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Effect of tomato, tomato-derived products and lycopene on metabolic inflammation: from epidemiological data to molecular mechanisms

Published online by Cambridge University Press:  18 December 2023

Jean-François Landrier Open the ORCID record for Jean-François Landrier [Opens in a new window] ,
Thomas Breniere ,
Léa Sani ,
Charles Desmarchelier ,
Lourdes Mounien  and
Patrick Borel
Jean-François Landrier*
Affiliation:
Aix-Marseille Université, C2VN, INRAE, INSERM, Marseille, France
Thomas Breniere
Affiliation:
Aix-Marseille Université, C2VN, INRAE, INSERM, Marseille, France INRAE-Centre d’Avignon UR1115 Plantes et Systèmes de Culture Horticoles, Avignon, France Laboratoire de Physiologie Expérimentale Cardiovasculaire (LAPEC), UPR-4278, Université d’Avignon, 84029 Avignon, France
Léa Sani
Affiliation:
Aix-Marseille Université, C2VN, INRAE, INSERM, Marseille, France
Charles Desmarchelier
Affiliation:
Aix-Marseille Université, C2VN, INRAE, INSERM, Marseille, France
Lourdes Mounien
Affiliation:
Aix-Marseille Université, C2VN, INRAE, INSERM, Marseille, France
Patrick Borel
Affiliation:
Aix-Marseille Université, C2VN, INRAE, INSERM, Marseille, France
*
*Corresponding author: Jean-François Landrier, email: jean-francois.landrier@univ-amu.fr
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Abstract

The goal of this narrative review is to summarise the current knowledge and limitations related to the anti-inflammatory effects of tomato, tomato-derived products and lycopene in the context of metabolic inflammation associated to cardiometabolic diseases. The potential of tomato and tomato-derived product supplementation is supported by animal and in vitro studies. In addition, intervention studies provide arguments in favour of a limitation of metabolic inflammation. This is also the case for observational studies depicting inverse association between plasma lycopene levels and inflammation. Nevertheless, current data of intervention studies are mixed concerning the anti-inflammatory effect of tomato and tomato-derived products and are not in favour of an anti-inflammatory effect of pure lycopene in humans. From epidemiological to mechanistic studies, this review aims to identify limitations of the current knowledge and gaps that remain to be filled to improve our comprehension in contrasted anti-inflammatory effects of tomato, tomato-derived products and pure lycopene.

Keywords

inflammationliver steatosislycopenemetabolic diseasesmetabolic inflammationNF-kB signallingobesitytomatotomato productstype 2 diabetes
Type
Review Article
Information
Nutrition Research Reviews , First View , pp. 1 - 17
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Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of The Nutrition Society

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