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Everyday memory: Self-perception and structural brain correlates in a healthy elderly population



Mapping the cerebral structural correlates of age-related cognitive decline is a growing area of research. The aim of the present study was to investigate the relationship between healthy elderly’s perceived memory functioning in daily life, neuropsychological test performance on a standardized test on verbal memory, and cortical thickness and subcortical volumes in brain regions implicated in memory networks, including the medial temporal lobe (MTL). Eighty-three healthy and cognitively well-functioning volunteers aged 60–85 years underwent MRI scans, Everyday Memory Questionnaire (EMQ), and neuropsychological assessment. Both self-perceived memory in daily life related to attention and executive functions and an objective measure of verbal recall (CVLT) were, independently, associated with thickness of the left MTL. The two cognitive variables were uncorrelated, and including both measures in the model nearly doubled the amount of explained variance on MTL thickness. This suggests that measures of perceived everyday memory might substantially inform and supplement studies investigating the relationships between neuropsychological test performance and brain morphology. The results are consistent with a bigger-is-better relationship in the MTL and suggest that EMQ and neuropsychological test performance have detectable and comparable structural correlates in a region critically involved in memory functions in the well-functioning elderly. (JINS, 2010, 16, 1115–1126.)


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*Correspondence and reprint requests to: Astrid Bjørnebekk, Department of Psychology, University of Oslo, PoB 1094 Blindern, 0317 Oslo, Norway. E-mail:


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Alexander, G.E., DeLong, M.R., & Strick, P.L. (1986). Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annual Review of Neuroscience, 9, 357381.
Allen, J.S., Bruss, J., Brown, C.K., & Damasio, H. (2005). Normal neuroanatomical variation due to age: The major lobes and a parcellation of the temporal region. Neurobiology of Aging, 26(9), 12451260; discussion 1279–1282.
Beason-Held, L.L., Kraut, M.A., & Resnick, S.M. (2008a). I. Longitudinal changes in aging brain function. Neurobiology of Aging, 29(4), 483496.
Beason-Held, L.L., Kraut, M.A., & Resnick, S.M. (2008b). II. Temporal patterns of longitudinal change in aging brain function. Neurobiology of Aging, 29(4), 497513.
Beck, A.T., Steer, R.A., & Brown, G.K. (1987). Beck depression inventory scoring manual. New York: The Psychological Corporation.
Bischoff-Grethe, A., Ozyurt, I.B., Busa, E., Quinn, B.T., Fennema-Notestine, C., Clark, C.P., et al. . (2007). A technique for the deidentification of structural brain MR images. Human Brain Mapping, 28(9), 892903.
Blatter, D.D., Bigler, E.D., Gale, S.D., Johnson, S.C., Anderson, C.V., Burnett, B.M., et al. . (1995). Quantitative volumetric analysis of brain MR: Normative database spanning 5 decades of life. AJNR American Journal of Neuroradiology, 16(2), 241251.
Boake, C., Freeland, J.C., Ringholz, G.M., Nance, M.L., & Edwards, K.E. (1995). Awareness of memory loss after severe closed-head injury. Brain Injury, 9(3), 273283.
Buckner, R.L. (2004). Memory and executive function in aging and AD: Multiple factors that cause decline and reserve factors that compensate. Neuron, 44(1), 195208.
Buckner, R.L., & Carroll, D.C. (2007). Self-projection and the brain. Trends in Cognitive Sciences, 11(2), 4957.
Buckner, R.L., Head, D., Parker, J., Fotenos, A.F., Marcus, D., Morris, J.C., et al. . (2004). A unified approach for morphometric and functional data analysis in young, old, and demented adults using automated atlas-based head size normalization: Reliability and validation against manual measurement of total intracranial volume. Neuroimage, 23(2), 724738.
Buckner, R.L., & Wheeler, M.E. (2001). The cognitive neuroscience of remembering. Nature Reviews Neuroscience, 2(9), 624634.
Cardenas, V.A., Chao, L.L., Studholme, C., Yaffe, K., Miller, B.L., Madison, C., et al. . (2009). Brain atrophy associated with baseline and longitudinal measures of cognition. Neurobiology of Aging; doi: 10.1016/j.neurobiolaging.2009.04.011.
Chaytor, N., & Schmitter-Edgecombe, M. (2003). The ecological validity of neuropsychological tests: A review of the literature on everyday cognitive skills. Neuropsychology Review, 13(4), 181197.
Chee, M.W., Chen, K.H., Zheng, H., Chan, K.P., Isaac, V., Sim, S.K., et al. . (2009). Cognitive function and brain structure correlations in healthy elderly East Asians. Neuroimage, 46(1), 257269.
Cornish, I.M. (2000). Factor structure of the everyday memory questionnaire. British Journal of Psychology, 91(Pt. 3), 427438.
Craik, F.I.M. (1994). Memory changes in normal aging. Current Directions in Psychological Science, 3(5), 155158.
Dale, A.M., Fischl, B., & Sereno, M.I. (1999). Cortical surface-based analysis. I. Segmentation and surface reconstruction. Neuroimage, 9(2), 179194.
Dale, A.M., & Sereno, M.I. (1993). Improved localization of cortical activity by combining EEG and MEG with MRI cortical surface reconstruction: A linear approach. Journal of Cognitive Neuroscience, 5, 162176.
de Groot, J.C., de Leeuw, F.E., Oudkerk, M., Hofman, A., Jolles, J., & Breteler, M.M. (2001). Cerebral white matter lesions and subjective cognitive dysfunction: The Rotterdam Scan Study. Neurology, 56(11), 15391545.
de Toledo-Morrell, L., Goncharova, I., Dickerson, B., Wilson, R.S., & Bennett, D.A. (2000). From healthy aging to early Alzheimer’s disease: In vivo detection of entorhinal cortex atrophy. Annals of the New York Academy of Sciences, 911, 240253.
Delis, D.C., Kramer, J.H., Kaplan, E., & Ober, B. (Eds.). (1987). California verbal learning test: adult version manual. San Antonio, TX: The Psychological Corporation.
Derouesne, C., Alperovitch, A., Arvay, N., Migeon, P., Moulin, F., Vollant, M., et al. . (1989). Memory complaints in the elderly: A study of 367 community-dwelling individuals from 50 to 80 years old. Archives of Gerontology and Geriatrics - Supplement, 1, 151163.
Desikan, R.S., Segonne, F., Fischl, B., Quinn, B.T., Dickerson, B.C., Blacker, D., et al. . (2006). An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. Neuroimage, 31(3), 968980.
Devanand, D.P., Pradhaban, G., Liu, X., Khandji, A., De Santi, S., Segal, S., et al. . (2007). Hippocampal and entorhinal atrophy in mild cognitive impairment: Prediction of Alzheimer disease. Neurology, 68(11), 828836.
Dickerson, B.C., Feczko, E., Augustinack, J.C., Pacheco, J., Morris, J.C., Fischl, B., et al. . (2009). Differential effects of aging and Alzheimer’s disease on medial temporal lobe cortical thickness and surface area. Neurobiology of Aging, 30(3), 432440.
Drysdale, K., Shores, A., & Levick, W. (2004). Use of the everyday memory questionnaire with children. Child Neuropsychology, 10(2), 6775.
Ferreira, L.K., Diniz, B.S., Forlenza, O.V., Busatto, G.F., & Zanetti, M.V. (2009). Neurostructural predictors of Alzheimer’s disease: A meta-analysis of VBM studies. Neurobiology of Aging; doi: 10.1016/j.neurobiolaging.2009.11.008.
Fischl, B., & Dale, A.M. (2000). Measuring the thickness of the human cerebral cortex from magnetic resonance images. Proceedings of the National Academy of Sciences of the United States of America, 97(20), 1105011055.
Fischl, B., Liu, A., & Dale, A.M. (2001). Automated manifold surgery: Constructing geometrically accurate and topologically correct models of the human cerebral cortex. IEEE Transactions on Medical Imaging, 20(1), 7080.
Fischl, B., Salat, D.H., Busa, E., Albert, M., Dieterich, M., Haselgrove, C., et al. . (2002). Whole brain segmentation: Automated labeling of neuroanatomical structures in the human brain. Neuron, 33(3), 341355.
Fischl, B., Sereno, M.I., & Dale, A.M. (1999). Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system. Neuroimage, 9(2), 195207.
Fischl, B., Sereno, M.I., Tootell, R.B., & Dale, A.M. (1999). High-resolution intersubject averaging and a coordinate system for the cortical surface. Human Brain Mapping, 8(4), 272284.
Fischl, B., van der Kouwe, A., Destrieux, C., Halgren, E., Segonne, F., Salat, D.H., et al. . (2004). Automatically parcellating the human cerebral cortex. Cerebral Cortex, 14(1), 1122.
Fjell, A.M., Westlye, L.T., Amlien, I., Espeseth, T., Reinvang, I., Raz, N., et al. . (2009). High consistency of regional cortical thinning in aging across multiple samples. Cerebral Cortex, 19(9), 20012012.
Fjell, A.M., Westlye, L.T., Greve, D.N., Fischl, B., Benner, T., van der Kouwe, A.J., et al. . (2008). The relationship between diffusion tensor imaging and volumetry as measures of white matter properties. Neuroimage, 42(4), 16541668.
Folstein, M.F., Folstein, S.E., & McHugh, P.R. (1975). “Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12(3), 189198.
Fotenos, A.F., Snyder, A.Z., Girton, L.E., Morris, J.C., & Buckner, R.L. (2005). Normative estimates of cross-sectional and longitudinal brain volume decline in aging and AD. Neurology, 64(6), 10321039.
Gabrieli, J.D.E., Singh, J., Stebbins, G.T., & Goetz, C.G. (1996). Reduced working memory span in Parkinson’s disease: Evidence for the role of frontostriatal system in working and strategic memory. Neuropsychology, 10(3), 322332.
Gazzaniga, M.S. (1995). Principles of human brain organization derived from split-brain studies. Neuron, 14(2), 217228.
Hanninen, T., Reinikainen, K.J., Helkala, E.L., Koivisto, K., Mykkanen, L., Laakso, M., et al. . (1994). Subjective memory complaints and personality traits in normal elderly subjects. Journal of the American Geriatrics Society, 42(1), 14.
Hedden, T., & Gabrieli, J.D.E. (2004). Insights into the aging mind: A view from cognitive neuroscience. Nature Reviews Neuroscience, 5(2), 8796.
Herrmann, D.J. (1982). Know thy memory: The use of questionnaires to assess and study memory. Psychological Bulletin, 92(2), 434452.
Hickox, A., & Sunderland, A. (1992). Questionnaire and checklist approaches to assessment of everyday memory problems. In Crawford, J.R.P.D.M.M.W.W. (Ed.), A handbook of neuropsychological assessment, (pp. 103113). Hillsdale, NJ, England: Lawrence Erlbaum Associates, Inc.
Jernigan, T.L., Archibald, S.L., Berhow, M.T., Sowell, E.R., Foster, D.S., & Hesselink, J.R. (1991). Cerebral structure on MRI, Part I: Localization of age-related changes. Biological Psychiatry, 29(1), 5567.
Jernigan, T.L., Archibald, S.L., Fennema-Notestine, C., Gamst, A.C., Stout, J.C., Bonner, J., et al. . (2001). Effects of age on tissues and regions of the cerebrum and cerebellum. Neurobiology of Aging, 22(4), 581594.
Kaiser, H.F. (1970). A second generation little jiffy. Psychometrika, 35(4), 401415.
Kaiser, H.F. (1974). An index of factorial simplicity. Psychometrika, 39(1), 3136.
Kinsella, K., & He, W. (2008). An aging world, 2008 (Bureau, U.S.C., Trans.). Washington DC: National Institute of Aging.
Kruggel, F. (2006). MRI-based volumetry of head compartments: Normative values of healthy adults. Neuroimage, 30(1), 111.
Lincoln, N.B., & Tinson, D.J. (1989). The relation between subjective and objective memory impairment after stroke. Feb 1989. British Journal of Clinical Psychology, 28(1), 6165.
Lovelace, E.A., & Twohig, P.T. (1990). Healthy older adults’ perceptions of their memory functioning and use of mnemonics. Bulletin of the Psychonomic Society, 28(2), 115118.
Lundervold, A.J., & Sundet, K. (2004). CVLT-norsk versjon. Sollentuna: Psykologforlaget AB.
McDonald, R.J., & White, N.M. (1993). A triple dissociation of memory systems: Hippocampus, amygdala, and dorsal striatum. Behavioral Neuroscience, 107(1), 322.
McDougall, G.J. Jr., Becker, H., & Arheart, K.L. (2006). Older adults in the SeniorWISE study at risk for mild cognitive impairment. Archives of Psychiatric Nursing, 20(3), 126134.
Minett, T.S., Dean, J.L., Firbank, M., English, P., & O’Brien, J.T. (2005). Subjective memory complaints, white-matter lesions, depressive symptoms, and cognition in elderly patients. American Journal of Geriatric Psychiatry, 13(8), 665671.
Miranda, B., Madureira, S., Verdelho, A., Ferro, J., Pantoni, L., Salvadori, E., et al. . (2008). Self-perceived memory impairment and cognitive performance in an elderly independent population with age-related white matter changes. Journal of Neurology, Neurosurgery & Psychiatry, 79(8), 869873.
Montgomery, C., & Fisk, J.E. (2007). Everyday memory deficits in ecstasy-polydrug users. Journal of Psychopharmacology, 21(7), 709717.
Nyberg, L., Backman, L., Erngrund, K., Olofsson, U., & Nilsson, L.G. (1996). Age differences in episodic memory, semantic memory, and priming: Relationships to demographic, intellectual, and biological factors. The Journals of Gerontology: Series B-Psychological Sciences and Social Sciences, 51(4), P234240.
O’Connor, D.W., Pollitt, P.A., Roth, M., Brook, P.B., & Reiss, B.B. (1990). Memory complaints and impairment in normal, depressed, and demented elderly persons identified in a community survey. Archives of General Psychiatry, 47(3), 224227.
Packard, M.G., & White, N.M. (1991). Dissociation of hippocampus and caudate nucleus memory systems by posttraining intracerebral injection of dopamine agonists. Behavioral Neuroscience, 105(2), 295306.
Panizzon, M.S., Fennema-Notestine, C., Eyler, L.T., Jernigan, T.L., Prom-Wormley, E., Neale, M., et al. . (2009). Distinct genetic influences on cortical surface area and cortical thickness. Cerebral Cortex, 19(11), 27282735.
Pfefferbaum, A., Mathalon, D.H., Sullivan, E.V., Rawles, J.M., Zipursky, R.B., & Lim, K.O. (1994). A quantitative magnetic resonance imaging study of changes in brain morphology from infancy to late adulthood. Archives of Neurology, 51(9), 874887.
Raz, N., Gunning-Dixon, F., Head, D., Rodrigue, K.M., Williamson, A., & Acker, J.D. (2004). Aging, sexual dimorphism, and hemispheric asymmetry of the cerebral cortex: Replicability of regional differences in volume. Neurobiology of Aging, 25(3), 377396.
Raz, N., Gunning, F.M., Head, D., Dupuis, J.H., McQuain, J., Briggs, S.D., et al. . (1997). Selective aging of the human cerebral cortex observed in vivo: Differential vulnerability of the prefrontal gray matter. Cerebral Cortex, 7(3), 268282.
Resnick, S.M., Pham, D.L., Kraut, M.A., Zonderman, A.B., & Davatzikos, C. (2003). Longitudinal magnetic resonance imaging studies of older adults: A shrinking brain. Journal of Neuroscience, 23(8), 32953301.
Richardson, J.T., & Chan, R.C. (1995). The constituent structure of subjective memory questionnaires: Evidence from multiple sclerosis. Memory, 3(2), 187200.
Rossi, R., Geroldi, C., Bresciani, L., Testa, C., Binetti, G., Zanetti, O., et al. . (2007). Clinical and neuropsychological features associated with structural imaging patterns in patients with mild cognitive impairment. Dementia and Geriatric Cognitive Disorders, 23(3), 175183.
Royle, J., & Lincoln, N.B. (2008). The Everyday Memory Questionnaire-revised: Development of a 13-item scale. Disability & Rehabilitation, 30(2), 114121.
Salat, D.H., Buckner, R.L., Snyder, A.Z., Greve, D.N., Desikan, R.S., Busa, E., et al. . (2004). Thinning of the cerebral cortex in aging. Cerebral Cortex, 14(7), 721730.
Salthouse, T.A. (2009). When does age-related cognitive decline begin? Neurobiology of Aging, 30(4), 507514.
Saykin, A.J., Wishart, H.A., Rabin, L.A., Santulli, R.B., Flashman, L.A., West, J.D., et al. . (2006). Older adults with cognitive complaints show brain atrophy similar to that of amnestic MCI. Neurology, 67(5), 834842.
Schwartz, A.F., & McMillan, T.M. (1989). Assessment of everyday memory after severe head injury. Cortex, 25(4), 665671.
Scoville, W.B., & Milner, B. (1957). Loss of recent memory after bilateral hippocampal lesions. Journal of Neurology, Neurosurgery & Psychiatry, 20(1), 1121.
Segonne, F., Dale, A.M., Busa, E., Glessner, M., Salat, D., Hahn, H.K., et al. . (2004). A hybrid approach to the skull stripping problem in MRI. Neuroimage, 22(3), 10601075.
Segonne, F., Grimson, E., & Fischl, B. (2005). A genetic algorithm for the topology correction of cortical surfaces. Information Processing in Medical Imaging, 19, 393405.
Squire, L.R., & Zola-Morgan, S. (1991). The medial temporal lobe memory system. Science, 253(5026), 13801386.
Sunderland, A., Harris, J.E., & Baddeley, A.D. (1983). Do laboratory tests predict everyday memory? A neuropsychological study. Journal of Verbal Learning & Verbal Behavior, 22(3), 341357.
Sunderland, A., Harris, J.E., & Gleave, J. (1984). Memory failures in everyday life following severe head injury. Journal of Clinical and Experimental Neuropsychology, 6(2), 127142.
Sunderland, A., Stewart, F.M., & Sluman, S.M. (1996). Adaptation to cognitive deficit? An exploration of apparent dissociations between everyday memory and test performance late after stroke Sep 1996. British Journal of Clinical Psychology, 35(3), 463476.
Taki, Y., Goto, R., Evans, A., Zijdenbos, A., Neelin, P., Lerch, J., et al. . (2004). Voxel-based morphometry of human brain with age and cerebrovascular risk factors. Neurobiology of Aging, 25(4), 455463.
Thurstone, L.L. (1951). Factorial analysis as a scientific method. L’Annee Psychologique. 50 1951, 6175.
van der Flier, W.M., van Buchem, M.A., Weverling-Rijnsburger, A.W., Mutsaers, E.R., Bollen, E.L., Admiraal-Behloul, F., et al. . (2004). Memory complaints in patients with normal cognition are associated with smaller hippocampal volumes. Journal of Neurology, 251(6), 671675.
Walhovd, K.B., Fjell, A.M., Amlien, I., Grambaite, R., Stenset, V., Bjørnerud, A., et al. . (2009). Multimodal imaging in mild cognitive impairment: Metabolism, morphometry and diffusion of the temporal-parietal memory network. Neuroimage, 45(1), 215223.
Walhovd, K.B., Fjell, A.M., Dale, A.M., Fischl, B., Quinn, B.T., Makris, N., et al. . (2006). Regional cortical thickness matters in recall after months more than minutes. Neuroimage, 31(3), 13431351.
Walhovd, K.B., Fjell, A.M., Reinvang, I., Lundervold, A., Dale, A.M., Eilertsen, D.E., et al. . (2005). Effects of age on volumes of cortex, white matter and subcortical structures. Neurobiology of Aging, 26(9), 12611270; discussion 1275–1268.
Wechsler, D. (1999). Wechsler abbreviated scale of intelligens. San Antonio, TX: The Psychological Corporation.
Westlye, L.T., Grydeland, H., Walhovd, K.B., & Fjell, A.M. (2010). Associations between regional cortical thickness and attentional networks as measured by the Attention Network Test. Cerebral Cortex; doi: 10.1093/cercor/bhq101.
Westlye, L.T., Walhovd, K.B., Bjørnerud, A., Due-Tønnessen, P., & Fjell, A.M. (2009). Error-related negativity is mediated by fractional anisotropy in the posterior cingulate gyrus—A study combining diffusion tensor imaging and electrophysiology in healthy adults. Cerebral Cortex, 19(2), 293304.
Westlye, L.T., Walhovd, K.B., Dale, A.M., Bjornerud, A., Due-Tonnessen, P., Engvig, A., et al. . (2010). Differentiating maturational and aging-related changes of the cerebral cortex by use of thickness and signal intensity. Neuroimage, 52(1), 172185.
Yonelinas, A.P., Widaman, K., Mungas, D., Reed, B., Weiner, M.W., & Chui, H.C. (2007). Memory in the aging brain: Doubly dissociating the contribution of the hippocampus and entorhinal cortex. Hippocampus, 17(11), 11341140.


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