Skip to main content Accessibility help
×
Home

Verbal memory deficits associated with fornix atrophy in carbon monoxide poisoning

  • SHELLI R. KESLER (a1), RAMONA O. HOPKINS (a1) (a2), LINDELL K. WEAVER (a2) (a3), DUANE D. BLATTER (a4), HOLLY EDGE-BOOTH (a1) and ERIN D. BIGLER (a1)...

Abstract

Magnetic resonance (MR) images and neuropsychological testing data of 69 carbon monoxide (CO) poisoned patients were prospectively obtained within 1 day of CO poisoning, two weeks and six months. CO patients' Day 1 cross-sectional fornix surface area measurements, corrected for head size by using a fornix-to-brain ratio (FBR), were compared to normal age and gender-matched controls. Additionally, a within-subjects analysis was performed comparing the mean areas between CO patients' Day 1, 2 weeks and 6-month FBR. The FBR was correlated with patients' neuropsychological data. There were no significant differences between CO patients' Day 1 fornix measurements compared to normal control subjects. However, significant atrophic changes in the fornix of CO poisoned patients occurred at two weeks with no progressive atrophy at 6 months. By 6 months, CO patients showed significant decline on tests of verbal memory (when practice effects were taken into account), whereas visual memory, processing speed and attention/concentration did not decline. This study indicates that CO results in brain damage and cognitive impairments in the absence of lesions and other neuroanatomic markers. (JINS, 2001, 7, 640–646.)

Copyright

Corresponding author

Reprint requests to: Ramona O. Hopkins, Ph.D., Psychology Department, 1001 SWKT, Brigham Young University, Provo, UT 84602. E-mail: mona_hopkins@byu.edu

Keywords

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed