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Mental object rotation in Parkinson's disease

Published online by Cambridge University Press:  12 February 2004

GREGORY P. CRUCIAN ,
ANNA M. BARRETT ,
DAVID W. BURKS ,
ALONSO R. RIESTRA ,
HEIDI L. ROTH ,
RONALD L. SCHWARTZ ,
WILLIAM J. TRIGGS ,
DAWN BOWERS ,
WILLIAM FRIEDMAN  and
MELVIN GREER
...Show all authors
GREGORY P. CRUCIAN
Affiliation:
Department of Neurology, University of Florida, Gainesville, Florida
ANNA M. BARRETT
Affiliation:
Division of Neurology, College of Medicine, Pennsylvania State University, Hershey, Pennsylvania
DAVID W. BURKS
Affiliation:
Department of Neurology, University of Florida, Gainesville, Florida Gainesville VA Medical Center, Gainesville, Florida
ALONSO R. RIESTRA
Affiliation:
Department of Neurology, University of Florida, Gainesville, Florida
HEIDI L. ROTH
Affiliation:
Department of Neurology, University of Florida, Gainesville, Florida
RONALD L. SCHWARTZ
Affiliation:
Hattiesburg Clinic, Department of Neurology, Hattiesburg, Mississippi
WILLIAM J. TRIGGS
Affiliation:
Department of Neurology, University of Florida, Gainesville, Florida
DAWN BOWERS
Affiliation:
Department of Clinical and Health Psychology, University of Florida, Gainesville, Florida
WILLIAM FRIEDMAN
Affiliation:
Department of Neurosurgery, University of Florida, Gainesville, Florida
MELVIN GREER
Affiliation:
Department of Neurology, University of Florida, Gainesville, Florida
KENNETH M. HEILMAN
Affiliation:
Department of Neurology, University of Florida, Gainesville, Florida Gainesville VA Medical Center, Gainesville, Florida
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Abstract

Deficits in visual-spatial ability can be associated with Parkinson's disease (PD), and there are several possible reasons for these deficits. Dysfunction in frontal–striatal and/or frontal–parietal systems, associated with dopamine deficiency, might disrupt cognitive processes either supporting (e.g., working memory) or subserving visual-spatial computations. The goal of this study was to assess visual–spatial orientation ability in individuals with PD using the Mental Rotations Test (MRT), along with other measures of cognitive function. Non-demented men with PD were significantly less accurate on this test than matched control men. In contrast, women with PD performed similarly to matched control women, but both groups of women did not perform much better than chance. Further, mental rotation accuracy in men correlated with their executive skills involving mental processing and psychomotor speed. In women with PD, however, mental rotation accuracy correlated negatively with verbal memory, indicating that higher mental rotation performance was associated with lower ability in verbal memory. These results indicate that PD is associated with visual–spatial orientation deficits in men. Women with PD and control women both performed poorly on the MRT, possibly reflecting a floor effect. Although men and women with PD appear to engage different cognitive processes in this task, the reason for the sex difference remains to be elucidated. (JINS, 2003, 9, 1078–1087.)

Keywords

Parkinson's diseaseVisual–spatial orientationMental rotationGender differences
Type
THEMATIC ARTICLES
Information
Journal of the International Neuropsychological Society , Volume 9 , Issue 7 , November 2003 , pp. 1078 - 1087
Copyright
© 2003 The International Neuropsychological Society

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References

REFERENCES

Alexander, G.E., Crutcher, M.D., & DeLong, M.R. (1990). Basal ganglia-thalamocortical circuits: Parallel substrates for motor, oculomotor, “prefrontal” and “limbic” functions. Progress in Brain Research, 85, 119–146.Google Scholar
Alexander, G.E., DeLong, M.R., & Strick, P.L. (1986). Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annual Review in Neuroscience, 9, 357–381.Google Scholar
Alivisatos, B. & Petrides, M. (1996). Functional activation of the human brain during mental rotation. Neuropsychologia, 35, 111–118.Google Scholar
Benton, A.B. & Tranel, D. (1993). Visuoperceptual, visuospatial, and visuoconstructional disorders. In K.M. Heilman & E. Valenstein (Eds.), Clinical neuropsychology (3rd ed., pp. 165–213). New York: Oxford Press.
Bodis-Wollner, I. (1990). Visual deficits related to dopamine deficiency in experimental animals and Parkinson's disease patients. Trends in Neuroscience, 13, 296–302.Google Scholar
Bodis-Wollner, I., Marx, M.S., Mitra, S., Bobak, P., Mylin, L., & Yahr, M. (1987). Visual dysfunction in Parkinson's disease. Brain, 110, 1675–1698.Google Scholar
Bodis-Wollner, I., Pang, S., & Falk, A. (1991). Vision and visual discrimination suffer in Parkinson's disease: Evoked potential evidence. Advances in Behavioral Biology, 39, 743–750.Google Scholar
Bodis-Wollner, I. & Tagliati, M. (1993). The visual system in Parkinson's disease. Advances in Neurology, 39, 390–394.Google Scholar
Boller, F., Passafiume, D., Keefe, N.C., Rogers, K., Morrow, L., & Kim, Y. (1984). Visuospatial impairment in Parkinson's disease. Archives of Neurology, 41, 485–490.Google Scholar
Bondi, M.W., Kaszniak, A., Bayles, K.A., & Vance, K.T. (1993). Contributions of frontal system dysfunction to memory and perceptual abilities in Parkinson's disease. Neuropsychology, 7, 89–102.Google Scholar
Brown, G.G., Kindermann, S.S., Siegle, G.J., Granholm, E., Wong, E.C., & Buxton, R.B. (1999). Brain activation and pupil response during covert performance of the Stroop Color Word Task. Journal of the International Neuropsychological Society, 5, 308–319.Google Scholar
Brown, R.G. & Marsden, C.D. (1986). Visuospatial function in Parkinson's disease. Brain, 109, 987–1002.Google Scholar
Brown, R.G. & Marsden, C.D. (1990). Cognitive function in parkinson's disease: From description to theory. Trends in Neuroscience, 13, 21–29.Google Scholar
Bryden, M.P. (1982). Laterality: Functional asymmetry in the intact brain. New York: Academic Press.
Bulla-Hellwig, M., Vollmer, J., Gotzen, A., Skreczek, W., & Hartje, W. (1996). Hemispheric asymmetry of arterial blood flow velocity changes during verbal and visuospatial tasks. Neuropsychologia, 34, 987–991.Google Scholar
Clower, D.M., Dum, R.P., & Strick, P.L. (2002). Substantia nigra pars reticulata provides input to area 7B of parietal cortex. Society for Neurosciences, Abstract Viewer/Itinerary Planner, online, No. 460. 1.Google Scholar
Cohen, M.S., Kosslyn, S.M., Breiter, H.C., DiGirolamo, G.J., Thompson, W.L., Anderson, A.K., Bookheimer, S.Y., Rosen, B.R., & Belliveau, J.W. (1996). Changes in cortical activity during mental rotation. A mapping study using functional mri. Brain, 119, 89–100.Google Scholar
Cohen, W. & Polich, J. (1989). No hemispheric differences for mental rotation of letters or polygons. Bulletin of the Psychonomic Society, 27, 25–28.Google Scholar
Corballis, M.C. (1997). Mental rotation and the right hemisphere. Brain and Language, 57, 100–121.Google Scholar
Corballis, M.C. & McLaren, R. (1984). Winding one's Ps and Qs: Mental rotation and mirror-image discrimination. Journal of Experimental Psychology: Human Perception and Performance, 10, 318–327.Google Scholar
Corballis, M.C. & Sergent, J. (1989). Hemispheric specialization for mental rotation. Cortex, 25, 15–25.Google Scholar
Cronin-Golomb, A. & Braun, A.E. (1997). Visuospatial dysfunction and problem solving in Parkinson's Disease. Neuropsychology, 11, 44–52.Google Scholar
Cummings, J.L. & Huber, S.J. (1992). Visuospatial abnormalities in parkinson's disease. In S.J. Huber & J.L. Cummings (Eds.), Parkinson's disease: Neurobehavioral aspects (pp. 59–73). New York: Oxford University Press.
Delis, D.C., Kramer, J.H., Kaplan, E., & Ober, B.A. (1987). California Verbal Learning Test manual. New York: Psychological Corporation.
Deutsch, G., Bourbon, W.T., Papanicolaou, A.C., & Eisenberg, H.M. (1988). Visuospatial tasks compared via activation of regional cerebral blood flow. Neuropsychologia, 26, 445–452.Google Scholar
Ditunno, P.L. & Mann, V.A. (1990). Right hemisphere specialization for mental rotation in normals and brain damaged subjects. Cortex, 26, 177–188.Google Scholar
Ekstrom, R.B., French, J.W., & Harmon, H.H. (1976). Manual for Kit of Factor-Referenced Cognitive Tests. Princeton, NJ: Educational Testing Service.
Fahn, S. & Elston, R.L. (1987). Unified parkinson's disease rating scale. In S. Fahn, C.D. Marsden, M. Goldstein, & D.B. Calne (Eds.). Recent developments in Parkinson's disease (Vol. 2, pp. 153–163). New York: MacMillan.
Fischer, S.C. & Pelligrino, J.W. (1988). Hemispheric differences for components of mental rotation. Brain and Cognition, 7, 1–15.Google Scholar
Folstein, M.F., Folstein, S.E., & McHugh, P.R. (1975). Mini-mental state: A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189–198.Google Scholar
Golden, C.J. (1978). The Stroop Color Word Test: A manual for clinical and experimental uses. Chicago: Stoelting Co.
Goldenberg, G., Wimmer, A., Auff, E., & Schnaberth, G. (1986). Impairment in motor planning in patients with Parkinson's disease: Evidence from ideomotor apraxia testing. Journal of Neurology, Neurosurgery, and Psychiatry, 49, 1266–1272.Google Scholar
Growdon, J.H. & Corkin, S. (1986). Cognitive impairments in parkinson's disease. Advances in Neurology, 45, 383–392.Google Scholar
Gur, R.C., Gur, R.E., Obrist, W.D., Hungerbuhler, J.P., Younkin, D., Rosen, A.D., Skolnick, B.E., & Reivich, M. (1982). Sex and handedness differences in cerebral blood flow during rest and cognitive activity. Science, 217, 659–660.Google Scholar
Halpern, D. (1992). Sex differences in cognitive abilities (2nd ed.). Hillsdale, NJ: Erlbaum.
Hampson, E. & Kimura, D. (1992). Sex differences and hormonal influences on cognitive function in humans. In J.B. Becker, S.M. Breedlove, & D. Crews (Eds.), Behavioral endocrinology (pp. 298–357). Cambridge, MA: MIT Press.
Harris, I.M., Egan, G.F., Sonkkila, C., Tochon-Danguy, H.J., Paxinos, G., & Watson, D.G. (2000). Selective right parietal lobe activation during mental rotation: A parametric PET study. Brain, 123, 65–73.Google Scholar
Harris, L.J. (1978). Sex differences in spatial ability: Possible environmental, genetic, and neurological factors. In M. Kinsbourne (Ed.), Asymmetrical function in the human brain (pp. 405–544). London: Cambridge University Press.
Hiscock, M., Israelian, M., Inch, R., Jacek, C., & Hiscock-Kalil, C. (1995). Is there a sex difference in human laterality? II. An exhaustive survey of visual laterality studies from six neuropsychology journals. Journal of Clinical and Experimental Neuropsychology, 17, 590–610.Google Scholar
Hoehn, M.M. & Yahr, M.D. (1967). Parkinsonism: Onset, progression, and mortality. Neurology, 17, 427–442.Google Scholar
Jones, B. & Anuza, T. (1982). Effects of sex, handedness, stimulus and visual field on “mental rotation.” Cortex, 18, 501–514.Google Scholar
Kaplan, E.F., Goodglass, H., Weintraub, S. (1983). The Boston Naming Test (2nd ed.). Philadelphia: Lea & Febiger.
Layman, S. & Greene, E. (1988). The effect of stroke on object recognition. Brain and Cognition, 7, 87–114.Google Scholar
Lazaruk, L. (1994). Visuospatial impairment in persons with idiopathic Parkinson's disease: A literature review. Physical and Occupational Therapy in Geriatrics, 12, 37–48.Google Scholar
Lee, A.C., Harris, J.P., & Calvert, J.E. (1998). Impairments of mental rotation in Parkinson's disease. Neuropsychologia, 36, 109–114.Google Scholar
Levy, J. (1974). Psychobiological implications of bilateral asymmetry. In S.J. Dimond & J.G. Beaumont (Eds.), Hemisphere function in the human brain (pp. 121–183). New York: Halstead Press, 1974.
Levy, J. & Heller, W. (1992). Gender differences in human neuropsychological function. In A.A. Gerall, H. Moltz, & I.L. Ward (Eds.), Sexual differentiation: Handbook of behavioral neurology (Vol. 11, pp. 263–272). New York: Plenum.
Levy, J. & Reid, M. (1978). Variation in cerebral organization as a function of handedness, hand posture in writing, and sex. Journal of Experimental Psychology: General, 107, 119–144.Google Scholar
Lezak, M.D. (1995). Neuropsychological assessment (3rd ed.). New York: Oxford University Press.
Linn, M.C. & Petersen, A.C. (1985). Emergence and characterization of sex differences in spatial ability: A meta-analysis. Child Development, 56, 1479–1498.Google Scholar
Maccoby, E.C. & Jacklin, C.N. (1974). The psychology of sex differences. Stanford, CA: Stanford University Press.
Malapani, C., Pillon, B., Dubois, B., & Agid, Y. (1994). Impaired simultaneous cognitive task performance in Parkinson's disease. Neurology, 44, 319–326.Google Scholar
McGee, M.G. (1979). Human spatial abilities: Sources of sex differences. New York: Praeger Publishers.
Mehta, Z., Newcombe, F., & Damasio, H. (1987). A left hemisphere contribution to visuospatial processing. Cortex, 23, 447–461.Google Scholar
Middleton, F.R. & Strick, P.L. (2000). Basal ganglia and cerebellar loops: Motor and cognitive circuits. Brain Research Reviews, 31, 236–250.Google Scholar
Ornstein, R., Johnstone, J., Herron, J., & Swencionis, C. (1980). Differential right hemisphere engagement in visuospatial tasks. Neuropsychologia, 18, 49–64.Google Scholar
Osaka, M. (1984). Peak alpha frequency of EEG during a mental task: Task difficulty and hemispheric differences. Psychophysiology, 21, 101–105.Google Scholar
Owen, A.N. (1997). Cognitive planning in humans: Neuropsychological, neuroanotomical, and neuropharmocological perspectives. Progress in Neurobiology, 53, 431–450.Google Scholar
Ratcliff, G. (1979). Spatial though, mental rotation and the right cerebral hemisphere. Neuropsychologia, 17, 49–54.Google Scholar
Raskin, S., Borod, J.C., & Tweedy, J.R. (1992). Set-shifting and spatial orientation in patients with Parkinson's disease. Journal of Clinical and Experimental Neuropsychology, 14, 801–821.Google Scholar
Reed, B.R., Mungas, D., & Jagust, W.J. (1997). Diagnostic implications of normal mental status test scores in patients presenting with symptoms of dementia. Neurology, 48, A234.Google Scholar
Reitan, R.M. & Wolfson, D. (1985). The Halstead-Reitan Neuropsychological Test Battery. Tuscon, AZ: Neuropsychology Press.
Saint-Cyr, J.A. (2003). Frontal–striatal circuit functions: Context, sequence, and consequence. Journal of the International Neuropsychological Society, 9, 103–127.Google Scholar
Shepard, R.N. (1978). The mental image. American Psychologist, 33, 125–137.Google Scholar
Shepard, R.N. & Cooper, L.A. (1982). Mental images and their transformations. Cambridge, MA: MIT Press.
Shepard, R.N. & Metzler, J. (1971). Mental rotation of three dimensional objects. Science, 171, 701–703.Google Scholar
Simion, F., Bagnara, S., Bisiacchi, P., Roncato, S., & Umilta, C. (1980). Laterality effects, levels of processing, and stimulus properties. Journal of Experimental Psychology: Human Perception and Performance, 6, 184–195.Google Scholar
Smith, M.C., Goldman, W.P., Janer, K.W., Baty, J.D., & Morris, J.C. (1998). Cognitive speed in nondemented parkinson's disease. Journal of International Neuropsychological Society, 4, 584–592.Google Scholar
Spreen, O. & Benton, A.L. (1977). Neurosensory Center Comprehensive Examination for Aphasia (NCCEA), Victoria, British Columbia, Canada: University of Victoria Neuropsychology Laboratory.
Spreen, O. & Strauss, E. (1998). A Compendium of Neuropsychological Tests (2nd ed.). New York: Oxford University Press.
Stern, Y. & Mayeux, R. (1986). Intellectual impairment in Parkinson's disease. Advances in Neurology, 45, 405–408.Google Scholar
Stumpf, H. & Eliot, J. (1999). A structural analysis of visual spatial ability in academically talented students. Learning and Individual Differences, 11, 137–151.Google Scholar
Tagaris, G.A., Kim, S.G., Strupp, J.P., Andersen, P., Ugurbil, K., & Georgopoulos, A.P. (1997). Mental rotation studies by functional magnetic resonance imaging at high field (4 Tesla): Performance and cortical activation. Journal of Cognitive Neuroscience, 9, 419–432.Google Scholar
Taylor, A.E., Saint-Cyr, J.A., & Lang, A.E. (1986). Frontal lobe dysfunction in Parkinson's disease. Brain, 109, 845–883.Google Scholar
Taylor, A.E. & Saint-Cyr, J.A. (1995). The neuropsychology of Parkinson's disease. Brain and Cognition, 28, 281–296.Google Scholar
Ueker, A. & Obrzut, J.E. (1993). Hemispheric and gender differences in mental rotations. Brain and Cognition, 22, 42–50.Google Scholar
Vandenberg, S.G. & Kuse, A.R. (1978). Mental rotations, a group test of three-dimensional spatial visualization. Perceptual and Motor Skills, 47, 599–604.Google Scholar
Van Strien, J.W. & Bouma, A. (1990). Mental rotation and laterally presented random shapes in males and females. Brain and Cognition, 12, 297–303.Google Scholar
Waterfall, M. & Crowe, S.F. (1995). Meta-analytic comparison of the components of visual cognition in Parkinson's disease. Journal of Clinical and Experimental Neuropsychology, 17, 759–772.Google Scholar
Wechsler, D. (1981). Wechsler Adult Intelligence Scale–Revised manual. San Antonio, TX: Psychological Corporation.
Wechsler, D. (1987). Wechsler Memory Scale–Revised manual. San Antonio, TX: Psychological Corporation.
Wilson, J.R., DeFries, J.C., McClearn, G.E., Vandenberg, S.G., Johnson, R.C., & Rashad, M.N. (1975). Cognitive abilities: Use of family data as a control to assess sex and age differences in two ethnic groups. International Journal of Aging and Human Development, 6, 261–276.Google Scholar
Yesavage, J.A., Brink, T.L., Rose, T.L., Lum, O., Huang, V., Adey, M.B., & Leirer, V.O. (1983). Development and validation of the geriatric depression rating scale: A preliminary report. Journal of Psychiatric Research, 17, 37–49.Google Scholar
Zacks, J., Rypma, B., Gabrieli, J.D.E., Tversky, B., & Glover, G.H. (1999). Imagined transformations of bodies: An fMRI investigation. Neuropsychologia, 37, 1029–1040.Google Scholar