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Vitamin E and cardiovascular diseases: an interest to public health?

Published online by Cambridge University Press:  29 June 2023

Ana Gabriella Costa Lemos da Silva Open the ORCID record for Ana Gabriella Costa Lemos da Silva [Opens in a new window] ,
Karla Danielly da Silva Ribeiro Open the ORCID record for Karla Danielly da Silva Ribeiro [Opens in a new window] ,
Graciele Eloise Alves de Araújo Open the ORCID record for Graciele Eloise Alves de Araújo [Opens in a new window] ,
Letícia da Silva Oliveira Open the ORCID record for Letícia da Silva Oliveira [Opens in a new window]  and
Clélia de Oliveira Lyra Open the ORCID record for Clélia de Oliveira Lyra [Opens in a new window]
Ana Gabriella Costa Lemos da Silva*
Affiliation:
Graduate Program in Public Health, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil
Karla Danielly da Silva Ribeiro
Affiliation:
Department of Nutrition, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil
Graciele Eloise Alves de Araújo
Affiliation:
Department of Nutrition, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil
Letícia da Silva Oliveira
Affiliation:
Department of Nutrition, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil
Clélia de Oliveira Lyra
Affiliation:
Graduate Program in Public Health, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil
*
*Corresponding author: Ana Gabriella C. L. da Silva, email: gabriella_lemos_06@yahoo.com.br
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Abstract

Cardiovascular diseases (CVD) are the leading cause of death worldwide. From this perspective, the role of vitamin E and its metabolites in preventing CVD has been studied, being supported by the findings that low vitamin E concentrations are associated with an increased risk of cardiovascular events. Despite this, no studies have analysed the co-existence of vitamin E deficiency (VED) and CVD on the basis of population studies. Facing that, this study summarises information on the relationship between vitamin E status and CVD, providing a basis for understanding the determining and protective factors for its development. VED may be a public health problem since it has been observed to vary from 0·6% to 55·5% worldwide, with higher percentages in Asia and Europe, where CVD mortality rates stand out. Intervention studies with α-tocopherol supplementation do not confirm cardioprotective action of vitamin E, which may reflect that α-tocopherol alone does not provide cardiovascular protection to individuals, but the consumption of all isomers found in food. Considering that low concentrations of α-tocopherol can lead to a higher susceptibility to diseases involving oxidative stress in the population, in addition to the high and growing prevalence of CVD and VED, it is essential to investigate or reinterpret the mechanisms of action of vitamin E and its metabolites in the cardiovascular process to better understand the co-existence of CVD and VED. It is also important to implement public health policies and programmes aimed at promoting the consumption of natural food sources of vitamin E and healthy fats.

Keywords

Vitamin Eα-TocopherolVitamin E deficiencyCardiovascular diseasesPopulation studies in public health
Type
Review Article
Information
Nutrition Research Reviews , First View , pp. 1 - 10
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Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of The Nutrition Society

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References

World Health Organization (2020). Global health estimates: the top 10 causes of death. https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death Google Scholar
Benjamin, EJ, Virani, SS, Callaway, CW, et al. (2018) Heart disease and stroke statistics – 2018 update: a report from the American Heart Association. Circulation 137, E67–E492.CrossRefGoogle ScholarPubMed
Artinian, NT, Fletcher, GF, Mozaffarian, D, et al. (2010) Interventions to promote physical activity and dietary lifestyle changes for cardiovascular risk factor reduction in adults: a scientific statement from the American Heart Association. Circulation 122, 406–441.CrossRefGoogle ScholarPubMed
Singh, U, Devaraj, S & Jialal, I. (2005) Vitamin E, oxidative stress, and inflammation. Annu Rev Nutr 25, 151–174.CrossRefGoogle ScholarPubMed
Helmersson, J, Ärnlv, J, Larsson, A, et al. (2009) Low dietary intake of β-carotene, α-tocopherol and ascorbic acid is associated with increased inflammatory and oxidative stress status in a Swedish cohort. Br J Nutr 101, 1775–1782.CrossRefGoogle Scholar
de Oliveira Otto, MCC, Alonso, A, Lee, DH, et al. (2011) Dietary micronutrient intakes are associated with markers of inflammation but not with markers of subclinical atherosclerosis. J Nutr 141, 1508–1515.CrossRefGoogle Scholar
Root, MM, Mcginn, MC, Nieman, DC, et al. (2012) Combined fruit and vegetable intake is correlated with improved inflammatory and oxidant status from a cross-sectional study in a community setting. Nutrients 4, 29–41.CrossRefGoogle Scholar
Micha, R, Peñalvo, JL, Cudhea, F, et al. (2017) Association between dietary factors and mortality from heart disease, stroke, and type 2 diabetes in the United States. JAMA 317, 912–924.CrossRefGoogle ScholarPubMed
Traber, MG. (2012) Vitamin E. In Present Knowledge in Nutrition, 10th ed., pp. 214–229 [JW Erdman Jr, IA Macdonald and SH Zeisel, editors]. Washington: Academic Press.CrossRefGoogle Scholar
Loffredo, L, Perri, L, Di Castelnuovo, A, et al. (2015) Supplementation with vitamin E alone is associated with reduced myocardial infarction: a meta-analysis. Nutr Metab Cardiovasc Dis 25, 354–363.CrossRefGoogle ScholarPubMed
Azzi, A (2018) Many tocopherols, one vitamin E. Mol Aspects Med 61, 92–103.CrossRefGoogle ScholarPubMed
Schubert, M, Kluge, S, Brunner, E, et al. (2022) The α-tocopherol-derived long-chain metabolite α-13′-COOH mediates endotoxin tolerance and modulates the inflammatory response via MAPK and NFκB pathways. Free Radic Biol Med 178, 83–96.CrossRefGoogle ScholarPubMed
Lawrence, WR, Lim, J, Huang, J, et al. (2022) Metabolomic analysis of serum alpha-tocopherol among men in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study. Eur J Clin Nutr 76, 1254–1265.CrossRefGoogle ScholarPubMed
Harris, A, Devaraj, S & Jialal, I (2002) Oxidative stress, alpha-tocopherol therapy, and atherosclerosis. Curr Atheroscler Rep 4, 373–380.CrossRefGoogle ScholarPubMed
Huang, J, Weinstein, SJ, Yu, K, et al. (2019) Relationship between serum alpha-tocopherol and overall and cause-specific mortality a 30-year prospective cohort analysis. Circ Res 125, 29–40.CrossRefGoogle Scholar
Nagao, M, Moriyama, Y, Yamagishi, K, et al. (2012) Relation of serum α- and γ-tocopherol levels to cardiovascular disease-related mortality among Japanese men and women. J Epidemiol 22, 402–410.CrossRefGoogle ScholarPubMed
Glynn, RJ, Ridker, PM, Goldhaber, SZ, et al. (2007) Effects of random allocation to vitamin E supplementation on the occurrence of venous thromboembolism: report from the women’s health study. Circulation 116, 1497–1503.CrossRefGoogle ScholarPubMed
Lee, IM, Cook, NR, Gaziano, JM, et al. (2005) Vitamin E in the primary prevention of cardiovascular disease and cancer. JAMA 294, 56–65.CrossRefGoogle ScholarPubMed
Lonn, E, Bosch, J, Yusuf, S, et al. (2005) Effects of long-term vitamin E supplementation on cardiovascular events and cancer. JAMA 293, 1338–1347.Google ScholarPubMed
Myung, SK, Ju, W, Cho, B, et al. (2013) Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials. BMJ 346, f10.CrossRefGoogle ScholarPubMed
Ye, Y, Li, J & Yuan, Z (2013) Effect of antioxidant vitamin supplementation on cardiovascular outcomes: a meta-analysis of randomized controlled trials. PLoS One 8, e56803.CrossRefGoogle ScholarPubMed
Bjelakovic, G, Nikolova, D, Gluud, LL, et al. (2012) Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database Syst Rev 3, CD007176.Google Scholar
Bjelakovic, G, Nikolova, D & Gluud, C (2013) Meta-regression analyses, meta-analyses, and trial sequential analyses of the effects of supplementation with beta-carotene, vitamin A, and vitamin E singly or in different combinations on all-cause mortality: do we have evidence for lack of harm? PLoS One 8, 1–14.CrossRefGoogle ScholarPubMed
Miller Iii, ER, Pastor-Barriuso, R, Dalal, D, et al. (2005) Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med 142, 37–46.CrossRefGoogle Scholar
Rychter, AM, Hryhorowicz, S, Słomski, R, et al. (2022) Antioxidant effects of vitamin E and risk of cardiovascular disease in women with obesity – a narrative review. Clin Nutr 41, 1557–1565.CrossRefGoogle ScholarPubMed
Sozen, E, Demirel, T & Ozer, NK (2019) Vitamin E: regulatory role in the cardiovascular system. Crit Rev 71, 401–522.Google ScholarPubMed
Ziegler, M, Wallert, M, Lorkowski, S, et al. (2020) Cardiovascular and metabolic protection by vitamin E: a matter of treatment strategy? Antioxidants 9, 1–40.CrossRefGoogle ScholarPubMed
Balakumar, P, Maung-U, K & Jagadeesh, G (2016) Prevalence and prevention of cardiovascular disease and diabetes mellitus. Pharmacol Res 113, 600–609.CrossRefGoogle ScholarPubMed
Lindstrom, M, DeCleene, N, Dorsey, H, et al. (2022) Global burden of cardiovascular diseases and risks collaboration, 1990–2021. J Am Coll Cardiol 80, 2372–2425.CrossRefGoogle ScholarPubMed
Précoma, DB, Oliveira, GMM de, Simão, AF, et al. (2019) Atualização da Diretriz de Prevenção Cardiovascular da Sociedade Brasileira de Cardiologia – 2019. Arq Bras Cardiol 113, 787–891.Google Scholar
Thomas, H, Diamond, J, Vieco, A, et al. (2018) Global atlas of cardiovascular disease 2000–2016: the path to prevention and control. Glob Heart 13, 143–163.CrossRefGoogle ScholarPubMed
Visseren, FLJ, Mach, F, Smulders, YM, et al. (2021) ESC guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J 42, 3227–3337.CrossRefGoogle ScholarPubMed
Iqbal, R, Anand, S, Ounpuu, S, et al. (2008) Dietary patterns and the risk of acute myocardial infarction in 52 countries: results of the INTERHEART study. Circulation 118, 1929–1937.CrossRefGoogle ScholarPubMed
Malekmohammad, K, Sewell, RDE & Rafieian-Kopaei, M (2019) Antioxidants and atherosclerosis: mechanistic aspects. Biomolecules 9, 1–19.CrossRefGoogle ScholarPubMed
Buijsse, B, Feskens, EJ, Schlettwein-Gsell, D, et al. (2005) Plasma carotene and-tocopherol in relation to 10-y all-cause and cause-specific mortality in European elderly: the survey in Europe on nutrition and the elderly, a concerted action (SENECA). Am J Clin Nutr 82, 879–886.CrossRefGoogle Scholar
Hak, AE, Stampfer, MJ, Campos, H, et al. (2003) Plasma carotenoids and tocopherols and risk of myocardial infarction in a low-risk population of US male physicians. Circulation 108, 802–807.CrossRefGoogle Scholar
Kamai-Eldin, A & Lars-Ake, A (1996) The chemistry and antioxidant properties of tocopherols and tocotrienols. Lipids 31, 671–701.CrossRefGoogle Scholar
Traber, MG (2021) Vitamin E. Adv Nutr 12, 1047–1048.CrossRefGoogle ScholarPubMed
Traber, MG (2013) Mechanisms for the prevention of vitamin E excess. J Lipid Res 54, 2295–2306.CrossRefGoogle ScholarPubMed
Traber, MG, Leonard, SW, Ebenuwa, I, et al. (2019) Vitamin E absorption and kinetics in healthy women, as modulated by food and by fat, studied using 2 deuterium-labeled α-tocopherols in a 3-phase crossover design. Am J Clin Nutr 110, 1148–1167.CrossRefGoogle Scholar
Traber, MG & Bruno, RS (2020) Vitamin E. In Present Knowledge in Nutrition, 11th ed, pp. 115–136 [Marriott, B, Birt, DF, Stalling, V and Yates, A, editors]. Washington: Academic Press.CrossRefGoogle Scholar
Qian, J, Morley, S, Wilson, K, et al. (2005) Intracellular trafficking of vitamin E in hepatocytes: the role of tocopherol transfer protein. J Lipid Res 46, 2072–2082.CrossRefGoogle ScholarPubMed
Schmölz, L, Birringer, M, Lorkowski, S, et al. (2016) Complexity of vitamin E metabolism. World J Biol Chem 7, 14–43.CrossRefGoogle ScholarPubMed
Kim, JE, Ferruzzi, MG & Campbell, WW (2016) Egg consumption increases vitamin E absorption from co-consumed raw mixed vegetables in healthy young men. J Nutr 146, 2199–2205.CrossRefGoogle ScholarPubMed
Traber, MG, Leonard, SW, Bobe, G, et al. (2015) α-Tocopherol disappearance rates from plasma depend on lipid concentrations: studies using deuterium-labeled collard greens in younger and older adults. Am J Clin Nutr 101, 752–759.CrossRefGoogle ScholarPubMed
Mah, E, Sapper, TN, Chitchumroonchokchai, C, et al. (2015) α-Tocopherol bioavailability is lower in adults with metabolic syndrome regardless of dairy fat co-ingestion: a randomized, double-blind, crossover trial. Am J Clin Nutr 102, 1070–1080.CrossRefGoogle ScholarPubMed
Traber, MG, Mah, E, Leonard, SW, et al. (2017) Metabolic syndrome increases dietary α-tocopherol requirements as assessed using urinary and plasma vitamin E catabolites: a double-blind, crossover clinical trial. Am J Clin Nutr 105, 571–579.CrossRefGoogle ScholarPubMed
Violet, PC, Ebenuwa, IC, Wang, Y, et al. (2020) Vitamin E sequestration by liver fat in humans. JCI Insight 5, 1–17.CrossRefGoogle ScholarPubMed
Traber, MG & Atkinson, J (2007) Vitamin E, antioxidant and nothing more. Free Radic Biol Med 43, 4–15.CrossRefGoogle ScholarPubMed
Li, P, Zhang, H, Chen, J, et al. (2014) Association between dietary antioxidant vitamins intake/blood level and risk of gastric cancer. Int J Cancer 135, 1444–1453.CrossRefGoogle ScholarPubMed
Azzi, A, Meydani, SN, Meydani, M, et al. (2016) The rise, the fall and the renaissance of Vitamin E. Arch Biochem Biophys 595, 100–108.CrossRefGoogle ScholarPubMed
Traber, MG & Head, B. (2021) Vitamin E: How much is enough, too much and why! Free Radic Biol Med 177, 212–225.CrossRefGoogle ScholarPubMed
Banerjee, C & Chimowitz, MI (2017) Stroke caused by atherosclerosis of the major intracranial arteries. Circulation Research 120, 502–513.CrossRefGoogle ScholarPubMed
Loh, HC, Lim, R, Lee, KW, et al. (2021) Effects of vitamin E on stroke: a systematic review with meta-analysis and trial sequential analysis. Stroke Vasc Neurol 6, 109–120.CrossRefGoogle ScholarPubMed
Pein, H, Vila, A, Passo, S, et al. (2018) Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase. Nat Commun 9, 1–17.CrossRefGoogle ScholarPubMed
Wallert, M, Schmölz, L, Koeberle, A, et al. (2015) α-Tocopherol long-chain metabolite α-13ʼ-COOH affects the inflammatory response of lipopolysaccharide-activated murine RAW264.7 macrophages. Mol Nutr Food Res 59, 1524–1534.CrossRefGoogle ScholarPubMed
Schmölz, L, Wallert, M, Rozzino, N, et al. (2017) Structure–function relationship studies in vitro reveal distinct and specific effects of long-chain metabolites of vitamin E. Mol Nutr Food Res 61, 1–9.CrossRefGoogle ScholarPubMed
Torquato, P, Giusepponi, D, Galarini, R, et al. (2019) Analysis of vitamin E metabolites. In Vitamin E: Chemistry and Nutritional Benefits, pp. 208–227 [Niki, E, editor]. London, UK: The Royal Society of Chemistry.CrossRefGoogle Scholar
Giusepponi, D, Galarini, R, Barola, C, et al. (2019) LC-MS/MS assay for the simultaneous determination of tocopherols, polyunsaturated fatty acids and their metabolites in human plasma and serum. Free Radic Biol Med 144, 134–143.CrossRefGoogle ScholarPubMed
Giusepponi, D, Torquato, P, Bartolini, D, et al. (2017) Determination of tocopherols and their metabolites by liquid-chromatography coupled with tandem mass spectrometry in human plasma and serum. Talanta 170, 552–561.CrossRefGoogle ScholarPubMed
Wallert, M, Schmölz, L, Galli, F, et al. (2014) Regulatory metabolites of vitamin E and their putative relevance for atherogenesis. Redox Biol 2, 495–503.CrossRefGoogle ScholarPubMed
Ciffolilli, S, Wallert, M, Bartolini, D, et al. (2015). Human serum determination and in vitro anti-inflammatory activity of the vitamin E metabolite α-(13′-hydroxy)-6-hydroxychroman. Free Radic Biol Med 89, 952–962.CrossRefGoogle Scholar
Bartolini, D, Marinelli, R, Giusepponi, D, et al. (2021) Alpha-tocopherol metabolites (the vitamin E metabolome) and their interindividual variability during supplementation. Antioxidants 10, 173–187.CrossRefGoogle ScholarPubMed
Ciarcià, G, Bianchi, S, Tomasello, B, et al. (2022) Vitamin E and non-communicable diseases: a review. Biomedicines 10, 2473–2494.CrossRefGoogle ScholarPubMed
França, CN, Izar, MCO, Hortêncio, MNS, et al. (2017) Monocyte subtypes and the CCR2 chemokine receptor in cardiovascular disease. Clin Sci 131, 1215–1224.CrossRefGoogle ScholarPubMed
O’Connor, T, Borsig, L & Heikenwalder, M (2015) CCL2-CCR2 signaling in disease pathogenesis. Endocr Metab Immune Disord Drug Targets 15, 105–118.CrossRefGoogle ScholarPubMed
Rose, CE Jr, Sung, S-SJ & Fu, SM (2003) Significant involvement of CCL2 (MCP-1) in inflammatory disorders of the lung. Microcirculation 10, 273–288.CrossRefGoogle ScholarPubMed
Maceyka, M & Spiegel, S (2014) Sphingolipid metabolites in inflammatory disease. Nature 510, 58–67.CrossRefGoogle ScholarPubMed
Norris, GH & Blesso, CN (2017) Dietary and endogenous sphingolipid metabolism in chronic inflammation. Nutrients 9, 1180–1204.CrossRefGoogle ScholarPubMed
Müller, M-C, Schäfer, C, Litta, G, et al. (2022) 100 years of vitamin E: from discovery to commercialization. Eur J Org Chem 45, 1–16.Google Scholar
Péter, S, Friedel, A, Roos, FF, et al. (2016) A systematic review of global alpha-tocopherol status as assessed by nutritional intake levels and blood serum concentrations. Int J Vitam Nutr Res 85, 261–281.CrossRefGoogle Scholar
Oldewage-Theron, WH, Samuel, FO & Djoulde, RD. (2010) Serum concentration and dietary intake of vitamins A and E in low-income South African elderly. Clin Nutr 29, 119–123.CrossRefGoogle Scholar
Institute of Medicine (2020) Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington (DC): National Academies Press (US).Google Scholar
Horwitt, MK, Harvey, CC, Duncan, CD, et al. (1956) Effects of limited tocopherol intake in man with relationships to erythrocyte hemolysis and lipid oxidations. Am J Clin Nutr 4, 408–419.CrossRefGoogle ScholarPubMed
Jenab, M, Salvini, S, Van Gils, CH, et al. (2009) Dietary intakes of retinol, β-carotene, vitamin D and vitamin E in the European prospective investigation into cancer and nutrition cohort. Eur J Clin Nutr 63, S150–S178.CrossRefGoogle ScholarPubMed
Gray, AN, Fleming, LTC (2011) A Focus on Nutrition: Key Findings of the 2008/09. New Zealand Adult Nutrition Survey. Wellington: Ministry of Health.Google Scholar
Chun, OK, Floegel, A, Chung, SJ, et al. (2010) Estimation of antioxidant intakes from diet and supplements in U.S. adults. J Nutr 140, 317–324.CrossRefGoogle ScholarPubMed
Leonard, SW & Traber, MG (2019) Methods for assessment of vitamin E. In Laboratory Assessment of Vitamin Status, pp. 79–105 [D Harrington, editor]. United States: Academic Press.CrossRefGoogle Scholar
Galli, F, Azzi, A, Birringer, M, et al. (2017) Vitamin E: emerging aspects and new directions. Free Radic Biol Med 102, 16–36.CrossRefGoogle ScholarPubMed
Dror, DK & Allen, LH (2011) Vitamin E deficiency in developing countries. Food Nutr Bull 32, 124–143.CrossRefGoogle ScholarPubMed
Michels, AJ, Leonard, SW, Uesugi, SL, et al. (2018) Daily consumption of Oregon hazelnuts affects α-tocopherol status in healthy older adults: A pre-post intervention study. J Nutr 148, 1924–1930.CrossRefGoogle ScholarPubMed
Wright, ME, Lawson, KA, Weinstein, SJ, et al. (2006) Higher baseline serum concentrations of vitamin E are associated with lower total and cause-specific mortality in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Am J Clin Nutr 84, 1200–1207.CrossRefGoogle ScholarPubMed
Lebold, KM, Ang, A, Traber, MG, et al. (2012) Urinary-carboxyethyl hydroxychroman can be used as a predictor of -tocopherol adequacy, as demonstrated in the energetics study. Am J Clin Nutr 96, 801–809.CrossRefGoogle ScholarPubMed
Rizvi, S, Raza, ST, Ahmed, F, et al. (2014) The role of vitamin E in human health and some diseases. SQU Med J 14, 157–165.Google ScholarPubMed
Cammisotto, V, Nocella, C, Bartimoccia, S, et al. (2021) The role of antioxidants supplementation in clinical practice: focus on cardiovascular risk factors. Antioxidants 10, 1–32.CrossRefGoogle ScholarPubMed
Gey, KF, Puska, P, Jordan, P, et al. (1991) Inverse correlation between plasma vitamin E and mortality from ischemic heart disease in cross-cultural epidemiology. Am J Clin Nutr 53, 326S–334S.CrossRefGoogle ScholarPubMed
Rimm, EB, Stampfer, MJ, Ascherio, A, et al. (1993) Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med 328, 1450–1456.CrossRefGoogle ScholarPubMed
Knekt, P, Reunanen, A, Jävinen, R, et al. (1994) Antioxidant vitamin intake and coronary mortality in a longitudinal population study. Am J Epidemiol 139, 1180–1189.CrossRefGoogle Scholar
Kushi, LH, Folsom, AR, Prineas, RJ, et al. (1996) Dietary antioxidant vitamins and death from coronary heart disease in postmenopausal women. N Engl J Med 334, 1156–1162.CrossRefGoogle ScholarPubMed
Losonczy, KG, Harris, TB & Havlik, RJ (1996) Vitamin E and vitamin C supplement use and risk of all-cause and coronary heart disease mortality in older persons: the established populations for epidemiologic studies of the elderly. Am J Clin Nutr 64, 190–196.CrossRefGoogle ScholarPubMed
Sesso, HD, Buring, JE, Christen, WG, et al. (2008) Vitamins E and C in the prevention of cardiovascular disease in men: the physicians’ health study II randomized controlled trial. JAMA 300, 2123–2133.CrossRefGoogle Scholar
Cook, NR, Albert, CM, Michael Gaziano, J, et al. (2007) A randomized factorial trial of vitamins C, E, and beta-carotene in the secondary prevention of cardiovascular events in women: results from the women’s antioxidant cardiovascular Study (WACS). Arch Intern Med 167, 1610–1618.CrossRefGoogle Scholar
Hercberg, S, Galan, P, Preziosi, P, et al. (2004) The SU.VI.MAX study a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals. Arch Intern Med 164, 2335–2342.CrossRefGoogle ScholarPubMed
Schwartz, SM, Schwartz, HT, Horvath, S, et al. (2012) A systematic approach to multifactorial cardiovascular disease: causal analysis. Arterioscler Thromb Vasc Biol 32, 2821–2835.CrossRefGoogle ScholarPubMed
Leonard, SW, Terasawa, Y, Farese, RV Jr, et al. (2002) Incorporation of deuterated RRR- or all-rac-α-tocopherol in plasma and tissues of α-tocopherol transfer protein–null mice. Am J Clin Nutr 75, 555–560.CrossRefGoogle ScholarPubMed
Lee, CH, Chan, RSM, Wan, HYL, et al. (2018) Dietary intake of anti-oxidant vitamins A, C, and E is inversely associated with adverse cardiovascular outcomes in Chinese – A 22-years population-based prospective study. Nutrients 10, 1–11.CrossRefGoogle Scholar
Arnett, DK, Blumenthal, RS, Albert, MA, et al. (2019) ACC/AHA guideline on the primary prevention of cardiovascular disease: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation 140, 596–646.Google Scholar
Kang, MJ, Lin, YC, Yeh, WH, et al. (2004) Vitamin E status and its dietary determinants in Taiwanese: results of the nutrition and health survey in Taiwan 1993–1996. Eur J Nutr 43, 86–92.CrossRefGoogle ScholarPubMed
Cheng, WYM, Fu, MLM, Wen, LJB, et al. (2005) Plasma retinol and α-tocopherol status of the Taiwanese elderly population. Asia Pac J Clin Nutr 14, 256–262.Google ScholarPubMed
Obeid, OA, Al-Ghali, RM, Khogali, M, et al. (2006) Vitamins A and E status in an urban Lebanese population: a case study at Dar Al-Fatwa area, Beirut. Int J Vitam Nutr Res 76, 3–8.CrossRefGoogle Scholar
Al-Saleh, I, El-Doush, I & Billedo, G. (2007) Age and gender-related reference values for serum dl-α-tocopherol and all-trans-retinol levels in Saudi population. Int J Vitam Nutr Res 77, 326–335.CrossRefGoogle ScholarPubMed
Assantachai, P & Lekhakula, S (2007) Epidemiological survey of vitamin deficiencies in older Thai adults: Implications for national policy planning. Public Health Nutr 10, 65–70.CrossRefGoogle ScholarPubMed
Hong, KH & Lee, Y (2020) Negative correlation between vitamin A and positive correlation between vitamin E and inflammation among healthy adults in Korea: based on the Korea national health and nutrition examination survey (KNHANES) 2016–2018 7th edition. J Inflamm Res 13, 799–811.CrossRefGoogle ScholarPubMed
Polito, A, Intorre, F, Andriollo-Sanchez, M, et al. (2005) Estimation of intake and status of vitamin A, vitamin E and folate in older European adults: the ZENITH. Eur J Clin Nutr 59, S42–S47.CrossRefGoogle ScholarPubMed
Cherubini, A, Martin, A, Andres-Lacueva, C, et al. (2005) Vitamin E levels, cognitive impairment and dementia in older persons: the InCHIANTI study. Neurobiol Aging 26, 987–994.CrossRefGoogle ScholarPubMed
Bartali, B, Frongillo, EA, Guralnik, JM, et al. (2008) Serum micronutrient concentrations and decline in physical function among older persons. JAMA 299, 308–315.Google ScholarPubMed
Waniek, S, Di Giuseppe, R, Esatbeyoglu, T, et al. (2018) Vitamin E (α-and γ-tocopherol) levels in the community: distribution, clinical and biochemical correlates, and association with dietary patterns. Nutrients 10, 2–17.CrossRefGoogle Scholar
Zhu, Y, Minović, I, Dekker, LH, et al. (2020) Vitamin status and diet in elderly with low and high socioeconomic status: the lifelines-MINUTHE study. Nutrients 12, 1–17.CrossRefGoogle ScholarPubMed
Ford, ES, Schleicher, RL, Mokdad, AH, et al. (2006) Distribution of serum concentrations of α-tocopherol and γ-tocopherol in the US population. Am J Clin Nutr 84, 375–383.CrossRefGoogle ScholarPubMed
McBurney, MI, Yu, EA, Ciappio, ED, et al. (2015) Suboptimal serum A-tocopherol concentrations observed among younger adults and those depending exclusively upon food sources, NHANES 2003-20061-3. PLoS One 10, 1–13.CrossRefGoogle Scholar