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Novel Substrates to Maintain Gut Integrity

Published online by Cambridge University Press:  14 December 2007

Keith R. Gardiner ,
Stephen J. Kirk  and
Brian J. Rowlands
Keith R. Gardiner
Affiliation:
Department of Surgery, The Queen's University of Belfast, Institute of Clinical Science, Grosvenor Road, Belfast BT12 6BJ, Northern Ireland, UK
Stephen J. Kirk
Affiliation:
Department of Surgery, The Queen's University of Belfast, Institute of Clinical Science, Grosvenor Road, Belfast BT12 6BJ, Northern Ireland, UK
Brian J. Rowlands
Affiliation:
Department of Surgery, The Queen's University of Belfast, Institute of Clinical Science, Grosvenor Road, Belfast BT12 6BJ, Northern Ireland, UK
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Abstract

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Type
Research Article
Information
Nutrition Research Reviews , Volume 8 , Issue 1 , January 1995 , pp. 43 - 66
Copyright
Copyright © The Nutrition Society 1995

References

1Adjei, A. A., Ohshiro, Y., Yamauchi, K., Nakasone, Y., Shimada, K., Iwanaga, M. & Yamamoto, S. (1994). Intraperitoneal administration of nucleoside-nucleotide mixture inhibits endotoxin-induced bacterial translocation in protein-deficient mice. Tohoku Journal of Experimental Medicine 174, 1–10.Google Scholar
2Adjei, A. A. & Yamamoto, S. (1995). A dietary nucleoside-nucleotide mixture inhibits endotoxin-induced bacterial translocation in mice fed protein-free diet. Journal of Nutrition 125, 42–48.Google ScholarPubMed
3Alexander, J. W., Boyce, S. T., Babcock, G. F., Gianotti, L., Peck, M. D., Dunn, D. L., Pyles, T., Childress, C. P. & Ash, S. K. (1990). The process of microbial translocation. Annals of Surgery 212, 496–512.CrossRefGoogle ScholarPubMed
4Alexander, J. W., MacMillan, B. G., Stinnett, J. D., Ogle, C. K., Bozian, R. C., Fischer, J. E., Oakes, J. B., Morris, M. J. & Krummel, R. (1980). Beneficial effects of aggressive protein feeding in severely burned children. Annals of Surgery 192, 505–517.CrossRefGoogle ScholarPubMed
5Alverdy, J. C., Aoys, B. S. & Moss, G. S. (1990). Effect of commercially available chemically defined liquid diets on the intestinal microflora and bacterial translocation from the gut. Journal of Parenteral and Enteral Nutrition 14, 1–6.CrossRefGoogle ScholarPubMed
6Ambrose, N. S., Johnson, M., Burdon, D. W. & Keighley, M. R. B. (1984). Incidence of pathogenic bacteria from mesenteric lymph nodes and ileal serosa during Crohn's disease surgery. British Journal of Surgery 71, 623–625.Google Scholar
7Ardawi, M. S. M. (1991). Effect of glutamine-enriched total parenteral nutrition on septic rats. Clinical Science 81, 215–222.CrossRefGoogle ScholarPubMed
8Ardawi, M. S. M. & Newsholme, E. A. (1985). Fuel utilization in colonocytes of the rat. Biochemical Journal 231, 713–719.CrossRefGoogle ScholarPubMed
9Asako, H., Wolf, R. E. & Granger, D. N. (1993). Leukocyte adherence in rat mesenteric venules: effects of adenosine and methotrexate. Gastroenterology 104, 31–37.Google Scholar
10Aslan, A. & Triadafilopoulos, G. (1992). Fish oil fatty acid supplementation in active ulcerative colitis: a doubleblind, placebo-controlled crossover study. American Journal of Gastroenterology 87, 432–437.Google ScholarPubMed
11Babst, R., Hörig, H., Stehle, P., Brand, O., Filgueira, L., Marti, W., Fischer, M., Oberholzer, M., Gudat, F., F¨rst, P. & Heberer, M. (1993). Glutamine peptide-supplemented long-term total parenteral nutrition: effects on intracellular and extracellular amino acid patterns, nitrogen economy, and tissue morphology in growing rats. Journal of Parenteral and Enteral Nutrition 17, 566–574 (erratum 18, 197).CrossRefGoogle ScholarPubMed
12Barber, A. E., Jones, W. G., Minei, J. P., Fahey, T. J., Lowry, S. F. & Shires, G. T. (1991). Bacterial overgrowth and intestinal atrophy in the etiology of gut barrier failure in the rat. American Journal of Surgery 161, 300–304.CrossRefGoogle ScholarPubMed
13Barber, A. E., Jones, W. G., Minei, J. P., Fahey, T. J., Moldawer, L. L., Rayburn, J. L., Fischer, E., Keogh, C. V., Shires, G. T. & Lowry, S. F. (1990). Glutamine or fiber supplementation of a defined formula diet: impact on bacterial translocation, tissue composition, and response to endotoxin. Journal of Parenteral and Enteral Nutrition 14, 335–343.CrossRefGoogle ScholarPubMed
14Barbul, A. (1986). Arginine: biochemistry, physiology, and therapeutic implications. Journal of Parenteral and Enteral Nutrition 10, 227–238.CrossRefGoogle ScholarPubMed
15Bark, T., Katouli, M., Ljungquist, O., Möllby, R. & Svenberg, T. (1995). Glutamine supplementation does not prevent bacterial translocation after non-lethal haemorrhage in rats. European Journal of Surgery 161, 3–8.Google Scholar
16Baskerville, A., Hambleton, P. & Benbough, J. E. (1980). Pathologic features of glutaminase toxicity. British Journal of Experimental Pathology 61, 132–138.Google ScholarPubMed
17Beaulieu, J.-F. & Calvert, R. (1985). Permissive effect of glutamine on the differentiation of fetal mouse small intestine in organ culture. Differentiation 29, 50–55.CrossRefGoogle ScholarPubMed
18Berg, R. D. (1981). Promotion of the translocation of enteric bacteria from the gastrointestinal tracts of mice by oral treatment with penicillin, clindamycin or metronidazole. Infection and Immunity 33, 854–861.CrossRefGoogle ScholarPubMed
19Berg, R. D. & Garlington, A. W. (1979). Translocation of certain indigenous bacteria from the gastrointestinal tract to the mesenteric lymph nodes and other organs in a gnotobiotic mouse model. Infection and Immunity 23, 403–411.CrossRefGoogle Scholar
20Blachier, F., Darcy-Vrillon, B., Sener, A., Duee, P. H. & Malaisse, W. J. (1991). Arginine metabolism in rat enterocytes. Biochimica et Biophysica Acta 1092, 304–310.CrossRefGoogle ScholarPubMed
21Blair, P., Rowlands, B. J., Lowry, K., Webb, H., Armstrong, P. & Smilie, J. (1991). Selective decontamination of the digestive tract: a stratified, randomized, prospective study in a mixed intensive care unit. Surgery 110, 303–310.Google Scholar
22Border, J. R., Hassett, J., LaDuca, J., Seibel, R., Steinberg, S., Mills, B., Losi, P. & Border, D. (1987). The gut origin septic states in blunt multiple trauma (ISS = 40) in the ICU. Annals of Surgery 206, 427–448.CrossRefGoogle ScholarPubMed
23Bower, R. H., Cerra, F. B., Bershadsky, B., LiCari, J. J., Hoyt, D. B., Jensen, G. L., van Buren, C. T., Rothkopf, M. M., Daly, J. M. & Adelsberg, B. R. (1995). Early enteral administration of a formula (Impact) supplemented with arginine, nucleotides, and fish oil in intensive care unit patients: results of a multicenter, prospective, randomized, clinical trial. Critical Care Medicine 23, 436–449.CrossRefGoogle ScholarPubMed
24Breuer, R. I., Buto, S. K., Christ, M. L., Bean, J., Vernia, P., Paoluzi, P., Di Paolo, M. C. & Caprilli, R. (1991). Rectal irrigation with short chain fatty acids for distal ulcerative colitis: preliminary report. Digestive Diseases and Sciences 36, 185–187.CrossRefGoogle ScholarPubMed
25Brock-Utne, J. G. & Gaffin, S. L. (1989). Endotoxins and anti-endotoxins (their relevance to the anaesthetist and the intensive care specialist). Anaesthesia and Intensive Care 17, 49–55.CrossRefGoogle Scholar
26Brunser, O., Espinoza, J., Araya, M., Cruchet, S. & Gil, A. (1994). Effect of dietary nucleotide supplementation on diarrhoeal disease in infants. Acta Paediatrica 83, 188–191.Google Scholar
27Bueno, J., Torres, M., Almendros, A., Carmona, R., Nuñez, M. C., Rios, A. & Gil, A. (1994). Effect of dietary nucleotides on small intestinal repair after diarrhoea. Histological and ultrastructural changes. Gut 35, 926–933.CrossRefGoogle ScholarPubMed
28Burke, D. J., Alverdy, J. C., Aoys, E. & Moss, G. S. (1989). Glutamine-supplemented total parenteral nutrition improves gut immune function. Archives of Surgery 124, 1396–1399.CrossRefGoogle ScholarPubMed
29Burrin, D. G., Shulman, R. J., Langston, C. & Storm, M. C. (1994). Supplemental alanylglutamine, organ growth and nitrogen metabolism in neonatal pigs fed by total parenteral nutrition. Journal of Parenteral and Enteral Nutrition 18, 313–319.CrossRefGoogle ScholarPubMed
30Busch, J., Hammer, M., Brunkhorst, R. & Wagner, P. (1988). [Determination of endotoxin in inflammatory rheumatic diseases. Effect of non-steroidal anti-inflammatory drugs on intestinal permeability.] Zeitschrift für Rheumatologie 47, 156–160.Google ScholarPubMed
31Bustamante, S. A., Sanches, N., Crosier, J., Miranda, D., Colombo, G. & Miller, M. J. S. (1994). Dietary nucleotides: effects on the gastrointestinal system in swine. Journal of Nutrition 124, 149S–156S.Google Scholar
32Byrne, T. A., Morrissey, T. B., Ziegler, T. R., Gatzen, C., Young, L. S. & Wilmore, D. W. (1992). Growth hormone, glutamine, and fiber enhanced adaptation of remnant bowel following massive intestinal resection. Surgical Forum 43, 151–153.Google Scholar
33Carrico, C. J., Meakins, J. L., Marshall, J. C., Fry, D. & Maier, R. V. (1986). Multiple organ failure syndrome. Archives of Surgery 121, 196–208.CrossRefGoogle ScholarPubMed
34Carver, J., Bustamante, S., Novak, D. & Barnes, L. (1993). Dietary nucleotides may act as growth factors in liver and intestine. FASEB Journal 7, A643.Google Scholar
35Carver, J. D. (1994). Dietary nucleotides: cellular immune, intestinal and hepatic system effects. Journal of Nutrition 124, 144S–148S.CrossRefGoogle ScholarPubMed
36Cerra, F. B., Lehman, S., Konstantinides, N., Konstantinides, F., Shronts, E. P. & Holman, R. (1990). Effect of enteral nutrient on in vitro tests of immune function in ICU patients: a preliminary report. Nutrition 6, 84–87.Google ScholarPubMed
37Chen, K., Okuma, T., Okamura, K., Torigoe, Y. & Miyauchi, Y. (1994). Glutamine-supplemented parenteral nutrition improves gut mucosa integrity and function in endotoxemic rats. Journal of Parenteral and Enteral Nutrition 18, 167–171.CrossRefGoogle ScholarPubMed
38Cruz, N., Alvarez, X., Berg, R. D. & Deitch, E. A. (1994). Bacterial translocation across enterocytes: results of a study of bacterial enterocyte interactions utilizing Caco-2 cells. Shock 1, 67–72.Google Scholar
39Cummings, J. H. & Branch, W. J. (1986). Fermentation and production of short chain fatty acids in the human large intestine. In Dietary fiber: Basic and Clinical Aspects. pp. 131–152 [ G. B., Vahouny and D., Kritchevsky, editors]. New York: Plenum Press.CrossRefGoogle Scholar
40Cynober, L. (1994). Can arginine and ornithine support gut functions. Gut 35 (Suppl. 1), S42–S45.CrossRefGoogle ScholarPubMed
41Cynober, L., Coudray-Lucas, C., De Bandt, J. P., Guéchot, J., Aussel, C., Salvucci, M. & Giboudeau, J. (1990). Action of ornithine α ketoglutarate, ornithine hydrochloride and calcium α-ketoglutarate on plasma amino acid and hormonal patterns in healthy subjects. Journal of the American College of Nutrition 9, 2–12.CrossRefGoogle ScholarPubMed
42Daly, J. M., Lieberman, M. D., Goldfine, J., Shou, J., Weintraub, F., Rosato, E. F. & Lavin, P. (1992). Enteral nutrition with supplemental arginine, RNA, and omega-3 fatty acids in patients after operation: immunologic, metabolic, and clinical outcome. Surgery 112, 56–67.Google ScholarPubMed
43Daly, J. M., Weintraub, F. N., Shou, J., Rosato, E. F. & Lucia, M. (1995). Enteral nutrition during multimodality therapy in upper gastrointestinal cancer patients. Annals of Surgery 221, 327–338.Google Scholar
44D'Argenio, G., Cosenza, V., Sorrentini, I, De Ritis, F., Gatto, A., Cave, M. D., D'Armiento, F. P. & Mazzacca, G. (1994). Butyrate, mesalamine, and factor XIII in experimental colitis in the rat: effects on transglutaminase activity. Gastroenterology 106, 399–404.CrossRefGoogle ScholarPubMed
45De Bruin, P. A. F., Crama-Bohbouth, G., Verspaget, H. W., Verheijen, J. H., Dooijewaard, G., Weterman, I. T. & Lamers, C. B. H. W. (1988). Plasminogen activators in the intestine of patients with inflammatory bowel disease. Thrombosis and Haemostasis 60, 262–266.Google Scholar
46Deitch, E. A. (1990 a). Bacterial translocation of the gut flora. Journal of Trauma 30, S184–189.CrossRefGoogle ScholarPubMed
47Deitch, E. A. (1990 b). Intestinal permeability is increased in burn patients shortly after injury. Surgery 107, 411–416.Google Scholar
48Deitch, E. A. (1991). Selective gut nutrition: food for thought or empty calories? Nutrition 7, 10–11.Google Scholar
49Deitch, E. A., Ma, W. J., Ma, L., Berg, R. D., & Specian, R. D. (1990 a) Protein malnutrition predisposes to inflammatory-induced gut-origin septic states. Annals of Surgery 211, 560–567.Google Scholar
50Deitch, E. A., Morrison, J., Berg, R. & Specian, R. D. (1990 b). Effect of hemorrhagic shock on bacterial translocation, intestinal morphology, and intestinal permeability in conventional and antibiotic-decontaminated rats. Critical Care Medicine 18, 529–536.Google Scholar
51Deitch, E. A., Specian, R. D. & Berg, R. D. (1991). Endotoxin-induced bacterial translocation and mucosal permeability: role of xanthine oxidase, complement activation, and macrophage products. Critical Care Medicine 19, 785–791.CrossRefGoogle ScholarPubMed
52Deitch, E. A., Xu, D., Naruhn, M., Deitch, D. C., Lu, Q. & Marino, A. A. (1995). Elemental diet and IV-TPN induced bacterial translocation is associated with loss of intestinal mucosal barrier function against bacteria. Annals of Surgery 221, 299–307.CrossRefGoogle ScholarPubMed
53Deitch, E. A., Xu, D., Qi, L. & Berg, R. (1993). Elemental diet-induced immune suppression is caused by both bacterial and dietary factors. Journal of Parenteral and Enteral Nutrition 17, 332–336.Google Scholar
54Dekker, A. W., Rozenberg-Arska, M., Sixma, J. J. & Verhoef, J. (1981). Prevention of infection by trimethoprim sulfamethoxazole plus amphotericin B in patients with acute non-lymphocytic leukemia. Annals of Internal Medicine 95, 555–559.Google Scholar
55Eade, M. N. & Brooke, B. N. (1969). Portal bacteraemia in cases of ulcerative colitis submitted to colectomy. Lancet i, 1008–1009.CrossRefGoogle Scholar
56Eastwood, G. L. (1977). Small bowel morphology and epithelial proliferation in intravenously alimented rabbits. Surgery 82, 613–620.Google ScholarPubMed
57Edlund, C., Bergan, T., Josefsson, K., Solberg, R. & Nord, C. E. (1987). Effect of norfloxacin on human oropharyngeal and colonic microflora and multiple-dose pharmacokinetics. Scandinavian Journal of Infactious Diseases 19, 113–121.Google Scholar
58Ellestad-Sayed, J. J., Nelson, R. A., Adson, M. A., Palmer, W. M., & Soule, E. H. (1976). Pantothenic acid., coenzyme A, and human chronic ulcerative and granulomatous colitis. American Journal of Clinical Nutrition 29, 1333–1338.CrossRefGoogle ScholarPubMed
59Elliott, R., Stephens, R. W. & Doe, W. F. (1987). Expression of urokinase-type plasminogen activator in the mucosal lesions of inflammatory bowel disease. Journal of Gastroenterlogy and Hepatology 2, 517–523.Google Scholar
60Elsen, R. J. & Bistrian, B. R. (1991). Recent developments in short-chain fatty acid metabolism. Nutrition 7, 7–10.Google ScholarPubMed
61Evers, B. M., Izukura, M., Townsend, C. M., Uchida, T. & Thompson, J. C. (1990). Differential effects of gut hormones on pancreatic and intestinal growth during administration of an elemental diet. Annals of Surgery 211, 630–638.Google Scholar
62Fink, M. P. (1991). Gastrointestinal mucosal injury in experimental models of shock, trauma, and sepsis. Critical Care Medicine 19, 627–641.CrossRefGoogle ScholarPubMed
63Flynn, W. J., Gosche, J. R. & Garrison, R. N. (1992). Intestinal blood flow is restored with glutamine or glucose suffusion after hemorrhage. Journal of Surgical Research 52, 499–504.CrossRefGoogle ScholarPubMed
64Fox, A. D., De Paula, J. A., Kripke, S. A., Palacio, J. C., Berman, J. M., Settle, R. G. & Rombeau, J. L. (1988 a). Glutamine-supplemented elemental diets reduce endotoxemia in a lethal model of enterocolitis. Surgical Forum 39, 46–48.Google Scholar
65Fox, A. D., Kripke, S. A., DePaula, J., Berman, J. M., Settle, R. G. & Rombeau, J. L. (1988 b). Effect of a glutamine-supplemented enteral diet on methotrexate-induced enterocolitis. Journal of Parenteral and Enteral Nutrition 12, 325–331.Google Scholar
66Frankel, W. L., Zhang, W., Afonso, J., Klurfeld, D. M., Don, S. H., Laitin, E., Deaton, D., Furth, E. E., Pietra, G. G., Naji, A. & Rombeau, J. L. (1993). Glutamine enhancement of structure and function in transplanted small intestine in the rat. Journal of Parenteral and Enteral Nutrition 17, 47–55.Google Scholar
67Frankel, W. L., Zhang, W., Singh, A., Klurfeld, D. M., Don, S., Sakata, T., Modlin, I. & Rombeau, J. L. (1994). Mediation of the trophic effects of short chain fatty acids on the rat jejunum and colon. Gastroenterology 106, 375–380.Google Scholar
68Friedel, D. & Levine, G. M. (1982). Effect of short-chain fatty acids on colonic function and structure. Journal of Parenteral and Enteral Nutrition 16, 1–4.Google Scholar
69Gardiner, K. R., Halliday, M. I., Barclay, G. R., Milne, L., Brown, D., Stephens, S., Maxwell, R. J. & Rowlands, B. J. (1995). Significance of systemic endotoxaemia in inflammatory bowel disease. Gut 36, 897–900.Google Scholar
70Gianotti, L., Alexander, J. W., Gennari, R., Pyles, T. & Babcock, G. F. (1995). Oral glutamine decreases bacterial translocation and improves survival in experimental gut-origin sepsis. Journal of Parenteral and Enteral Nutrition 19, 69–74.CrossRefGoogle ScholarPubMed
71Gianotti, L., Alexander, J. W., Pyles, T. & Fukushima, R. (1993). Arginine-supplemented diets improve survival in gut-derived sepsis and peritonitis by modulating bacterial clearance. Annals of Surgery 217, 644–654.CrossRefGoogle ScholarPubMed
72Gibson, P. R., Rosella, O., Rosella, G. & Young, G. P. (1994). Butyrate is a potent inhibitor of urokinase secretion by normal colonic epithelium in vitro. Gastroenterology 107, 410–419.Google Scholar
73Gil, A., Corral, E., Martinez, A. & Molina, J. A. (1986). Effects of the addition of nucleotides to an adapted milk formula on the microbial pattern of faeces in at term newborn infants. Journal of Clinical Nutrition and Gastroenterology 1, 127–132.Google Scholar
74Go, L. L., Healey, P. J., Watkins, S. C., Simmons, R. L. & Rowe, M. I. (1995). The effect of endotoxin on intestinal mucosal permeability to bacteria in vitro. Archives of Surgery 130, 53–58.Google Scholar
75Gonce, S. J., Peck, M. D., Alexander, J. W. & Miskell, P. W. (1990). Arginine supplementation and its effect on established peritonitis in guinea pigs. Journal of Parenteral and Enteral Nutrition 14, 237–244.Google Scholar
76Gottschlich, M. M., Jenkins, M., Warden, G. D., Baumer, T., Havens, P., Snook, J. T. & Alexander, P. W. (1990). Differential effects of 3 enteral dietary regimens on selected outcome variables in burn patients. Journal of Parenteral and Enteral Nutrition 14, 225–236.Google Scholar
77Grant, J. P. & Snyder, P. J. (1988). Use of L-glutamine in total parenteral nutrition. Journal of Surgical Research 44, 406–513.Google Scholar
78Grimble, G. K. (1993). Essential and conditionally-essential nutrients in clinical nutrition. Nutrition Research Reviews 6, 97–119.Google Scholar
79Grimble, G. K. (1994). Dietary nucleotides and gut mucosal defence. Gut 35 (Suppl. 1), S46–S51.CrossRefGoogle ScholarPubMed
80Grisham, M. B., Hernandez, L. A. & Granger, D. N. (1989). Adenosine inhibits ischemia-reperfusion-induced leukocyte adherence and extravasation. American Journal of Physiology 257, H1334–H1339.Google ScholarPubMed
81Guarner, F., Vilaseca, J. & Malagelada, J. R. (1992). Dietary manipulation in experimental inflammatory bowel disease. Agents and Actions Special Issue 1, C10–C14.Google Scholar
82Guedon, C., Schmitz, J., Lerebours, E., Metayer, J., Audran, E., Hemet, J. & Colin, R. (1986). Decreased brush border hydrolase activities without gross morphologic changes in human intestinal mucosa after prolonged total parenteral nutrition of adults. Gastroenterology 90, 373–378.Google Scholar
83Hammarqvist, F., Wernerman, J., Ali, R. & Vinnars, E. (1990). Effects of an amino acid solution enriched with either branched-chain amino acids or ornithine-alpha-ketoglutarate on the postoperative intracellular amino acid concentration of skeletal muscle. British Journal of Surgery 77, 214–218.CrossRefGoogle ScholarPubMed
84Harig, J. M., Soergel, K. H., Komorowski, R. A. & Wood, C. M. (1989). Treatment of diversion colitis with short chain fatty acid irrigation. New England Journal of Medicine 320, 23–28.CrossRefGoogle ScholarPubMed
85Harvey, L. P., McAnena, O. J., Mehta, B. M. & Daly, J. M. (1987). Reversibility of elemental liquid diet enhanced methotrexate toxicity by refeeding with chow. Journal of Parenteral and Enteral Nutrition 11, 119–123.Google Scholar
86Hawkey, C. J. & Rampton, D. S. (1985). Prostaglandins and the gastrointestinal mucosa: are they important in its function, disease, or treatment? Gastroenterology 89, 1162–1188.Google Scholar
87Hawthorne, A. B., Daneshment, T. K., Hawkey, C. J., Shaheen, M. Z., Edwards, T. J., Filipowicz, B. L. & Everitts, J. (1990). A randomized controlled trial of fish oil in ulcerative colitis. Gastroenterology 98, A174.Google Scholar
88He, Y., Chu, S-H. W. & Walker, W. A. (1993). Nucleotide supplements alter proliferation and differentiation of cultured human (Caco-2) and rat (IEC-6) intestinal epithelial cells. Journal of Nutrition 123, 1017–1027.Google Scholar
89Helton, S., Smith, R., Hong, R., Rounds, J. & Wilmore, D. (1991). Are intestinal permeability, bacterial translocation and intestinal atrophy during TPN and enteral feeding related? Journal of Parenteral and Enteral Nutrition 15 (Suppl.), 17.Google Scholar
90Higashiguchi, T., Hasselgren, P-O, Wagner, K. & Fischer, J. E. (1993). Effect of glutamine on protein synthesis in isolated intestinal epithelial cells. Journal of Parenteral and Enteral Nutrition 17, 307–314.Google Scholar
91Hoch, R. C., Rodriguez, R., Manning, T., Bishop, M., Mead, P., Shoemaker, W. C. & Abraham, E. (1993). Effects of accidental trauma on cytokine and endotoxin production. Critical Care Medicine 21, 839–845.Google Scholar
92Houdijk, A. P., van Leeuwen, P. A., Boermeester, M. A., van Lambalgen, T., Teerlink, T., Flinkerbusch, E. L., Sauerwein, H. P. & Wesdorp, R. I. (1994). Glutamine-enriched enteral diet increases splanchnic blood flow in the rat. American Journal of Physiology 267, G1035–1040.Google Scholar
93Iijima, S., Tsujinaka, T., Kido, Y., Hayashida, Y., Ishida, H., Homma, T., Yokoyama, H. & Mori, T. (1993). Intravenous administration of nucleosides and a nucleotide mixture diminishes intestinal mucosal atrophy induced by total parenteral nutrition. Journal of Parenteral and Enteral Nutrition 17, 265–270.Google Scholar
94Illig, K. A., Ryan, C. K., Hardy, D. J., Rhodes, J., Locke, W., Sax, H. C., Schoerb, P. A., Lucas, C. E. & Fischer, J. E. (1992). Total parenteral nutrition-induced changes in gut mucosal function: atrophy alone is not the issue. Surgery 112, 631–637.Google Scholar
95Inoue, Y., Grant, J. P. & Snyder, P. J. (1993 a). Effect of glutamine-supplemented intravenous nutrition on survival after Escherichia coli-induced peritonitis. Journal of Parenteral and Enteral Nutrition 17, 41–46.Google Scholar
96Inoue, Y., Grant, J. P. & Snyder, P. J. (1993 b). Effect of glutamine-supplemented parental nutrition on recovery of the small intestine after starvation atrophy. Journal of Parental and Enternal Nutrition 17, 165–170.CrossRefGoogle Scholar
97Jacobs, D. O., Evans, D. A., Mealy, K., O'Dwyer, S. T., Smith, R. J. & Wilmore, D. W. (1988). Combined effects of glutamine and epidermal growth factor on the rat intestine. Surgery 104, 358–364.Google Scholar
98Jacobs, D. O., Evans, D. A., O'Dwyer, S. T., Smith, R. J. & Wilmore, D. W. (1987). Disparate effects of 5-fluorouracil on the ileum and colon of enterally fed rats with protection by dietary glutamine. Surgical Forum 38, 45–46.Google Scholar
99Jacobs, D., Evans, D., O'Dwyer, S. T., Smith, R. J. & Wilmore, D. W. (1988). Trophic effects of glutamine enriched parenteral nutrition on colonic mucosa. Journal of Parenteral and Enteral Nutrition 12 (Suppl. 1), 6.Google Scholar
100Jacobs, L. R. & Lupton, J. R. (1984). Effect of dietary fibers on rat large bowel mucosal growth and cell proliferation. American Journal of Physiology 246: G378–G385.Google Scholar
101Jensen, J. C., Schaefer, R., Nwokedi, E., Bevans, D. W., Baker, M. L., Pappas, A. A., Westbrook, K. C. & Klimberg, V. S. (1994). Prevention of chronic radiation enteropathy by dietary glutamine. Annals of Surgical Oncology 1, 157–163.Google Scholar
102Jiang, Z.-M., Wang, L.-J., Qi, Y., Liu, T.-H., Qiu, M.-R., Yang, N.-F. & Wilmore, D. W. (1993). Comparison of parenteral nutrition supplemented with L-glutamine or glutamine dipeptides. Journal of Parenteral and Enteral Nutrition 17, 134–141.Google Scholar
103Kamath, P. S., Phillips, S. F. & Zinsmeister, A. R. (1988). Short-chain fatty acids stimulate ileal motility in humans. Gastroenterology 95, 1496–1502.Google Scholar
104Kaminski, P. M. & Proctor, K. G. (1992). Extracellular and intracellular actions of adenosine and related compounds in the reperfused rat intestine. Circulation Research 71, 720–731.Google Scholar
105Kaneko, H., Ogawa, N. & Chen, K. (1993). Effects of alanine-glutamine supplemented total parenteral nutrition on protein metabolism and bacterial translocation in septic rats induced by endotoxin. Journal of the Japanese Society of Parenteral and Enteral Nutrition 8, 32–35.Google Scholar
106Karatzas, T., Scopa, S., Tsoni, I., Panagopoulos, K., Spiliopolou, I., Moschos, S., Vagianos, K. & Kalfarentzos, F. (1991). Effect of glutamine on intestinal mucosal integrity and bacterial translocation after abdominal radiation. Clinical Nutrition 10, 199–205.CrossRefGoogle ScholarPubMed
107Kelley, C. J., Ingoldby, C. J. H., Blenkharn, J. I. & Wood, C. B. (1985). Colonoscopy related endotoxemia. Surgery, Gynecology and Obstetrics 161, 332–334.Google ScholarPubMed
108Kirk, S. J. & Barbul, A. (1990). Role of arginine in trauma, sepsis, and immunity. Journal of Parenteral and Enteral Nutrition 14, (Suppl. 5) 226S–229S.Google Scholar
109Klimberg, V. S., Nwokedi, E., Hutchins, L. F., Pappas, A. A., Lang, N. P., Broadwater, J. R., Read, R. C. & Westbrook, K. C. (1992). Glutamine facilitates chemotherapy while reducing toxicity. Journal of Parenteral and Enteral Nutrition 16, 83S–87S.Google Scholar
110Klimberg, V. S., Salloum, R. M., Kasper, M., Plumley, D. A., Dolson, D. J., Hautamaki, R. D., Mendenhall, W. R., Bova, F. C., Bland, K. I., Copeland, E. M. & Souba, W. W. (1990 a). Oral glutamine accelerates healing of the small intestine and improves outcome after whole abdominal radiation. Archives of Surgery 125, 1040–1047.Google Scholar
111Klimberg, V. S., Souba, W. W., Dolson, D. J., Salloum, R. M., Hautamaki, R. D., Plumley, D. A., Mendenhall, W. M., Bova, F. J., Khan, S. R., Hackett, R. L., Bland, K. I. & Copeland, E. M. (1990 b). Prophylactic glutamine protects the intestinal mucosa from radiation injury. Cancer 66, 62–68.Google Scholar
112Koga, Y., Ikeda, K., Inokuchi, K., Watanabe, H. & Hashimoto, N. (1975). The digestive tract in total parenteral nutrition. Archives of Surgery 110, 742–745.CrossRefGoogle ScholarPubMed
113Koruda, M. J., Rolandelli, R. H., Bliss, D. Z., Hastings, J., Rombeau, J. L. & Settle, R. G. (1990). Parenteral nutrition supplemented with short-chain fatty acids: effect on the small-bowel mucosa in normal rats. American Journal of Clinical Nutrition 51, 685–689.Google Scholar
114Koruda, M. J., Rolandelli, R. H., Settle, R. G., Saul, S. H. & Rombeau, J. L. (1986). The effect of a pectin supplemented elemental diet on intestinal adaptation to massive small bowel resection. Journal of Parenteral and Enteral Nutrition 10, 343–350.CrossRefGoogle ScholarPubMed
115Koruda, M. J., Rolandelli, R. H., Settle, R. G., Zimmaro, D. M. & Rombeau, J. L. (1988). Effect of parehteral nutrition supplemented with short chain fatty acids on adaptation to massive small bowel resection. Gastroenterology 95, 715–720.Google Scholar
116Kripke, S. A., Fox, A. D., Berman, J. M., De Paula, J. A., Rombeau, J. L. & Settle, G. (1988). Inhibition of TPN associated colonic atrophy with β-hydroxybutyrate. Surgical Forum 39, 48–50.Google Scholar
117Kubes, P. (1993). Ischemia-reperfusion in feline small intestine: a role for nitric oxide. American Journal of Physiology 264, G143–G149.Google Scholar
118Kudsk, K. A. (1994). Gut mucosal nutritional support – enteral nutrition as primary therapy after multiple system trauma. Gut (Suppl. 1), S52–S54.Google Scholar
119Kvietys, P. R. & Granger, D. N. (1981). Effect of volatile fatty acids on blood flow and oxygen uptake by the dog colon. Gastroenterology 80, 962–969.CrossRefGoogle ScholarPubMed
120Langkamp-Henken, B., Glezer, J. A. & Kudsk, K. A. (1992). Immunologic structure and function of the gastrointestinal tract. Nutrition in Clinical Practice 7, 100–108.Google Scholar
121Lauritzen, K., Hansen, J., Bytzer, P., Bukhave, K. & Rask-Madsen, J. (1984). Effects of sulphasalazine and disodium azodisalicylate on colonic PGE2 concentrations determined by equilibrium in vivo dialysis of faeces of patients with ulcerative colitis and healthy controls. Gut 25, 1271–1278.CrossRefGoogle Scholar
122Lee, T. H., Hoover, R. L., Williams, J. D., Sperling, R. I., Ravalese, J., Spur, B. W., Robinson, D. R., Corey, E. J., Lewis, R. A. & Austen, K. F. (1985). Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function. New England Journal of Medicine 312, 1217–1224.CrossRefGoogle ScholarPubMed
123LeLeiko, N. S., Bronstein, A. D., Baliga, B. S. & Munro, H. N. (1983). De novo purine nucleotide synthesis in the rat small and large intestine: effect of dietary protein and purines. Journal of Pediatric Gastroenterology and Nutrition 2, 313–319.Google Scholar
124Lescut, D., Colombel, J. F., Vincent, P., Cortot, A., Fournier, L., Quandalle, P., Vankemmel, M., Triboulet, J. P., Wurtz, A., Paris, J. C. & Leclerc, H. (1990). Bacterial translocation in colorectal cancers. Gastroenterologie Clinique et Biologique 14, 811–814.Google ScholarPubMed
125Levine, G. M., Deren, J. J., Steiger, E. & Zinno, R. (1974). Role of oral intake in maintenance of gut mass and disaccharidase activity. Gastroenterology 67, 975–982.Google Scholar
126LeVoyer, T., Cioffi, W. G., Pratt, L., Shippee, R., McManus, W. F., Mason, A. D. & Pruitt, B. A. (1992). Alterations in intestinal permeability after thermal injury. Archives of Surgery 127, 26–30.Google Scholar
127Li, J., Langkamp-Henken, B., Suzuki, K. & Stahlgren, L. H. (1994). Glutamine prevents parenteral nutrition induced increases in intestinal permeability. Journal of Parenteral and Enteral Nutrition 18, 303–307.Google Scholar
128MacBurney, M., Young, L., Ziegler, T. R. & Wilmore, D. W. (1994). A cost-evaluation of glutamine supplemented parenteral nutrition in adult bone marrow transplant patients. Journal of the American Dietetic Association 94, 1263–1266.CrossRefGoogle ScholarPubMed
129McCall, T. B., O'Leary, D., Bloomfield, J. & O'Morain, C. A. (1989). Therapeutic potential of fish oil in the treatment of ulcerative colitis. Alimentary Pharmacology and Therapeutics 3, 415–424.Google Scholar
130McCauley, R., Platell, C., Hall, J. & McCulloch, R. (1991). Effects of glutamine infusion on colonic anastomotic strength in the rat. Journal of Parenteral and Enteral Nutrition 15, 437–439.Google Scholar
131Madden, H. P., Breslin, R. J., Wasserkrug, H. L., Efron, G. & Barbul, A. (1988). Stimulation of T cell immunity by arginine enhances survival in peritonitis. Journal of Surgical Research 44, 658–663.Google Scholar
132Marshall, J. C., Christou, N. V., Horn, R. & Meakins, J. L. (1988). The microbiology of multiple organ failure. The proximal gastrointestinal tract as an occult reservoir of pathogens. Archives of Surgery 123, 309–315.Google Scholar
133Mascioli, E. A., Iwasa, Y., Trimbo, S., Leader, L., Bistrian, B. R. & Blackburn, G. L. (1989). Endotoxin challenge after menhaden oil diet: effects on survival of guinea pigs. American Journal of Clinical Nutrition 49, 277–282.Google Scholar
134Miller, M. J. S., Sadowska-Krowicka, H., Chotinaruemol, S., Kakkis, J. L. & Clark, D. A. (1993 a). Amelioration of chronic ileitis by nitric oxide synthase inhibition. Journal of Pharmacology and Experimental Therapeutics 264, 11–16.Google Scholar
135Miller, M. J. S., Zhang, X.-J., Sadowska-Krowicka, H., Chotinaruemol, S., McIntyre, J. A., Clark, D. A. & Bustamante, S. A. (1993 b). Nitric oxide release in response to gut injury. Scandinavian Journal of Gastroenterology 28, 149–154.Google Scholar
136Moore, F. A., Feliciano, D. V., Andrassy, R. J., McArdle, A. H., Booth, F. V. McL., Morgenstein-Wagner, T. B., Kellum, J. M., Welling, R. E. & Moore, E. E. (1992). Early enteral feeding, compared with parenteral, reduces postoperative septic complications. The results of a meta-analysis. Annals of Surgery 216, 172–183.CrossRefGoogle ScholarPubMed
137Moore, F. A., Moore, E. E., Jones, T. N., McCroskey, B. L. & Peterson, V. M. (1989). TEN versus TPN following major abdominal trauma-reduced septic morbidity. Journal of Trauma 29, 916–923.Google Scholar
138Moore, F. A., Moore, E. E., Poggetti, R., McAnena, O. J., Peterson, V. M., Abernathy, C. M. & Parsons, P. E. (1991). Gut bacterial translocation via the portal vein: a clinical perspective with major torso trauma. Journal of Trauma 31, 629–638.Google Scholar
139Moore, R. S. & Cerra, F. B. (1991). Sepsis. In Total Parenteral Nutrition, pp. 347–365. [ Fischer, J. E., editor]. Boston: Little, Brown.Google Scholar
140Mortensen, F. V., Hessov, I., Birke, H., Korsgaard, N. & Nielsen, H. (1991). Microcirculatory and trophic effects of short chain fatty acids in the human rectum after Hartmann's procedure. British Journal of Surgery 78, 1208–1211.Google Scholar
141Murphy, M. S., Eastham, E. J., Nelson, R., Pearson, A. D. & Laker, M. F. (1989). Intestinal permeability in Crohn's disease. Archives of Disease in Childhood 64, 321–325.Google Scholar
142Neilly, P. J. D., Anderson, N. H., Kirk, S. J., Gardiner, K. R., Halliday, M. I. & Rowlands, B. J. (1993). L- Arginine exacerbates the inflammatory response in experimental inflammatory bowel disease. Gut 34, S60.Google Scholar
143Neilly, P. J. D., Kirk, S. J., Gardiner, K. R., Anderson, N. H. & Rowlands, B. J. (1995). Manipulation of the L- arginine-nitric oxide pathway in experimental colitis. British Journal of Surgery 82, 1188–1191.Google Scholar
144Nuñez, M. C., Ayudarte, M. V., Morales, D., Suarez, M. D. & Gil, A. (1990). Effect of dietary nucleotides on intestinal repair in rats with experimental chronic diarrhea. Journal of Parenteral and Enteral Nutrition 14, 598–604.CrossRefGoogle ScholarPubMed
145O'Dwyer, S. T., Michie, H. R., Ziegler, T. R., Revhaug, A., Smith, R. J., & Wilmore, D. W. (1988). A single dose of endotoxin increases intestinal permeability in healthy humans. Archives of Surgery 123, 1459–1464.Google Scholar
146O'Dwyer, S. T., Scott, T., Smith, R. J. & Wilmore, D. W. (1987). 5-fluorouracil toxicity on small intestinal mucosa but not white blood cells is decreased by glutamine. Clinical Research 35, 369a.Google Scholar
147O'Dwyer, S. T., Smith, R. J., Hwang, T. L. & Wilmore, D. W. (1989). Maintenance of small bowel mucosa with glutamine-enriched parenteral nutrition. Journal of Parenteral and Enteral Nutrition 13, 579–585.CrossRefGoogle ScholarPubMed
148Okabe, S., Honda, K., Takeuchi, K. & Takagi, K. (1975). Inhibitory effect of L-glutamine on gastric irritation and back diffusion of gastric acid in response to aspirin in the rat. American Journal of Digestive Diseases 20, 626–631.Google Scholar
149Parrilli, G., Iaffaioli, V., Capuano, G., Budillon, G. & Bianco, R. (1982). Changes in intestinal permeability to lactulose induced by cytotoxic chemotherapy. Cancer Treatment Reports 66, 1435–1436.Google Scholar
150Petros, A., Bennett, D. & Vallance, P. (1991). Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock. Lancet 338, 1557–1558.CrossRefGoogle ScholarPubMed
151Pironi, L., Miglioni, M., Ruggeri, E., Levorato, M., Dallasa, M. A., Corbelli, C., Nibali, M. G. & Barbara, L. (1990). Relationship between intestinal permeability to 51Cr-EDTA and inflammatory activity in asymptomatic patients with Crohn's disease. Digestive Diseases and Sciences 35, 582–588.Google Scholar
152Platell, C., McCauley, R., McCulloch, R. & Hall, J. (1993). The influence of parenteral glutamine and branched chain amino acids on total parenteral nutrition-induced atrophy of the gut. Journal of Parenteral and Enteral Nutrition 17, 348–354.Google Scholar
153Pscheidl, E. M., Wan, J. M., Blackburn, G. L., Bistrian, B. R. & Istfan, N. W. (1992). Influence of ω-3 fatty acids on splanchnic blood flow and lactate metabolism in an endotoxemic rat model. Metabolism 41, 698–705.Google Scholar
154Reilly, K. J., Adamson, W. T., Bain, A. M. & Rombeau, J. L. (1995). Short chain fatty acids (SCFA) induce colonotrophism by stimulating ornithine decarboxylase (ODC) activity. Journal of Parenteral and Enteral Nutrition 19, 24S.Google Scholar
155Rémésy, C., Demigné, C. & Chartier, F. (1980). Origin and utilization of volatile fatty acids in the rat. Reproduction, Nutrition, Dévelopment 20, 1339–1349.Google Scholar
156Roediger, W. E. W. (1982). Utilization of nutrients by isolated epithelial cells of the rat colon. Gastroenterology 83, 424–429.Google Scholar
157Roediger, W. E. W. (1990). The starved colon – diminished mucosal nutrition, diminished absorption, and colitis. Diseases of the Colon and Rectum 33, 858–862.CrossRefGoogle ScholarPubMed
158Rolandelli, R., Koruda, M. J., Settle, R. G. & Rombeau, J. L. (1986 a). Effects of intraluminal infusion of short chain fatty acids on the healing of colonic anastomoses in the rat. Surgery 100, 198–204.Google Scholar
159Rolandelli, R. H., Koruda, M. J., Settle, R. G. & Rombeau, J. L. (1986 b). The effect of enteral feedings supplemented with pectin on the healing of colonic anastomoses in the rat. Surgery 99, 703–707.Google Scholar
160Rolandelli, R. H., Saul, S. H., Settle, R. G., Jacobs, D. O., Trerotola, S. O. & Rombeau, J. L. (1988). Comparison of parenteral nutrition and enteral feeding with pectin in experimental colitis in the rat. American Journal of Clinical Nutrition 47, 715–721.CrossRefGoogle ScholarPubMed
161Ross, E. (1993). The role of marine fish oils in the treatment of ulcerative colitis. Nutrition Reviews 51, 47–49.Google Scholar
162Roumen, R. M. H., Hendriks, T., Wevers, R. A. & Goris, R. J. A. (1993). Intestinal permeability after severe trauma and hemorrhagic shock is increased without relation to septic complications. Archives of Surgery 128, 453–457.Google Scholar
163Rozenberg-Arska, M. & Dekker, A. W. (1987). Ciprofloxacin for infection prevention in patients with acute leukaemia. Pharmaceutische Weekblad (Scientific Edition) 9 (Suppl.) 45–7.CrossRefGoogle Scholar
164Rudolph, F. B., Kulkarni, A. D., Fanslow, W. C., Pizzini, R. P., Kumar, S. & Van Buren, C. T. (1990). Role of RNA as a dietary source of pyrimidines and purines in immune function. Nutrition 6, 45–52.Google Scholar
165Rush, B. F., Sori, A. J., Murphy, T. F., Smith, S., Flanagan, J. J. & Machiedo, G. W. (1988). Endotoxemia and bacteremia during hemorrhagic shock. The link between trauma and sepsis? Annals of Surgery 207, 549–554.Google Scholar
166Saadia, R., Schein, M., McFarlane, C. & Boffard, K. D. (1990). Gut barrier function and the surgeon. British Journal of Surgery 77, 487–492.Google Scholar
167Saito, H., Trocki, O., Alexander, J. W., Kopcha, R., Heyd, T. & Joffe, S. N. (1987 a). The effect of route of nutrient administration on the nutritional state, catabolic hormone secretion, and gut mucosal integrity after burn injury. Journal of Parenteral and Enteral Nutrition 11, 1–7.Google Scholar
168Saito, H., Trocki, O., Wang, S.-L., Gonce, S. J., Joffe, S. N. & Alexander, J. W. (1987 b). Metabolic and immune effects of dietary arginine supplementation after burn. Archives of Surgery 122, 784–789.Google Scholar
169Sakata, T. (1987). Stimulatory effect of short chain fatty acids on epithelial cell proliferation in the rat intestine. A possible explanation for trophic effects of fermentable fibre, gut microbes and luminal trophic factors. British Journal of Nutrition 58, 95–103.CrossRefGoogle ScholarPubMed
170Salloum, R. M., Copeland, E. M. & Souba, W. W. (1991). Brush border transport of glutamine and other substrates during sepsis and endotoxemia. Annals of Surgery 213, 401–410.Google Scholar
171Salloum, R. M., Souba, W. W., Klimberg, V. S., Plumley, D. A., Dolson, D. J., Bland, K. I. & Copeland, E. M. (1989). Glutamine is superior to glutamate in supporting gut metabolism, stimulating intestinal glutaminase activity, and preventing bacterial translocation. Surgical Forum 40, 6–8.Google Scholar
172Salomon, P., Kornbluth, A. A. & Janowitz, H. D. (1990). Treatment of ulcerative colitis with fish oil n-3 fatty acid: an open trial. Journal of Clinical Gastroenterology 12, 157–161.Google Scholar
173Sartor, R. B. (1990). Role of intestinal microflora in initiation and perpetuation of inflammatory bowel disease. Canadian Journal of Gastroenterology 4, 271–277.CrossRefGoogle Scholar
174Savaiano, D. A. & Clifford, A. J. (1981). Adenine, the precursor of nucleic acids in intestinal cells unable to synthesize purines de novo. Journal of Nutrition 111, 1816–1822.Google Scholar
175Sawmiller, D. R. & Chou, C. C. (1991). Adenosine is a vasodilator in the intestinal mucosa. American Journal of Physiology 261, G9–G15.Google Scholar
176Scheppach, W. (1994). Effects of short chain fatty acids on gut morphology and function. Gut 35 (Suppl. 1), S35–S38.Google Scholar
177Scheppach, W., Pomare, E. W., Elia, M. & Cummings, J. H. (1991). The contribution of the large intestine to blood acetate in man. Clinical Science 80, 177–182.Google Scholar
178Scheppach, W., Sachs, M., Bartram, P. & Kasper, H. (1989). Faecal short-chain fatty acids after colonic surgery. European Journal of Clinical Nutrition 43, 21–25.Google Scholar
179Scheppach, W., Sommer, H., Kirchner, T., Paganelli, G.-M., Bartram, P., Christl, S., Richter, F., Dusel, G. & Kasper, H. (1992). Effect of butyrate enemas on the colonic mucosa in distal ulcerative colitis. Gastroenterology 103, 51–56.Google Scholar
180Schloerb, P. R. & Amare, M. (1993). Total parenteral nutrition with glutamine in bone marrow transplantation and other clinical applications (a randomized, double-blind study). Journal of Parenteral and Enteral Nutrition 17, 407–413.Google Scholar
181Scott, T. E. & Moellman, J. R. (1992). Intravenous glutamine fails to improve gut morphology after radiation injury. Journal of Parenteral and Enteral Nutrition 16, 440–444.Google Scholar
182Sedman, P. C., MacFie, J., Sagar, P., Mitchell, C. J., May, J., Mancey-Jones, B. & Johnstone, D. (1994). The prevalence of gut translocation in humans. Gastroenterology 107, 643–649.CrossRefGoogle ScholarPubMed
183Sedman, P. C., May, J., Brooks, S. G., Sagar, P., Johnson, D., Tring, I., Mitchell, C. J. & MacFie, J. (1993). Total parenteral nutrition does not predispose to gut translocation in man. Gut 34, S64.Google Scholar
184Sharon, P., Ligumsky, M., Rachmilewitz, D. & Zor, U. (1978). Role of prostaglandins in ulcerative colitis. Enhanced production during active disease and inhibition by sulfasalazine. Gastroenterology 75, 638–640.Google Scholar
185Shou, J., Lieberman, M. D., Hofmann, K., Leon, P., Redmond, H. P., Davies, H. & Daly, J. M. (1991). Dietary manipulation of methotrexate-induced enterocolitis. Journal of Parenteral and Enteral Nutrition 15, 307–312.Google Scholar
186Simopoulos, A. P. (1991). Omega-3 fatty acids in health and disease and in growth and development. Review. American Journal of Clinical Nutrition 54, 438–463.Google Scholar
187Sitren, H. S., Bryant, M. & Ellis, L. M. (1992). Species differences in TPN-induced intestinal villus atrophy. Journal of Parenteral and Enteral Nutrition 16, 30S.Google Scholar
188Smith, R. J. & Wilmore, D. W. (1990). Glutamine nutrition and requirements. Journal of Parenteral and Enteral Nutrition 14 (Suppl. 4), 94S–99S.Google Scholar
189Souba, W. W. & Copeland, E. M. (1992). Cytokine modulation of sodium-dependent glutamine transport across the brush border membrane of monolayers of human intestinal Caco-2 cells. Annals of Surgery 215, 536–545.CrossRefGoogle Scholar
190Souba, W. W., Herskowitz, K., Austgen, T. R., Chen, M. K. & Salloum, R. M. (1990 a). Glutamine nutrition: theoretical considerations and therapeutic impact. Journal of Parenteral and Enteral Nutrition 14, 237–243S.CrossRefGoogle ScholarPubMed
191Souba, W. W., Herskowitz, K., Klimberg, V. S., Salloum, R. M., Plumley, D. A., Flynn, T. C. & Copeland, E. M. (1990 b). The effects of sepsis and endotoxemia on gut glutamine metabolism. Annals of Surgery 211, 543–551.Google Scholar
192Souba, W. W., Klimberg, V. S., Hautamaki, R. D., Mendenhall, W. H., Bova, F. C., Howard, R. J., Bland, K. I. & Copeland, E. M. (1990 c). Oral glutamine reduces bacterial translocation following abdominal radiation. Journal of Surgical Research 48, 1–5.Google Scholar
193Souba, W. W., Smith, R. J. & Wilmore, D. W. (1985). Glutamine metabolism by the intestinal tract. Journal of Parenteral and Enteral Nutrition 9, 608–617.Google Scholar
194Spaeth, G., Berg, R. D., Specian, R. & Deitch, E. A. (1990). Food without fiber promotes bacterial translocation from the gut. Surgery 108, 240–247.Google Scholar
195Spaeth, G., Gottwald, T., Haas, W. & Holmer, M. (1993). Glutamine peptide does not improve gut barrier function and mucosal immunity in total parenteral nutrition. Journal of Parenteral and Enieral Nutrition 17, 317–323.Google Scholar
196Spaeth, G., Gott.wald, T., Specian, R. D., Mainous, M. R., Berg, R. D. & Deitch, E. A. (1994). Secretory immunoglobulin A, intestinal mucin, and mucosal permeability in nutritionally induced bacterial translocation in rats. Annals of Surgery 220, 798–808.CrossRefGoogle ScholarPubMed
197Stehle, P., Zander, J., Mertes, N., Albers, S., Puchstein, Ch., Lawin, P. & F¨rst, P. (1989). Effect of parenteral glutamine peptide supplements on muscle glutamine loss and nitrogen balance after major surgery. Lancet i, 231–233.Google Scholar
198Stenson, W. F., Cort, D., Beeken, W., Rodgers, J. & Burakoff, R. (1990). A trial of fish oil supplemental diet in ulcerative colitis. Gastroenterology 98, A475.Google Scholar
199Tamada, H., Nezu, R., Imamura, I., Matsuo, Y., Takagi, Y., Kamata, S. & Okada, A. (1992). The dipeptide alanyl-glutamine prevents intestinal mucosal atrophy in parenterally fed rats. Journal of Parenteral and Enteral Nutrition 16, 110–116.Google Scholar
200Tancrede, C. H. & Andremont, A. O. (1985). Bacterial translocation and gram-negative bacteremia in patients with hematological malignancies. Journal of Infectious Diseases 152, 99–103.Google Scholar
201Tobin, A., Suzuki, Y. & O'Morain, C. (1990). A controlled double blind crossover study in ulcerative colitis. Gastroenterology 98, A207.Google Scholar
202Tran, D. D., Cuesta, M. A., van Leeuwen, P. A. M., Nauta, J. J. P. & Wesdorp, R. I. C. (1993). Risk factors for multiple organ system failure and death in critically injured patients. Surgery 114, 21–30.Google Scholar
203Travis, S. & Menzies, I. (1992). Intestinal permeability: functional assessment and significance. Review. Clinical Science 82, 471–488.Google Scholar
204Tremel, H., Kienle, B., Weilemann, L. S., Stehle, P. & Furst, P. (1994). Glutamine dipeptide-supplemented parenteral nutrition maintains intestinal function in the critically ill. Gastroenterology 107, 1595–1601.Google Scholar
205Uauy, R., Stringel, G., Thomas, R. & Quan, R. (1990). Effect of dietary nucleosides on growth and maturation of the developing gut in the rat. Journal of Pediatric Gastroenterology and Nutrition 10, 497–503.Google Scholar
206van Buren, C. T., Kulkarni, A. D. & Rudolph, F. B. (1994). The role of nucleotides in adult nutrition. Journal of Nutrition 124, 160S–164S.Google Scholar
207van der Hulst, R. R. W. J., van Kreel, B. K., von Meyenfeldt, M. F., Brummer, R. J. M., Arends, J. W., Deutz, N. E. P. & Soeters, P. B. (1993). Glutamine and the preservation of gut integrity. Lancet 341, 1363–1365.Google Scholar
208van Leeuwen, P. A. M., Boermeester, M. A., Houdijk, A. P. J., Ferwerda, Ch. C., Cuesta, M. A., Meyer, S. & Wesdorp, R. I. C. (1994). Clinical significance of translocation. Gut 35 (Suppl. 1), S28–S34.Google Scholar
209van Zaanen, H. C. T., van der Lelie, H., Timer, J. G., Furst, P. & Sauerwein, H. P. (1994). Parenteral glutamine dipeptide supplementation does not ameliorate chemotherapy-induced toxicity. Cancer 74, 2879–2884.Google Scholar
210Vaubourdolle, M., Jardel, A., Coudray-Lucas, C., Ekindjian, O. G., Agneray, J. & Cynober, L. (1989). Fate of enterally administered omnithine in healthy animals: interactions with alpha-ketoglutarate. Nutrition 5, 183–187.Google Scholar
211Vernia, P., Gnaedinger, A., Hauck, W. & Breuer, R. I. (1988). Organic anions and the diarrhea of inflammatory bowel disease. Digestive Diseases and Sciences 33, 1353–1358.Google Scholar
212Vilaseca, J., Salas, A., Guarner, F., Rodriguez, R., Martinez, M. & Malagelada, J. R. (1990). Dietary fish oil reduces progression of chronic inflammatory lesions in a rat model of granulomatous colitis. Gut 31, 539–544.Google Scholar
213Wang, X., Jacobs, D. O., O'Dwyer, S. T., Smith, R. J. & Wilmore, D. W. (1988). Glutamine-enriched parenteral nutrition prevents mucosal atrophy following massive small bowel resection. Surgical Forum 39, 44–46.Google Scholar
214Wellmann, W., Fink, P. C., Benner, F. & Schmidt, F. W. (1986). Endotoxaemia in active Crohn's disease. Treatment with whole gut irrigation and 5-aminosalicylic acid. Gut 27, 814–820.Google Scholar
215Wells, C. L., Jechorek, R. P. & Erlandsen, S. L. (1990). Evidence for the translocation of Enterococcus faecalis across the mouse intestinal tract. Journal of Infectious Diseases 162, 82–90.Google Scholar
216Wells, C. L., Jechorek, R. P., Olmsted, S. B. & Erlandsen, S. L. (1993). Effect of LPS on epithelial integrity and bacterial uptake in the polarized human enterocyte-like cell line Caco-2. Circulation Shock 40, 276–288.Google Scholar
217Wilmore, D. W. (1994). Glutamine and the gut. Gastroenterology 107, 1885–1886.Google Scholar
217Wilmore, D. W., Smith, R. J., O'Dwyer, S. T., Jacobs, D. O., Ziegler, T. R. & Wang, X. D. (1988). The gut: a central organ after surgical stress. Surgery 104, 917–923.Google Scholar
218Windmueller, H. (1982). Glutamine utilization by the small intestine. Advances in Enzymology 53, 202–237.Google Scholar
219Wischmeyer, P., Pemberton, J. H. & Phillips, S. F. (1993). Chronic pouchitis after ileal pouch-anal anastomosis: responses to butyrate and glutamine suppositories in a pilot study. Mayo Clinic Proceedings 68, 978–981.CrossRefGoogle ScholarPubMed
220Wusteman, M., Tate, H., Weaver, L., Austin, S., Neale, G. & Elia, M. (1995). The effect of enteral glutamine deprivation and supplementation on the structure of rat small-intestine mucosa during a systemic injury response. Journal of Parenteral and Enteral Nutrition 19, 22–27.Google Scholar
221Yoshida, S., Leskiw, M. J., Schluter, M. D., Bush, K. T., Nagele, R. G., Lanza-Jacoby, S. & Stein, T. P. (1992). Effect of total parenteral nutrition, systemic sepsis, and glutamine on gut mucosa in rats. American Journal of Physiology 263, E368–373.Google Scholar
222Zaloga, G. P., Knowles, R., Black, K. W. & Prielipp, R. (1991). Total parenteral nutrition increases mortality after hemorrhage. Critical Care Medicine 19, 54–59.Google Scholar
223Zhang, W., Frankel, W. L., Bain, A., Choi, D., Klurfeld, D. M. & Rombeau, J. L. (1995). Glutamine reduces bacterial translocation after small bowel transplantation in cyclosporine-treated rats. Journal of Surgical Research 58, 159–164.CrossRefGoogle ScholarPubMed
224Ziegler, T. R., Smith, R. J., O'Dwyer, S. T., Demling, R. H. & Wilmore, D. W. (1988). Increased intestinal permeability associated with infection in burn patients. Archives of Surgery 123, 1313–1319.CrossRefGoogle ScholarPubMed
225Ziegler, T. R., Young, L. S., Benfell, K., Scheltinga, M., Hortos, K., Bye, R., Morrow, F. D., Jacobs, D. O., Smith, R. J., Antin, J. H. & Wilmore, D. W. (1992). Clinical and metabolic efficacy of glutamine-supplemented total parenteral nutrition after bone marrow transplantation. A randomized, double-blind, controlled study. Annals of Internal Medicine 116, 821–828.Google Scholar