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Detection of dementia of the Alzheimer type in a population-based sample: Neuropsychological test performance

  • Deborah A. Cahn (a1) (a2), David P. Salmon (a3), Nelson Butters (a1), Wigbert C. Wiederholt (a3), Jody Corey-Bloom (a3), Sharon L. Edelstein (a4) and Elizabeth Barrett-Connor (a4)...

Abstract

The ability to detect dementia of the Alzheimer type (DAT) in a community-dwelling sample of elderly individuals on the basis of neuropsychological test performance was examined. Three hundred sixty community-dwelling individuals were identified by neurological examination as having probable or possible Alzheimer’s disease, being at risk for Alzheimer’s disease, or having no cognitive impairment. A logistic model comprised of tests of verbal and nonverbal memory, mental flexibility, and confrontation naming correctly classified 82% of DAT subjects and 98% of normal elderly subjects. The logistic model classified 77% of subjects who were diagnosed as at risk for Alzheimer's disease as being cognitively normal. A cross-validation with a clinically based sample of subjects correctly classified 89% of DAT patients and 100% of normal control subjects. The results suggest that psychometric discrimination of dementia may be less accurate in community-dwelling populations than in clinically based samples. (JINS, 1995, I, 252–260.)

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Keywords

Detection of dementia of the Alzheimer type in a population-based sample: Neuropsychological test performance

  • Deborah A. Cahn (a1) (a2), David P. Salmon (a3), Nelson Butters (a1), Wigbert C. Wiederholt (a3), Jody Corey-Bloom (a3), Sharon L. Edelstein (a4) and Elizabeth Barrett-Connor (a4)...

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