Hostname: page-component-76fb5796d-vfjqv Total loading time: 0 Render date: 2024-04-26T21:19:49.516Z Has data issue: false hasContentIssue false
  • English
  • Français

Imaging Carbon Nanoparticles in Cells

Published online by Cambridge University Press:  14 March 2018

Mhairi Gass  and
Alexandra Porter
Mhairi Gass*
Affiliation:
SuperSTEM, Daresbury Laboratory, Daresbury, U.K.
Alexandra Porter
Affiliation:
Imperial College London, London, U.K.
*
m.h.gass@liv.ac.uk

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The application of nanotechnology in disciplines as varied as medicine and electronics is advancing rapidly with carbon nanoparticles (CNPs) such as fullerenes (C60) and nanotubes at the forefront. However, a lack of understanding of the interaction of such small structures with cellular material has resulted in concerns over their impact on human health and since the individual structures have a diameter of ~1 nm they are potentially small enough to penetrate through ion channels or diffuse through pores in the nuclear membrane. Assessing their toxicity is imperative. In response to these concerns there has been an increase in the number of papers addressing the toxicity of carbon nanoparticles over the last few years but much of this data appears contradictory. It is therefore essential to understand how the human body interacts with CNPs and more specifically to elucidate pathways by which CNPs enter the cell and their distribution within.

Type
Research Article
Information
Microscopy Today , Volume 16 , Issue 1 , January 2008 , pp. 42 - 47
Copyright
Copyright © Microscopy Society of America 2008

References

1 Shvedova, AA, Castranona, V, Kisin, ER, Schwegler-Berry, D, Murray, AR, Gandelsman, VZ and Baron, P, J. Toxicol. Environ. Health A, 2003, 66, 1909 CrossRefGoogle Scholar
2 Manna, SK, Sarkar, S, Bar, J, Wise, K, Barrrera, EV, Jejelowo, O, Rice-Ficht, A and Ramesh, G, Nano Lett. 2005, 5(9), 1676 CrossRefGoogle Scholar
3Chui D, Tian, F, Ozkan, CS, Want, M, Gao, H, Toxicol. Lett. 2005, 155, 73Google Scholar
4 Worle-Knirsch, JM, Pulskamp, K and Krug, HF, Nano Lett. 2006, 6(6), 1261 CrossRefGoogle Scholar
5 Sayes, CM, Liang, F, Hudson, JL, Mendez, J, Guo, W, Beach, JM, Moore, VC, Doyle, CD, West, JL,Billups, WE, Ausman, KD and Colvin, VL, Toxicol. Lett. 2006, 161(2), 135 CrossRefGoogle Scholar
6 Nimmagadda, A, Thurston, K, Nollert, MU, McFetridge, PS, J. Biomed. Mater. Res. A. 2006, 1:76(3), 614 CrossRefGoogle Scholar
7 Porter, AE, Gass, M, Muller, K, Skepper, JN, Midgley, PA and Welland, M., Nature Nanotechnology, 2007, 2, 713 CrossRefGoogle Scholar
8 Porter, A. E., Muller, K., Skepper, J., Midgley, P., Welland, M., Acta. Biomater., 2006, 2(4), 409-19.CrossRefGoogle Scholar
9 Porter, A. E., Gass, M., Muller, K., Skepper, J. N., Midgley, P. and Welland, M., Environmental Science & Technology 2007, 41, 3012 CrossRefGoogle Scholar
10 Thomas, P. J. and Midgley, P.A., Ultramicroscopy, 2001, 88(3), 179 CrossRefGoogle Scholar
11 Midgley, PA, Ward, EPWW, Hungría, AB and Thomas, JM., Chem. Soc. Rev., 2007, 36, 1477 CrossRefGoogle Scholar
12 Gass, M. H., Koziol, K. K., Windle, A., Midgley, P., Nano Letter 2006, 6(3), 376-379 CrossRefGoogle Scholar