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Immune responses during the acute stages of infection with the intestinal trematode Echinostoma caproni

Published online by Cambridge University Press:  01 June 2000

L. R. BRUNET
Affiliation:
Department of Pathology, Cambridge University, Tennis Court Road, Cambridge CB2 1QP, UK
S. JOSEPH
Affiliation:
Department of Pathology, Cambridge University, Tennis Court Road, Cambridge CB2 1QP, UK
D. W. DUNNE
Affiliation:
Department of Pathology, Cambridge University, Tennis Court Road, Cambridge CB2 1QP, UK
B. FRIED
Affiliation:
Department of Biology, Lafayette College, Easton, PA 18042, USA

Abstract

This study investigated the nature of the immune response of C57BL/6 mice infected with the trematode Echinostoma caproni. To determine the preferential development of either a Th1 or Th2 cytokine pattern during early stages of infection, cytokine production by spleen and mesenteric lymph node (MLN) cells during the first 3 weeks of infection was followed. Whereas spleen cells failed to respond to antigen stimulation, MLN cells produced IFN-γ and to a lesser extent IL-4. IL-5 levels were elevated throughout the period studied. The humoral response was consistent with a Th1 cytokine pattern as antigen-specific IgG2a antibodies were preferentially developed. We investigated whether IFN-γ is critical for establishment of E. caproni infection. Worm burden in infected mice treated with a single injection of anti-IFN-γ mAb was significantly reduced compared to that of animals treated with a control antibody.

Type
Research Article
Copyright
2000 Cambridge University Press

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