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Verbal Fluency in Patients Receiving Bilateral versus Left-Sided Deep Brain Stimulation of the Subthalamic Nucleus for Parkinson's Disease

  • Rickard L. Sjöberg (a1), Elin Lidman (a2), Björn Häggström (a1), Marwan I. Hariz (a1) (a3), Jan Linder (a1), Anna Fredricks (a1) and Patric Blomstedt (a1)...

Abstract

The purpose of this study was to investigate the relative effects of unilateral (left-sided) versus bilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) on verbal fluency. To do this, 10 Parkinson's disease patients with predominantly bilateral motor symptoms who received bilateral STN DBS were compared with 6 patients suffering from predominantly unilateral symptoms who received STN DBS on the left side only. The results suggest that unilateral STN DBS of the speech dominant hemisphere is associated with significantly less declines in measures of verbal fluency as compared to bilateral stimulation. (JINS, 2012, 18, 606–611)

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Corresponding author

Correspondence and reprint requests to: Rickard L. Sjöberg, Department of Neurosurgery, University Hospital of Northern Sweden, SE-901 85 Umeå, Sweden. E-mail: rickard.l.sjoberg@gmail.com

References

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Alberts, J.L., Hass, C.J., Vitek, J.L., Okun, M.S. (2008). Are two leads always better than one: An emerging case for unilateral deep brain stimulation in Parkinson's Disease. Experimental Neurology, 214, 15.
Alexander, G.E., DeLong, M.R., Strick, P.L. (1986). Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annual Review of Neuroscience, 9, 357381.
Blomstedt, P., Hariz, M.I. (2006). Are complications less common in deep brain stimulation than in ablative procedures for movement disorders? Stereotactic and Functional Neurosurgery, 84(2–3), 7281.
Claeson, L.-E., Esbjörnsson, E., Tännérus, B.M., Wahlin, M. (1998). Claeson-Dahls test för inlärning och minne: CD-testet (Revised version by Håkan Nyman). Stockholm: Hogrefe Psykologiförlaget AB.
Corrigan, J.D., Hinkeldey, M.S. (1987). Relationships between parts A and B of the Trail Making Test. Journal of Clinical Psychology, 43(4), 402409.
Gladsjo, J.A., Miller, S.W., Heaton, R.K. (1999). Norms for letter and category fluency: Demographic corrections for age, education and ethnicity. Odessa, TX: Psychological Assessment Resources Inc.
Gronwall, D.M. (1977). Paced auditory serial-addition task: A measure of recovery from concussion. Perceptual and Motor Skills, 44, 367373.
Heo, J.-H., Lee, K.-M., Paek, S.H., Kim, M.-J., Lee, J.-Y., Kim, J.-Y., Jeon, B.S. (2008). The effects of bilateral subthalamic nucleus deep brain stimulation (STN DBS) on cognition in Parkinson disease. Journal of the Neurological Sciences, 273, 1924.
Howell, D.C. (1992). Statistical methods for psychology (3rd ed.). Belmont CA: Duxbury Press.
Hugdahl, K., Asbjornsen, A. (1994). Dikotisk lyssning med CV-stavelser: Manual. Stockholm: Psykologiförlaget.
Kongs, S.K., Thompson, L.L., Iverson, G.L., Heaton, G.L. (2000). WCST-64, Wisconsin Card Sorting Test-64 Card Version, Professional Manual. Odessa, FL: Psychological Assessment Resources Inc.
Lezak, M.D., Howieson, D.B., Loring, D.W. (2004). Neuropsychological assessment (3rd ed.). New York: Oxford University Press, Inc.
Mikos, A., Bowers, D., Noecker, A.M., McIntyre, C.C., Won, M., Chaturvedi, A., Okun, M.S. (2011). Patient specific analysis of the relationship between the volume of tissue activated during DBS and verbal fluency. Neuroimage, 54, S238S246.
Parsons, T.D., Rogers, S.A., Braaten, A.J., Woods, S.P., Tröster, A. (2006). Cognitive sequelae of subthalamic nucleus deep brain stimulation in Parkinson's disease: A meta analysis. The Lancet Neurology, 5, 578588.
Reitan, R.M. (1958). Validity of the Trail Making test as an indicator of organic brain damage. Perceptual and Motor Skills, 8, 271276.
Stuss, D.T., Alexander, M.P., Hamer, L., Palumbo, C., Dempster, R., Binns, M., Izukawa, D. (1998). The effect of focal anterior and posterior brain lesions on verbal fluency. Journal of the International Neuropsychological Society, 4, 265278.
Taba, H.A., Wu, S.S., Foote, K.D., Hass, C.J., Fernandez, H.H., Malaty, I.A., Okun, M.S. (2010). A closer look at unilateral versus bilateral deep brain stimulation: Results of the National Institutes of Health COMPARE cohort. Journal of Neurosurgery, 113, 12241229.
Troyer, A. (2000). Normative data for clustering and switching on verbal fluency tasks. Journal of Clinical and Experimental Neuropsychology, 22, 370378.
Weaver, F.M., Follet, K., Stern, M., Hur, K., Harris, C., Marks, W.J. Jr., Huang, G.D. (2009). Bilateral deep brain stimulation vs best medical therapy for patients with advanced Parkinson disease: A randomized controlled trial. Journal of the American Medical Association, 301, 6373.
Williams, A., Gill, S., Varma, T., Jenkinson, C., Quinn, N., Mitchell, R., Wheatley, K. (2010) Deep brain stimulation plus best medical therapy versus best medical therapy alone for advanced Parkinson's disease (PD SURG trial): A randomized open-label trial. The Lancet Neurology, 9, 581591.
York, M.K., Dulay, M., Macias, A., Levin, H.S., Grossman, R., Simpson, R., Jankovic, J. (2008). Cognitive declines following bilateral subthalamic nucleus deep brain stimulation for the treatment of Parkinson's disease. Journal of Neurology, Neurosurgery, and Psychiatry, 79, 789795.

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