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A Neurophysiological Study of Semantic Processing in Parkinson’s Disease

Published online by Cambridge University Press:  05 December 2016

Anthony J. Angwin ,
Nadeeka N.W. Dissanayaka ,
Alison Moorcroft ,
Katie L. McMahon ,
Peter A. Silburn  and
David A. Copland
Anthony J. Angwin*
Affiliation:
University of Queensland, School of Health and Rehabilitation Sciences, Brisbane, Australia
Nadeeka N.W. Dissanayaka
Affiliation:
University of Queensland, UQ Centre for Clinical Research, Brisbane, Australia Neurology Research Centre, Royal Brisbane & Women’s Hospital, Brisbane, Australia
Alison Moorcroft
Affiliation:
University of Queensland, School of Health and Rehabilitation Sciences, Brisbane, Australia
Katie L. McMahon
Affiliation:
University of Queensland, Centre for Advanced Imaging, Brisbane, Australia
Peter A. Silburn
Affiliation:
University of Queensland, UQ Centre for Clinical Research, Brisbane, Australia Neurology Research Centre, Royal Brisbane & Women’s Hospital, Brisbane, Australia
David A. Copland
Affiliation:
University of Queensland, School of Health and Rehabilitation Sciences, Brisbane, Australia University of Queensland, UQ Centre for Clinical Research, Brisbane, Australia
*
Correspondence and reprint requests to:Anthony Angwin, University of Queensland, School of Health and Rehabilitation Sciences, Brisbane, Queensland, 4072 Australia E-mail: a.angwin@uq.edu.au
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Abstract

Objectives: Cognitive-linguistic impairments in Parkinson’s disease (PD) have been well documented; however, few studies have explored the neurophysiological underpinnings of semantic deficits in PD. This study investigated semantic function in PD using event-related potentials. Methods: Eighteen people with PD and 18 healthy controls performed a semantic judgement task on written word pairs that were either congruent or incongruent. Results: The mean amplitude of the N400 for new incongruent word pairs was similar for both groups, however the onset latency was delayed in the PD group. Further analysis of the data revealed that both groups demonstrated attenuation of the N400 for repeated incongruent trials, as well as attenuation of the P600 component for repeated congruent trials. Conclusions: The presence of N400 congruity and N400 repetition effects in the PD group suggests that semantic processing is generally intact, but with a slower time course as evidenced by the delayed N400. Additional research will be required to determine whether N400 and P600 repetition effects are sensitive to further cognitive decline in PD. (JINS, 2017, 23, 78–89)

Keywords

Event-related potentialsN400P600Parkinson’s diseaseSemanticsmemory
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 23 , Issue 1 , January 2017 , pp. 78 - 89
Copyright
Copyright © The International Neuropsychological Society 2016 

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