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Social Cognition and Emotional Assessment (SEA) is a Marker of Medial and Orbital Frontal Functions: A Voxel-Based Morphometry Study in Behavioral Variant of Frontotemporal Degeneration

  • Maxime Bertoux (a1) (a2) (a3) (a4), Emmanuelle Volle (a1) (a2), Aurélie Funkiewiez (a3) (a4), Leonardo Cruz de Souza (a1) (a2) (a3) (a4), Delphine Leclercq (a5) and Bruno Dubois (a1) (a2) (a3) (a4)...

Abstract

The aim of this study was to explore the cerebral correlates of functional deficits that occur in behavioral variant frontotemporal dementia (bvFTD). A specific neuropsychological battery, the Social cognition & Emotional Assessment (SEA; Funkiewiez et al., 2012), was used to assess impaired social and emotional functions in 20 bvFTD patients who also underwent structural MRI scanning. The SEA subscores of theory of mind, reversal-learning tests, facial emotion identification, and apathy evaluation were entered as covariates in a voxel-based morphometry analysis. The results revealed that the gray matter volume in the rostral part of the medial prefrontal cortex [mPFC, Brodmann area (BA) 10] was associated with scores on the theory of mind subtest, while gray matter volume within the orbitofrontal (OFC) and ventral mPFC (BA 11 and 47) was related to the scores observed in the reversal-learning subtest. Gray matter volume within BA 9 in the mPFC was correlated with scores on the emotion recognition subtest, and the severity of apathetic symptoms in the Apathy scale covaried with gray matter volume in the lateral PFC (BA 44/45). Among these regions, the mPFC and OFC cortices have been shown to be atrophied in the early stages of bvFTD. In addition, SEA and its abbreviated version (mini-SEA) have been demonstrated to be sensitive to early impairments in bvFTD (Bertoux et al., 2012). Taken together, these results suggest a differential involvement of orbital and medial prefrontal subregions in SEA subscores and support the use of the SEA to evaluate the integrity of these regions in the early stages of bvFTD. (JINS, 2012, 18, 972–985)

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Corresponding author

Correspondence and reprint requests to: Maxime Bertoux, Institut de la Mémoire et de la Maladie d'Alzheimer, Pavillon Lhermitte, Groupe hospitalier Pitié-Salpêtrière, 47 boulevard de l'Hôpital, 75013 Paris, France. E-mail: maximel.bertoux@gmail.com

References

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Adenzato, M., Cavallo, M., Enrici, I. (2010). Theory of mind ability in the behavioural variant of frontotemporal dementia: An analysis of the neural, cognitive, and social levels. Neuropsychologia, 48(1), 212.
Adolphs, R. (2002). Neural systems for recognizing emotion. Current Opinion in Neurobiology, 12(2), 169177.
Agosta, F., Canu, E., Sarro, L., Comi, G., Filippi, M. (2012). Neuroimaging findings in frontotemporal lobar degeneration spectrum of disorders. Cortex, 48(4), 389413.
Allman, J.M., Tetreault, N.A., Hakeem, A.Y., Manaye, K.F., Semendeferi, K., Erwin, J.M., Hof, P.R. (2011). The von Economo neurons in the frontoinsular and anterior cingulate cortex. Annals of the New York Academy of Sciences, 1225, 5971.
Amodio, D.M., Frith, C.D. (2006). Meeting of minds: The medial frontal cortex and social cognition. Nature Review Neuroscience, 7(4), 268277.
Apostolova, L.G., Thompson, P.M. (2008). Mapping progressive brain structural changes in early Alzheimer's disease and mild cognitive impairment. Neuropsychologia, 46(6), 15971612.
Aron, A.R., Fletcher, P.C., Bullmore, E.T., Sahakian, B.J., Robbins, T.W. (2003). Stop-signal inhibition disrupted by damage to right inferior frontal gyrus in humans. Nature Neuroscience, 6(2), 115116.
Ashburner, J. (2007). A fast diffeomorphic image registration algorithm. Neuroimage, 38(1), 95113.
Ashburner, J., Friston, K.J. (2005). Unified segmentation. Neuroimage, 26(3), 839851.
Badre, D. (2008). Cognitive control, hierarchy, and the rostro-caudal organization of the frontal lobes. Trends in Cognitive Sciences, 12(5), 193200.
Baron-Cohen, S., Ring, H., Moriarty, J., Schmitz, B., Costa, D., Ell, P. (1994). Recognition of mental state terms. Clinical findings in children with autism and a functional neuroimaging study of normal adults. The British Journal of Psychiatry, 165(5), 640649.
Beckmann, M., Johansen-Berg, H., Rushworth, M.F. (2009). Connectivity-based parcellation of human cingulate cortex and its relation to functional specialization. Journal of Neuroscience, 29(4), 11751190.
Bertoux, M., Delavest, M., de Souza, L.C., Funkiewiez, A., Lepine, J.P., Fossati, P., Sarazin, M. (2012). Social cognition and emotional assessment differentiates frontotemporal dementia from depression. Journal of Neurology, Neurosurgery and Psychiatry, 83(4), 411416.
Blair, K.S., Smith, B.W., Mitchell, D.G., Morton, J., Vythilingam, M., Pessoa, L., Blair, R.J. (2007). Modulation of emotion by cognition and cognition by emotion. Neuroimage, 35(1), 430440.
Boccardi, M., Sabattoli, F., Laakso, M.P., Testa, C., Rossi, R., Beltramello, A., Frisoni, G.B. (2005). Frontotemporal dementia as a neural system disease. Neurobiology of Aging, 26(1), 3744.
Botvinick, M.M. (2007). Conflict monitoring and decision making: reconciling two perspectives on anterior cingulate function. Cognive and Affective Behavioral Neuroscience, 7(4), 356366.
Braver, T.S., Barch, D.M., Gray, J.R., Molfese, D.L., Snyder, A. (2001). Anterior cingulate cortex and response conflict: effects of frequency, inhibition and errors. Cerebral Cortex, 11(9), 825836.
Broe, M., Hodges, J.R., Schofield, E., Shepherd, C.E., Kril, J.J., Halliday, G.M. (2003). Staging disease severity in pathologically confirmed cases of frontotemporal dementia. Neurology, 60(6), 10051011.
Bush, G., Vogt, B.A., Holmes, J., Dale, A.M., Greve, D., Jenike, M.A., Rosen, B.R. (2002). Dorsal anterior cingulate cortex: a role in reward-based decision making. Proc Natl Acad Sci U S A, 99(1), 523528.
Carrington, S.J., Bailey, A.J. (2009). Are there theory of mind regions in the brain? A review of the neuroimaging literature. Human Brain Mapping, 30(8), 23132335.
Cools, R., Clark, L., Owen, A.M., Robbins, T.W. (2002). Defining the neural mechanisms of probabilistic reversal learning using event-related functional magnetic resonance imaging. Journal of Neuroscience, 22(11), 45634567.
Dove, A., Pollmann, S., Schubert, T., Wiggins, C.J., von Cramon, D.Y. (2000). Prefrontal cortex activation in task switching: An event-related fMRI study. Brain Research: Cognitive Brain Research, 9(1), 103109.
Dubois, B., Slachevsky, A., Litvan, I., Pillon, B. (2000). The FAB: A frontal assessment battery at bedside. Neurology, 55(11), 16211626.
Ekman, P., Friesen, W.V. (1975). Unmasking the face: A guide to recognizing emotions from facial clues. Oxford: Prentice-Hall.
Elliott, R., Dolan, R.J., Frith, C.D. (2000). Dissociable functions in the medial and lateral orbitofrontal cortex: Evidence from human neuroimaging studies. Cerebral Cortex, 10(3), 308317.
Fellows, L.K. (2007). The role of orbitofrontal cortex in decision making: A component process account. Annals of the New York Academy of Sciences, 1121, 421430.
Fellows, L.K., Farah, M.J. (2003). Ventromedial frontal cortex mediates affective shifting in humans: Evidence from a reversal learning paradigm. Brain, 126(Pt 8), 18301837.
Folstein, M.F., Folstein, S.E., McHugh, P.R. (1975). “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatry Research, 12(3), 189198.
Franceschi, M., Anchisi, D., Pelati, O., Zuffi, M., Matarrese, M., Moresco, R.M., Perani, D. (2005). Glucose metabolism and serotonin receptors in the frontotemporal lobe degeneration. Annals of Neurology, 57(2), 216225.
Frith, C.D., Frith, U. (2006). The neural basis of mentalizing. Neuron, 50(4), 531534.
Funkiewiez, A., Bertoux, M., de Souza, L.C., Levy, R., Dubois, B. (2012). The SEA (social cognition and emotional assessment): A clinical neuropsychological tool for early diagnosis of frontal variant of frontotemporal lobar degeneration. Neuropsychology, 26(1), 8190.
Gallagher, H.L., Happe, F., Brunswick, N., Fletcher, P.C., Frith, U., Frith, C.D. (2000). Reading the mind in cartoons and stories: An fMRI study of ‘theory of mind’ in verbal and nonverbal tasks. Neuropsychologia, 38(1), 1121.
Gehring, W.J., Willoughby, A.R. (2002). The medial frontal cortex and the rapid processing of monetary gains and losses. Science, 295(5563), 22792282.
Ghahremani, D.G., Monterosso, J., Jentsch, J.D., Bilder, R.M., Poldrack, R.A. (2010). Neural components underlying behavioral flexibility in human reversal learning. Cerebral Cortex, 20(8), 18431852.
Gilbert, S.J., Gonen-Yaacovi, G., Benoit, R.G., Volle, E., Burgess, P.W. (2010). Distinct functional connectivity associated with lateral versus medial rostral prefrontal cortex: A meta-analysis. Neuroimage, 53(4), 13591367.
Gilbert, S.J., Spengler, S., Simons, J.S., Steele, J.D., Lawrie, S.M., Frith, C.D., Burgess, P.W. (2006). Functional specialization within rostral prefrontal cortex (area 10): A meta-analysis. Journal of Cognitive Neuroscience, 18(6), 932948.
Gislason, T.B., Sjogren, M., Larsson, L., Skoog, I. (2003). The prevalence of frontal variant frontotemporal dementia and the frontal lobe syndrome in a population based sample of 85 year olds. Journal of Neurology, Neurosurgery and Psychiatry, 74(7), 867871.
Goya-Maldonado, R., Walther, S., Simon, J., Stippich, C., Weisbrod, M., Kaiser, S. (2010). Motor impulsivity and the ventrolateral prefrontal cortex. Psychiatry Research, 183(1), 8991.
Gregory, C., Lough, S., Stone, V., Erzinclioglu, S., Martin, L., Baron-Cohen, S., Hodges, J.R. (2002). Theory of mind in patients with frontal variant frontotemporal dementia and Alzheimer's disease: Theoretical and practical implications. Brain, 125(Pt 4), 752764.
Heberlein, A.S., Padon, A.A., Gillihan, S.J., Farah, M.J., Fellows, L.K. (2008). Ventromedial frontal lobe plays a critical role in facial emotion recognition. Journal of Cognitive Neuroscience, 20(4), 721733.
Hornak, J., Bramham, J., Rolls, E.T., Morris, R.G., O'Doherty, J., Bullock, P.R., Polkey, C.E. (2003). Changes in emotion after circumscribed surgical lesions of the orbitofrontal and cingulate cortices. Brain, 126(Pt 7), 16911712.
Hornak, J., O'Doherty, J., Bramham, J., Rolls, E.T., Morris, R.G., Bullock, P.R., Polkey, C.E. (2004). Reward-related reversal learning after surgical excisions in orbito-frontal or dorsolateral prefrontal cortex in humans. Journal of Cognitive Neuroscience, 16(3), 463478.
Hornberger, M., Geng, J., Hodges, J.R. (2011). Convergent grey and white matter evidence of orbitofrontal cortex changes related to disinhibition in behavioural variant frontotemporal dementia. Brain, 134(Pt 9), 25022512.
Ibach, B., Koch, H., Koller, M., Wolfersdorf, M.; Workgroup for Geriatric Psychiatry of the Psychiatric State Hospitals of Germany; Workgroup for Clinical Research of the Psychiatric State Hospitals of Germany (2003). Hospital admission circumstances and prevalence of frontotemporal lobar degeneration: A multicenter psychiatric state hospital study in Germany. Dementia and Geriatric Cognitive Disorders, 16(4), 253264.
Kennerley, S.W., Behrens, T.E., Wallis, J.D. (2011). Double dissociation of value computations in orbitofrontal and anterior cingulate neurons. Nature Neuroscience, 14(12), 15811589.
Keysers, C., Gazzola, V. (2007). Integrating simulation and theory of mind: From self to social cognition. Trends in Cognitive Sciences, 11(5), 194196.
Koechlin, E., Ody, C., Kouneiher, F. (2003). The architecture of cognitive control in the human prefrontal cortex. Science, 302(5648), 11811185.
Koechlin, E., Summerfield, C. (2007). An information theoretical approach to prefrontal executive function. Trends in Cognitive Sciences, 11(6), 229235.
Kringelbach, M.L., Rolls, E.T. (2004). The functional neuroanatomy of the human orbitofrontal cortex: Evidence from neuroimaging and neuropsychology. Progress in Neurobiology, 72(5), 341372.
Krueger, C.E., Dean, D.L., Rosen, H.J., Halabi, C., Weiner, M., Miller, B.L., Kramer, J.H. (2010). Longitudinal rates of lobar atrophy in frontotemporal dementia, semantic dementia, and Alzheimer's disease. Alzheimer Disease and Associated Disorders, 24(1), 4348.
Kumral, E., Bayulkem, G., Evyapan, D., Yunten, N. (2002). Spectrum of anterior cerebral artery territory infarction: Clinical and MRI findings. European Journal of Neurology, 9(6), 615624.
Kumral, E., Evyapan, D., Balkir, K. (1999). Acute caudate vascular lesions. Stroke, 30(1), 100108.
Lamm, C., Batson, C.D., Decety, J. (2007). The neural substrate of human empathy: Effects of perspective-taking and cognitive appraisal. Journal of Cognitive Neuroscience, 19(1), 4258.
Lane, R.D., Reiman, E.M., Bradley, M.M., Lang, P.J., Ahern, G.L., Davidson, R.J., Schwartz, G.E. (1997). Neuroanatomical correlates of pleasant and unpleasant emotion. Neuropsychologia, 35(11), 14371444.
Lavenu, I., Pasquier, F. (2005). Perception of emotion on faces in frontotemporal dementia and Alzheimer's disease: A longitudinal study. Dementia and Geriatric Cognitive Disorders, 19(1), 3741.
Leslie, K.R., Johnson-Frey, S.H., Grafton, S.T. (2004). Functional imaging of face and hand imitation: Towards a motor theory of empathy. Neuroimage, 21(2), 601607.
Levy, R., Dubois, B. (2006). Apathy and the functional anatomy of the prefrontal cortex-basal ganglia circuits. Cerebral Cortex, 16(7), 916928.
Lough, S., Kipps, C.M., Treise, C., Watson, P., Blair, J.R., Hodges, J.R. (2006). Social reasoning, emotion and empathy in frontotemporal dementia. Neuropsychologia, 44(6), 950958.
Lutz, A., Greischar, L.L., Perlman, D.M., Davidson, R.J. (2009). BOLD signal in insula is differentially related to cardiac function during compassion meditation in experts vs. novices. Neuroimage, 47(3), 10381046.
Massimo, L., Powers, C., Moore, P., Vesely, L., Avants, B., Gee, J., Grossman, M. (2009). Neuroanatomy of apathy and disinhibition in frontotemporal lobar degeneration. Dementia and Geriatric Cognitive Disorders, 27(1), 96104.
Mattis, S. (1976). Mental status examination for organic mental syndrome in the elderly patients. In L. Bellak & T. Karasu (Eds.), Geriatrics psychiatry: A handbook for psychiatrists and primary care physicians (pp. 77121). New York: Grune & Stratton.
McKhann, G.M., Albert, M.S., Grossman, M., Miller, B., Dickson, D., Trojanowski, J.Q., Work Group on Frontotemporal Dementia and Pick's Disease (2001). Clinical and pathological diagnosis of frontotemporal dementia: Report of the Work Group on Frontotemporal Dementia and Pick's Disease. Archives of Neurology, 58(11), 18031809.
Mitchell, D.G., Rhodes, R.A., Pine, D.S., Blair, R.J. (2008). The contribution of ventrolateral and dorsolateral prefrontal cortex to response reversal. Behavioural Brain Research, 187(1), 8087.
Mitz, A.R., Godschalk, M., Wise, S.P. (1991). Learning-dependent neuronal activity in the premotor cortex: Activity during the acquisition of conditional motor associations. Journal of Neuroscience, 11(6), 18551872.
Nakano, S., Asada, T., Yamashita, F., Kitamura, N., Matsuda, H., Hirai, S., Yamada, T. (2006). Relationship between antisocial behavior and regional cerebral blood flow in frontotemporal dementia. Neuroimage, 32(1), 301306.
Neary, D., Snowden, J.S., Gustafson, L., Passant, U., Stuss, D., Black, S., Benson, D.F. (1998). Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria. Neurology, 51(6), 15461554.
Nelson, H.E. (1976). A modified card sorting test sensitive to frontal lobe defects. Cortex, 12(4), 313324.
O'Doherty, J., Kringelbach, M.L., Rolls, E.T., Hornak, J., Andrews, C. (2001). Abstract reward and punishment representations in the human orbitofrontal cortex. Nature Neuroscience, 4(1), 95102.
O'Doherty, J.P., Dolan, R.J. (2006). The role of human orbitofrontal cortex in reward prediction and behavioural choice: Insights from neuroimaging. In: D. Zald & S.L. Rauch (Eds.), The orbitofrontal cortex. Oxford: Oxford University Press.
Ochsner, K.N., Knierim, K., Ludlow, D.H., Hanelin, J., Ramachandran, T., Glover, G., Mackey, S.C. (2004). Reflecting upon feelings: An fMRI study of neural systems supporting the attribution of emotion to self and other. Journal of Cognitive Neuroscience, 16(10), 17461772.
Peelen, M.V., Atkinson, A.P., Vuilleumier, P. (2010). Supramodal representations of perceived emotions in the human brain. Journal of Neuroscience, 30(30), 1012710134.
Perry, R.J., Graham, A., Williams, G., Rosen, H., Erzinclioglu, S., Weiner, M., Hodges, J. (2006). Patterns of frontal lobe atrophy in frontotemporal dementia: A volumetric MRI study. Dementia and Geriatric Cognitive Disorders, 22(4), 278287.
Picton, T.W., Stuss, D.T., Alexander, M.P., Shallice, T., Binns, M.A., Gillingham, S. (2007). Effects of focal frontal lesions on response inhibition. Cerebral Cortex, 17(4), 826838.
Piguet, O., Hornberger, M., Mioshi, E., Hodges, J.R. (2011). Behavioural-variant frontotemporal dementia: Diagnosis, clinical staging, and management. Lancet Neurology, 10(2), 162172.
Rabinovici, G.D., Seeley, W.W., Kim, E.J., Gorno-Tempini, M.L., Rascovsky, K., Pagliaro, T.A., Rosen, H.J. (2007). Distinct MRI atrophy patterns in autopsy-proven Alzheimer's disease and frontotemporal lobar degeneration. American Journal of Alzheimer's Disease and Other Dementias, 22(6), 474488.
Rahman, S., Sahakian, B.J., Hodges, J.R., Rogers, R.D., Robbins, T.W. (1999). Specific cognitive deficits in mild frontal variant frontotemporal dementia. Brain, 122(Pt 8), 14691493.
Rascovsky, K., Hodges, J.R., Knopman, D., Mendez, M.F., Kramer, J.H., Grossman, M., Miller, B.L., on behalf of the International bvFTD Criteria Consortium (FTDC) (2012). Reply: Considering the frontomedian cortex in revised criteria for behavioural variant frontotemporal dementia. Brain, 135(Pt 4), e213.
Rascovsky, K., Hodges, J.R., Knopman, D., Mendez, M.F., Kramer, J.H., Neuhaus, J., Miller, B.L. (2011). Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain, 134(Pt 9), 24562477.
Roca, M., Torralva, T., Gleichgerrcht, E., Woolgar, A., Thompson, R., Duncan, J., Manes, F. (2011). The role of Area 10 (BA10) in human multitasking and in social cognition: A lesion study. Neuropsychologia, 49(11), 35253531.
Roesch, M.R., Olson, C.R. (2003). Impact of expected reward on neuronal activity in prefrontal cortex, frontal and supplementary eye fields and premotor cortex. Journal of Neurophysiology, 90(3), 17661789.
Rolls, E.T., Hornak, J., Wade, D., McGrath, J. (1994). Emotion-related learning in patients with social and emotional changes associated with frontal lobe damage. Journal of Neurology, Neurosurgery and Psychiatry, 57(12), 15181524.
Rosen, H.J., Allison, S.C., Schauer, G.F., Gorno-Tempini, M.L., Weiner, M.W., Miller, B.L. (2005). Neuroanatomical correlates of behavioural disorders in dementia. Brain, 128(Pt 11), 26122625.
Rushworth, M.F., Behrens, T.E. (2008). Choice, uncertainty and value in prefrontal and cingulate cortex. Nature Neuroscience, 11(4), 389397.
Rushworth, M.F., Behrens, T.E., Rudebeck, P.H., Walton, M.E. (2007). Contrasting roles for cingulate and orbitofrontal cortex in decisions and social behaviour. Trends in Cognitive Sciences, 11(4), 168176.
Rushworth, M.F., Walton, M.E., Kennerley, S.W., Bannerman, D.M. (2004). Action sets and decisions in the medial frontal cortex. Trends in Cognitive Sciences, 8(9), 410417.
Salmon, E., Garraux, G., Delbeuck, X., Collette, F., Kalbe, E., Zuendorf, G., Herholz, K. (2003). Predominant ventromedial frontopolar metabolic impairment in frontotemporal dementia. Neuroimage, 20(1), 435440.
Sarazin, M., Dubois, B., de Souza, L.C., Bertoux, M. (2012). Should the social cognition and emotional assessment replace standard neuropsychological tests for frontotemporal dementia? Expert Reviews in Neurotherapeutics, 12(6), 633635.
Schroeter, M.L. (2012). Considering the frontomedian cortex in revised criteria for behavioural variant frontotemporal dementia. Brain, 135(Pt 4), e213; author reply e214. doi:aws030.
Schroeter, M.L., Raczka, K., Neumann, J., von Cramon, D.Y. (2008). Neural networks in frontotemporal dementia--a meta-analysis. Neurobiology of Aging, 29(3), 418426.
Schroeter, M.L., Raczka, K., Neumann, J., Yves von Cramon, D. (2007). Towards a nosology for frontotemporal lobar degenerations-a meta-analysis involving 267 subjects. Neuroimage, 36(3), 497510.
Seelaar, H., Rohrer, J.D., Pijnenburg, Y.A., Fox, N.C., van Swieten, J.C. (2011). Clinical, genetic and pathological heterogeneity of frontotemporal dementia: A review. Journal of Neurology, Neurosurgery and Psychiatry, 82(5), 476486.
Seeley, W.W. (2010). Anterior insula degeneration in frontotemporal dementia. Brain Structure and Function, 214(5-6), 465475.
Seeley, W.W., Crawford, R., Rascovsky, K., Kramer, J.H., Weiner, M., Miller, B.L., Gorno-Tempini, M.L. (2008). Frontal paralimbic network atrophy in very mild behavioral variant frontotemporal dementia. Archives of Neurology, 65(2), 249255.
Seeley, W.W., Zhou, J., Kim, E.J. (2011). Frontotemporal dementia: What can the behavioral variant teach us about human brain organization? Neuroscientist, 18(4), 373385.
Seilhean, D., Le Ber, I., Sarazin, M., Lacomblez, L., Millecamps, S., Salachas, F., Duyckaerts, C. (2011). Fronto-temporal lobar degeneration: Neuropathology in 60 cases. Journal of Neural Transmission, 118(5), 753764.
Shamay-Tsoory, S.G., Aharon-Peretz, J., Perry, D. (2009). Two systems for empathy: A double dissociation between emotional and cognitive empathy in inferior frontal gyrus versus ventromedial prefrontal lesions. Brain, 132(Pt 3), 617627.
Shamay-Tsoory, S.G., Tomer, R., Berger, B.D., Goldsher, D., Aharon-Peretz, J. (2005). Impaired “affective theory of mind” is associated with right ventromedial prefrontal damage. Cognitive Behavioral Neurology, 18(1), 5567.
Starkstein, S.E., Mayberg, H.S., Preziosi, T.J., Andrezejewski, P., Leiguarda, R., Robinson, R.G. (1992). Reliability, validity, and clinical correlates of apathy in Parkinson's disease. Journal of Neuropsychiatry and Clinical Neurosciences, 4(2), 134139.
Stone, V.E., Baron-Cohen, S., Knight, R.T. (1998). Frontal lobe contributions to theory of mind. Journal of Cognitive Neuroscience, 10(5), 640656.
Torralva, T., Kipps, C.M., Hodges, J.R., Clark, L., Bekinschtein, T., Roca, M., Manes, F. (2007). The relationship between affective decision-making and theory of mind in the frontal variant of fronto-temporal dementia. Neuropsychologia, 45(2), 342349.
Torralva, T., Roca, M., Gleichgerrcht, E., Bekinschtein, T., Manes, F. (2009). A neuropsychological battery to detect specific executive and social cognitive impairments in early frontotemporal dementia. Brain, 132(Pt 5), 12991309.
Tsuchida, A., Doll, B.B., Fellows, L.K. (2010). Beyond reversal: A critical role for human orbitofrontal cortex in flexible learning from probabilistic feedback. Journal of Neuroscience, 30(50), 1686816875.
Van der Linden, M., Coyette, F., Thomas-Anterion, C., Sellal, F., Poitrenaud, J., Gély-Nargeot, M.C., Deweer, B. (2006). L’évaluation des troubles de la mémoire – Présentation de qutre tests de mémoire épisodique (avec leur étalonnage). Paris: Solal.
Van Overwalle, F. (2009). Social cognition and the brain: A meta-analysis. Human Brain Mapping, 30(3), 829858.
Viskontas, I.V., Possin, K.L., Miller, B.L. (2007). Symptoms of frontotemporal dementia provide insights into orbitofrontal cortex function and social behavior. Annals of the New York Academy of Sciences, 1121, 528545.
Vogeley, K., Bussfeld, P., Newen, A., Herrmann, S., Happe, F., Falkai, P., Zilles, K. (2001). Mind reading: Neural mechanisms of theory of mind and self-perspective. Neuroimage, 14(1 Pt 1), 170181.
Walther, S., Goya-Maldonado, R., Stippich, C., Weisbrod, M., Kaiser, S. (2010). A supramodal network for response inhibition. Neuroreport, 21(3), 191195.
Wheeler, E.Z., Fellows, L.K. (2008). The human ventromedial frontal lobe is critical for learning from negative feedback. Brain, 131(Pt 5), 13231331.
Zaki, J., Weber, J., Bolger, N., Ochsner, K. (2009). The neural bases of empathic accuracy. Proceedings of the National Academy of Sciences of the United States of America, 106(27), 1138211387.
Zald, D.H., Andreotti, C. (2010). Neuropsychological assessment of the orbital and ventromedial prefrontal cortex. Neuropsychologia, 48(12), 33773391.
Zamboni, G., Huey, E.D., Krueger, F., Nichelli, P.F., Grafman, J. (2008). Apathy and disinhibition in frontotemporal dementia: Insights into their neural correlates. Neurology, 71(10), 736742.

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