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Saccadic trajectory in Huntington's disease

Published online by Cambridge University Press:  27 June 2006

JOANNE FIELDING ,
NELLIE GEORGIOU-KARISTIANIS ,
LYNETTE MILLIST ,
MICHAEL FAHEY  and
OWEN WHITE
JOANNE FIELDING
Affiliation:
Experimental Neuropsychology Research Unit, Department of Psychology, School of Psychology, Psychiatry and Psychological Medicine, Clayton Campus, Monash University, Victoria 3800, Australia Brain Systems Laboratory, Mental Health Research Institute, Parkville, 3052, Victoria, Australia
NELLIE GEORGIOU-KARISTIANIS
Affiliation:
Experimental Neuropsychology Research Unit, Department of Psychology, School of Psychology, Psychiatry and Psychological Medicine, Clayton Campus, Monash University, Victoria 3800, Australia Brain Systems Laboratory, Mental Health Research Institute, Parkville, 3052, Victoria, Australia
LYNETTE MILLIST
Affiliation:
Brain Systems Laboratory, Mental Health Research Institute, Parkville, 3052, Victoria, Australia
MICHAEL FAHEY
Affiliation:
Bruce Lefroy Centre for Genetic Health Research, Murdoch Children's Research Institute, Parkville 3052, Victoria, Australia Department of Paediatrics, Royal Children's Hospital, Parkville 3052, Victoria, Australia
OWEN WHITE
Affiliation:
Experimental Neuropsychology Research Unit, Department of Psychology, School of Psychology, Psychiatry and Psychological Medicine, Clayton Campus, Monash University, Victoria 3800, Australia Brain Systems Laboratory, Mental Health Research Institute, Parkville, 3052, Victoria, Australia Department of Neurology, Royal Melbourne Hospital, Parkville 3050, Victoria, Australia
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Abstract

Trajectories of saccadic eye movements can be modulated by the presence of a competing visual distractor. It is proposed that the superior colliculus (SC) controls the initial deviation through competitive lateral interactions. Given the ramifications of connections between basal ganglia (BG) thalamo-cortical circuitry and the SC, it was anticipated that this modulation would be differentially effected in those with Huntington's disease, which in its early stages is primarily a disorder of the BG. Horizontal deviation was determined for exogenously driven and endogenously driven vertical saccades in the presence of peripheral distractors. For neurologically healthy participants, the initial trajectories of both saccade types curved away from distractor locations, as predicted. However, for HD participants exogenous saccades consistently deviated leftwards, irrespective of distractor location. Endogenous saccades also revealed anomalous horizontal deviation, with significant leftward deviation evident for saccades directed upward and significant rightward deviation for saccades directed downward. Further, both groups generated a comparable proportion of erroneous responses to distractor stimuli, but only neurologically healthy participants demonstrated a response time advantage for compatible target/distractor presentation. These results suggest anomalous regulation of distractor-related activity in HD. (JINS, 2006, 12, 455–464.)

Keywords

Basal gangliaSuperior colliculusNeurodegenerative diseasesSaccadic eye movementsAttentionHereditary neurodegenerative diseases
Type
Research Article
Information
Journal of the International Neuropsychological Society , Volume 12 , Issue 4 , July 2006 , pp. 455 - 464
Copyright
© 2006 The International Neuropsychological Society

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