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Social Cognition and Emotional Assessment (SEA) is a Marker of Medial and Orbital Frontal Functions: A Voxel-Based Morphometry Study in Behavioral Variant of Frontotemporal Degeneration

Published online by Cambridge University Press:  16 November 2012

Maxime Bertoux ,
Emmanuelle Volle ,
Aurélie Funkiewiez ,
Leonardo Cruz de Souza ,
Delphine Leclercq  and
Bruno Dubois
Maxime Bertoux*
Affiliation:
Université Pierre et Marie Curie (Sorbonne Université) - Paris 6, Paris, France UMRS 975 – Institut du Cerveau et de la Moelle Epinière - Institut National de la Santé et de la Recherche Médicale, Paris, France Institut de la Mémoire et de la Maladie d'Alzheimer, Groupe Hospitalier Pitié-Salpêtrière, Paris, France Centre de Références Démences Rares, Groupe Hospitalier Pitié-Salpêtrière, Paris, France
Emmanuelle Volle
Affiliation:
Université Pierre et Marie Curie (Sorbonne Université) - Paris 6, Paris, France UMRS 975 – Institut du Cerveau et de la Moelle Epinière - Institut National de la Santé et de la Recherche Médicale, Paris, France
Aurélie Funkiewiez
Affiliation:
Institut de la Mémoire et de la Maladie d'Alzheimer, Groupe Hospitalier Pitié-Salpêtrière, Paris, France Centre de Références Démences Rares, Groupe Hospitalier Pitié-Salpêtrière, Paris, France
Leonardo Cruz de Souza
Affiliation:
Université Pierre et Marie Curie (Sorbonne Université) - Paris 6, Paris, France UMRS 975 – Institut du Cerveau et de la Moelle Epinière - Institut National de la Santé et de la Recherche Médicale, Paris, France Institut de la Mémoire et de la Maladie d'Alzheimer, Groupe Hospitalier Pitié-Salpêtrière, Paris, France Centre de Références Démences Rares, Groupe Hospitalier Pitié-Salpêtrière, Paris, France
Delphine Leclercq
Affiliation:
Service de Neuroradiologie, Groupe Hospitalier Pitié-Salpêtrière, Paris, France
Bruno Dubois
Affiliation:
Université Pierre et Marie Curie (Sorbonne Université) - Paris 6, Paris, France UMRS 975 – Institut du Cerveau et de la Moelle Epinière - Institut National de la Santé et de la Recherche Médicale, Paris, France Institut de la Mémoire et de la Maladie d'Alzheimer, Groupe Hospitalier Pitié-Salpêtrière, Paris, France Centre de Références Démences Rares, Groupe Hospitalier Pitié-Salpêtrière, Paris, France
*
Correspondence and reprint requests to: Maxime Bertoux, Institut de la Mémoire et de la Maladie d'Alzheimer, Pavillon Lhermitte, Groupe hospitalier Pitié-Salpêtrière, 47 boulevard de l'Hôpital, 75013 Paris, France. E-mail: maximel.bertoux@gmail.com
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Abstract

The aim of this study was to explore the cerebral correlates of functional deficits that occur in behavioral variant frontotemporal dementia (bvFTD). A specific neuropsychological battery, the Social cognition & Emotional Assessment (SEA; Funkiewiez et al., 2012), was used to assess impaired social and emotional functions in 20 bvFTD patients who also underwent structural MRI scanning. The SEA subscores of theory of mind, reversal-learning tests, facial emotion identification, and apathy evaluation were entered as covariates in a voxel-based morphometry analysis. The results revealed that the gray matter volume in the rostral part of the medial prefrontal cortex [mPFC, Brodmann area (BA) 10] was associated with scores on the theory of mind subtest, while gray matter volume within the orbitofrontal (OFC) and ventral mPFC (BA 11 and 47) was related to the scores observed in the reversal-learning subtest. Gray matter volume within BA 9 in the mPFC was correlated with scores on the emotion recognition subtest, and the severity of apathetic symptoms in the Apathy scale covaried with gray matter volume in the lateral PFC (BA 44/45). Among these regions, the mPFC and OFC cortices have been shown to be atrophied in the early stages of bvFTD. In addition, SEA and its abbreviated version (mini-SEA) have been demonstrated to be sensitive to early impairments in bvFTD (Bertoux et al., 2012). Taken together, these results suggest a differential involvement of orbital and medial prefrontal subregions in SEA subscores and support the use of the SEA to evaluate the integrity of these regions in the early stages of bvFTD. (JINS, 2012, 18, 972–985)

Keywords

Frontotemporal dementiaSEAbvFTDTheory of mindReversal learningMedial prefrontal cortex
Type
Symposia
Information
Journal of the International Neuropsychological Society , Volume 18 , Issue 6 , November 2012 , pp. 972 - 985
Copyright
Copyright © The International Neuropsychological Society 2012

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