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Verbal Fluency in Patients Receiving Bilateral versus Left-Sided Deep Brain Stimulation of the Subthalamic Nucleus for Parkinson's Disease

  • Rickard L. Sjöberg (a1), Elin Lidman (a2), Björn Häggström (a1), Marwan I. Hariz (a1) (a3), Jan Linder (a1), Anna Fredricks (a1) and Patric Blomstedt (a1)...


The purpose of this study was to investigate the relative effects of unilateral (left-sided) versus bilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) on verbal fluency. To do this, 10 Parkinson's disease patients with predominantly bilateral motor symptoms who received bilateral STN DBS were compared with 6 patients suffering from predominantly unilateral symptoms who received STN DBS on the left side only. The results suggest that unilateral STN DBS of the speech dominant hemisphere is associated with significantly less declines in measures of verbal fluency as compared to bilateral stimulation. (JINS, 2012, 18, 606–611)


Corresponding author

Correspondence and reprint requests to: Rickard L. Sjöberg, Department of Neurosurgery, University Hospital of Northern Sweden, SE-901 85 Umeå, Sweden. E-mail:


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