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Perspectives on ruminant nutrition and metabolism. II. Metabolism in ruminant tissues

  • E. F Annison (a1) and W. L Bryden (a1)

Abstract

The discovery of the dominance of short-chain fatty acids as energy sources in the 1940s and 1950s, as discussed in part I of this review (Annison & Bryden, 1998) led to uncertainties concerning the interrelationships of glucose and acetate in ruminant metabolism. These were resolved in the following decade largely by use of 14C-labelled substrates. Although only small amounts of glucose are absorbed in most dietary situations, glucose availability to ruminant tissues as measured by isotope dilution was shown to be substantial, indicating that gluconeogenesis is a major metabolic activity in both fed and fasted states. Studies with 14C-labelled glucose and acetate revealed that in contrast to non-ruminants, acetate and not glucose is the major precursor of long-chain fatty acids in ruminant tissues. Interest in the measurement of energy metabolism in livestock grew rapidly from the 1950s. Most laboratories adopted indirect calorimetry and precise measurements of the energy expenditure of ruminants contributed to the development of new feeding systems. More recently, alternative approaches to the measurement of energy expenditure have included the use of NMR spectroscopy, isotope dilution and the application of the Fick principle to measure O2 consumption in the whole animal and in defined tissues. The refinement of the classical arterio-venous difference procedure in the study of mammary gland metabolism in the 1960s, particularly when combined with isotope dilution, encouraged the use of these methods to generate quantitative data on the metabolism of a range of defined tissues. The recent introduction of new methods for the continuous monitoring of both blood flow and blood O2 content has greatly increased the precision and scope of arterio-venous difference measurements. The impact of data produced by these and other quantitative procedures on current knowledge of the metabolism of glucose, short-chain fatty acids and lipids, and on N metabolism, is outlined. The role of the portal-drained viscera and liver in N metabolism is discussed in relation to data obtained by the use of multi-catheterized animals. Protein turnover, and the impact of stress (physical, social and disease related) on protein metabolism have been reviewed. The growth of knowledge of mammary gland metabolism and milk synthesis since the first quantitative studies in the 1960s has been charted. Recent findings on the regulation of amino acid uptake and utilization by the mammary gland, and on the control of milk secretion, are of particular interest and importance.

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Corresponding author

*Corresponding author:Professor E.F. Annison, fax +61 2 4655 0693, email lizt@camden.usyd.edu.au

References

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Agricultural and Food Research Council Technical Committee on Responses to Nutrients (1990) Report no. 5, Nutritive requirements of ruminant animals: Energy. Nutrition Abstracts and Reviews (Series B) 60, 729804.
Ahaix, D & Arnal, M (1987) Protein synthesis and growth in the gastrointestinal tract of the young pre-ruminant lamb. British Journal of Nutrition 58, 159169.
Annison, EF (1954) Some observations on volatile fatty acids in the sheep's rumen. Biochemical Journal 57, 400–405.
Annison, EF (1964) Plasma free fatty acids. In Metabolism and Physiological Significance of Lipids, pp. 289324 [Dawson, RMC & Rhodes, DN, editors]. London: Wiley.
Annison, EF (1983) Metabolite utilization by the ruminant mammary gland. In Biochemistry of Lactation, pp. 399436 [Mepham, TB, editor]. Amsterdam: Elsevier.
Annison, EF (1984) The metabolism of neutral and acidic lipids by tissues of the ruminant. In Herbivore Nutrition in the Subtropics and Tropics, pp. 549570 [Gilchrist, FMC & Mackie, RI, editors]. Pretoria: The Science Press.
Annison, EF (1991) Measurement of metabolism in whole animals and their tissues – overview. Proceedings of the Nutrition Society of Australia 16, 146153.
Annison, EF & Armstrong, DG (1970) Volatile fatty acid metabolism. In Physiology of Digestion and Metabolism in the Ruminant, pp. 422437 [Phillipson, AT, editor]. Newcastle-upon-Tyne: Oriel Press.
Annison, EF, Brown, RE, Leng, RA, Lindsay, DB & West, CE (1967 a) Rates of entry and oxidation of acetate, glucose, D(-)-β-hydroxybutyrate, palmitate, oleate and stearate, and rates of production and oxidation of propionate and butyrate in fed and starved sheep. Biochemical Journal 104, 135147.
Annison, EF & Bryden, WL (1998) Perspectives in ruminant nutrition and metabolism. I. Metabolism in the rumen. Nutrition Research Reviews 11, 173198.
Annison, EF, Hill, KJ & Lewis, D (1957) Studies on the portal blood of sheep. 2. Absorption of volatile fatty acids from the rumen of the sheep. Biochemical Journal 66, 592599.
Annison, EF & Leng, RA (1991) A history of the use of isotopic tracer technology in ruminant nutrition: lessons for present research. In Isotope and Related Techniques in Animal Production and Health, pp. 323. Vienna: International Atomic Energy Agency.
Annison, EF & Lindsay, DB (1961) Acetate utilization in sheep. Biochemical Journal 78, 777785.
Annison, EF & Linzell, JL (1964) The oxidation and utilization of glucose and acetate by the mammary gland in relation to their overall metabolism and to milk formation. Journal of Physiology, London 175, 372385.
Annison, EF, Linzell, JL, Fazakerley, S & Nichols, BN (1967 b) The oxidation and utilization of palmitate, stearate, oleate and acetate by the mammary gland of the fed goat in relation to their overall metabolism, and the role of phospholipids and neutral lipids in milk fat synthesis. Biochemical Journal 102, 637647.
Annison, EF & Pennington, RJ (1954) The metabolism of short-chain fatty acids in the sheep. 3. Formic, n-valeric and branched-chain acids. Biochemical Journal 57, 685692.
Annison, EF, Scott, TW & Waites, GMH (1963) The role of glucose and acetate in the oxidative metabolism of the testis and epidymis of the ram. Biochemical Journal 88, 482.
Annison, EF & White, RR (1961) Glucose utilization in sheep. Biochemical Journal 80, 162169.
Annison, EF & White, RR (1962 a) Formate metabolism in sheep. Biochemical Journal 84, 552557.
Annison, EF & White, RR (1962 b) Further studies on the entry rates of acetate and glucose in sheep, with special reference to endogenous production of acetate. Biochemical Journal 84, 546552.
Arkins, S, Dantzer, R & Kelley, KW (1993) Somatolactogens, somatomedins and immunity. Journal of Dairy Science 76, 24372450.
Armstrong, DG (1965) Carbohydrate metabolism in ruminants and energy supply. In Physiology of Digestion in the Ruminant, pp. 272288 [Dougherty, RW, Allen, RS, Burroughs, W, Jacobson, NL & McGilliard, AD, editors]. Washington, DC: Butterworths.
Armstrong, DG & Blaxter, KL (1957) The heat increment of steam-volatile fatty acids in fasting sheep. British Journal of Nutrition 11, 247271.
Armstrong, DG, Blaxter, KL & Graham, NMcC (1957) The heat increments of mixtures of steam-volatile fatty acids in fasting sheep. British Journal of Nutrition 11, 392408.
Armstrong, DG, Blaxter, KL & Graham, NMcC (1961) The heat increment in fasting sheep of acetic acid partially neutralized with sodium hydroxide. British Journal of Nutrition 15, 169175.
Aston, R, Holder, AT, Ivanyi, J & Bomford, R (1987) Enhancement of bovine growth hormone activity in vivo by monoclonal antibodies. Molecular Immunology 24, 143150.
Backwell, FRC, Bequette, BJ, Wilson, D, Calder, AG, Metcalf, JA, Wray-Cahen, D, MacRae, JC, Beever, DE & Lobley, GE (1994) Utilization of dipeptides by the caprine mammary gland for milk protein synthesis. American Journal of Physiology 267, R1R6.
Backwell, FRC, Bequette, BJ, Wilson, D, Metcalf, JA, Franklin, MF, Beever, DE, Lobley, GE & MacRae, JC (1996) Evidence for the utilization of peptides for milk protein synthesis in the lactating cow in vivo American Journal of Physiology 271, R955R960.
Baldwin, RL (1995) Modelling Ruminant Digestion and Metabolism. London: Chapman & Hall.
Ball, AJ, Oddy, VH & Thompson, JM (1997) Nutritional manipulation of body composition and efficiency in ruminants. In Recent Advances in Animal Nutrition in Australia, 1997, pp. 192208 [Corbett, JL, Choct, M, Nolan, JV & Rowe, JB, editors]. Armidale, NSW, Australia: University of New England.
Ballard, FJ, Filsell, DH & Jarrett, IG (1972) Effects of carbohydrate availability on lipogenesis in sheep. Biochemical Journal 226, 193200.
Ballard, FJ, Hanson, RW & Kronfeld, DS (1969) Gluconeogenesis and lipogenesis in tissue from ruminant and non-ruminant animals. Federation Proceedings 28, 218231.
Balmain, JH, Folley, SJ & Glascock, RF (1954) Relative utilization of glucose and acetate carbon for lipogenesis by mammary gland slices, studied with tritium, 13C and 14C. Biochemical Journal 46, 234239.
Barcroft, J, McAnally, RA & Phillipson, AT (1944) Absorption of volatile fatty acids from the alimentary tract of sheep and other species. Journal of Experimental Biology 20, 120129.
Barry, JM (1952) The source of lysine, tyrosine and phosphorus for casein synthesis. Journal of Biological Chemistry 195, 795803.
Bauman, DE (1984) Regulation of nutrient partitioning. In Herbivore Nutrition in the Subtropics and Tropics, pp. 505524 [Gilchrist, FMC & Mackie, RI, editors]. Pretoria, South Africa: The Science Press.
Bauman, DE (1992) Bovine somatotrophin: review of an emerging animal technology. Journal of Dairy Science 75, 34323451.
Bauman, DE & McCutcheon, SN (1986) The effects of growth hormone and prolactin on metabolism. In Control of Digestion and Metabolism in Ruminants, pp. 436458 [Milligan, LP, Grovum, WL & Dobson, A, editors]. Englewood Cliffs, NJ: Prentice-Hall.
Bell, AW, Bauman, DE, Beermann, DH & Harrell, RJ (1998) Nutrition, development and efficacy of growth modifiers in livestock species. Journal of Nutrition 128, 360S–363S.
Bequette, BJ & Backwell, FRC (1997) Amino acid supply and metabolism by the ruminant mammary gland. Proceedings of the Nutrition Society 56, 593605.
Bequette, BJ, Backwell, FRC & Crompton, LA (1998) Current concepts of amino acid and protein metabolism in the mammary gland of the lactating ruminant. Journal of Dairy Science (In the Press).
Bequette, BJ, Backwell, FRC, Dhanoa, MS, Walker, A, Calder, AG, Wray-Cahen, D, Metcalf, JA, Sutton, JD, Beever, DE, Lobley, GE & MacRae, JC (1994) Kinetics of blood free and milk casein amino acid labelling in the dairy goat at two stages of lactation. British Journal of Nutrition 72, 211220.
Bergen, WG & Merkel, RA (1991) Body composition of animals treated with partitioning agents: implications for human health. FASEB Journal 5, 29512957.
Bergman, EN (1973) Glucose metabolism in ruminants. Cornell Veterinarian 63, 341382.
Bergman, EN (1975) Production and utilization of metabolites by the alimentary tract as measured in portal and hepatic blood. In Digestion and Metabolism in the Ruminant, pp. 292305 [McDonald, IW & Warner, ACI, editors]. Armidale, NSW, Australia: University of New England Publishing Unit.
Bergman, EN (1990) Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. Physiological Reviews 70, 567590.
Bergman, EN & Wolff, JE (1971) Metabolism of volatile fatty acids by liver and portal drained viscera of sheep. American Journal of Physiology 221, 586592.
Bickerstaffe, R, Annison, EF & Linzell, JL (1974) The metabolism of glucose, acetate, lipids and amino acids in lactating cows. Journal of Agricultural Science, Cambridge 82, 7185.
Black, JL (1974) Manipulation of body composition through nutrition. Proceedings of the Australian Society of Animal Production 10, 211218.
Black, JL, Davies, GT & Fleming, JF (1993) Role of computer simulation in the application of knowledge to the animal industries. Australian Journal of Agricultural Research 44, 541551.
Black, JL, Gill, M, Beever, DE, Thornley, JM & Oldham, JD (1987) Simulation of the metabolism of absorbed energy-yielding nutrients in young sheep: efficiency of utilization of acetate. Journal of Nutrition 117, 105115.
Blalock, JE (1989) A molecular basis for bidirectional communication between the immune and neuroendocrine systems. Physiological Reviews 69, 132.
Blaxter, KL (1962) The Energy Metabolism of Ruminants. London: Hutchinson.
Blaxter, KL (1967) The Energy Metabolism of Ruminants, 2nd impression, pp. 267279. London: Hutchinson.
Blaxter, KL (1989) Energy Metabolism in Animals and Man. Cambridge: Cambridge University Press.
Blaxter, KL (1991) Animal production and food: real problems and paranoia. Animal Production 53, 261269.
Breier, BH & Sauerwein, H (1995) Regulation of growth in ruminants by the somatotrophic axis. In Ruminant Physiology: Digestion, Metabolism, Growth and Reproduction, pp. 451467 [Engelhardt, WV, Leonhard-Marek, S, Breves, G & Giesecke, D, editors]. Stuttgart, Germany: Ferdinand Enke Verlag.
Bryant, MP & Robinson, IM (1962) Some nutritional characteristics of predominant culturable ruminal bacteria. Journal of Bacteriology 84, 605611.
Buttery, PJ & Dawson, JM (1990) Growth promotion in farm animals. Proceedings of the Nutrition Society 49, 459466.
Buttery, PJ & Sinnett-Smith, PA (1984) The mode of action of anabolic agents with special reference to their effects on protein metabolism - some speculations. In Manipulation of Growth of Farm Animals, pp. 211219 [Roche, JF & O'Callaghan, D, editors]. Boston, MA: Martinus Nijhoff.
Campbell, PN & Work, TS (1952) The biosynthesis of proteins. I. Uptake of glycine, serine, valine and lysine by the mammary gland of the rabbit. Biochemical Journal 52, 217227.
Carstens, GE, Johnson, DE, Ellenberger, MA & Tatum, JD (1991) Physical and chemical components of the empty body during compensatory growth in beef steers. Journal of Animal Science 69, 32513264.
Chalupa, W & Sniffen, CJ (1994) Carbohydrate, protein and amino acid nutrition of dairy cows. In Recent Advances in Animal Nutritio, pp. 265275 [Garnsworthy, PC & Cole, DJA, editors]. Nottingham: Nottingham University Press.
Christie, WW (Editor) (1981) Lipid Metabolism in Ruminant Animals. Oxford: Pergamon Press.
Clark, JH (1975) Lactation responses to postruminal administration of proteins and amino acids. Journal of Dairy Science 58, 11781197.
Corbett, JL, Farrell, DJ, Leng, RA, McClymont, GL & Young, BA (1971) Determination of energy expenditure of penned and grazing sheep from estimates of CO2 entry rate. British Journal of Nutrition 26, 277291.
Costa, ND, McIntosh, GH & Snoswell, AM (1976) Production of endogenous acetate by the liver in lactating ewes. Australian Journal of Biological Sciences 29, 3342.
Cryer, A, Williams, SE & Cryer, J (1992) Dietary and other factors involved in the proliferation, determination and differentiation of adipocyte precursor cells. Proceedings of the Nutrition Society 51, 379385.
Danfaer, A (1994) Nutrient metabolism and utilization in the liver. Livestock Production Science 39, 115117.
Davies, DT, Holt, C & Christie, WW (1983) The composition of milk. In Biochemistry of Lactation, pp. 71120 [Mepham, TB, editor]. Amsterdam, The Netherlands: Elsevier.
Davis, SR & Bickerstaffe, R (1978) Mammary glucose uptake in the lactating ewe and the use of methionine arteriovenous difference for the calculation of mammary blood flow. Australian Journal of Biological Sciences 31, 133140.
Dils, RR (1983) Milk fat synthesis. In Biochemistry of Lactation, pp. 141158 [Mepham, TB, editor]. Amsterdam, The Netherlands: Elsevier.
Dole, VP (1956) A relation between non-esterified fatty acids in plasma and the metabolism of glucose. Journal of Clinical Investigation 35, 150154.
Elsasser, TH (1993) Endocrine-immune interactions that impact on animal health and productivity. Proceedings of the Maryland Nutrition Conference, pp. 8188 [Thomas, DP, editor]. College Park, MD: University of Maryland.
Elsden, SR (1946) The application of the silica gel partition chromatogram to the estimation of volatile fatty acids. Biochemical Journal 40, 252256.
Elsden, SR & Phillipson, AT (1948) Ruminant digestion. Annual Review of Biochemistry 17, 705726.
Emery, RS (1979) Deposition, secretion, transport and oxidation of fat in ruminants. Journal of Animal Science 48, 15301537.
Fleet, IR & Mepham, TB (1983) Physiological methods used in the study of mammary substrate utilization in ruminants. In Biochemistry of Lactation, pp. 469492 [Mepham, TB, editor]. Amsterdam, The Netherlands: Elsevier.
Flint, DJ (1992) Regulation of fat and lean deposition by the immune system. In The Control of Fat and Lean Deposition, pp. 299313 [Buttery, PJ, Boorman, KN & Lindsay, DB, editors]. Oxford: Butterworth-Heinemann.
Flint, DJ (1996) Immunological manipulation of adiposity. Biochemical Society Transactions 24, 418422.
Forbes, JM (1995) Voluntary Food Intake and Diet Selection in Farm Animals. Wallingford: CAB International.
Forsyth, IA (1983) The endocrinology of lactation. In Biochemistry of Lactation, pp. 309350 [Mepham, TB, editor]. Amsterdam, The Netherlands: Elsevier.
German, JB, Morand, L, Dillard, CJ & Xu, R (1997) Milk fat composition: targets for alteration of function and nutrition. In Milk Composition, Production and Biotechnology, pp. 3572 [Welch, RAS, Burns, DJS, Davis, SR, Popay, AI & Prosser, CG, editors]. Hamilton, New Zealand: CAB International.
Giles, LR, Annison, EF, Black, JL, Tucker, RG & Gooden, JM (1995) A new procedure for the continuous measurement of O2 consumption in pigs. Journal of Agricultural Science, Cambridge 124, 113118.
Gill, M, Thornley, JMH, Black, JL, Oldham, JD & Beever, DE (1984) Simulation of the metabolism of absorbed energy-yielding nutrients in young sheep. British Journal of Nutrition 52, 621649.
Gordon, RS & Cherkes, A (1956) Unesterified fatty acid in human blood plasma. Journal of Clinical Investigation 35, 206212.
Gray, GM (1992) Starch digestion and absorption in non-ruminants. Journal of Nutrition 122, 172177.
Griffin, JFT (1989) Stress and immunity: a unifying concept. Veterinary Immunology and Immunopathology 20, 263312.
Guerino, F, Huntingdon, GB & Erdman, RA (1991) The net portal and hepatic flux of metabolites and O2 consumption in growing beef steers given postruminal casein. Journal of Animal Science 69, 387395.
Hardwick, DC, Linzell, JL & Price, SM (1961) The effect of glucose and acetate on milk secretion in the perfused goat udder. Biochemical Journal 80, 3745.
Harmon, DL (1992) Dietary influences on carbohydrases and small intestinal starch hydrolysis capacity in ruminants. Journal of Nutrition 122, 203210.
Harmon, DL (1993) Nutritional regulation of postruminal digestive enzymes in ruminants. Journal of Dairy Science 76, 21022111.
Harris, PM, Waghorn, GC & Lee, J (1990) Nutritional partitioning of growth for productive gain. Proceedings of the New Zealand Society of Animal Production 50, 8190.
Hartmann, PE, Atwood, CS, Cox, DB & Daly, SEJ (1995) Endocrine and autocrine strategies for the control of lacation in women and sows. In Intercellular Signaling in the Mammary Gland, pp. 203244 [Wilde, CJ, Peaker, M & Knight, CH, editors]. New York, NY: Plenum Press.
Havel, RJ (1997) Milk fat consumption and human health: recent NIH and other American Governmental recommendations. In Milk Composition, Production and Biotechnology, pp. 1322 [Welch, RAS, Burns, DJW, Davis, SR, Popay, AI & Prosser, CG, editors]. Hamilton, New Zealand: CAB International.
Heald, PJ (1952) The assessment of glucose-containing substances in rumen micro-organisms during a digestion cycle in sheep. British Journal of Nutrition 5, 8493.
Hilditch, TP (1941) The Chemical Constituents of Natural Fats. New York, NY: John Wiley.
Hungate, RE (1966) The Rumen and its Microbes. New York, NY: Academic Press.
Huntington, GB (1989) Hepatic urea synthesis and site and route of urea removal from blood of beef steers fed alfalfa hay or a concentrate diet. Canadian Journal of Animal Science 69, 215223.
Huntington, GB (1997) Starch utilization by ruminants: from basics to the bunk. Journal of Animal Science 75, 852867.
Huntingdon, GB & Reynolds, PJ (1986) Net absorption of glucose, L-lactate, volatile fatty acids and nitrogenous compounds by bovine given abomasal infusions of starch or glucose. Journal of Dairy Science 69, 24282436.
Husband, AJ (1995) The immune system and integrated homeostasis. Immunology and Cell Biology 73, 377382.
Husband, AJ & Bryden, WL (1996) Nutrition, stress and immune activation. Proceedings of the Nutrition Society of Australia 20, 6070.
James, AT & Martin, AJP (1952) Gas-liquid partition chromatography: the separation and micro-estimation of volatile fatty acids from formic acid to dodecanoic acid. Biochemical Journal 50, 679690.
Janes, AN, Weekes, TEC & Armstrong, DG (1985) Absorption and metabolism of glucose by the mesenteric-drained viscera of sheep fed on dried grass or ground maize based diets. British Journal of Nutrition 54, 449458.
Johnson, RW, Arkins, S, Dantzer, R & Kelley, KW (1997) Hormones, lymphohemopoietic cytokines and the neuroimmune axis. Comparative Biochemistry and Physiology 116A, 183201.
Kelley, KW (1988) Cross-talk between the immune and endocrine systems. Journal of Animal Science 66, 20952108.
King, KR, Gooden, JM & Annison, EF (1985) Acetate metabolism in the mammary gland of the lactating ewe. Australian Journal of Biological Sciences 38, 2331.
Klasing, KC (1988) Nutritional aspects of leukocytic cytokines. Journal of Nutrition 118, 14361446.
Knight, CH (1998) Extended lactation. In Hannah Research Institute Yearbook, pp. 3039 [Taylor, E, editor]. Ayr, Scotland: Hannah Research Institute.
Kristensen, NB, Danfaer, A, Tetens, V & Agergaard, N (1996) Portal recovery of intraruminally infused short-chain fatty acids in sheep. Acta Agriculturae Scandinavica Section A, Animal Science 46, 2638.
Lacasse, P, Farr, VC, Davis, SR & Prosser, CG (1996) Local secretion of nitric oxide and the control of mammary blood flow. Journal of Dairy Science 79, 13691374.
Lauryssens, M, Verbeke, R, Peeters, G & Reinards, MT (1960) Incorporation of [1-14C] and [3-14C] butyrate into milk constituents by the perfused cow's udder. Journal of Dairy Research 27, 151160.
Lean, IJ & Westwood, CT (1997) Challenges to achieving high production from dairy cows in Australia. In Recent Advances in Animal Nutrition in Australia, 1997, pp. 192208 [Corbett, JL, Choct, M, Nolan, JV & Rowe, JB, editors]. Armidale, NSW, Australia: University of New England.
Leng, RA (1990) Factors affecting the utilization of `poor quality' forages by ruminants, particularly under tropical conditions. Nutrition Research Reviews 3, 277303.
Lescale-Matys, L, Dyer, J, Scott, D, Freeman, TC, Wright, EM & Shirazi-Beechey, SP (1993) Regulation of the ovine intestinal Na+-glucose co-transporter (SGLT1) is dissociated from mRNA abundance. Biochemical Journal 291, 435440.
Lewis, D, Hill, KJ & Annison, EF (1957) Studies on the portal blood of sheep. 1. Absorption of NH3 from the rumen of the sheep. Biochemical Journal 66, 587592.
Lifson, N, Gordon, GV & McClintock, R (1955) Measurement of total CO2 production by means of D2O18 Journal of Applied Physiology 7, 704710.
Lindsay, DB (1959) The significance of carbohydrate in ruminant nutrition. Veterinary Reviews Annotations 5, 103128.
Lindsay, DB (1970) Carbohydrate metabolism in the ruminant. In Physiology of Digestion and Metabolism in the Ruminant, pp. 438451 [Phillipson, AT, editor]. Newcastle-upon-Tyne: Oriel Press.
Lindsay, DB (1975) Fatty acids as energy sources. Proceedings of the Nutrition Society 34, 241248.
Lindsay, DB (1978) Gluconeogenesis in ruminants. Biochemical Society Transactions 8, 11521156.
Lindsay, DB (1993 a) Making the sums add up – the importance of quantification in nutrition. Australian Journal of Agricultural Research 44, 479493.
Lindsay, DB (1993 b) Metabolism of the portal-drained viscera. In Quantitative Aspects of Ruminant Digestion and Metabolism, pp. 267289 [Forbes, JM & France, J, editors]. Cambridge: CAB International.
Linzell, JL (1960) Valvular incompetence in the venous drainage of the udder. Journal of Physiology, London 153, 481491.
Linzell, JL (1974) Mammary blood flow and methods of identifying and measuring precursors of milk. In Lactation, vol. 1, pp. 143225 [Larson, BL & Smith, VR, editors]. New York, NY: Academic Press.
Linzell, JL & Annison, EF (1975) Methods of measuring the utilization of metabolites absorbed from the alimentary tract. In Digestion and Metabolism in the Ruminant, pp. 306319 [McDonald, IW & Warner, ACI, editors]. Armidale, NSW, Australia: University of New England Publishing Unit.
Linzell, JL, Fleet, IR, Mepham, TB & Peaker, M (1972) Perfusion of the isolated mammary gland of the goat. Quarterly Journal of Experimental Physiology 57, 139161.
Linzell, JL & Peaker, M (1971 a) Mechanism of milk secretion. Physiological Reviews 51, 564597.
Linzell, JL & Peaker, M (1971 b) The effects of oxytocin and milk removal on milk secretion in the goat. Journal of Physiology, London 216, 717734.
Lobley, GE (1991) Organ and tissue metabolism: present status and future trends. In Energy Metabolism of Farm Animals. EAAP Publication no. 58. pp. 8087 [Wenk, C & Boessinger, M, editors]. Zurich, Switzerland: Institut für Nutztierwissenschaften.
Lobley, GE (1993) Protein metabolism and turnover. In Quantitative Aspects of Ruminant Digestion and Metabolism, pp. 313340 [Forbes, JM & France, J, editors]. Cambridge: CAB International.
Lobley, GE, Connell, A, Lomax, MA, Brown, DS, Milne, E, Calder, AG & Farningham, DAH (1995) Hepatic detoxification in the ovine liver; possible consequences for amino acid catabolism. British Journal of Nutrition 73, 667685.
Lomax, MA & Baird, GD (1983) Blood flow and nutrient exchange across the liver and gut of the dairy cow. British Journal of Nutrition 49, 481496.
McClymont, GL (1951) Volatile fatty acid metabolism of ruminants, with special reference to the lactating bovine mammary gland and the composition of milk. Australian Journal of Agricultural Research 2, 158180.
McLean, JA & Tobin, G (1987) Animal and Human Calorimetry. Cambridge: Cambridge University Press.
Maltby, SA, Reynolds, CK, Lomax, MA & Beever, DE (1993) The effect of increased absorption of NH3 and arginine on splanchnic metabolism of beef steers. Animal Production 56, 462.
Masson, MJ & Phillipson, AT (1951) The absorption of acetate, propionate and butyrate from the rumen of sheep. Journal of Physiology, London 113, 189206.
Mepham, TB (1971) Amino acid utilisation by the lactating mammary gland. In Lactation, pp. 297315 [Falconer, IR, editor]. London: Butterworths.
Mepham, TB (1993) The development of ideas on the role of glucose in regulating milk secretion. Australian Journal of Agricultural Research 44, 509522.
Mepham, TB & Linzell, JL (1966) A quantitative assessment of the contribution of individual plasma amino acids to the synthesis of milk proteins by the goat mammary gland. Biochemical Journal 101, 7683.
Meyer, HHD, Stoffel, B & Hagen-Mann, K (1995) β-Agonists, anabolic steroids and their receptors: new aspects in growth regulation. In Ruminant Physiology: Digestion, Metabolism, Growth and Reproduction, pp. 475481 [Engelhardt, WV, Leonhard-Marek, S, Breves, G & Giesecke, D, editors]. Stuttgart, Germany: Ferdinand Enke Verlag.
Moore, JH & Christie, WW (1979) Lipid metabolism in the mammary gland of ruminant animals. Progress in Lipid Research 17, 347395.
Munro, HN (1964) Introduction. In Mammalian Protein Metabolism, vol. 1 [Munro, HN & Allison, JB, editors]. New York, NY: Academic Press.
Nehring, K, Schiemann, R & Hoffmann, L (1969) A new system of energetic evaluation of food on the basis of net energy for fattening. In Energy Metabolism of Farm Animals, pp. 4150 [Blaxter, KL, Kielanowski, J & Thorbek, G, editors]. Newcastle-upon-Tyne: Oriel Press.
Neutze, SA, Gooden, JM & Oddy, VH (1996) Uptake of labelled phenylalanine into different blood fractions in the portal vein and cranial mesenteric vein of lambs. Journal of Agricultural Science, Cambridge 126, 511518.
Oldham, JD (1993) Protein requirement systems for ruminants. In Progress in Dairy Science, pp. 328 [Phillips, CJC, editor]. Hamilton, New Zealand: CAB International.
Ørskov, ER (1990) Utilization of the energy of absorbed nutrients. In Energy Nutrition in Ruminants, pp. 84101 [Ørskov, ER, editor]. London: Butterworths.
Ørskov, ER & MacLeod, NA (1993) Effect of level of input of different proportions of volatile fatty acids on energy utilization in growing ruminants. British Journal of Nutrition 70, 679687.
Owens, FN & Goetsch, AL (1986) Digesta passage and microbial protein synthesis. In Control of Digestion and Metabolism in Ruminants, pp. 196223 [Milligan, LP, Grovum, WL & Dobson, A, editors]. Englewood Cliffs, NJ: Prentice-Hall.
Owens, FN, Zinn, RA & Kim, YK (1986) Limits to starch digestion in the ruminant small intestine. Journal of Animal Science 63, 16341648.
Peaker, M (1995) Autocrine control of milk secretion: development of the concept. In Intercellular Signaling in the Mammary Gland, pp. 193202 [Wilde, CJ, Peaker, M & Knight, CH, editors]. New York, NY: Plenum Press.
Peaker, M & Wilde, CJ (1996) Feedback control of milk secretion from milk. Journal of Mammary Gland Biology and Neoplasia 1, 307315.
Pell, JM & Flint, DJ (1997) Immunomodulation of lactation. In Milk Composition, Production and Biotechnology, pp. 307317 [Welch, RAS, Burns, DJW, Davis, SR, Popay, AI & Prosser, CG, editors]. Hamilton, New Zealand: CAB International.
Pennington, RJ (1952) The metabolism of short-chain fatty acids in the sheep. Biochemical Journal 51, 251258.
Pennington, RJ (1954) The metabolism of short-chain fatty acids in the sheep. 2. Further studies with rumen epithelium. Biochemical Journal 56, 410416.
Pennington, RJ & Sutherland, TM (1956) The metabolism of short-chain fatty acids in the sheep. 4. The pathway of propionate metabolism in rumen epithelial tissue. Biochemical Journal 63, 618628.
Pethick, DW (1993) Carbohydrate and lipid oxidation during exercise. Australian Journal of Agricultural Research 44, 431441.
Pethick, DW & Dunshea, FR (1993) Fat metabolism and turnover. In Quantitative Aspects of Ruminant Digestion and Metabolism, pp. 291312 [Forbes, JM & France, J, editors]. Cambridge: CAB International.
Pethick, DW, Miller, CM & Harman, NG (1991) Exercise in Merino sheep – the relationships between work intensity, endurance, anaerobic threshold and glucose metabolism. Australian Journal of Agricultural Research 42, 599620.
Pond, CM (1996) Adipose tissue differentiation and development. Biochemical Society Transactions 24, 393400.
Popjak, G, French, TH & Folley, SJ (1951 a) Utilization of acetate for milk fat synthesis in the lactating goat. Biochemical Journal 48, 411416.
Popjak, G, French, TH, Hunter, GD & Martin, SJP (1951 b) Mode of formation of milk fatty acids from acetate in the goat. Biochemical Journal 48, 612618.
Preston, TR & Leng, RA (1987) Matching Ruminant Production in the Tropics and Sub-Tropics, p. 49. Armidale, NSW, Australia: Penambul Books.
Prior, RL (1978) Effect of level of feed intake on lactate and acetate metabolism and lipogenesis in vivo in sheep. Journal of Nutrition 108, 926935.
Prosser, CG (1988) Mechanism of the decrease in hexose transport by mouse mammary epithelial cells caused by fasting. Biochemical Journal 249, 149154.
Rajczyk, ZK, Sweeting, A, Lean, IJ & Gooden, JM (1995) Postural effects on mammary blood flow and nutrient uptake. Proceedings of the Nutrition Society of Australia 19, 119.
Reeds, PJ (1991) Growth. In Energy Metabolism of Farm Animals. EAAP Publication no. 58, pp. 206208 [Wenk, C & Boessinger, M, editors]. Zurich, Switzerland: Institut für Nutztierwissenschaften.
Reid, RL (1950) Studies on the carbohydrate metabolism of sheep. II. The uptake by tissues of glucose and acetic acid from the peripheral circulation. Australian Journal of Agricultural Research 1, 338354.
Reid, RL (1952) Studies on the carbohydrate metabolism of sheep. V. The effect of hyperglycemia and insulin on the rate of extrahepatic glucose assimilation. Australian Journal of Agricultural Research 3, 160167.
Reithel, FJ, Horowitz, MG, Davidson, HM & Kittinger, GW (1952) Formation of lactose in homogenates of mammary gland. Journal of Biological Chemistry 194, 839848.
Reynolds, CK (1995) Quantitative aspects of liver metabolism in ruminants. In Ruminant Physiology: Digestion, Metabolism, Growth and Reproduction, pp. 351371 [Engelhardt, WV, Leonhard-Marek, S, Breves, G & Giesecke, D, editors]. Stuttgart, Germany: Ferdinand Enke Verlag.
Reynolds, CK, Casper, DP, Harmon, DL & Milton, CT (1992 a) Effect of CP and ME intake on visceral nutrient metabolism in beef steers. Journal of Animal Science 70, Suppl. 1, 315.
Reynolds, CK, Harmon, DL, Prior, RL & Tyrrell, HF (1994) Effects of mesenteric vein L-alanine infusion on liver metabolism of organic acids in beef heifers fed diets differing in forage to concentrate ratio. Journal of Animal Science 72, 31963206.
Reynolds, CK, Huntington, GB, Tyrrell, HF & Reynolds, PJ (1988) Net portal-drained visceral and hepatic metabolism of glucose, L-lactate and nitrogenous compounds in lactating Holstein cows. Journal of Dairy Science 71, 23952405.
Reynolds, CK, Lapierre, H, Tyrrell, HF, Elsasser, TH, Staples, RC, Gaudreau, P & Brazeau, P (1992 b) Effect of growth hormone releasing factor and feed intake on energy metabolism in growing beef steers: net nutrient metabolism by portal drained viscera and liver. Journal of Animal Science 70, 752763.
Rittenberg, D & Bloch, K (1945) The utilization of acetic acid for the synthesis of fatty acids. Journal of Biological Chemistry 160, 417424.
Rocha, HJG, Connell, A & Lobley, GE (1994) Whole body and trans-organ bicarbonate kinetics in sheep: effects of nutritional status. In Energy Metabolism of Farm Animals. EAAP publication no. 76, pp. 2730 [Aguilera, JF, editor]. Zurich, Switzerland: Institut für Nutztierwissenschaften.
Rowe, JB & Pethick, DW (1994) Starch digestion in ruminants – problems, solutions and opportunities. Proceedings of the Nutrition Society of Australia 18, 4052.
Russell, JB, O'Connor, JD, Fox, DG, Van Soest, PJ & Sniffen, CJ (1992) A net carbohydrate and protein system for evaluating cattle diets. II. Carbohydrate and protein availability. Journal of Animal Science 70, 35623577.
Schams, D (1995) Recent implications of the hormonal control of lactation. In Ruminant Physiology: Digestion, Metabolism, Growth and Reproduction, pp. 429450 [Engelhardt, WV, Leonhard-Marek, S, Breves, G & Giesecke, D, editors]. Stuttgart, Germany: Ferdinand Enke Verlag.
Schiemann, R (1969) The scientific demands made of a system for evaluating feeds as energy sources and progress made towards their realization. In Energy Metabolism of Farm Animals, pp. 3140 [Blaxter, KL, Kielanowski, J & Thorbek, G, editors]. Newcastle-upon-Tyne: Oriel Press.
Schoenheimer, R, Ratner, S & Rittenberg, D (1939) Studies in protein metabolism. VII. The metabolism of tyrosine. Journal of Biological Chemistry 127, 333344.
Schoenheimer, R & Rittenberg, D (1935) Deuterium as indicator in the study of intermediary metabolism. Science 82, 158159.
Scollan, ND (1994) Studying metabolic systems in vivo; the role of nuclear magnetic resonance spectroscopy. In Energy Metabolism in Farm Animals. EAAP Publication no. 76, pp. 4145 [Aguilera, JF, editor]. Zurich, Switzerland: Institut für Nutztierwissenschaften.
Scott, PJ (1997) Milk consumption and individual responses. In Milk Composition, Production and Biotechnology, pp. 2334 [Welch, RAS, Burns, DJW, Davis, SR, Popay, AI & Prosser, CG, editors]. Hamilton, New Zealand: CAB International.
Seal, CJ & Reynolds, CK (1993) Nutritional implications of gastrointestinal and liver metabolism in ruminants. Nutrition Research Reviews 6, 185208.
Seale, JL, Rumpler, WV & Conway, JM (1989) Comparison of energy expenditure determined by direct/indirect calorimetry and doubly labelled water in adult men. In Energy Metabolism in Farm Animals. EAAP Publication no. 43, pp. 337340 [Honing, Y van der & Close, WH, editors]. Zurich, Switzerland: Institut für Nutztierwissenschaften.
Searle, TW, Graham, NMcC & O'Callaghan, M (1972) Growth in sheep. 1. The chemical composition of the body. Journal of Agricultural Science, Cambridge 79, 371382.
Selye, H (1936 a) A syndrome produced by diverse nocuous agents. Nature 138, 32.
Selye, H (1936 b) Thymus and adrenals in the response of the organism to injuries and intoxication. British Journal of Experimental Pathology 17, 234248.
Shahneh, AZ, Giles, LR, Newman, R, Rigby, RDG, Gooden, JM & Wynn, PC (1994) Energy expenditure in exercising sheep immunized against adrenocorticotrophin (ACTH). In Energy Metabolism of Farm Animals. EAAP Publication no. 76, pp. 109112 [Aguilera, JF, editor]. Zurich, Switzerland: Institut für Nutztierwissenschaften.
Sharpe, PM, Buttery, PJ & Haynes, NB (1986) The effect of manipulating growth in sheep by diet or anabolic agents on plasma cortisol and muscle glucocorticoid receptors. British Journal of Nutrition 56, 289304.
Shirazi-Beechey, SP, Wood, IS, Dyer, J, Scott, D & King, TP (1995) Intestinal sugar transport in ruminants. In Ruminant Physiology: Digestion, Metabolism, Growth and Reproduction, pp. 117134 [Engelhardt, WV, Leonhard-Marek, S, Breves, G & Giesecke, D, editors]. Stuttgart, Germany: Ferdinand Enke Verlag.
Skou, JC (1991) The energy coupled exchange of Na+ for K+ across the cell membrane. The Na+, K+ pump. FEBS Letters 268, 314324.
Spady, DK, Woollet, LA & Dietschy, JM (1993) Regulation of plasma LDL-cholesterol levels by dietary cholesterol and fatty acids. Annual Review of Nutrition 13, 355381.
Steinhour, WD & Bauman, DE (1988) Propionate metabolism: a new interpretation. In Aspects of Digestive Physiology in Ruminants, pp. 238256 [Dobson, A & Dobson, MJ, editors]. Ithaca, NY: Comstock Publishing Associates.
Sutton, JD, Hart, IC, Moran, E, Schuler, AD & Simmonds, AD (1988) Feeding frequency for lactating cows: diurnal patterns of hormones and metabolites in peripheral blood in relation to milk-fat concentration. British Journal of Nutrition 60, 265274.
Tagari, H & Bergman, EN (1978) Intestinal disappearance and portal blood appearance of amino acids in sheep. Journal of Nutrition 108, 790803.
Taniguchi, K, Huntington, GB & Glenn, BP (1995) Net nutrient flux by visceral tissues of beef steers given abomasal and ruminal infusions of casein and starch. Journal of Animal Science 73, 236249.
Taniguchi, KY, Sunada, Y & Obitsu, T (1993) Starch digestion in the small intestine of sheep sustained by intragastric infusion without protein supply. Animal Science and Technology, Japan 64, 892898.
Threadgold, LC, Coore, HG & Kuhn, NJ (1982) Monosaccharide transport into lactating rat mammary acini. Biochemical Journal 204, 493501.
Tyrrell, HF, Reynolds, PJ & Moe, PW (1979) Effect of diet on partial efficiency of acetate use for body tissue synthesis by mature cattle. Journal of Animal Science 48, 598606.
Valeur, J (1997) Milk protein production and market prospects. In Milk Composition, Production and Biotechnology, pp. 93140 [Welch, RAS, Burns, DJW, Davis, SR, Popay, AI & Prosser, CG, editors]. Hamilton, New Zealand: CAB International.
van der Walt, JG (1984) Metabolic interactions of lipogenic precursors in the ruminant. In Herbivore Nutrition in the Subtropics and Tropics, pp. 571596 [Gilchrist, FMC & Mackie, RI, editors]. Pretoria, South Africa: The Science Press.
van der Walt, JG (1993) Nitrogen metabolism of the ruminant liver. Australian Journal of Agricultural Science 44, 381403.
van Es, AJH (1978) Feed evaluation for ruminants. 1. The systems in use from May 1977 onwards in The Netherlands. Livestock Production Science 5, 331345.
van Es, AJH (1994) The symposia on energy metabolism of farm animals of the EAAP. In Energy Metabolism of Farm Animals, pp. 409418 [Aguilera, JF, editor]. Madrid, Spain: CSIC Publishing Service.
Vermorel, M (1978) Feed evaluation for ruminants. II. The new energy systems proposed in France. Livestock Production Science 5, 347365.
Vernon, RG (1981) Lipid metabolism in the adipose tissue of ruminant animals. In Lipid Metabolism in Ruminant Animals, pp. 279362 [Christie, WW, editor]. Oxford: Pergamon Press.
Vernon, RG (1998) Homeorhesis. In Hannah Research Institute Yearbook, pp. 6473 [Taylor, E, editor]. Ayr, Scotland: Hannah Research Institute.
Vernon, RG & Sasaki, S (1991) Control of responsiveness of tissues to hormones. In Physiological Aspects of Digestion and Metabolism in Ruminants, pp. 155182 [Tsuda, T, Sasaki, Y & Kawashima, R, editors]. San Diego, CA: Academic Press.
Ward, KA & Nancarrow, CD (1995) The commercial and agricultural applications of animal transgenesis. Molecular Biotechnology 4, 167178.
Ward, S & MacLeod, MG (1991) Doubly labelled water measurements of the energy metabolism of an avian species under different ambient temperatures and reproductive states. In Energy Metabolism of Farm Animals. EAAP Publication no. 43, pp. 230233 [Wenk, C & Boessinger, M, editors]. Zurich, Switzerland: Institut für Nutztierwissenschaften.
Waterlow, JC, Garlick, PJ & Millward, DJ (1978) Protein Turnover in Mammalian Tissues and in the Whole Body. Amsterdam, Holland: North Holland Publishing Company.
Webb, KE (1990) Intestinal absorption of protein hydrolysis products: a review. Journal of Animal Science 68, 30113022.
Webb, KE Jr, Matthews, JC & DiRienzo, DB (1992) Peptide absorption: a review of current concepts and future perspectives. Journal of Animal Science 70, 32483257.
Webster, AJF (1989) Energy utilization during growth and reproduction. In Energy Metabolism of Farm Animals. EAAP Publication no. 43, pp. 8588 [Honing, Y van der & Close, WH, editors]. Zurich, Switzwerland: Institut für Nutztierwissenschaften.
Webster, AJF (1992) The metabolisable protein system for ruminants. In Recent Advances in Animal Nutrition – 1992, pp. 93110 [Garnsworthy, PC, editor]. London: Butterworths.
Weekes, TE (1991) Hormonal control of glucose metabolism. In Physiological Aspects of Digestion and Metabolism in Ruminants, pp. 183200 [Tsuda, T, Sasaki, Y & Kawashima, R, editors]. San Diego, CA: Academic Press.
West, CE, Bickerstaffe, R, Annison, EF & Linzell, JL (1972) Studies on the mode of uptake of blood triglycerides by the mammary gland of the lactating goat. The uptake and incorporation into milk fat and mammary lymph of labelled glycerol, fatty acids and triglycerides. Biochemical Journal 126, 477490.
White, RG & Leng, RA (1969) Carbon dioxide entry rate as an index of energy expenditure in lambs. Proceedings of the Australian Society of Animal Production 7, 335341.
Whitelaw, FG, Brockway, JM & Reid, RS (1972) Measurement of CO2 production in sheep by isotope dilution. Quarterly Journal of Experimental Physiology 57, 3755.
Wilde, CJ, Addey, CVP, Boddy-Finch, LM & Peaker, M (1995) Autocrine control of milk secretion: from concept to application. In Intercellular Signaling in the Mammary Gland, pp. 227237 [Wilde, CJ, Peaker, M & Knight, CM, editors]. New York, NY: Plenum Press.
Wilde, CJ & Kuhn, NJ (1981) Lactose synthesis and utilization of glucose by rat mammary acini. International Journal of Biochemistry 132, 311316.
Williams, SR & Gadian, DR (1986) Tissue metabolism studied in vivo by nuclear magnetic resonance. Quarterly Journal of Experimental Physiology 71, 335360.
Wolff, JE & Bergman, EN (1972) Gluconeogenesis from plasma amino acids in fed sheep. American Journal of Physiology 223, 455460.
Yang, YT & McElligott, M (1989) Multiple action of β-adrenergic agonists on skeletal muscle and adipose tissue. Biochemistry 261, 110.
Young, VR (1996) Protein and amino acid metabolism and nutrition: what have we learned between the 6th and 7th International Symposium. In Protein Metabolism and Nutrition, pp. 340 [Nunes, AF, Portugal, AV, Costa, JP & Ribeiro, JR, editors]. Santarém, Portugal: Instituto Nacional de Investigacao Agraria.
Zierler, KL (1961) Theory of the use of arterio-venous concentration differences for measuring metabolism in steady and non-steady states. Journal of Clinical Investigation 40, 21112125.
Zierler, KL (1976) Fatty acids as substrates for heart and skeletal muscle. Circulation Research 38, 459463.

Keywords

Perspectives on ruminant nutrition and metabolism. II. Metabolism in ruminant tissues

  • E. F Annison (a1) and W. L Bryden (a1)

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