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“Subcortical” cognitive impairment in patients with systemic lupus erythematosus

  • ELIZABETH LERITZ (a1), JASON BRANDT (a1), MELISSA MINOR (a2), FRANCES REIS-JENSEN (a2) and MICHELLE PETRI (a2)...

Abstract

Studies of cognitive functioning in patients with systemic lupus erythematosus (SLE) have found deficits even in patients without other evidence of neurologic involvement. The present study used scores on the 11 items of the Mini-Mental State Exam (MMSE) to classify the cognitive impairment of 93 SLE patients as suggestive of “cortical” or “subcortical” dysfunction using a validated statistical algorithm. Ninety-five percent of patients were categorized as having “subcortical” deficits, and 5% were categorized as having “cortical” deficits. When the analysis was limited to only those with total MMSE scores ≤ 24, 81% were classified as “subcortical” and 19% as “cortical.” These results suggest that SLE patients can have psychomotor and mental tracking deficits of a type seen in patients with subcortical brain disease, even in the absence of gross neurologic involvement. (JINS, 2000, 6, 821–825.)

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Corresponding author

Address correspondence to: Elizabeth Leritz, University of Florida, Health Science Center, Department of Clinical and Health Psychology, Box 100165, Gainesville, FL 32610-0165. phone: (352)265-0680 ext. 6887, fax: (352)265-0468. E-mail: bleritz@ufl.edu.
Reprint requests to: Jason Brandt, Ph.D., Department of Psychiatry and Behavioral Sciences, Meyer 218, Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287-7218.

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“Subcortical” cognitive impairment in patients with systemic lupus erythematosus

  • ELIZABETH LERITZ (a1), JASON BRANDT (a1), MELISSA MINOR (a2), FRANCES REIS-JENSEN (a2) and MICHELLE PETRI (a2)...

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