Hostname: page-component-6d856f89d9-fb4gq Total loading time: 0 Render date: 2024-07-16T04:06:56.986Z Has data issue: false hasContentIssue false
  • English
  • Français

Comparison of single and split-dose flubendazole treatment for the nematode parasite Trichostrongylus tenuis in experimentally infected grey partridges Perdix perdix

Published online by Cambridge University Press:  31 July 2012

D. PURDY ,
N. J. AEBISCHER  and
C. DAVIS
D. PURDY
Affiliation:
Game & Wildlife Conservation Trust, Burgate Manor, Fordingbridge, Hants SP6 1EF, UK
N. J. AEBISCHER*
Affiliation:
Game & Wildlife Conservation Trust, Burgate Manor, Fordingbridge, Hants SP6 1EF, UK
C. DAVIS
Affiliation:
Game & Wildlife Conservation Trust, Burgate Manor, Fordingbridge, Hants SP6 1EF, UK
*
*Corresponding author: Tel: 01425 652381. Fax: 01425 655848. E-mail: naebischer@gwct.org.uk
Get access Rights & Permissions [Opens in a new window]

Summary

Different therapeutic regimes using flubendazole for the treatment of Trichostrongylus tenuis infection in experimentally infected grey partridges Perdix perdix were examined. Flubendazole dosages of 4, 8 and 20 mg/kg were administered orally as a single dose or split into 3 or 9 parts given over 9 days. The efficacy against adult worms in the caeca improved with dose rate. Split doses were at least as effective as single doses, which removed up to 83% of adult T. tenuis. A dose of 20 mg/kg administered on a daily basis over 3 or 9 days gave the best clearance of T. tenuis, resulting in a reduction of at least 95% in worm burden.

Keywords

Lagopus lagopus scoticusPerdix perdixTrichostrongylus tenuisflubendazole
Type
Research Article
Information
Parasitology , Volume 139 , Issue 13 , November 2012 , pp. 1780 - 1783
Copyright
Copyright © Cambridge University Press 2012

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Adam, A., Webster, L. M. I., Mullen, W., Keller, L. F. and Johnson, P. C. D. (2011). Quantifying fenbendazole and its metabolites in self-medicating wild red grouse Lagopus lagopus scoticus using an HPLC-MS-MS approach. Veterinary Parasitology 177, 383–386.CrossRefGoogle ScholarPubMed
Calvete, C., Estrada, R., Lucientes, J., Estrada, A. and Telletxea, I. (2003). Correlates of helminth community in the red-legged partridge (Alectoris rufa L.) in Spain. Journal of Parasitology 89, 445–451.CrossRefGoogle Scholar
Connan, R. M. and Wise, D. (1993 a). Hypobiosis of Trichostrongylus tenuis in experimentally infected grey partridges. Research in Veterinary Science 54, 259–260.CrossRefGoogle ScholarPubMed
Connan, R. M. and Wise, D. (1993 b). Development and survival at low temperature of the free living stages of Trichostrongylus tenuis. Research in Veterinary Science 55, 20–24.CrossRefGoogle ScholarPubMed
Dobson, A. P. and Hudson, P. J. (1992). Regulation and stability of a free living host-parasite system, Trichostrongylus tenuis in red grouse.II. Population models. Journal of Animal Ecology 61, 487–498.CrossRefGoogle Scholar
Draycott, R., Woodburn, M., Ling, D. and Sage, R. (2006). The effect of an indirect anthelmintic treatment on parasites and breeding success of free-living pheasants Phasianus colchicus. Journal of Helminthology 80, 409–415.CrossRefGoogle ScholarPubMed
Edgington, E. S. and Onghena, P. (2007). Randomization Tests, 4th Edn.Chapman and Hall, London, UK.CrossRefGoogle Scholar
Hudson, P. J., Dobson, A. P. and Newborn, D. (1985). Cyclic and non-cyclic populations of red grouse: a role for parasitism?Ecology and Genetics of Host-Parasite Interactions (ed. Rollinson, D. and Anderson, R. M.), pp. 79–89. Academic Press, London, UK.Google Scholar
Hudson, P. J. (1992). Grouse in Space and Time. The Game Conservancy Trust, Fordingbridge, UK.Google Scholar
Hudson, P. J., Dobson, A. P. and Newborn, D. (1998). Prevention of population cycles by parasite removal. Science 282, 2256–2258.CrossRefGoogle ScholarPubMed
Miller, M., Vayhinger, J., Bonden, D., Roush, S., Verry, T., Torres, A. and Jurgens, V. (2000). Drug treatments for lungworm in bighorn sheep: re-evaluation of a 20-year-old management prescription. Journal of Wildlife Management 64, 505–512.CrossRefGoogle Scholar
Newborn, D. and Foster, R. (2002). Control of parasite burdens in wild red grouse Lagopus lagopus scoticus through indirect application of anthelmintics. Journal of Applied Ecology 39, 909–914.CrossRefGoogle Scholar
Portal, M. and Collinge, W. E. (1932). Partridge Disease and its Causes. Country Life, London, UK.Google Scholar
Potts, G. R. (1986). The Partridge: Pesticides, Predation and Conservation. Collins, London, UK.Google Scholar