their occurrence and outcome during melarsoprol treatment of human African trypanosomiasis. Tropical Medicine & International Health 6, 390400.
Boibessot, I., Turner, C. M., Watson, D. G., Goldie, E., Connel, G., McIntosh, A., Grant, M. H. and Skellern, G. G. (2002). Metabolism and distribution of phenanthridine trypanocides in Trypanosoma brucei . Acta Tropica 84, 219228.
Boid, R., Jones, T. W. and Payne, R. C. (1989). Malic enzyme type VII isoenzyme as an indicator of suramin resistance in Trypanosoma evansi . Experimental Parasitology 69, 317323.
Brun, R. and Kunz, C. (1989). In vitro drug sensitivity test for Trypanosoma brucei subgroup bloodstream trypomastigotes. Acta Tropica 46, 361368.
Brun, R. and Lun, Z. R. (1994). Drug sensitivity of Chinese Trypanosoma evansi and Trypanosoma equiperdum isolates. Veterinary Parasitology 52, 3746.
Brun, R. and Moloo, S. K. (1982). In vitro cultivation of animal-infective forms of a West African Trypanosoma vivax stock. Acta Tropica 39, 135141.
Brun, R., Hecker, H. and Lun, Z. R. (1998). Trypanosoma evansi and T. equiperdum: distribution, biology, treatment and phylogenetic relationship (a review). Veterinary Parasitology 79, 95107.
Brun, R., Don, R., Jacobs, R. T., Wang, M. Z. and Barrett, M. P. (2011). Development of novel drugs for human African trypanosomiasis. Future Microbiology 6, 677691.
Cadioli, F. A., Barnabé, P. A., Machado, R. Z., Teixeira, M. C., André, M. R., Sampaio, P. H., Fidélis Junior, O. L., Teixeira, M. M. and Marques, L. C. (2012). First report of Trypanosoma vivax outbreak in dairy cattle in Sao Paulo state, Brazil. Revista Brasileira de Parasitologia Veterinaria 21, 118124.
Carnes, J., Anupama, A., Balmer, O., Jackson, A., Lewis, M., Brown, R., Cestari, I., Desquesnes, M., Gendrin, C., Hertz-Fowler, C., Imamura, H., Ivens, A., Koreny, L., Lai, D. H., MacLeod, A., McDermott, S. M., Merritt, C., Monnerat, S., Moon, W., Myler, P., Phan, I., Ramasamy, G., Sivam, D., Lun, Z. R., Lukes, J., Stuart, K. and Schnaufer, A. (2015). Genome and phylogenetic analyses of Trypanosoma evansi reveal extensive similarity to T. brucei and multiple independent origins for dyskinetoplasty. PLoS Neglected Tropical Diseases 9, e3404.
Carter, N. S. and Fairlamb, A. H. (1993). Arsenical-resistant trypanosomes lack an unusual adenosine transporter. Nature 361, 173176.
Carter, N. S., Berger, B. J. and Fairlamb, A. H. (1995). Uptake of diamidine drugs by the P2 nucleoside transporter in melarsen-sensitive and -resistant Trypanosoma brucei brucei . Journal of Biological Chemistry 270, 2815328157.
Cecchi, G. and Mattioli, R. C. (2009). Geospacial Datasets and Analyses for an Environmental Approach to African Trypanosomiasis. PAAT Technical and Scientific Series No. 9. Food and Agriculture Organisation of the United Nations (FAO), Rome, Italy.
Cecchi, G., Paone, M., Feldmann, U., Vreysen, M. J., Diall, O. and Mattioli, R. C. (2014). Assembling a geospatial database of tsetse-transmitted animal trypanosomosis for Africa. Parasites & Vectors 7, 39.
Chitambo, H. and Arakawa, A. (1992 a). Trypanosoma congolense: manifestation of resistance to Berenil and Samorin in cloned trypanosomes isolated from Zambian cattle. Zentralblatt fur Bakteriologie 277, 371381.
Chitambo, H. and Arakawa, A. (1992 b). Trypanosoma congolense: the in vitro akinetoplastic induction sensitivity assay. Parasitology Research 78, 136141.
Chitanga, S., Marcotty, T., Namangala, B., Van den Bossche, P., Van Den Abbeele, J. and Delespaux, V. (2011). High prevalence of drug resistance in animal trypanosomes without a history of drug exposure. PLoS Neglected Tropical Diseases 5, e1454.
Claes, F., Buscher, P., Touratier, L. and Goddeeris, B. M. (2005). Trypanosoma equiperdum: master of disguise or historical mistake? Trends in Parasitology 21, 316321.
Clausen, P. H., Sidibe, I., Kabore, I. and Bauer, B. (1992). Development of multiple drug resistance of Trypanosoma congolense in Zebu cattle under high natural tsetse fly challenge in the pastoral zone of Samorogouan, Burkina Faso. Acta Tropica 51, 229236.
Clausen, P. H., Leendertz, F. H., Blankenburg, A., Tietjen, U., Mehlitz, D., Sidibe, I. and Bauer, B. (1999). A drug incubation glossina infectivity test (DIGIT) to assess the susceptibility of Trypanosoma congolense bloodstream forms to trypanocidal drugs (Xenodiagnosis). Acta Tropica 72, 111117.
Cnops, J., Magez, S. and De Trez, C. (2015). Escape mechanisms of African trypanosomes: why trypanosomosis is keeping us awake. Parasitology 142, 417427.
Codjia, V., Mulatu, W., Majiwa, P. A., Leak, S. G., Rowlands, G. J., Authie, E., d'Ieteren, G. D. and Peregrine, A. S. (1993). Epidemiology of bovine trypanosomiasis in the Ghibe valley, southwest Ethiopia. 3. Occurrence of populations of Trypanosoma congolense resistant to diminazene, isometamidium and homidium. Acta Tropica 53, 151163.
Coles, J. A., Myburgh, E., Ritchie, R., Hamilton, A., Rodgers, J., Mottram, J. C., Barrett, M. P. and Brewer, J. M. (2015). Intravital imaging of a massive lymphocyte response in the cortical dura of mice after peripheral infection by trypanosomes. PLoS Neglected Tropical Diseases 9, e0003714.
Connor, R. J. (1992). The diagnosis, treatment and prevention of animal trypanosomiasis under field conditions. In Programme for the Control of African Animal Trypanosomiasis and Related Development: Ecological and Technical Aspects. FAO Animal Production and Health Paper No. 100. Food and Agriculture Organisation of the United Nations (FAO), Rome, Italy.
Cortez, A. P., Ventura, R. M., Rodrigues, A. C., Batista, J. S., Paiva, F., Anez, N., Machado, R. Z., Gibson, W. C. and Teixeira, M. M. (2006). The taxonomic and phylogenetic relationships of Trypanosoma vivax from South America and Africa. Parasitology 133, 159169.
Coustou, V., Guegan, F., Plazolles, N. and Baltz, T. (2010). Complete in vitro life cycle of Trypanosoma congolense: development of genetic tools. PLoS Neglected Tropical Diseases 4, e618.
Cox, B. A., Yielding, L. W. and Yielding, K. L. (1984). Subcellular localization of photoreactive ethidium analogs in Trypanosoma brucei by fluorescence microscopy. Journal of Parasitology 70, 694702.
Creek, D. J., Nijagal, B., Kim, D. H., Rojas, F., Matthews, K. R. and Barrett, M. P. (2013). Metabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei . Antimicrobial Agents and Chemotherapy 57, 27682779.
Creek, D. J., Mazet, M., Achcar, F., Anderson, J., Kim, D. H., Kamour, R., Morand, P., Millerioux, Y., Biran, M., Kerkhoven, E. J., Chokkathukalam, A., Weidt, S. K., Burgess, K. E., Breitling, R., Watson, D. G., Bringaud, F. and Barrett, M. P. (2015). Probing the metabolic network in bloodstream-form Trypanosoma brucei using untargeted metabolomics with stable isotope labelled glucose. PLoS Pathogens 11, e1004689.
Curd, F. H. and Davey, D. G. (1950). Antrycide – a new trypanocidal drug. British Journal of Pharmacology 5, 2532.
D'Archivio, S., Medina, M., Cosson, A., Chamond, N., Rotureau, B., Minoprio, P. and Goyard, S. (2011). Genetic engineering of Trypanosoma (Dutonella) vivax and in vitro differentiation under axenic conditions. PLoS Neglected Tropical Diseases 5, e1461.
D'Archivio, S., Cosson, A., Medina, M., Lang, T., Minoprio, P. and Goyard, S. (2013). Non-invasive in vivo study of the Trypanosoma vivax infectious process consolidates the brain commitment in late infections. PLoS Neglected Tropical Diseases 7, e1976.
Dagnachew, S., Terefe, G., Abebe, G., Barry, D., McCulloch, R. and Goddeeris, B. (2015). In vivo experimental drug resistance study in Trypanosoma vivax isolates from tsetse infested and non-tsetse infested areas of Northwest Ethiopia. Acta Tropica 146, 95100.
Dargantes, A. P., Mercado, R. T., Dobson, R. J. and Reid, S. A. (2009). Estimating the impact of Trypanosoma evansi infection (surra) on buffalo population dynamics in southern Philippines using data from cross-sectional surveys. International Journal for Parasitology 39, 11091114.
Da Silva, A. S., Garcia Perez, H. A., Costa, M. M., Franca, R. T., De Gasperi, D., Zanette, R. A., Amado, J. A., Lopes, S. T., Teixeira, M. M. and Monteiro, S. G. (2011). Horses naturally infected by Trypanosoma vivax in southern Brazil. Parasitology Research 108, 2330.
De Koning, H. P. (2001 a). Transporters in African trypanosomes: role in drug action and resistance. International Journal for Parasitology 31, 512522.
De Koning, H. P. (2001 b). Uptake of pentamidine in Trypanosoma brucei brucei is mediated by three distinct transporters: implications for cross-resistance with arsenicals. Molecular Pharmacology 59, 586592.
De Koning, H. P. (2008). Ever-increasing complexities of diamidine and arsenical crossresistance in African trypanosomes. Trends in Parasitology 24, 345349.
De Koning, H. P. and Jarvis, S. M. (1999). Adenosine transporters in bloodstream forms of Trypanosoma brucei brucei: substrate recognition motifs and affinity for trypanocidal drugs. Molecular Pharmacology 56, 11621170.
De Koning, H. P., Anderson, L. F., Stewart, M., Burchmore, R. J., Wallace, L. J. and Barrett, M. P. (2004). The trypanocide diminazene aceturate is accumulated predominantly through the TbAT1 purine transporter: additional insights on diamidine resistance in African trypanosomes. Antimicrobial Agents and Chemotherapy 48, 15151519.
De Koning, H. P., Gould, M. K., Sterk, G. J., Tenor, H., Kunz, S., Luginbuehl, E. and Seebeck, T. (2012). Pharmacological validation of Trypanosoma brucei phosphodiesterases as novel drug targets. Journal of Infectious Diseases 206, 229237.
Dean, S., Gould, M. K., Dewar, C. E. and Schnaufer, A. C. (2013). Single point mutations in ATP synthase compensate for mitochondrial genome loss in trypanosomes. Proceedings of the National Academy of Sciences of the United States of America 110, 1474114746.
Defontis, M., Richartz, J., Engelmann, N., Bauer, C., Schwierk, V. M., Buscher, P. and Moritz, A. (2012). Canine Trypanosoma evansi infection introduced into Germany. Veterinary Clinical Pathology 41, 369374.
Delespaux, V. and de Koning, H. P. (2007). Drugs and drug resistance in African trypanosomiasis. Drug Resistance Updates 10, 3050.
Delespaux, V., Geysen, D., Majiwa, P. A. and Geerts, S. (2005). Identification of a genetic marker for isometamidium chloride resistance in Trypanosoma congolense . International Journal for Parasitology 35, 235243.
Delespaux, V., Chitanga, S., Geysen, D., Goethals, A., Van den Bossche, P. and Geerts, S. (2006). SSCP analysis of the P2 purine transporter TcoAT1 gene of Trypanosoma congolense leads to a simple PCR–RFLP test allowing the rapid identification of diminazene resistant stocks. Acta Tropica 100, 96102.
Delespaux, V., Dinka, H., Masumu, J., Van den Bossche, P. and Geerts, S. (2008 a). Five-fold increase in Trypanosoma congolense isolates resistant to diminazene aceturate over a seven-year period in Eastern Zambia. Drug Resistance Updates 11, 205209.
Delespaux, V., Geysen, D., Van den Bossche, P. and Geerts, S. (2008 b). Molecular tools for the rapid detection of drug resistance in animal trypanosomes. Trends in Parasitology 24, 236242.
Desowitz, R. S. (1956). Observations on the metabolism of Trypanosoma vivax . Experimental Parasitology 5, 250259.
Desowitz, R. S. (1957). Suramin complexes. II. Prophylactic activity against Trypanosoma vivax in cattle. Annals of Tropical Medicine and Parasitology 51, 457463.
Desquesnes, M. and Dia, M. L. (2003). Mechanical transmission of Trypanosoma congolense in cattle by the African tabanid Atylotus agrestis . Experimental Parasitology 105, 226231.
Desquesnes, M. and Davila, A. M. (2002). Applications of PCR-based tools for detection and identification of animal trypanosomes: a review and perspectives. Veterinary Parasitology 109, 213231.
Desquesnes, M., de La Rocque, S. and Peregrine, A. S. (1995). French Guyanan stock of Trypanosoma vivax resistant to diminazene aceturate but sensitive to isometamidium chloride. Acta Tropica 60, 133136.
Desquesnes, M., Bossard, G., Patrel, D., Herder, S., Patout, O., Lepetitcolin, E., Thevenon, S., Berthier, D., Pavlovic, D., Brugidou, R., Jacquiet, P., Schelcher, F., Faye, B., Touratier, L. and Cuny, G. (2008). First outbreak of Trypanosoma evansi in camels in metropolitan France. Veterinary Record 162, 750752.
Desquesnes, M., Biteau-Coroller, F., Bouyer, J., Dia, M. L. and Foil, L. (2009). Development of a mathematical model for mechanical transmission of trypanosomes and other pathogens of cattle transmitted by tabanids. International Journal for Parasitology 39, 333346.
Desquesnes, M., Kamyingkird, K., Vergne, T., Sarataphan, N., Pranee, R. and Jittapalapong, S. (2011). An evaluation of melarsomine hydrochloride efficacy for parasitological cure in experimental infection of dairy cattle with Trypanosoma evansi in Thailand. Parasitology 138, 11341142.
Desquesnes, M., Dargantes, A., Lai, D. H., Lun, Z. R., Holzmuller, P. and Jittapalapong, S. (2013 a). Trypanosoma evansi and surra: a review and perspectives on transmission, epidemiology and control, impact, and zoonotic aspects. BioMed Research International 2013, 321237.
Desquesnes, M., Holzmuller, P., Lai, D. H., Dargantes, A., Lun, Z. R. and Jittaplapong, S. (2013 b). Trypanosoma evansi and surra: a review and perspectives on origin, history, distribution, taxonomy, morphology, hosts, and pathogenic effects. BioMed Research International 2013, 194176.
Diaz, R., Luengo-Arratta, S. A., Seixas, J. D., Amata, E., Devine, W., Cordon-Obras, C., Rojas-Barros, D. I., Jimenez, E., Ortega, F., Crouch, S., Colmenarejo, G., Fiandor, J. M., Martin, J. J., Berlanga, M., Gonzalez, S., Manzano, P., Navarro, M. and Pollastri, M. P. (2014). Identification and characterization of hundreds of potent and selective inhibitors of Trypanosoma brucei growth from a kinase-targeted library screening campaign. PLoS Neglected Tropical Diseases 8, e3253.
Dobson, R. J., Dargantes, A. P., Mercado, R. T. and Reid, S. A. (2009). Models for Trypanosoma evansi (surra), its control and economic impact on small-hold livestock owners in the Philippines. International Journal for Parasitology 39, 11151123.
Dolan, R. B., Okech, G., Alushula, H., Mutugi, M., Stevenson, P., Sayer, P. D. and Njogu, A. R. (1990). Homidium bromide as a chemoprophylactic for cattle trypanosomiasis in Kenya. Acta Tropica 47, 137144.
Doua, F., Miezan, T. W., Sanon Singaro, J. R., Boa Yapo, F. and Baltz, T. (1996). The efficacy of pentamidine in the treatment of early-late stage Trypanosoma brucei gambiense trypanosomiasis. The American Journal of Tropical Medicine and Hygiene 55, 586588.
Dougherty, G. and Waring, M. J. (1982). The interaction between prothidium dibromide and DNA at the molecular level. Biophysical Chemistry 15, 2740.
Dowler, M. E., Schillinger, D. and Connor, R. J. (1989). Notes on the routine intravenous use of isometamidium in the control of bovine trypanosomiasis on the Kenya coast. Tropical Animal Health and Production 21, 410.
Eisler, M. C. (1996). Pharmacokinetics of the chemoprophylactic and chemotherapeutic trypanocidal drug isometamidium chloride (Samorin) in cattle. Drug Metabolism and Disposition 24, 13551361.
Eisler, M. C., Arowolo, R. O., Gault, E. A., Moloo, S. K., Holmes, P. H. and Peregrine, A. S. (1994). Isometamidium concentrations in the sera of Boran cattle: correlation with prophylaxis against tsetse-transmitted Trypanosoma congolense . Acta Tropica 56, 3950.
Eisler, M. C., McDermott, J. J., Mdachi, R., Murilla, G. A., Sinyangwe, L., Mubanga, J., Machila, N., Mbwambo, H., Coleman, P. G., Clausen, P. H., Bauer, B., Sidibé, I., Geerts, S., Holmes, P. H. and Peregrine, A. S. (2000). Rapid method for the assessment of trypanocidal drug resistance in the field. In Proceedings of the 9th Symposium of the International Society for Veterinary Epidemiology and Economics, Nairobi, Kenya, paper 353 1–3.
Eisler, M. C., Brandt, J., Bauer, B., Clausen, P. H., Delespaux, V., Holmes, P. H., Ilemobade, A., Machila, N., Mbwambo, H., McDermott, J., Mehlitz, D., Murilla, G., Ndung'u, J. M., Peregrine, A. S., Sidibe, I., Sinyangwe, L. and Geerts, S. (2001). Standardised tests in mice and cattle for the detection of drug resistance in tsetse-transmitted trypanosomes of African domestic cattle. Veterinary Parasitology 97, 171182.
El Banna, H. A., Abo el-Sooud, K. and Soliman, G. A. (1999). Comparative pharmacokinetics of diminazene in lactating goats and sheep. Zentralblatt für Veterinärmedizin. Reihe A 46, 4957.
El Rayah, I. E., Kaminsky, R., Schmid, C. and El Malik, K. H. (1999). Drug resistance in Sudanese Trypanosoma evansi . Veterinary Parasitology 80, 281287.
Eperon, G., Balasegaram, M., Potet, J., Mowbray, C., Valverde, O. and Chappuis, F. (2014). Treatment options for second-stage gambiense human African trypanosomiasis. Expert Review of Anti-Infective Therapy 12, 14071417.
Eze, A. A., Gould, M. K., Munday, J. C., Tagoe, D., Stelmanis, V., Schnaufer, A. C. and de Koning, H. P. (2016). Loss of mitochondrial membrane potential is a late adaptation of Trypanosoma brucei brucei to isometamidium preceded by mutations in the γ subunit of the F 1 F 0-ATPase. PLoS Neglected Tropical Diseases 10, e0004791.
Faccio, L., Da Silva, A. S., Gressler, L. T., Tonin, A. A., Lazzarotto, C. R., Miletti, L. C. and Monteiro, S. G. (2013). Susceptibility of Brazilian isolates of Trypanosoma evansi to suramin sodium: test in experimentally infected mice. Experimental Parasitology 134, 309312.
Fairlamb, A. H. (2003). Chemotherapy of human African trypanosomiasis: current and future prospects. Trends in Parasitology 19, 488494.
Fairlamb, A. H. and Bowman, I. B. (1980). Uptake of the trypanocidal drug suramin by bloodstream forms of Trypanosoma brucei and its effect on respiration and growth rate in vivo . Molecular and Biochemical Parasitology 1, 315333.
FAO (1990). Residues of Some Veterinary Drugs in Animals and Foods. FAO Food and Nutrition paper No. 41/2. Food and Agriculture Organization of the United Nations (FAO), Rome, Italy.
Gardiner, P. R. (1989). Recent studies of the biology of Trypanosoma vivax . Advances in Parasitology 28, 229317.
Geerts, S. and Holmes, P. H. (1998). Drug Management and Parasite Resistance in Bovine Trypanosomiasis in Africa. PAAT Technical and Scientific Series No. 1. Food and Agriculture Organisation of the United Nations (FAO), Rome, Italy.
Geerts, S., Brandt, J. and De Deken, R. (1999). Laboratory and field evaluation of biodegradable polyesters for sustained release of isometamidium and ethidium – Minireview. Memórias do Instituto Oswaldo Cruz 94, 211214.
Geerts, S., Holmes, P. H., Eisler, M. C. and Diall, O. (2001). African bovine trypanosomiasis: the problem of drug resistance. Trends in Parasitology 17, 2528.
Gibson, W. (2012). The origins of the trypanosome genome strains Trypanosoma brucei brucei TREU 927, T. b. gambiense DAL 972, T. vivax Y486 and T. congolense IL3000. Parasites & Vectors 5, 71.
Gill, B. S. (1971). Drug-resistance in Trypanosoma evansi . Tropical Animal Health and Production 3, 195198.
Gould, M. K. and Schnaufer, A. (2014). Independence from kinetoplast DNA maintenance and expression is associated with multidrug resistance in Trypanosoma brucei in vitro . Antimicrobial Agents and Chemotherapy 58, 29252928.
Grab, D. J. and Kennedy, P. G. (2008). Traversal of human and animal trypanosomes across the blood-brain barrier. Journal of Neurovirology 14, 344351.
Grace, D., Randolph, T., Affognon, H., Dramane, D., Diall, O. and Clausen, P. H. (2009). Characterisation and validation of farmers’ knowledge and practice of cattle trypanosomosis management in the cotton zone of West Africa. Acta Tropica 111, 137143.
Graf, F. E., Ludin, P., Wenzler, T., Kaiser, M., Brun, R., Pyana, P. P., Buscher, P., de Koning, H. P., Horn, D. and Maser, P. (2013). Aquaporin 2 mutations in Trypanosoma brucei gambiense field isolates correlate with decreased susceptibility to pentamidine and melarsoprol. PLoS Neglected Tropical Diseases 7, e2475.
Graf, F. E., Baker, N., Munday, J. C., de Koning, H. P., Horn, D. and Maser, P. (2015). Chimerization at the AQP2-AQP3 locus is the genetic basis of melarsoprol-pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates. International Journal for Parasitology: Drugs and Drug Resistance 5, 6568.
Gray, M. A., Kimarua, R. W., Peregrine, A. S. and Stevenson, P. (1993). Drug sensitivity screening in vitro of populations of Trypanosoma congolense originating from cattle and tsetse flies at Nguruman, Kenya. Acta Tropica 55, 19.
Griffin, L. (1983). Congenital transmission of Trypanosoma congolense in mice. Journal of Comparative Pathology 93, 489492.
Gu, Y., Gettinby, G., McKendrick, I., Murry, M., Peregrine, A. S. and Revie, C. (1999). Development of a decision support system for trypanocidal drug control of bovine trypanosomosis in Africa. Veterinary Parasitology 87, 923.
Gutierrez, C., Corbera, J. A., Bayou, K. and van Gool, F. (2008). Use of cymelarsan in goats chronically infected with Trypanosoma evansi . Annals of the New York Academy of Sciences 1149, 331333.
Gutierrez, C., Desquesnes, M., Touratier, L. and Buscher, P. (2010). Trypanosoma evansi: recent outbreaks in Europe. Veterinary Parasitology 174, 2629.
Gutteridge, W. E. (1985). Existing chemotherapy and its limitations. British Medical Bulletin 41, 162168.
Haag, J., O'hUigin, C. and Overath, P. (1998). The molecular phylogeny of trypanosomes: evidence for an early divergence of the Salivaria. Molecular and Biochemical Parasitology 91, 3749.
Hagos, A., Goddeeris, B. M., Yilkal, K., Alemu, T., Fikru, R., Yacob, H. T., Feseha, G. and Claes, F. (2010). Efficacy of Cymelarsan and Diminasan against Trypanosoma equiperdum infections in mice and horses. Veterinary Parasitology 171, 200206.
Hanau, S., Rippa, M., Bertelli, M., Dallocchio, F. and Barrett, M. P. (1996). 6-Phosphogluconate dehydrogenase from Trypanosoma brucei. Kinetic analysis and inhibition by trypanocidal drugs. European Journal of Biochemistry 240, 592599.
Haridy, F. M., El-Metwally, M. T., Khalil, H. H. and Morsy, T. A. (2011). Trypanosoma evansi in dromedary camel: with a case report of zoonosis in greater Cairo, Egypt. Journal of the Egyptian Society of Parasitology 41, 6576.
Hawking, F. (1963). Chemotherapy of trypanosomiasis. In Experimental Chemotherapy, Vol. 1 (ed. Schnitzer, R. J. and Hawking, F.), pp. 129256. Academic Press, New York and London.
Hemphill, A., Frame, I. and Ross, C. A. (1994). The interaction of Trypanosoma congolense with endothelial cells. Parasitology 109 (Pt 5), 631641.
Hettlich, B. F., Ryan, K., Bergman, R. L., Marks, S. L., Lewis, B. C., Bahr, A., Coates, J. R., Mansell, J. and Barton, C. L. (2003). Neurologic complications after melarsomine dihydrochloride treatment for Dirofilaria immitis in three dogs. Journal of the American Veterinary Medical Association 223, 14561461, 1434.
Hide, G. and Tait, A. (2004). Genetics and molecular epidemiology of trypanosomes. In The Trypanosomiases (ed. Maudlin, I., Holmes, P. H. and Miles, M. A.), pp. 7793. CAB International, Wallingford, UK.
Hirumi, H. and Hirumi, K. (1994). Axenic culture of African trypanosome bloodstream forms. Parasitology Today 10, 8084.
Holmes, P. (2013). Tsetse-transmitted trypanosomes – their biology, disease impact and control. Journal of Invertebrate Pathology 112 (Suppl.), S11S14.
Holmes, P. H., Eisler, M. C. and Geerts, S. (2004). Current chemotherapy of animal trypanosomiasis. In The Trypanosomiases (ed. Maudlin, I., Holmes, P. H. and Miles, M. A.), pp. 431444. CAB International, Wallingford, UK.
Horn, D. (2014). Antigenic variation in African trypanosomes. Molecular and Biochemical Parasitology 195, 123129.
Howie, S., Guy, M., Fleming, L., Bailey, W., Noyes, H., Faye, J. A., Pepin, J., Greenwood, B., Whittle, H., Molyneux, D. and Corrah, T. (2006). A Gambian infant with fever and an unexpected blood film. PLoS Medicine 3, e355.
Ibrahim, H. M., Al-Salabi, M. I., El Sabbagh, N., Quashie, N. B., Alkhaldi, A. A., Escale, R., Smith, T. K., Vial, H. J. and de Koning, H. P. (2011). Symmetrical choline-derived dications display strong anti-kinetoplastid activity. Journal of Antimicrobial Chemotherapy 66, 111125.
Igoli, J. O., Blackburn, G., Gray, A. I., Sutcliffe, O. B., Watson, D. G., Euerby, M. R. and Skellern, G. G. (2015). Chromatographic and spectroscopic analysis of the components present in the phenanthridinium trypanocidal agent isometamidium. Analytical and Bioanalytical Chemistry 407, 11711180.
Inoue, N., Otsu, K., Ferraro, D. M. and Donelson, J. E. (2002). Tetracycline-regulated RNA interference in Trypanosoma congolense . Molecular and Biochemical Parasitology 120, 309313.
Jackson, A. P., Berry, A., Aslett, M., Allison, H. C., Burton, P., Vavrova-Anderson, J., Brown, R., Browne, H., Corton, N., Hauser, H., Gamble, J., Gilderthorp, R., Marcello, L., McQuillan, J., Otto, T. D., Quail, M. A., Sanders, M. J., van Tonder, A., Ginger, M. L., Field, M. C., Barry, J. D., Hertz-Fowler, C. and Berriman, M. (2012). Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species. Proceedings of the National Academy of Sciences of the United States of America 109, 34163421.
Jacobs, R. T., Nare, B., Wring, S. A., Orr, M. D., Chen, D., Sligar, J. M., Jenks, M. X., Noe, R. A., Bowling, T. S., Mercer, L. T., Rewerts, C., Gaukel, E., Owens, J., Parham, R., Randolph, R., Beaudet, B., Bacchi, C. J., Yarlett, N., Plattner, J. J., Freund, Y., Ding, C., Akama, T., Zhang, Y. K., Brun, R., Kaiser, M., Scandale, I. and Don, R. (2011). SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis. PLoS Neglected Tropical Diseases 5, e1151.
Jittapalapong, S., Inpankaew, T., Sarataphan, N., Herbreteau, V., Hugot, J. P., Morand, S. and Stich, R. W. (2008). Molecular detection of divergent trypanosomes among rodents of Thailand. Infection, Genetics and Evolution 8, 445449.
Jodrell, D. I., Reyno, L. M., Sridhara, R., Eisenberger, M. A., Tkaczuk, K. H., Zuhowski, E. G., Sinibaldi, V. J., Novak, M. J. and Egorin, M. J. (1994). Suramin: development of a population pharmacokinetic model and its use with intermittent short infusions to control plasma drug concentration in patients with prostate cancer. Journal of Clinical Oncology 12, 166175.
Jones, T. W. and Davila, A. M. (2001). Trypanosoma vivax–out of Africa. Trends in Parasitology 17, 99101.
Jones, D., Nyalwidhe, J., Tetley, L. and Barrett, M. P. (2007). McArthur revisited: fluorescence microscopes for field diagnostics. Trends in Parasitology 23, 468469.
Joshi, P. P., Shegokar, V. R., Powar, R. M., Herder, S., Katti, R., Salkar, H. R., Dani, V. S., Bhargava, A., Jannin, J. and Truc, P. (2005). Human trypanosomiasis caused by Trypanosoma evansi in India: the first case report. American Journal of Tropical Medicine and Hygiene 73, 491495.
Joshua, R. A. and Kayit, Y. S. (1984). The course of fatal Trypanosoma simiae infection in domestic sheep. Acta Tropica 41, 9192.
Joshua, R. A., Obwolo, M. J., Bwangamoi, O. and Mandebvu, E. (1995). Resistance to diminazine aceturate by Trypanosoma congolense from cattle in the Zambezi Valley of Zimbabwe. Veterinary Parasitology 60, 16.
Kaminsky, R. and Brun, R. (1993). In vitro assays to determine drug sensitivities of African trypanosomes: a review. Acta Tropica 54, 279289.
Kaminsky, R., Gumm, I. D., Zweygarth, E. and Chuma, F. (1990). A drug incubation infectivity test (DIIT) for assessing resistance in trypanosomes. Veterinary Parasitology 34, 335343.
Kazibwe, A. J., Nerima, B., de Koning, H. P., Maser, P., Barrett, M. P. and Matovu, E. (2009). Genotypic status of the TbAT1/P2 adenosine transporter of Trypanosoma brucei gambiense isolates from Northwestern Uganda following melarsoprol withdrawal. PLoS Neglected Tropical Diseases 3, e523.
Kellner, H. M., Eckert, H. G. and Volz, M. H. (1985). Studies in cattle on the disposition of the anti-trypanosomal drug diminazene diaceturate (Berenil). Tropical Medicine and Parasitology 36, 199204.
Kihurani, D. O., Nantulya, V. M., Mbiuki, S. M., Mogoa, E., Nguhiu-Mwangi, J. and Mbithi, P. M. (1994). Trypanosoma brucei, T. congolense and T. vivax infections in horses on a farm in Kenya. Tropical Animal Health and Production 26, 95101.
Kinabo, L. D. (1993). Pharmacology of existing drugs for animal trypanosomiasis. Acta Tropica 54, 169183.
Kinabo, L. D. and Bogan, J. A. (1988). The pharmacology of isometamidium. Journal of Veterinary Pharmacology and Therapeutics 11, 233245.
Knobloch, J., Tischendorf, F., Konig, J. and Mehlitz, D. (1984). Evaluation of immunoassays for diagnosis and management of sleeping sickness in Liberia. Tropenmedizin und Parasitologie 35, 137140.
Knoppe, T. N., Bauer, B., McDermott, J. J., Peregrine, A. S., Mehlitz, D. and Clausen, P. H. (2006). Isometamidium sensitivity of Trypanosoma congolense stocks from cattle in West Africa tested in mice and the drug incubation infectivity test. Acta Tropica 97, 108116.
Kocher, A., Desquesnes, M., Yangtara, S., Morand, S. and Jittapalapong, S. (2015). Is the oriental house rat (Rattus tanezumi) a potential reservoir for Trypanosoma evansi in Thailand? Journal of Wildlife Diseases 51, 719723.
Kroubi, M., Karembe, H. and Betbeder, D. (2011). Drug delivery systems in the treatment of African trypanosomiasis infections. Expert Opinion on Drug Delivery 8, 735747.
Kupper, W. and Wolters, M. (1983). Observation on drug resistance of Trypanosoma (Nannomonas) congolense and Trypanosoma (Duttonella) vivax in cattle at a feedlot in the Northern Ivory Coast. Tropenmedizin und Parasitologie 34, 203205.
Kuriakose, S., Muleme, H. M., Onyilagha, C., Singh, R., Jia, P. and Uzonna, J. E. (2012). Diminazene aceturate (Berenil) modulates the host cellular and inflammatory responses to Trypanosoma congolense infection. PLoS ONE 7, e48696.
La Greca, F. and Magez, S. (2011). Vaccination against trypanosomiasis: can it be done or is the trypanosome truly the ultimate immune destroyer and escape artist? Human Vaccines 7, 12251233.
Lai, D. H., Hashimi, H., Lun, Z. R., Ayala, F. J. and Lukes, J. (2008). Adaptations of Trypanosoma brucei to gradual loss of kinetoplast DNA: Trypanosoma equiperdum and Trypanosoma evansi are petite mutants of T. brucei . Proceedings of the National Academy of Sciences of the United States of America 105, 19992004.
Lanteri, C. A., Tidwell, R. R. and Meshnick, S. R. (2008). The mitochondrion is a site of trypanocidal action of the aromatic diamidine DB75 in bloodstream forms of Trypanosoma brucei . Antimicrobial Agents and Chemotherapy 52, 875882.
Leach, T. M. and Roberts, C. J. (1981). Present status of chemotherapy and chemoprophylaxis of animal trypanosomiasis in the Eastern hemisphere. Pharmacology & Therapeutics 13, 91147.
Liao, D. and Shen, J. (2010). Studies of quinapyramine-resistance of Trypanosoma brucei evansi in China. Acta Tropica 116, 173177.
Lindner, A. K. and Priotto, G. (2010). The unknown risk of vertical transmission in sleeping sickness–a literature review. PLoS Neglected Tropical Diseases 4, e783.
Livingstone, D. (1858). Arsenic as a remedy for the tsetse bite. British Medical Journal 1, 360361.
Luckins, A. G. (1988). Trypanosoma evansi in Asia. Parasitology Today 4, 137142.
Lun, Z. R., Fang, Y., Wang, C. J. and Brun, R. (1993). Trypanosomiasis of domestic animals in China. Parasitology Today 9, 4145.
Lun, Z. R., Lai, D. H., Li, F. J., Lukes, J. and Ayala, F. J. (2010). Trypanosoma brucei: two steps to spread out from Africa. Trends in Parasitology 26, 424427.
Magona, J. W., Walubengo, J. and Odimin, J. T. (2008). Acute haemorrhagic syndrome of bovine trypanosomosis in Uganda. Acta Tropica 107, 186191.
Maia da Silva, F., Marcili, A., Ortiz, P. A., Epiphanio, S., Campaner, M., Catao-Dias, J. L., Shaw, J. J., Camargo, E. P. and Teixeira, M. M. (2010). Phylogenetic, morphological and behavioural analyses support host switching of Trypanosoma (Herpetosoma) lewisi from domestic rats to primates. Infection, Genetics and Evolution 10, 522529.
Mamman, M., Aliu, Y. O. and Peregrine, A. S. (1993). Comparative pharmacokinetics of diminazene in noninfected Boran (Bos indicus) cattle and Boran cattle infected with Trypanosoma congolense . Antimicrobial Agents and Chemotherapy 37, 10501055.
Mamoudou, A., Delespaux, V., Chepnda, V., Hachimou, Z., Andrikaye, J. P., Zoli, A. and Geerts, S. (2008). Assessment of the occurrence of trypanocidal drug resistance in trypanosomes of naturally infected cattle in the Adamaoua region of Cameroon using the standard mouse test and molecular tools. Acta Tropica 106, 115118.
Masumu, J., Marcotty, T., Geysen, D., Geerts, S., Vercruysse, J., Dorny, P. and Van den Bossche, P. (2006). Comparison of the virulence of Trypanosoma congolense strains isolated from cattle in a trypanosomiasis endemic area of eastern Zambia. International Journal for Parasitology 36, 497501.
Mathis, A. M., Holman, J. L., Sturk, L. M., Ismail, M. A., Boykin, D. W., Tidwell, R. R. and Hall, J. E. (2006). Accumulation and intracellular distribution of antitrypanosomal diamidine compounds DB75 and DB820 in African trypanosomes. Antimicrobial Agents and Chemotherapy 50, 21852191.
Matovu, E., Stewart, M. L., Geiser, F., Brun, R., Maser, P., Wallace, L. J., Burchmore, R. J., Enyaru, J. C., Barrett, M. P., Kaminsky, R., Seebeck, T. and de Koning, H. P. (2003). Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei . Eukaryotic Cell 2, 10031008.
Mbwambo, H. A., Mella, P. N. and Lekaki, K. A. (1988). Berenil (diminazene aceturate)-resistant Trypanosoma congolense in cattle under natural tsetse challenge at Kibaha, Tanzania. Acta Tropica 45, 239244.
McCall, J. W., McTier, T. L., Dzimianski, M. T., Raynaud, J. P. and Holmes, R. A. (1994). Clinical prophylactic activity of melarsomine dihydrochloride (RM 340) against Dirofilaria immitis in heartworm-naive beagles exposed to natural infection in three southeastern states. Veterinary Parasitology 55, 205219.
Mdachi, R. E., Murilla, G. A., Omukuba, J. N. and Cagnolati, V. (1995). Disposition of diminazene aceturate (Berenil) in trypanosome-infected pregnant and lactating cows. Veterinary Parasitology 58, 215225.
Mehlitz, D., Zillmann, U., Scott, C. M. and Godfrey, D. G. (1982). Epidemiological studies on the animal reservoir of Gambiense sleeping sickness. Part III. Characterization of trypanozoon stocks by isoenzymes and sensitivity to human serum. Tropenmedizin und Parasitologie 33, 113118.
Melendez, R. D., Forlano, M. and Figueroa, W. (1993). Perinatal infection with Trypanosoma vivax in a calf in Venezuela. Journal of Parasitology 79, 293294.
Moloo, S. K., Kabata, J. M. and Gitire, N. M. (2000). Study on the mechanical transmission by tsetse fly Glossina morsitans centralis of Trypanosoma vivax, T. congolense or T. brucei brucei to goats. Acta Tropica 74, 105108.
Moti, Y., Fikru, R., Van Den Abbeele, J., Buscher, P., Van den Bossche, P., Duchateau, L. and Delespaux, V. (2012). Ghibe river basin in Ethiopia: present situation of trypanocidal drug resistance in Trypanosoma congolense using tests in mice and PCR–RFLP. Veterinary Parasitology 189, 197203.
Moti, Y., De Deken, R., Thys, E., Van Den Abbeele, J., Duchateau, L. and Delespaux, V. (2015). PCR and microsatellite analysis of diminazene aceturate resistance of bovine trypanosomes correlated to knowledge, attitude and practice of livestock keepers in South-Western Ethiopia. Acta Tropica 146, 4552.
Moulton, J. E. (1986). Relapse infection after chemotherapy in goats experimentally infected with Trypanosoma brucei: pathological changes in central nervous system. Veterinary Pathology 23, 2128.
Mulla, A. F. and Rickman, L. R. (1988). How do African game animals control trypanosome infections? Parasitology Today 4, 352354.
Munday, J. C., Rojas Lopez, K. E., Eze, A. A., Delespaux, V., Van Den Abbeele, J., Rowan, T., Barrett, M. P., Morrison, L. J. and de Koning, H. P. (2013). Functional expression of TcoAT1 reveals it to be a P1-type nucleoside transporter with no capacity for diminazene uptake. International Journal for Parasitology: Drugs and Drug Resistance 3, 6976.
Munday, J. C., Eze, A. A., Baker, N., Glover, L., Clucas, C., Aguinaga, A. D., Natto, M. J., Teka, I. A., McDonald, J., Lee, R. S., Graf, F. E., Ludin, P., Burchmore, R. J., Turner, C. M., Tait, A., MacLeod, A., Maser, P., Barrett, M. P., Horn, D. and de Koning, H. P. (2014). Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs. Journal of Antimicrobial Chemotherapy 69, 651663.
Munday, J. C., Settimo, L. and de Koning, H. P. (2015 a). Transport proteins determine drug sensitivity and resistance in a protozoan parasite, Trypanosoma brucei . Frontiers in Pharmacology 6, 32.
Munday, J. C., Tagoe, D. N., Eze, A. A., Krezdorn, J. A., Rojas Lopez, K. E., Alkhaldi, A. A., McDonald, F., Still, J., Alzahrani, K. J., Settimo, L. and de Koning, H. P. (2015 b). Functional analysis of drug resistance-associated mutations in the Trypanosoma brucei adenosine transporter 1 (TbAT1) and the proposal of a structural model for the protein. Molecular Microbiology 96, 887900.
Mungube, E. O., Vitouley, H. S., Allegye-Cudjoe, E., Diall, O., Boucoum, Z., Diarra, B., Sanogo, Y., Randolph, T., Bauer, B., Zessin, K. H. and Clausen, P. H. (2012). Detection of multiple drug-resistant Trypanosoma congolense populations in village cattle of south-east Mali. Parasites & Vectors 5, 155.
Munstermann, S., Mbura, R. J., Maloo, S. H. and Lohr, K. F. (1992). Trypanosomiasis control in Boran cattle in Kenya: a comparison between chemoprophylaxis and a parasite detection and intravenous treatment method using isometamidium chloride. Tropical Animal Health and Production 24, 1727.
Murilla, G. A., Mdachi, R. E., Ismail, A. A. and Karanja, W. M. (1996). Bioavailability, pharmacokinetics, and tissue distribution of 14C homidium after parenteral administration to Boran cattle. Journal of Veterinary Pharmacology and Therapeutics 19, 142148.
Murilla, G. A., Holmes, P. H., Peregrine, A. S., Eisler, M. C. and Ndung'u, J. M. (1999). Some pharmacokinetic parameters of the trypanocidal drug homidium bromide in Friesian and Boran steers using an enzyme-linked immunosorbent assay (ELISA). Journal of Veterinary Pharmacology and Therapeutics 22, 295300.
Murray, M., Morrison, W. I. and Whitelaw, D. D. (1982). Host susceptibility to African trypanosomiasis: trypanotolerance. Advances in Parasitology 21, 168.
Mutugi, M. W., Boid, R. and Luckins, A. G. (1994). Experimental induction of suramin-resistance in cloned and uncloned stocks of Trypanosoma evansi using immunosuppressed and immunocompetent mice. Tropical Medicine and Parasitology 45, 232236.
Myburgh, E., Coles, J. A., Ritchie, R., Kennedy, P. G., McLatchie, A. P., Rodgers, J., Taylor, M. C., Barrett, M. P., Brewer, J. M. and Mottram, J. C. (2013). In vivo imaging of trypanosome-brain interactions and development of a rapid screening test for drugs against CNS stage trypanosomiasis. PLoS Neglected Tropical Diseases 7, e2384.
Naessens, J. (2006). Bovine trypanotolerance: a natural ability to prevent severe anaemia and haemophagocytic syndrome? International Journal for Parasitology 36, 521528.
Nare, B., Wring, S., Bacchi, C., Beaudet, B., Bowling, T., Brun, R., Chen, D., Ding, C., Freund, Y., Gaukel, E., Hussain, A., Jarnagin, K., Jenks, M., Kaiser, M., Mercer, L., Mejia, E., Noe, A., Orr, M., Parham, R., Plattner, J., Randolph, R., Rattendi, D., Rewerts, C., Sligar, J., Yarlett, N., Don, R. and Jacobs, R. (2010). Discovery of novel orally bioavailable oxaborole 6-carboxamides that demonstrate cure in a murine model of late-stage central nervous system African trypanosomiasis. Antimicrobial Agents and Chemotherapy 54, 43794388.
Ndoutamia, G., Moloo, S. K., Murphy, N. B. and Peregrine, A. S. (1993). Derivation and characterization of a quinapyramine-resistant clone of Trypanosoma congolense . Antimicrobial Agents and Chemotherapy 37, 11631166.
Newton, B. A. (1962). Inactivation of ribosomes by antrycide. Biochemical Journal 84, 109.
Newton, B. A. (1966). Effects of antrycide on nucleic acid synthesis and function. Symposium of the Society for General Microbiology 16, 213234.
Osman, A. S., Jennings, F. W. and Holmes, P. H. (1992). The rapid development of drug-resistance by Trypanosoma evansi in immunosuppressed mice. Acta Tropica 50, 249257.
Osorio, A. L., Madruga, C. R., Desquesnes, M., Soares, C. O., Ribeiro, L. R. and Costa, S. C. (2008). Trypanosoma (Duttonella) vivax: its biology, epidemiology, pathogenesis, and introduction in the New World–a review. Memórias do Instituto Oswaldo Cruz 103, 113.
Paine, M. F., Wang, M. Z., Generaux, C. N., Boykin, D. W., Wilson, W. D., de Koning, H. P., Olson, C. A., Pohlig, G., Burri, C., Brun, R., Murilla, G. A., Thuita, J. K., Barrett, M. P. and Tidwell, R. R. (2010). Diamidines for human African trypanosomiasis. Current Opinion in Investigational Drugs 11, 876883.
Pal, A., Hall, B. S. and Field, M. C. (2002). Evidence for a non-LDL-mediated entry route for the trypanocidal drug suramin in Trypanosoma brucei . Molecular and Biochemical Parasitology 122, 217221.
Pascucci, I., Di Provvido, A., Camma, C., Di Francesco, G., Calistri, P., Tittarelli, M., Ferri, N., Scacchia, M. and Caporale, V. (2013). Diagnosis of dourine in outbreaks in Italy. Veterinary Parasitology 193, 3038.
Payne, R. C., Sukanto, I. P., Djauhari, D., Partoutomo, S., Wilson, A. J., Jones, T. W., Boid, R. and Luckins, A. G. (1991). Trypanosoma evansi infection in cattle, buffaloes and horses in Indonesia. Veterinary Parasitology 38, 109119.
Payne, R. C., Sukanto, I. P., Partoutomo, S. and Jones, T. W. (1994). Efficacy of Cymelarsan treatment of suramin resistant Trypanosoma evansi in cattle. Tropical Animal Health and Production 26, 9294.
Pepin, J. and Khonde, N. (1996). Relapses following treatment of early-stage Trypanosoma brucei gambiense sleeping sickness with a combination of pentamidine and suramin. Transactions of the Royal Society of Tropical Medicine and Hygiene 90, 183186.
Peregrine, A. S. (1994). Chemotherapy and delivery systems: haemoparasites. Veterinary Parasitology 54, 223248.
Peregrine, A. S. and Mamman, M. (1993). Pharmacology of diminazene: a review. Acta Tropica 54, 185203.
Peregrine, A. S., Gray, M. A. and Moloo, S. K. (1997). Cross-resistance associated with development of resistance to isometamidium in a clone of Trypanosoma congolense . Antimicrobial Agents and Chemotherapy 41, 16041606.
Pinder, M. and Authie, E. (1984). The appearance of isometamidium resistant Trypanosoma congolense in West Africa. Acta Tropica 41, 247252.
Portugal, J. (1994). Berenil acts as a poison of eukaryotic topoisomerase II. FEBS Letters 344, 136138.
Pospichal, H., Brun, R., Kaminsky, R. and Jenni, L. (1994). Induction of resistance to melarsenoxide cysteamine (Mel Cy) in Trypanosoma brucei brucei . Acta Tropica 58, 187197.
Priotto, G., Kasparian, S., Mutombo, W., Ngouama, D., Ghorashian, S., Arnold, U., Ghabri, S., Baudin, E., Buard, V., Kazadi-Kyanza, S., Ilunga, M., Mutangala, W., Pohlig, G., Schmid, C., Karunakara, U., Torreele, E. and Kande, V. (2009). Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial. Lancet 374, 5664.
Pumhom, P., Morand, S., Tran, A., Jittapalapong, S. and Desquesnes, M. (2015). Trypanosoma from rodents as potential source of infection in human-shaped landscapes of South-East Asia. Veterinary Parasitology 208, 174180.
Ranjithkumar, M., Saravanan, B. C., Yadav, S. C., Kumar, R., Singh, R. and Dey, S. (2014). Neurological trypanosomiasis in quinapyramine sulfate-treated horses-a breach of the blood–brain barrier? Tropical Animal Health and Production 46, 371377.
Räz, B., Iten, M., Grether-Buhler, Y., Kaminsky, R. and Brun, R. (1997). The Alamar Blue® assay to determine drug sensitivity of African trypanosomes (T. b. rhodesiense and T.b. gambiense) in vitro . Acta Tropica 68, 139147.
Reid, S. A. (2002). Trypanosoma evansi control and containment in Australasia. Trends in Parasitology 18, 219224.
Riou, G. F., Belnat, P. and Benard, J. (1980). Complete loss of kinetoplast DNA sequences induced by ethidium bromide or by acriflavine in Trypanosoma equiperdum . Journal of Biological Chemistry 255, 51415144.
Rowlands, G. J., Leak, S. G., Peregrine, A. S., Nagda, S. M., Mulatu, W. and d'Ieteren, G. D. (2001). The incidence of new and the prevalence and persistence of recurrent trypanosome infections in cattle in southwest Ethiopia exposed to a high challenge with drug-resistant parasites. Acta Tropica 79, 149163.
Roy Chowdhury, A., Bakshi, R., Wang, J., Yildirir, G., Liu, B., Pappas-Brown, V., Tolun, G., Griffith, J. D., Shapiro, T. A., Jensen, R. E. and Englund, P. T. (2010). The killing of African trypanosomes by ethidium bromide. PLoS Pathogens 6, e1001226.
Sahin, A., Asencio, C., Izotte, J., Pillay, D., Coustou, V., Karembe, H. and Baltz, T. (2014). The susceptibility of Trypanosoma congolense and Trypanosoma brucei to isometamidium chloride and its synthetic impurities. Veterinary Parasitology 203, 270275.
Salim, B., Bakheit, M. A. and Sugimoto, C. (2014). Molecular detection of equine trypanosomes in the Sudan. Veterinary Parasitology 200, 246250.
Sanderson, L., Dogruel, M., Rodgers, J., De Koning, H. P. and Thomas, S. A. (2009). Pentamidine movement across the murine blood-brain and blood-cerebrospinal fluid barriers: effect of trypanosome infection, combination therapy, P-glycoprotein, and multidrug resistance-associated protein. Journal of Pharmacology and Experimental Therapeutics 329, 967977.
Sarataphan, N., Vongpakorn, M., Nuansrichay, B., Autarkool, N., Keowkarnkah, T., Rodtian, P., Stich, R. W. and Jittapalapong, S. (2007). Diagnosis of a Trypanosoma lewisi-like (Herpetosoma) infection in a sick infant from Thailand. Journal of Medical Microbiology 56, 11181121.
Schnaufer, A., Domingo, G. J. and Stuart, K. (2002). Natural and induced dyskinetoplastic trypanosomatids: how to live without mitochondrial DNA. International Journal for Parasitology 32, 10711084.
Schumann, B. G., Jutzi, P. and Roditi, I. (2011). Genome-wide RNAi screens in bloodstream form trypanosomes identify drug transporters. Molecular and Biochemical Parasitology 175, 9194.
Scott, A. G., Tait, A. and Turner, C. M. (1996). Characterisation of cloned lines of Trypanosoma brucei expressing stable resistance to MelCy and suramin. Acta Tropica 60, 251262.
Seidl, A., Moraes, A. S., Aguilar, R. and Silva, M. S. (1998). A financial analysis of treatment strategies for Trypanosoma evansi in the Brazilian Pantanal. Preventive Veterinary Medicine 33, 219234.
Seidl, A., Davila, A. M. and Silva, R. A. (1999). Estimated financial impact of Trypanosoma vivax on the Brazilian pantanal and Bolivian lowlands. Memórias do Instituto Oswaldo Cruz 94, 269272.
Shameer, S., Logan-Klumpler, F. J., Vinson, F., Cottret, L., Merlet, B., Achcar, F., Boshart, M., Berriman, M., Breitling, R., Bringaud, F., Butikofer, P., Cattanach, A. M., Bannerman-Chukualim, B., Creek, D. J., Crouch, K., de Koning, H. P., Denise, H., Ebikeme, C., Fairlamb, A. H., Ferguson, M. A., Ginger, M. L., Hertz-Fowler, C., Kerkhoven, E. J., Maser, P., Michels, P. A., Nayak, A., Nes, D. W., Nolan, D. P., Olsen, C., Silva-Franco, F. et al. (2015). TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei . Nucleic Acids Research 43, D637D644.
Shapiro, T. A. and Englund, P. T. (1990). Selective cleavage of kinetoplast DNA minicircles promoted by antitrypanosomal drugs. Proceedings of the National Academy of Sciences of the United States of America 87, 950954.
Shaw, A. P., Cecchi, G., Wint, G. R., Mattioli, R. C. and Robinson, T. P. (2014). Mapping the economic benefits to livestock keepers from intervening against bovine trypanosomosis in Eastern Africa. Preventive Veterinary Medicine 113, 197210.
Shaw, A. P., Wint, G. R., Cecchi, G., Torr, S. J., Mattioli, R. C. and Robinson, T. P. (2015). Mapping the benefit-cost ratios of interventions against bovine trypanosomosis in Eastern Africa. Preventive Veterinary Medicine 122, 406416.
Simarro, P. P., Franco, J., Diarra, A., Postigo, J. A. and Jannin, J. (2012). Update on field use of the available drugs for the chemotherapy of human African trypanosomiasis. Parasitology 139, 842846.
Simo, G. and Rayaisse, J. B. (2015). Challenges facing the elimination of sleeping sickness in west and central Africa: sustainable control of animal trypanosomiasis as an indispensable approach to achieve the goal. Parasites & Vectors 8, 640.
Singla, L. D., Juyal, P. D. and Sharma, N. S. (2010). Immune responses to haemorrhagic septicaemia (HS) vaccination in Trypanosoma evansi infected buffalo-calves. Tropical Animal Health and Production 42, 589595.
Sinyangwe, L., Delespaux, V., Brandt, J., Geerts, S., Mubanga, J., Machila, N., Holmes, P. H. and Eisler, M. C. (2004). Trypanocidal drug resistance in eastern province of Zambia. Veterinary Parasitology 119, 125135.
Song, J., Baker, N., Rothert, M., Henke, B., Jeacock, L., Horn, D. and Beitz, E. (2016). Pentamidine is not a permeant but a nanomolar inhibitor of the Trypanosoma brucei aquaglyceroporin-2. PLoS Pathogens 12, e1005436.
Spinks, A. (1950). Absorption and persistence of antrycide. British Journal of Pharmacology and Chemotherapy 5, 445454.
Steinmann, P., Stone, C. M., Sutherland, C. S., Tanner, M. and Tediosi, F. (2015). Contemporary and emerging strategies for eliminating human African trypanosomiasis due to Trypanosoma brucei gambiense: review. Tropical Medicine & International Health 20, 707718.
Stephen, L. E. (1966). Pig Trypanosomiasis in Tropical Africa. In Review Series of the Commonwealth Bureau of Animal Health, Vol. 8. Commonwealth Agricultural Bureaux, Farnham House, Farnham Royal, Bucks, UK.
Stevenson, P., Sones, K. R., Gicheru, M. M. and Mwangi, E. K. (1995). Comparison of isometamidium chloride and homidium bromide as prophylactic drugs for trypanosomiasis in cattle at Nguruman, Kenya. Acta Tropica 59, 7784.
Steverding, D. (2008). The history of African trypanosomiasis. Parasites & Vectors 1, 3.
Steverding, D. (2010). The development of drugs for treatment of sleeping sickness: a historical review. Parasites & Vectors 3, 15.
Stewart, M. L., Krishna, S., Burchmore, R. J., Brun, R., de Koning, H. P., Boykin, D. W., Tidwell, R. R., Hall, J. E. and Barrett, M. P. (2005). Detection of arsenical drug resistance in Trypanosoma brucei with a simple fluorescence test. Lancet 366, 486487.
Stewart, M. L., Burchmore, R. J., Clucas, C., Hertz-Fowler, C., Brooks, K., Tait, A., MacLeod, A., Turner, C. M., de Koning, H. P., Wong, P. E. and Barrett, M. P. (2010). Multiple genetic mechanisms lead to loss of functional TbAT1 expression in drug-resistant trypanosomes. Eukaryotic Cell 9, 336343.
Suswam, E. A., Ross, C. A. and Martin, R. J. (2003). Changes in adenosine transport associated with melaminophenyl arsenical (Mel CY) resistance in Trypanosoma evansi: down-regulation and affinity changes of the P2 transporter. Parasitology 127, 543549.
Suswam, E. A., Taylor, D. W., Ross, C. A. and Martin, R. J. (2001). Changes in properties of adenosine transporters in Trypanosoma evansi and modes of selection of resistance to the melaminophenyl arsenical drug, Mel Cy. Veterinary Parasitology 102, 193208.
Sutcliffe, O. B., Skellern, G. G., Araya, F., Cannavan, A., Sasanya, J. J., Dungu, B., van Gool, F., Munstermann, S. and Mattioli, R. C. (2014). Animal trypanosomosis: making quality control of trypanocidal drugs possible. Revue Scientifique et Technique (International Office of Epizootics) 33, 813830.
Sutherland, I. A. and Holmes, P. H. (1993). Alterations in drug transport in resistant Trypanosoma congolense . Acta Tropica 54, 271278.
Sutherland, I. A., Mounsey, A. and Holmes, P. H. (1992). Transport of isometamidium (Samorin) by drug-resistant and drug-sensitive Trypanosoma congolense . Parasitology 104 (Pt 3), 461467.
Swallow, B. M. (2000). Impacts of Trypanosomiasis on African Agriculture. PAAT Technical and Scientific Series No. 2. Food and Agriculture Organisation of the United Nations (FAO), Rome, Italy.
Takeet, M. I., Fagbemi, B. O., De Donato, M., Yakubu, A., Rodulfo, H. E., Peters, S. O., Wheto, M. and Imumorin, I. G. (2013). Molecular survey of pathogenic trypanosomes in naturally infected Nigerian cattle. Research in Veterinary Science 94, 555561.
Tamarit, A., Gutierrez, C., Arroyo, R., Jimenez, V., Zagala, G., Bosch, I., Sirvent, J., Alberola, J., Alonso, I. and Caballero, C. (2010). Trypanosoma evansi infection in mainland Spain. Veterinary Parasitology 167, 7476.
Tamarit, A., Tejedor-Junco, M. T., Gonzalez, M., Alberola, J. and Gutierrez, C. (2011). Morphological and biometrical features of Trypanosoma evansi isolates from an outbreak in mainland Spain. Veterinary Parasitology 177, 152156.
Taylor, K. and Authié, E. M.-L. (2004). Pathogenesis of animal trypanosomiasis. In The Trypanosomiases (ed. Maudlin, I., Holmes, P. H. and Miles, M. A.), pp. 331353. CAB International, Wallingford, UK.
Tchamdja, E., Kulo, A. E., Akoda, K., Teko-Agbo, A., Assoumy, A. M., Niang, E. M., Batawui, K., Adomefa, K., Bankole, A. A., Kombiagou, K., Hoppenheit, A., Clausen, P. H., Mattioli, R. C., Peter, R., Napier, G. B., De Deken, R., Marcotty, T., Van Den Abbeele, J. and Delespaux, V. (2016). Drug quality analysis through high performance liquid chromatography of isometamidium chloride hydrochloride and diminazene diaceturate purchased from official and unofficial sources in Northern Togo. Preventive Veterinary Medicine 126, 151158.
Teka, I. A., Kazibwe, A. J., El-Sabbagh, N., Al-Salabi, M. I., Ward, C. P., Eze, A. A., Munday, J. C., Maser, P., Matovu, E., Barrett, M. P. and de Koning, H. P. (2011). The diamidine diminazene aceturate is a substrate for the high-affinity pentamidine transporter: implications for the development of high resistance levels in trypanosomes. Molecular Pharmacology 80, 110116.
Toro, M., Leon, E., Lopez, R., Pallota, F., Garcia, J. A. and Ruiz, A. (1983). Effect of isometamidium on infections by Trypanosoma vivax and T. evansi in experimentally-infected animals. Veterinary Parasitology 13, 3543.
Tran, T., Napier, G., Rowan, T., Cordel, C., Labuschagne, M., Delespaux, V., Van Reet, N., Erasmus, H., Joubert, A. and Buscher, P. (2014). Development and evaluation of an ITS1 “Touchdown” PCR for assessment of drug efficacy against animal African trypanosomosis. Veterinary Parasitology 202, 164170.
Truc, P., Buscher, P., Cuny, G., Gonzatti, M. I., Jannin, J., Joshi, P., Juyal, P., Lun, Z. R., Mattioli, R., Pays, E., Simarro, P. P., Teixeira, M. M., Touratier, L., Vincendeau, P. and Desquesnes, M. (2013). Atypical human infections by animal trypanosomes. PLoS Neglected Tropical Diseases 7, e2256.
Tuntasuvan, D., Sarataphan, N. and Nishikawa, H. (1997). Cerebral trypanosomiasis in native cattle. Veterinary Parasitology 73, 357363.
Tuntasuvan, D., Jarabrum, W., Viseshakul, N., Mohkaew, K., Borisutsuwan, S., Theeraphan, A. and Kongkanjana, N. (2003). Chemotherapy of surra in horses and mules with diminazene aceturate. Veterinary Parasitology 110, 227233.
Uilenberg, G. (1998). A Field Guide for the Diagnosis, Treatment, and Prevention of African Animal Trypanosomosis. Food and Agriculture Organisation of the United Nations (FAO), Rome, Italy.
Unciti-Broceta, J. D., Arias, J. L., Maceira, J., Soriano, M., Ortiz-Gonzalez, M., Hernandez-Quero, J., Munoz-Torres, M., de Koning, H. P., Magez, S. and Garcia-Salcedo, J. A. (2015). Specific cell targeting therapy bypasses drug resistance mechanisms in African trypanosomiasis. PLoS Pathogens 11, e1004942.
Van den Bossche, P. and Delespaux, V. (2011). Options for the control of tsetse-transmitted livestock trypanosomosis. An epidemiological perspective. Veterinary Parasitology 181, 37–2.
Van den Bossche, P., Doran, M. and Connor, R. J. (2000). An analysis of trypanocidal drug use in the Eastern Province of Zambia. Acta Tropica 75, 247258.
Vanhollebeke, B., Truc, P., Poelvoorde, P., Pays, A., Joshi, P. P., Katti, R., Jannin, J. G. and Pays, E. (2006). Human Trypanosoma evansi infection linked to a lack of apolipoprotein L-I. New England Journal of Medicine 355, 27522756.
Vansterkenburg, E. L., Coppens, I., Wilting, J., Bos, O. J., Fischer, M. J., Janssen, L. H. and Opperdoes, F. R. (1993). The uptake of the trypanocidal drug suramin in combination with low-density lipoproteins by Trypanosoma brucei and its possible mode of action. Acta Tropica 54, 237250.
Van Vinh, C. N., Buu, C. L., Desquesnes, M., Herder, S., Phu Huong, L. N., Campbell, J. I., Van Cuong, N., Yimming, B., Chalermwong, P., Jittapalapong, S., Ramon Franco, J., Tri Tue, N., Rabaa, M. A., Carrique-Mas, J., Pham Thi Thanh, T., Tran Vu Thieu, N., Berto, A., Thi Hoa, N., Van Minh Hoang, N., Canh Tu, N., Khac Chuyen, N., Wills, B., Tinh Hien, T., Thwaites, G. E., Yacoub, S. and Baker, S. (2016). A clinical and epidemiological investigation of the first reported human infection with the zoonotic parasite Trypanosoma evansi in Southeast Asia. Clinical Research in Infectious Diseases 62, 10021008.
Vincent, I. M., Creek, D., Watson, D. G., Kamleh, M. A., Woods, D. J., Wong, P. E., Burchmore, R. J. and Barrett, M. P. (2010). A molecular mechanism for eflornithine resistance in African trypanosomes. PLoS Pathogens 6, e1001204.
Vitouley, H. S., Sidibe, I., Bengaly, Z., Marcotty, T., Van Den Abbeele, J. and Delespaux, V. (2012). Is trypanocidal drug resistance a threat for livestock health and production in endemic areas? Food for thoughts from Sahelian goats infected by Trypanosoma vivax in Bobo Dioulasso (Burkina Faso). Veterinary Parasitology 190, 349354.
Voogd, T. E., Vansterkenburg, E. L., Wilting, J. and Janssen, L. H. (1993). Recent research on the biological activity of suramin. Pharmacological Reviews 45, 177203.
Wainwright, M. (2010). Dyes, trypanosomiasis and DNA: a historical and critical review. Biotechnic & Histochemistry 85, 341354.
Welburn, S. C., Beange, I., Ducrotoy, M. J. and Okello, A. L. (2015). The neglected zoonoses–the case for integrated control and advocacy. Clinical Microbiology and Infection 21, 433443.
Wellde, B. T., Chumo, D. A., Adoyo, M., Kovatch, R. M., Mwongela, G. N. and Opiyo, E. A. (1983). Haemorrhagic syndrome in cattle associated with Trypanosoma vivax infection. Tropical Animal Health and Production 15, 95102.
Wenzler, T., Yang, S., Braissant, O., Boykin, D. W., Brun, R. and Wang, M. Z. (2013). Pharmacokinetics, Trypanosoma brucei gambiense efficacy, and time of drug action of DB829, a preclinical candidate for treatment of second-stage human African trypanosomiasis. Antimicrobial Agents Chemotherapy 57, 53305343.
Wesongah, J. O., Jones, T. W., Kibugu, J. K. and Murilla, G. A. (2004). A comparative study of the pharmacokinetics of isometamidium chloride in sheep and goats. Small Ruminant Research 53, 914.
Whitelaw, D. D., Gardiner, P. R. and Murray, M. (1988). Extravascular foci of Trypanosoma vivax in goats: the central nervous system and aqueous humor of the eye as potential sources of relapse infections after chemotherapy. Parasitology 97 (Pt 1), 5161.
Wilkes, J. M., Peregrine, A. S. and Zilberstein, D. (1995). The accumulation and compartmentalization of isometamidium chloride in Trypanosoma congolense, monitored by its intrinsic fluorescence. The Biochemical Journal 312 (Pt 1), 319327.
Wilkes, J. M., Mulugeta, W., Wells, C. and Peregrine, A. S. (1997). Modulation of mitochondrial electrical potential: a candidate mechanism for drug resistance in African trypanosomes. Biochemical Journal 326 (Pt 3), 755761.
Williamson, J. (1970). Review of chemotherapeutic and chemoprophylactic agents. In The African Trypanosomiases (ed. Mulligan, H. W.), pp. 125221. George Allen and Unwin Ltd., London.
Williamson, J. and Desowitz, R. S. (1956). Prophylactic activity of suramin complexes in animal trypanosomiasis. Nature 177, 10741075.
Wilson, W. D., Tanious, F. A., Mathis, A., Tevis, D., Hall, J. E. and Boykin, D. W. (2008). Antiparasitic compounds that target DNA. Biochimie 90, 9991014.
Witola, W. H., Inoue, N., Ohashi, K. and Onuma, M. (2004). RNA-interference silencing of the adenosine transporter-1 gene in Trypanosoma evansi confers resistance to diminazene aceturate. Experimental Parasitology 107, 4757.
Witola, W. H., Tsuda, A., Inoue, N., Ohashi, K. and Onuma, M. (2005). Acquired resistance to berenil in a cloned isolate of Trypanosoma evansi is associated with upregulation of a novel gene, TeDR40. Parasitology 131, 635646.
Zhang, Z. Q., Giroud, C. and Baltz, T. (1991). In vivo and in vitro sensitivity of Trypanosoma evansi and T. equiperdum to diminazene, suramin, MelCy, quinapyramine and isometamidium. Acta Tropica 50, 101110.
Zhou, J., Shen, J., Liao, D., Zhou, Y. and Lin, J. (2004). Resistance to drug by different isolates Trypanosoma evansi in China. Acta Tropica 90, 271275.
Zweygarth, E., Gray, M. A. and Kaminsky, R. (1991). Axenic in vitro cultivation of Trypanosoma vivax trypomastigote forms. Tropical Medicine and Parasitology 42, 4548.
Zweygarth, E., Moloo, S. K., Kaminsky, R. and Gray, M. A. (1992). Axenic in vitro cultivation of Trypanosoma simiae bloodstream trypomastigotes. Acta Tropica 52, 7981.