Skip to main content Accessibility help
×
Home

Episodic memory function in advanced aging and early Alzheimer's disease

  • C. Munro Cullum (a1), C. M. Filley (a2) (a3) (a4) and E. Kozora (a3) (a5)

Abstract

Despite some well-documented differences, normal aging and Alzheimer's disease (AD) share a number of common neuropathological and neuropsychological features. Many of the reported differences are largely quantitative in nature and there is often overlap between the respective distributions of these populations. To assess the issue of overlap and distinguishing features in memory functions between these groups, and to minimize aging effects per se, samples of older individuals in good health (ages 75–95 yr) and younger patients in the early stages of AD (age < 75 yr) were selected to be similar in global cognitive functioning. Despite comparable language and visuospatial scores, these preliminary results suggest important qualitative differences in episodic memory functions between these conditions, even when “low-functioning” or “at-risk” controls are compared with early AD patients. These findings furthermore highlight some of the challenges in defining “normality” among the oldest segment of our population. (JINS, 1995, I, 100–103.)

Copyright

References

Hide All
Bennett, D.A. & Evans, D.A. (1992). Alzheimer's disease. Disease Monographs, 38, 164.
Bondi, M.W., Monsch, A.U., Galasko, D., Butters, N., Salmon, D.P., & Delis, D.C. (1994). Preclinical cognitive markers of dementia of the alzheimer type. Neuropsychology, 8, 374384.
Butters, N., Salmon, D.P., Cullum, C.M., Cairns, P., Troster, A.I., & Jacobs, D. (1988). Differentiation of amnesic and demented patients with the Wechsler Memory Scale-Revised. The Clinical Neuropsychologist, 2, 133148.
Crystal, H., Dickson, D., Fuld, P., Masur, D., Scott, R., Mehler, M., Marsdeu, M., Kawas, C., Aronson, M., & Wolfson, L. (1988). Clinico-pathologic studies in dementia: Nonde-mented subjects with pathologically confirmed Alzheimer's disease. Neurology, 38, 16821687.
Cullum, C.M., Butters, N., Troster, A.I., & Salmon, D. (1990). Normal aging and forgetting rates on the Wechsler Memory Scale-Revised. Archives of Clinical Neuropsychology, 5, 2330.
Delis, D.C., Kramer, J.H., Kaplan, E., & Ober, B. (1987). California Verbal Learning Test: Research Edition. San Antonio: The Psychological Corporation.
Delis, D.C., Massman, P.J., Butters, N., Salmon, D.P., Cermak, L.S., & Kramer, J.H. (1991). Profiles of demented and amnesic patients on the California Verbal Learning Test: Implications for the assessment of memory disorders. Psychological Assessment, 3, 1926.
Evans, D.A., Funkenstein, H.H., Albert, M.S., Scherr, I., Cook, N., Chown, M., Hebert, L.I., Hennekens, C.H., & Taylor, J.O. (1989). Prevalence of Alzheimer's Disease in a community population of older persons. Journal of the American Medical Association, 262, 25512556.
Folstein, M.F., Folstein, S.E., & McHugh, P. (1975). “Mini-Mental State”: A practical method for grading the cognitive state of outpatients for the clinician. Journal of Psychiatric Research, 12, 189198.
Goodglass, H. & Kaplan, E. (1983). The assessment of aphasia and related disorders. Philadelphia: Lea & Febiger.
Hart, R.P., Kwentus, J.A., Harkins, S.W., & Taylor, R.R. (1988). Rate of forgetting in mild Alzheimer's-type dementia. Brain and Cognition, 7, 3138.
Ivnik, R.J., Malec, J.F., Smith, E.G., Tangalos, E.C., Peter-sen, R.C., Kokmen, E., & Kurland, L.T. (1992). Mayo's older americans normative studies: WMS-R norms for age 56 to 94. The Clinical Neuropsychologist, 6, 4982.
Khachaturian, Z.S. (1985). Diagnosis of Alzheimer's Disease. Archives of Neurology, 42, 10971105.
Mattis, S. (1988). Dementia rating scale. Odessa, FL: Psychological Assessment Resources, Inc..
McKhann, G., Drachman, D., Folstein, M, Katzman, R., Price, D., & Stadlan, E M. (1984). Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's disease. Neurology, 34, 939944.
Mitrushina, M., Satz, P., & Van Gorp, W. (1989). Some putative cognitive precursors in subjects hypothesized to be at-risk for dementia. Archives of Clinical Neuropsychology, 4, 323333.
Monsch, A.U., Bondi, M.W., Butters, N., Paulsen, J.S., Salmon, D.P., Brugger, P., & Swenson, M.R. (1994). A comparison of category and letter fluency in Alzheimer's disease and Huntington's disease. Neuropsychology, 8, 2530.
Petersen, R.C., Smith, G.E., Ivnik, R.J., Kokmen, E., & Tangalos, E.G. (1994). Memory function in very early Alzheimer's disease. Neurology, 44, 867872.
Roman, G.C., Tatemichi, T.K., Erkinjuntti, T., Cummings, J.L., Masdeu, J.C., Garcia, J.H., Amaducci, L., Orgogorzo, J.-M., Brun, A., Hofman, A., Moody, D.M., O'Brien, M.D., Yamaguchi, T., Grafman, J., Drayer, B.P., Bennett, D.A., Fisher, M., Ogata, J., Kokmen, E., Bermejo, F., Wolf, P.A., Gorebek, P.B., Bick, K.L., Pajeau, A.K., Bell, M.A., DeCarli, C., Colebras, A., Korczyn, A.D., Bogous-slavsky, J., Hartmann, A., & Scheinberg, P. (1993). Vascular dementia: Diagnostic criteria for research studies: Report of the NINDS-AIREN International Workshop. Neurology, 43, 250260.
Troster, A.I., Butters, N., Salmon, D.P., Cullum, C.M., Jacobs, D., Brandt, J., & White, R.F. (1993). The diagnostic utility of savings scores: Differentiating Alzheimer's and Huntington's diseases with the logical memory and visual reproduction tests. Journal of Clinical and Experimental Neuropsychology, 15(5), 773788.

Keywords

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed