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Performance of the NINDS-CSN 5-Minute Protocol in a National Population-Based Sample

  • Richard E. Kennedy (a1), Virginia G. Wadley (a1), Leslie A. McClure (a2), Abraham J. Letter (a3), Frederick W. Unverzagt (a4), Michael Crowe (a5), David Nyenhius (a6), Brendan J. Kelley (a7), Bhumika Kana (a1), Janice Marceaux (a5), Manjula Kurella Tamura (a8), Virginia Howard (a9) and George Howard (a1)...


In 2006, the National Institute of Neurological Disorders and Stroke-Canadian Stroke Network (NINDS-CSN) Vascular Cognitive Impairment Harmonization Standards recommended a 5-Minute Protocol as a brief screening instrument for vascular cognitive impairment (VCI). We report demographically adjusted norms for the 5-Minute Protocol and its relation to other measures of cognitive function and cerebrovascular risk factors. We performed a cross-sectional analysis of 7199 stroke-free adults in the REasons for Geographic And Racial Differences in Stroke (REGARDS) study on the NINDS-CSN 5-Minute Protocol score. Total scores on the 5-Minute Protocol were inversely correlated with age and positively correlated with years of education, and performance on the Six-Item Screener, Word List Learning, and Animal Fluency (all p-values <.001). Higher cerebrovascular risk on the Framingham Stroke Risk Profile (FSRP) was associated with lower total 5-Minute Protocol scores (p <.001). The 5-Minute Protocol also differentiated between participants with and without confirmed stroke and with and without stroke symptom histories (p <.001). The NINDS-CSN 5-Minute Protocol is a brief, easily administered screening measure that is sensitive to cerebrovascular risk and offers a valid method of screening for cognitive impairment in populations at risk for VCI. (JINS, 2014, 20, 1–12)


Corresponding author

Correspondence and reprint requests to: Richard E. Kennedy, Division of Gerontology, Geriatrics, and Palliative Care, Department of Medicine, University of Alabama at Birmingham, 933 19th Street South, CH19-218R, Birmingham, AL. E-mail:


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Performance of the NINDS-CSN 5-Minute Protocol in a National Population-Based Sample

  • Richard E. Kennedy (a1), Virginia G. Wadley (a1), Leslie A. McClure (a2), Abraham J. Letter (a3), Frederick W. Unverzagt (a4), Michael Crowe (a5), David Nyenhius (a6), Brendan J. Kelley (a7), Bhumika Kana (a1), Janice Marceaux (a5), Manjula Kurella Tamura (a8), Virginia Howard (a9) and George Howard (a1)...


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