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The Nematode Caenorhabditis elegans A Model Animal “Made for Microscopy”

Published online by Cambridge University Press:  14 March 2018

David H. Hall*
Affiliation:
Albert Einstein College of Medicine

Extract

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The small unassuming nematode, Caenorhabditis elegans is only one millimeter long and lives in the soil munching on bacteria. While many nematode (roundworm) species are parasites with medical or agricultural importance, C. elegans seems to harm no one. Yet, this animal has attained a status in medical science that compares to more complex organisms such as the mouse or fruit fly in its utility for scientific discovery. It has been the subject of thousands of studies dealing with topics as diverse as nutrition, aging, and nervous system development. About 5000 scientists are now pursuing this single species in hundreds of laboratories worldwide. In 2002, the Nobel Prize in Medicine was awarded to three of the pioneers in establishing C. elegans as a “model organism“: Sydney Brenner, John Sulston, and H. Robert Horvitz. Why study worms?

Sydney Brenner first turned his attention to C. elegans in the 1960's. Working at the Medical Research Council in England, he was looking for a small animal with inexpensive tastes that could be easily cultured in the laboratory.

Type
Research Article
Copyright
Copyright © Microscopy Society of America 2004

References

1. Brenner, S.. The genetics of C. elegans. Genetics 77: 7194, 1974.Google Scholar
2. Sulston, J.E. et al. The embryonic cell lineage of the nematode, C. elegans. Dev, Biol. 100: 64119, 1983.Google Scholar
3. Sulston, J.E. and Horvitz, H.R.. Post-embryonic cell lineages of the nematode C. elegans. Dev. Biol. 56: 110156, 1977.Google Scholar
4. Ellis, H.M. and H.R. Horvitz, . Genetic control of programmed cell death in the nematode C. elegans. Cell 44: 817829,1986.Google Scholar
5. White, J.G. et al. The structure of the nervous system of the nematode G elegans, (The Mind ofa Worm) Phil. Trans. Royal Soc.Lond B 314: 1-340, 1986.Google Scholar
6. Jin,, Y. Synaptogenesis; insights from fly and worm. Curr. Opinion in Neurobiology 12: 7179, 2002.Google Scholar
7. Suzuki, H. et al. El vivo imaging of C. elegans mecbansosenory neurons demonstrates a specific role for the MEC-4 channel in the process of gentle touch sensation. Neuron 39: 10051017, 2003.Google Scholar
8.The C. elegans sequencing constjrtiixm. Genome sequence of the nematode C. elegans: A platform for investigating biology, Science'282: 2012-2018, 1998.Google Scholar
9. Nass, R. et al, Neurotoxhi-induced neurodegeneration oi dopamine neurons in C. etegans. PNAS 99: 32643269, 2002.Google Scholar
10. Herndon, L. et al. Stochastic and genetic factors influence tissue-specific decline in aging C. elegans. Nature 419: 788794, 2002.Google Scholar
11. Melendez, A. et al. Autophagy genes are essential for development and life span extension in C. elegans, Science 301: 13871391, 2003.CrossRefGoogle ScholarPubMed
12. Hall, D.H. et al. Ultrastructural features of the adult hermaphrodite gonad of C. elegans. Relations between germline and soma. Dev. Biol. 212: 101123, 1999.Google Scholar
13. Buechner, M. et al. Cystic canal mutants in C. elegans defective in the apical membrane domain of the renal (excretory) cell, Dev. Biol. 214: 227241, 1999.Google Scholar
16.Worm literature and the Worm Community, http://www.elegans.swmed.edu Google Scholar
17.The nematode expression pattern database, http://www.nematode.lab.nig.ac.jp/db/index.html Google Scholar
19.Our applet was devised by Costantinos Polydorou, with help from Paul Coddiugton and Yuh-Jye Chang; http://www.dhpc.adelaide.edu.au/proiects/vishuman2/VisibleHuman.html Google Scholar
20. Sulston, J.E. et al. The C. elegans male; Postembryonic development of non-gonadal structures. Dev. Biology 78: 542576, 1980.Google Scholar