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Host protective humoral immune responses to Schistosoma mansoni infections in the rat. Kinetics of hyperimmune serum-dependent sensitivity and elimination of schistosomes in a passive transfer system

Published online by Cambridge University Press:  06 April 2009


Beverley L. Mangold
Affiliation:
Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912
P. M. Knopf
Affiliation:
Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912

Summary

A passive transfer system, dependent upon hyperimmune rat serum, was used to study in vivo protective humoral immunity to Schistosoma mansoni infection in Fischer rats. Infected recipients of hyperimmune serum exhibited a significant reduction (51%) in the number of recovered adult schistosomes relative to infected recipients of normal rat serum. Furthermore, schistosomula were equally sensitive to the effects of hyperimmune serum injected up to and including 7 days post-infection, a phenomenon which was termed ‘extended sensitivity’. Schistosomula were beginning to lose sensitivity to the effects of hyperimmune serum by the 8th day post-infection and were completely refractile by the 9th day. In addition, it was demonstrated that parasite elimination occurred after the lung stage. Some protection was also observed when hyperimmune rat serum was transferred to mice as late as 5 days post-infection.


Type
Research Article
Copyright
Copyright © Cambridge University Press 1981

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References

Blum, K. & Cioli, D. (1981). Schistosoma mansoni: age-dependent susceptibility to immune elimination of schistosomula artificially introduced into pre-infected mice. Parasite Immunology (in the Press).CrossRefGoogle Scholar
Butterworth, A. E. (1977). Effector mechanisms against schistosomes in vitro. American Journal of Tropical Medicine and Hygiene 26, 2938.CrossRefGoogle ScholarPubMed
Cioli, D., Knopf, P. M. & Senft, A. W. (1977). A study of Schistosoma mansoni transferred into permissive and nonpermissive hosts. International Journal for Parasitology 7, 293–7.CrossRefGoogle ScholarPubMed
Dean, D. A., Minard, P., Murrell, K. D. & Vannier, W. E. (1978). Resistance of mice to secondary infection with Schistosoma mansoni. II. Evidence for a correlation between egg deposition and worm elimination. American Journal of Tropical Medicine and Hygiene 27, 957–65.CrossRefGoogle Scholar
Goldring, O. L., Sher, A., Smithers, S. R. & McLaren, D. J. (1977). Host antigens and parasite antigens of murine Schistosoma mansoni. Transactions of the Royal Society of Tropical Medicine and Hygiene 71, 144–8.CrossRefGoogle ScholarPubMed
Knopf, P. M., Nutman, T. B. & Reasoner, J. A. (1977). Schistosoma mansoni: resistance to reinfection in the rat. Experimental Parasitology 41, 7482.CrossRefGoogle ScholarPubMed
Maddison, S. E. & Kagan, I. G. (1979). Adoptive transfer of protective immunity in experimental schistosomiasis in the mouse. Journal of Parasitology 65, 515–19.CrossRefGoogle ScholarPubMed
Mangold, B. L. & Knopf, P. M. (1978). The effect of assay conditions on the recovery of schistosomula from the lungs of normal and resistant rats infected with Schistosoma mansoni. Journal of Parasitology 64, 813–21.CrossRefGoogle ScholarPubMed
McLaren, D. J., Clegg, J. A. & Smithers, S. R. (1975). Acquisition of host antigens by young Schistosoma mansoni in mice: correlation with failure to bind antibody in vitro. Parasitology 70, 6775.CrossRefGoogle ScholarPubMed
Perez, H., Clegg, J. A. & Smithers, S. R. (1974). Acquired immunity to Schistosoma mansoni in the rat: measurement of immunity by the lung recovery technique. Parasitology 69, 349–59.CrossRefGoogle ScholarPubMed
Phillips, S. M. & Colley, D. G. (1978). Immunologic aspects of host responses to schistosomiasis: resistance, immunopathology and eosinophil involvement. Progress in Allergy 24, 49182.Google ScholarPubMed
Phillips, S. M., Reid, W. A., Bruce, J. I., Hedlund, K., Colvin, R. C., Campbell, R., Diggs, C. L. & Sadun, E. H. (1975). The cellular and humoral immune response to Schistosoma mansoni infection in inbred rat. I. Mechanism during initial exposure. Cell Immunology 19, 99116.CrossRefGoogle Scholar
Phillips, S. M., Reid, W. A. & Sadun, E. H. (1977). The cellular and humoral immune response to Schistosoma mansoni infections in inbred rats. II. Mechanisms during reexposure. Cell Immunology 28, 7589.CrossRefGoogle ScholarPubMed
Sher, A., MacKenzie, P. & Smithers, S. R. (1974). Decreased recovery of invading parasites from the lungs as a parameter of acquired immunity to schistosomiasis in the mouse. Journal of Infectious Diseases 130, 626–33.CrossRefGoogle ScholarPubMed
Sher, A., Smithers, S. R. & MacKenzie, P. (1975). Passive transfer of acquired resistance to Schistosoma mansoni in laboratory mice. Parasitology 70, 347–57.CrossRefGoogle ScholarPubMed
Sher, A., Smithers, S. R., MacKenzie, P. & Broomfield, K. (1977). Schistosoma mansoni immunoglobulins involved in passive immunization of laboratory mice. Experimental Parasitology 41, 160–6.CrossRefGoogle ScholarPubMed
Smith, M. A. & Clegg, J. A. (1976). Different levels of acquired immunity to Schistosoma mansoni in two strains of hamsters. Parasitology 73, 4752.CrossRefGoogle Scholar
Smithers, S. R. (1976). Immunity to trematode infections with special reference to schistosomiasis and fascioliasis. In Immunology of Parasitic Infections, (ed. Cohen, S. and Sadun, E.). Oxford: Blackwell.Google Scholar
Smithers, S. R. & Gammage, K. (1980). Recovery of Schistosoma mansoni from the skin, lungs and hepatic portal system of naive mice and mice previously exposed to S. mansoni: evidence for two phases of parasite attrition in immune mice. Parasitology 80, 289300.CrossRefGoogle Scholar
Smithers, S. R. & Terry, R. J. (1965). The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of the adult worm. Parasitology 55, 695700.CrossRefGoogle Scholar
Smithers, S. R. & Terry, R. J. (1976). The immunology of schistosomiasis. Advances in Parasitology 14, 399433.CrossRefGoogle ScholarPubMed
Stirewalt, M. A. (1959). Chronological analysis, pattern and rate of migration of cercariae of Schistosoma mansoni in body, ear and tail skin of mice. Annals of Tropical Medicine and Parasitology 53, 400–13.CrossRefGoogle Scholar

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Host protective humoral immune responses to Schistosoma mansoni infections in the rat. Kinetics of hyperimmune serum-dependent sensitivity and elimination of schistosomes in a passive transfer system
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