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Visual attention in long-term survivors of leukemia receiving cranial radiation therapy

Published online by Cambridge University Press:  01 March 2004

JEFFREY SCHATZ ,
JOEL H. KRAMER ,
ARTHUR R. ABLIN  and
KATHERINE K. MATTHAY
JEFFREY SCHATZ
Affiliation:
Department of Psychology, University of South Carolina, Columbia
JOEL H. KRAMER
Affiliation:
Department of Psychiatry, University of California at San Francisco Department of Pediatrics, University of California at San Francisco
ARTHUR R. ABLIN
Affiliation:
Department of Pediatrics, University of California at San Francisco Children's Cancer Program, University of California at San Francisco
KATHERINE K. MATTHAY
Affiliation:
Department of Pediatrics, University of California at San Francisco Children's Cancer Program, University of California at San Francisco
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Abstract

The effect of cranial radiation therapy (CRT) on visual attention was examined in long-term survivors of childhood acute lymphoblastic leukemia (ALL) compared to peers with no history of ALL (n = 24) using a cued orienting task and a global–local task. ALL participants treated with CRT (n = 13) demonstrated an increased cost in response time with invalid spatial orienting cues and inefficient shifts of attention across hierarchical levels. ALL participants treated only with chemotherapy (n = 8) showed performance similar to the non-ALL comparison group. Participants with exposure to CRT early in life appeared to largely account for the attention deficits, and showed particular difficulties with shifting attention from the local level of stimuli to the global level. The data are consistent with prior reports emphasizing attention deficits following CRT, and suggest that attention shifting may be particularly affected by CRT early in life. (JINS, 2004, 10, 211–220.)

Keywords

Late effectsLeukemiaAttentionCranial radiation therapy (CRT)Acute Lymphoblastic Leukemia (ALL)
Type
Research Article
Information
Journal of the International Neuropsychological Society , Volume 10 , Issue 2 , March 2004 , pp. 211 - 220
Copyright
© 2004 The International Neuropsychological Society

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References

REFERENCES

Anderson, V., Smibert, E., Ekert, H., & Godber, T. (1994). Intellectual, educational, and behavioural sequelae after cranial irradiation and chemotherapy. Archives of Disease in Childhood, 70, 476–483.Google Scholar
Balsom, W.R., Bleyer, A., Bobison, L.L., Heyn, R.M., Meadows, A.T., Sitarz, A., Blatt, J., Sather, H.N., & Hammond, G.D. (1991). Intellectual function in long-term survivors of childhood acute lymphoblastic leukemia: Protective effect of pre-irradiation methotrexate? A Children's Cancer Study Group study. Medicine and Pediatric Oncology, 19, 486–492.Google Scholar
Bleyer, W.A. & Griffin, T.W. (1980). White matter nectosis, mineralizing microangiopathy, and intellectual abilities in survivors of childhood leukemia: associations with central nervous system irradiation and methotrexate therapy. In H.A. Gilbert & A.R. Kagan (Eds.), Radiation damage to the nervous system (pp. 155–174). New York: Raven Press.
Brouwers, P. & Poplack, D. (1990). Memory and learning sequelae in long-term survivors of acute lymphoblastic leukemia: Association with attention deficit. American Journal of Pediatric Hematology Oncology, 12, 174–181.Google Scholar
Brouwers, P., Riccardi, R., Poplack, D., & Fedio, P. (1984). Attentional deficits in long-term survivors of childhood acute lymphoblastic leukemia (ALL). Journal of Clinical Neuropsychology, 6, 325–336.Google Scholar
Chessels, J.M., Cox, T.C., Kendall, B., Cavanagh, N.P., Jannoun, L., & Richards, S. (1990). Neurotoxicity in lymphoblastic leukaemia: comparison of oral and intramuscular methotrexate and two doses of radiation. Archives of Disease in Childhood, 65, 416–422.Google Scholar
Christie, D., Leiper, A.D., Chessells, J.M., & Vargha-Khadem, F. (1995). Intellectual performance after presymptomatic cranial radiotherapy for leukaemia: Effects of age and sex. Archives of Diseases in Childhood, 73, 136–140.Google Scholar
Ciesielski, K.T., Yanofsky, R., Ludwig, R.N., Hill, D.E., Hart, B.L., Astur, R.S., & Snyder, T. (1994). Hypoplasia of the cerebellar vermis and cognitive deficits in survivors of childhood leukemia. Archives of Neurology, 51, 985–993.Google Scholar
Cohen, R.A., Sparling-Cohen, Y.A., & O'Donnell, B.F. (1993). The neuropsychology of attention. New York: Plenum Press.
Copeland, D.R., Dowell, R.E., Fletcher, J.M., & Bordeaux, D. (1988). Neuropsychological effects of childhood cancer treatment. Journal of Child Neurology, 3, 53–62.Google Scholar
Copeland, D.R., Fletcher, J.M., Pfefferbaum, B., Jaffe, N., Ried, H., & Maor, M. (1985). Neurological sequelae of childhood cancer in long-term survivors. Pediatrics, 75, 745–753.Google Scholar
Cousens, P., Ungerer, J.A., Crawford, J.A., & Stevens, M. (1988a). Cognitive effects of childhood leukemia therapy: A case for four specific deficits. Journal of Pediatric Psychology, 16, 475–488.Google Scholar
Cousens, P., Waters, B., Said, J., & Stevens, M. (1988b). Cognitive effects of cranial irradiation in leukaemia: A survey and meta-analysis. Journal of Child Psychology and Psychiatry and Allied Disciplines, 29, 839–852.Google Scholar
Craft, S., Gourovitch, M.L., Dowton, B., Swanson, J.M., & Bonforte, S. (1992). Lateralized deficits in visual attention in males with developmental dopamine depletion. Neuropsychologia, 30, 341–352.Google Scholar
Craft, S., Schatz, J., Glauser, T., Lee, B., & DeBaun, M.R. (1994b). The effects of bifrontal stroke during childhood on visual attention: Evidence from children with sickle cell anemia. Developmental Neuropsychology, 10, 285–297.Google Scholar
Craft, S., White, D.A., Park, T.S., & Figiel, G. (1994a). Visual attention in children with perinatal brain injury: Asymmetric effects of bilateral lesions. Journal of Cognitive Neuroscience, 6, 165–173.Google Scholar
Delis, D.C., Robertson, L.C., & Efron, R. (1986). Hemispheric specialization of memory for visual hierarchical stimuli. Neuropsychologia, 24, 205–214.Google Scholar
Fink, G.R., Halligan, P.W., Marshall, J.C., Frith, C.D., Frackowiak, R.S.J., & Dolan, R.J. (1996). Where in the brain does visual attention select the forest and the trees? Nature, 382, 626–628.Google Scholar
Fletcher, J.M. & Copeland, D.R. (1988). Neurobehavioural effects of central nervous system prophylactic treatment of cancer in children. Journal of Clinical and Experimental Neuropsychology, 10, 495–538.Google Scholar
Goff, J.R., Anderson, H.R., & Cooper, P.F. (1980). Distractibility and memory deficits in long-term surivors of acute lymphoblastic leukemia. Developmental and Behavioral Pediatrics, 1, 158–161Google Scholar
Halberg, F.E., Kramer, J.H., Moore, I.M., Wara, W.M., Matthay, K.K., & Ablin, A.R. (1992). Prophylactic cranial irradiation dose effects on late cognitive function in children treated for acute lymphoblastic leukemia. International Journal of Radiation Oncology, Biology, and Physics, 22, 13–16.Google Scholar
Heffelfinger, A., Craft, S., & Shyken, J. (1997). Visual attention in children with prenatal cocaine exposure. Journal of the International Neuropsychological Society, 3, 237–245.Google Scholar
Hertzberg, H., Huk, W.J., Ueberall, M.A., Langer, T., Meier, W., Dopfer, R., Skalej, M., Lackner, H., Bode, U., Janben, G., Zintel, F., & Beck, J.D. (1997). CNS late effects after ALL therapy in childhood. Part I: Neuroradiological findings in long-term survivors of ALL—an evaluation of the interferences between morphology and neuropsychological performance. Medical and Pediatric Oncology, 28, 387–400.Google Scholar
Jankovic, M., Brouwers, P., Valsecchi, M.G., Veldhuizen, A.V., Huisman, J., Kamphuis, R., Kingma, A., Mor, W., Van Dongen-Melman, J., Ferronato, L., Mancini, M.A., Spinetta, J.J., & Masera, G. (1994). Association of 1800 cGy cranial irradiation with intellectual function in children with acute lymphoblastic leukaemia. Lancet, 344, 224–227.Google Scholar
Jannoun, L. (1983). Are cognitive and educational development affected by age at which prophylactic therapy is given in acute lymphoblastic leukemia? Archives of Disease in Childhood, 58, 953–958.Google Scholar
Johnson, M.H., Tucker, L.A., Stiles, J., & Trauner, D. (1998). Visual attention in infants with perinatal brain damage: Evidence of the importance of anterior lesions. Developmental Science, 1, 53–58.Google Scholar
Kaufman, A.S. (1985). The Kaufman Brief Intelligence Test (K-BIT). Circle Pines, MN: American Guidance Services.
Lamb, M.R., Pond, H.M., & Zahir, G. (2000). Contributions of automatic and controlled processes to the analysis of hierarchical structure. Journal of Experimental Psychology: Human Perception and Performance, 26, 234–245.Google Scholar
Lamb, M.R. & Yund, E.W. (1993). The role of spatial frequency in the processing of hierarchically organized stimuli. Perception and Psychophysics, 54, 773–784.Google Scholar
Lamb, M.R., Yund, E.W., & Pond, H.M. (1999). Is attentional selection to different levels of hierarchical structure based on spatial frequency? Journal of Experimental Psychology: General, 128, 88–94.Google Scholar
Lansky, S.B., Cairns, N.U., Lansky, L.L., Cairns, G.F., Stephenson, L., & Garin, G. (1984). Central nervous system prophylaxis: Studies showing impairment in verbal skills and academic achievement. American Journal of Pediatric Hematology/Oncology, 6, 83–90.Google Scholar
Lockwood, K.A., Bell, T.S., & Colegrove, R.W. (1999). Long-term effects of cranial radiation therapy on attention functioning in survivors of childhood leukemia. Journal of Pediatric Psychology, 24, 55–66.Google Scholar
Michimata, C., Okubo, M., & Mugishima, Y. (1999). Effects of background color on the global and local processing of hierarchically organized stimuli. Journal of Cognitive Neuroscience, 11, 1–8.Google Scholar
Moore, I.M., Kramer, J.H., Wara, W., Halberg, F., & Ablin, A.R. (1991). Cognitive function in children with leukemia. Effect of radiation dose and time since irradiation. Cancer, 68, 1913–1917.Google Scholar
Mulhern, R.K., Fairclough, D., & Ochs, J. (1991). A prospective comparison of neuropsychologic performance of children surviving leukemia who received 18-Gy, or 24-Gy, or no cranial irradiation. Journal of Clinical Oncology, 9, 1348–1356.Google Scholar
Mullenix, P.J., Kernan, W.J., Schunior, A., Howes, A., Waber, D.P., Sallan, S.E., & Tarbell, N.J. (1994). Interactions of steroid, methotrexate, and radiation determine neurotoxicity in an animal model to study therapy for childhood leukemia. Pediatric Research, 35, 171–178.Google Scholar
Navon, D. (1977). Forest before trees: The precedence of global features in visual perception. Cognitive Psychology, 9, 353–383.Google Scholar
Ochs, J., Mulhern, D., Fairclough, D., Parvey, L., Whitaker, J., & Ch'ien, L. (1991). Comparison of the neuropsychologic functioning and clinical indicators of neurotoxicity in long-term survivors of childhood leukemia given cranial radiation or parenteral methotrexate: A prospective study. Journal of Clinical Oncology, 9, 145–151.Google Scholar
Posner, M.I. (1980). Orienting of attention. The VIIth Sir Frederic Bartlett Lecture. Quarterly Journal of Experimental Psychology, 32, 3–25.Google Scholar
Posner, M.I. (1988). Structures and functions of selective attention. In T. Boll & B. Bryant (Eds.), Clinical neuropsychology and brain function: Research, measurement, and practice (pp. 173–202). Washington DC: American Psychological Association.
Rafal, R.D. & Robertson, L.C. (1995). The neurology of visual attention. In M. Gazzaniga (Ed.), Handbook of cognitive neuroscience (pp. 625–648). Cambridge, MA: MIT Press.
Robertson, L.C. (1996). Attention persistence for features of hierarchical patterns. Journal of Experimental Psychology: General, 125, 227–249Google Scholar
Robertson, L.C., Egly, R., Lamb, M.R., & Kerth, L. (1993). Spatial attention and cuing to global and local levels of hierarchical structure. Journal of Experimental Psychology: Human Perception and Performance, 19, 471–487.Google Scholar
Robertson, L.C. & Lamb, M.R. (1991). Neuropsychological contributions to theories of part/whole organization. Cognitive Psychology, 23, 299–330.Google Scholar
Robertson, L.C., Lamb, M.R., & Knight, R.T. (1988). Effects of lesions of temporal-parietal junction on perceptual and attentional processing in humans. Journal of Neuroscience, 8, 3757–3769.Google Scholar
Robison, L.L., Nesbit, M.E., Sather, H.N., Meadows, A.T., Ortega, J.A., & Hammond, G.D. (1984). Factors associated with IQ scores in long-term survivors of childhood acute lymphoblastic leukemia. American Journal of Pediatric Hematology/Oncology, 6, 115–121.Google Scholar
Rogers, J., Britton, P.G., Morris, R.G., Kernahan, J., & Craft, A. (1992). Memory after treatment for acute lymphoblastic leukemia. Archives of Disabled Children, 67, 266–268.Google Scholar
Rubenstein, C.L., Varni, J.W., & Katz, E.R. (1990). Cognitive functioning in long-term survivors of childhood leukemia: A prospective analysis. Journal of Developmental Behavioral Pediatrics, 11, 301–305.Google Scholar
Schatz, J., Craft, S., DeBaun, M.R., & Koby, M. (1998). Spatial deficits following unilateral versus bilateral childhood stroke [Abstract]. Journal of the International Neuropsychological Society, 4, 71.Google Scholar
Schatz, J. & Erlandson, F.B. (2003). Level-repetition effects in hierarchical stimulus processing: Timing and location of cortical activity. International Journal of Psychophysiology, 47, 255–269.Google Scholar
Schatz, J., Kramer, J.H., Ablin, A., & Matthay, K.K. (2000). Processing speed, working memory, and IQ: A developmental model of cognitive deficits following cranial radiation therapy. Neuropsychology, 14, 189–200.Google Scholar
Schultheiss, T.E., Kun, L.E., Ang, K.K., & Stephens, L.C. (1995). Radiation response of the central nervous system. International Journal of Radiation Oncology: Biology, Physics, 31, 1093–1112.Google Scholar
Schunior, A., Mullenix, P.J., Landy, H., Zengel, A.E., Howes, A., & Tarbell, N.J. (1994). Radiation effects on growth are altered in rats by prednisone and methotrexate. Pediatric Research, 34, 416–423.Google Scholar
Shallice, T. (1988). From neuropsychology to mental structure. New York: Cambridge University Press.
Überall, M.A., Haupt, K., Hertzberg, H., Langer, T., Meier, W., Huk, W.J., Beck, J.D., & Wenzel, D. (1996a). Quantitative EEG in long-term survivors of acute lymphoblastic leukemia. Pediatric Neurology, 15, 293–298.Google Scholar
Überall, D. (1996b). P300 abnormalities in long-time survivors of acute lymphoblastic leukemia in childhood—side effects of CNS prophylaxis? Neuropediatrics, 27, 130–135.Google Scholar
Van Kleeck, M.H. (1989). Hemispheric differences in global versus local processing of hierarchical visual stimuli by normal subjects: New data and a meta-analysis of previous data. Neuropsychologia, 27, 1165–1178.Google Scholar
Waber, D.P., Tarbell, N.J., Fairclough, D., Atmore, K., Castro, R., Isquith, P., Lussier, F., Romero, I., Carpernter, P.J., Schiller, M., & Sallan, S.E. (1995). Cognitive sequelae of treatment in childhood acute lymphoblastic leukemia: Cranial radiation requires an accomplice. Journal of Clinical Oncology, 13, 2490–2496.Google Scholar
Waber, D.P., Tarbell, N.J., Kahn, C.M., Gelber, R.D., & Sallan, S.E. (1992). The relationship of sex and treatment modality to neuropsychological outcome in childhood acute lymphoblastic leukemia. Journal Clinical Oncology, 10, 810–817.Google Scholar
Waber, D.P., Urion, K.D., Tarbell, N.H., Niemeyer, C.C., Gelber, R., & Sallan, S.E. (1990). Late effects of central nervous system treatment of acute lymphoblastic leukemia in childhood are sex-dependent. Developmental Medicine and Child Neurology, 32, 238–248.Google Scholar
Ward, L.M. (1982). Determinants of attention to local and global features of visual forms. Journal of Experimental Psychology: Human Perception and Performance, 8, 562–581.Google Scholar
Williams, J.M., Ochs, J., & Davis, K.S. (1986). The subacute effects of CNS prophylaxis for acute lymphoblastic leukemia on neuropsychogical performance: A composition of four protocols. Archives of Clinical Neuropsychology, 1, 183–192.Google Scholar