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Incident major depression does not affect neuropsychological functioning in HIV-infected men

  • LUCETTE A. CYSIQUE (a1), REENA DEUTSCH (a2), J. HAMPTON ATKINSON (a1) (a3), CORINNA YOUNG (a1), THOMAS D. MARCOTTE (a1), LAUREN DAWSON (a4), IGOR GRANT (a1) (a3), ROBERT K. HEATON (a1) (a3) and THE HNRC GROUPThe HIV Neurobehavioral Research Center (HNRC) is supported by Center award MH 62512 from NIMH....

Abstract

The diagnosis of lifetime major depressive disorders (MDDs) and of current major depressive episodes (MDEs) are relatively common in HIV-infected individuals, and often are assumed to influence neuropsychological (NP) performance. Although cross-sectional studies of HIV-infected individuals generally have found no systematic link between current MDE or depressive symptoms and NP performance, longitudinal studies are needed to clarify whether incident MDE may impact NP functioning in at least some cases. Two hundred twenty-seven human immunodeficiency virus (HIV)-infected adult men, who did not meet criteria for a current MDE at baseline, participated in a longitudinal NP study for an average of two years. Participants received repeated NP assessments, as well as structured psychiatric interviews to ascertain presence or absence of both lifetime MDD and current MDE. Ninety-eight participants had a lifetime history of MDD, and 23 participants met criteria for incident MDE at one of their follow-up evaluations. Groups with and without lifetime MDD and/or incident MDE had comparable demographics, HIV disease status and treatment histories at baseline, and numbers of intervening assessments between baseline and the final follow-up. Lifetime MDD was associated with greater complaints of cognitive difficulties in everyday life, and such complaints were increased at the times of incident MDE. However, detailed group comparisons revealed no NP performance differences in association with either lifetime or incident major depression. Finally, NP data from consistently nondepressed participants were used to develop “norms for change” and these findings failed to show any increased rates of NP worsening among individuals with incident MDE. Our results suggest that neurocognitive impairment and major depression should be considered as two independent processes. (JINS, 2007, 13, 1–11.)

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Corresponding author

Correspondence and reprint requests to: Lucette Cysique, HIV Neurobehavioral Research Center (HNRC), 150 Washington Street, 2nd floor, San Diego, CA 92103, USA. E-mail: lcysique@ucsd.edu

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REFERENCES

American Academy of Neurology, &Dana Consortium. (1996). Clinical confirmation of the American Academy of Neurology algorithm for HIV-1-associated cognitive/motor disorder (DANA consortium on therapy for HIV dementia and related cognitive disorders). Neurology, 47, 12471253.
Atkinson, H.J. & Grant, I. (1994). Natural history of neuropsychiatric manifestations of HIV disease. Psychiatric Clinics of North America, 17, 1733.
Austin, M.P., Mitchell, P., & Goodwin, G.M. (2001). Cognitive deficits in depression: Possible implications for functional neuropathology. British Journal of Psychiatry, 178, 200206.
Austin, M.P., Mitchell, P., Wilhelm, K., Parker, G., Hickie, I., Brodaty, H., Chan, J., Eyers, K., Milic, M., & Hadzi-Pavlovic, D. (1999). Cognitive function in depression: A distinct pattern of frontal impairment in melancholia? Psychological Medicine, 29, 7385.
Basso, M.R. & Bornstein, R.A. (1999). Neuropsychological deficits in psychotic versus nonpsychotic unipolar depression. Neuropsychology, 13, 6975.
Beck, A. (1976). Cognitive therapy and the emotional disorders. New York: Hoeber.
Bornstein, R., Pace, P., & Rosenberger, P. (1993). Depression and neuropsychological performance in asymptomatic HIV infection. American Journal of Psychiatry, 150, 922927.
Bulbena, A. & Berrios, G.E. (1993). Cognitive function in the affective disorders: A prospective study. Psychopathology, 26, 612.
Carey, C.L., Woods, S.P., Gonzalez, R., Conover, E., Marcotte, T.D., Grant, I., & Heaton, R.K. (2004). Predictive validity of global deficit scores in detecting neuropsychological impairment in HIV infection. Journal of Clinical and Experimental Neuropsychology, 26, 307319.
Carter, S.L., Rourke, S.B., Murji, S., Shore, D., & Rourke, B.P. (2003). Cognitive complaints, depression, medical symptoms, and their association with neuropsychological functioning in HIV infection: A structural equation model analysis. Neuropsychology, 17, 410419.
Cassens, G., Wolfe, L., & Zola, M. (1990). The neuropsychology of depressions. Journal of Neuropsychiatry and Clinical Neurosciences, 2, 202213.
Chelune, G., Heaton, R., & Lehman, R. (1986). Neuropsychological and personality correlates of patient's complaints of disability. In R. Tarter & G. Goldstein (Eds.), Advances in clinical neuropsychology (pp. 95126). New York: New York Plenum Press.
Ciesla, J.A. & Roberts, J.E. (2001). Meta-analysis of the relationship between HIV infection and risk for depressive disorders. American Journal of Psychiatry, 185, 725730.
Coello, E., Ardila, A., & Rosselli, M. (1990). Is there a cognitive marker in major depression? International Journal of Neurosciences, 50, 137145.
Goggin, K.J., Zisook, S., Heaton, R.K., Atkinson, H.J., Marshall, S., McCuthchan, J.A., Chandler, J.L, & Grant, I. (1997). Neuropsychological performance of HIV-1 infected men with major depression. Journal of the International Neuropsychological Society, 3, 457464.
Grant, I., Olshen, R., Atkinson, J., Heaton, R., Nelson, J., McCuthchan, J.A., & Weinrich, J.D. (1993). Depressed mood does not explain neuropsychological deficits in HIV-infected persons. Neuropsychology, 7, 5361.
Grant, M.M., Thase, M.E., & Sweeney, J.A. (2001). Cognitive disturbance in outpatient depressed younger adults: Evidence of modest impairment. Biological Psychiatry, 50, 3543.
Hamilton, M. (1960). A rating scale for depression. Journal of Neurology, Neurosurgery, and Psychiatry, 23, 5662.
Heaton, R.K. (1992). Comprehensive norms for an expanded Halstead-Reitan Battery: A supplement for the WAIS-R. Odessa, FL: Psychological Assessment Resources, Inc.
Heaton, R., Grant, I., Butters, N., White, D.A., Kirson, D., Atkinson, H.J., McCuthchan, J.A., Taylor, M., Kelly, M.D., Ellis, R.J., Wolfson, T., Velin, R.A., Marcotte, T.D., Hesselink, J.R., Jernigan, T.L., Chandler, J., Wallace, M., Abramason, I., & the HNRC group. (1995). The HNRC 500-neuropsychology of HIV infection at different disease stages. Journal of the International Neuropsychological Society, 1, 231251.
Heaton, R.K., Grant, I., & Mathew, C.G. (1991). Comprehensive norms for an expanded Halstead-Reitan Battery: Demographic corrections, research findings, and clinical applications. Odessa, FL: Psychological Assessment Resources, Inc.
Heaton, R., Marcotte, T.D., Rivera Mindt, M., Sadek, J., Moore, D., Bentley, H., McCutchan, A.J., Reicks, C., & Grant, I. (2004). The impact of HV-associated neuropsychological impairment on everyday functioning. Journal of the International Neuropsychological Society, 10, 317331.
Heaton, R., Temkin, N., Dikmen, S., Avitable, N., Taylor, M., Marcotte, T., & Grant, I. (2001). Detecting change: A comparison of three neuropsychological methods, using normal and clinical samples. Archives of Clinical Neuropsychology, 16, 7591.
Hinkin, C.H., Castellon, S.A., Atkinson, H.J., & Goodkin, K. (2001). Neuropsychiatric aspects of HIV infection among older adults. Journal of Clinical Epidemiology, 54, S44S52.
Hinkin, C.H., Van Gorp, W.G., Satz, P., Weisman, J.D., Thommes, J., & Buckingham, S. (1992). Depressed mood and its relationship to neuropsychological test performance in HIV-1-seropositive individuals. Journal of Experimental and Clinical Neuropsychology, 14, 289297.
Jeste, D.V., Heaton, S.C., Paulsen, J.S., Ercoli, L., Harris, J., & Heaton, R.K. (1996). Clinical and neuropsychological comparison of psychotic depression with nonpsychotic depression and schizophrenia. American Journal of Psychiatry, 153, 490496.
Marcos, T., Salamero, M., Gutierrez, F., Catalan, R., Gasto, C., & Lazaro, L. (1994). Cognitive dysfunctions in recovered melancholic patients. Journal of Affective Disorders, 32, 133137.
McNeil, J.K. (1999). Neuropsychological characteristics of the dementia syndrome of depression: Onset, resolution, and three-year follow-up. The Clinical Neuropsychologist, 13, 136146.
Millikin, C.P., Rourke, S.B., Hallman, M.H., & Power, C. (2003). Fatigue in HIV/AIDS is associated with depression and subjective complaints but not neuropsychological functioning. Journal of Clinical and Experimental Neuropsychology, 25, 201215.
Navia, B.A., Cho, E.S., Petito, C.K., & Price, R.W. (1986). The AIDS Dementia Complex: II neuropathology. Annals of Neurology, 19, 525535.
Porter, R.J., Gallagher, P., Thompson, J.M., & Young, A.H. (2003). Neurocognitive impairment in drug-free patients with major depressive disorder. British Journal of Psychiatry, 182, 214220.
Richardson, M.A., Satz, P., Myers, H.F., Miller, E., Bing, E.G., Fawzy, F.I., & Maj, M. (1999). Effects of depressed mood versus clinical depression on neuropsychological test performance among African American men impacted with HIV/AIDS. Journal of Clinical and Experimental Neuropsychology, 21, 769783.
Spielberger, C.D. (1983). Manual for the state–trait anxiety inventory. Palo Alto, CA: Consulting Psychologists Press.
Spitzer, R., Williams, J.B., Gibbon, M., & First, M. (1990). Structured clinical interview for DSM-III-R. Washington, DC: American Psychiatric Association.
Stoudemire, A., Hill, C.D., Morris, R., Martino-Saltzman, D., Markwalter, H., & Lewison, B. (1991). Cognitive outcome following tricyclic and electroconvulsive treatment of major depression in the elderly. American Journal of Psychiatry, 148, 13361340.
Tarbuck, A.F. & Paykel, E.S. (1995). Effects of major depression on the cognitive function of younger and older subjects. Psychological Medicine, 25, 285295.
Tekin, S. & Cummings, J.L. (2002). Frontal-subcortical neuronal circuits and clinical neuropsychiatry: An update. Journal of Psychosomatic Research, 53, 647654.
von Giesen, H.J., Backer, R., Hefter, H., & Arendt, G. (2001). Depression does not influence basal ganglia-mediated psychomotor speed in HIV-1 infection. Journal of Neuropsychiatry and Clinical Neurosciences, 13, 8894.
Wechsler, D. (1981). Wechsler Adult Intelligence Scale-Revised. New York: The Psychological Corporation.
Weiland-Fiedler, P., Erickson, K., Waldeck, T., Luckenbaugh, D.A., Pike, D., Bonne, O., Charney, D.S., & Neumeister, A. (2003). Evidence for continuing neuropsychological impairments in depression. Journal of Affective Disorders, 82, 253258.
White, D.A., Heaton, R., & Monsch, A.U. (1995). Neuropsychological studies of asymptomatic human immunodeficiency virus-type 1 infected individuals. Journal of the International Neuropsychological Society, 1, 304315.
Woods, S.P., Rippeth, J.D., Frol, A.B., Levy, J.K., Ryan, E., Soukup, V.M., Hinkin, C.H., Lazzaretto, D., Cherner, M., Marcotte, T.D., Gelman, B.B., Morgello, S., Singer, E.J., Grant, I., & Heaton, R.K. (2004). Interrater reliability of clinical ratings and neurocognitive diagnoses in HIV. Journal of Clinical and Experimental Neuropsychology, 26, 759778.

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