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Preventing Nuclear Artifact in Hematologic Specimens
Published online by Cambridge University Press: 14 March 2018
Abstract
The bubbled, popcorn or moth-eaten appearance of nuclei hampered accurate microscopic evaluation of bone marrow and lymph node biopsies. This artifact was also noticed in skin biopsies, but had little bearing on diagnosis. All aspects of specimen handling processing and staining were scrutinized and improved morphological detail was attained only after blocks were recut and allowed to dry completely before staining.
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- Research Article
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- Copyright © Microscopy Society of America 1998