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Perception of cognitive change by individuals with Parkinson’s disease or essential tremor seeking deep brain stimulation: Utility of the cognitive change index

Published online by Cambridge University Press:  06 October 2023

Katie Rodriguez Open the ORCID record for Katie Rodriguez [Opens in a new window] ,
Rachel N. Schade ,
Francesca V. Lopez ,
Lauren E. Kenney ,
Adrianna M. Ratajska ,
Joshua Gertler  and
Dawn Bowers
Katie Rodriguez*
Affiliation:
Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA
Rachel N. Schade
Affiliation:
Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA
Francesca V. Lopez
Affiliation:
Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA
Lauren E. Kenney
Affiliation:
Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA
Adrianna M. Ratajska
Affiliation:
Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA
Joshua Gertler
Affiliation:
Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA
Dawn Bowers
Affiliation:
Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA Department of Neurology, Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, USA
*
Corresponding author: Katie Rodriguez; Email: katierod@ufl.edu
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Abstract

Objective:

The Cognitive Change Index (CCI-20) is a validated questionnaire that assesses subjective cognitive complaints (SCCs) across memory, language, and executive domains. We aimed to: (a) examine the internal consistency and construct validity of the CCI-20 in patients with movement disorders and (b) learn how the CCI-20 corresponds to objective neuropsychological and mood performance in individuals with Parkinson’s disease (PD) or essential tremor (ET) seeking deep brain stimulation (DBS).

Methods:

216 participants (N = 149 PD; N = 67 ET) underwent neuropsychological evaluation and received the CCI-20. The proposed domains of the CCI-20 were examined via confirmatory (CFA) and exploratory (EFA) factor analyses. Hierarchical regressions were used to assess the relationship among subjective cognitive complaints, neuropsychological performance and mood symptoms.

Results:

PD and ET groups were similar across neuropsychological, mood, and CCI-20 scores and were combined into one group who was well educated (m = 15.01 ± 2.92), in their mid-60’s (m = 67.72 ± 9.33), predominantly male (63%), and non-Hispanic White (93.6%). Previously proposed 3-domain CCI-20 model failed to achieve adequate fit. Subsequent EFA revealed two CCI-20 factors: memory and non-memory (p < 0.001; CFI = 0.924). Regressions indicated apathy and depressive symptoms were associated with greater memory and total cognitive complaints, while poor executive function and anxiety were associated with more non-memory complaints.

Conclusion:

Two distinct dimensions were identified in the CCI-20: memory and non-memory complaints. Non-memory complaints were indicative of worse executive function, consistent with PD and ET cognitive profiles. Mood significantly contributed to all CCI-20 dimensions. Future studies should explore the utility of SCCs in predicting cognitive decline in these populations.

Keywords

Movement disordersFactor analysisStatisticalCognitive dysfunctionDepressionAnxietyApathy
Type
Research Article
Information
Journal of the International Neuropsychological Society , Volume 30 , Issue 4 , May 2024 , pp. 370 - 379
Copyright
Copyright © INS. Published by Cambridge University Press 2023

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