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Confrontation naming does not add incremental diagnostic utility in MCI and Alzheimer's disease

  • JULIE A. TESTA (a1), ROBERT J. IVNIK (a1) (a2), BRADLEY BOEVE (a2) (a3), RONALD C. PETERSEN (a2) (a3), V. SHANE PANKRATZ (a4), DAVID KNOPMAN (a2) (a3), ERIC TANGALOS (a2) (a5) and GLENN E. SMITH (a1) (a2)...

Abstract

As the incidence of dementia increases, there is a growing need to determine the diagnostic utility of specific neuropsychological tests in the early diagnosis of Alzheimer's disease (AD). In this study, the relative utility of Boston Naming Test (BNT) in the diagnosis of AD was examined and compared to the diagnostic utility of other neuropsychological measures commonly used in the evaluation of AD. Individuals with AD (n = 306), Mild Cognitive Impairment (MCI; n = 67), and cognitively normal subjects (n = 409) with at least 2 annual evaluations were included. Logistic regression analysis suggested that initial BNT impairment is associated with increased risk of subsequent AD diagnosis. However, this risk is significantly less than that imparted by measures of delayed recall impairments. A multivariate Cox proportional hazards regression analysis suggested that BNT impairment imparted no additional risk for subsequent AD diagnosis after delayed recall impairments were included in the model. Although BNT impairment occurred in all severity groups, it was ubiquitous only in moderate to severe dementia. Collectively these results suggest that although BNT impairments become more common as AD progresses, they are neither necessary for the diagnosis of AD nor particularly useful in identifying early AD. (JINS, 2004, 10, 504–512.)

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Corresponding author

Reprint requests to: Julie A. Testa, Ph.D., Department of Psychiatry & Psychology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905. E-mail: julietesta@hotmail.com

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REFERENCES

Albert, M., Moss, M.B., Tanzi, R., & Jones, K. (2001). Preclinical prediction of AD using neuropsychological tests. Journal of the International Neuropsychological Society, 7, 631639.
Appell, J., Kertesz, A., & Fisman, M. (1982). A study of language functioning in Alzheimer's disease. Brain and Language, 17, 7391.
Bayles, K.A. (1982). Language function in senile dementia. Brain and Language, 16, 265280.
Bayles, K.A. & Tomoeda, C.K. (1983). Confrontation naming impairment in dementia. Brain and Language, 19, 98114.
Bayles, K.A. & Kaszniak, A.W. (1987). Communication and cognition in normal aging and dementia. Boston: College Hill/Little, Brown, and Company.
Bayles, K.A., Tomoeda, C.K., & Trosset, M.W. (1992). Relation of linguistic communication abilities of Alzheimer's patients to stage of disease. Brain and Language, 42, 454472.
Bondi, M., Monsch, A., Galasko, D., Butters, N., Salmon, D., & Delis, D. (1994). Preclinical cognitive markers of dementia of the Alzheimer type. Neuropsychology, 8, 374384.
Bondi, M.W., Salmon, D.P., Galasko, D., Thomas, R.G., & Thal, L.J. (1999). Neuropsychological function and apolipoprotein E genotype in the preclinical detection of Alzheimer's disease. Psychology of Aging, 14, 295303.
Bowles, N.L., Obler, L.K., & Albert, M.L. (1987). Naming errors in healthy aging and dementia of the Alzheimer type. Cortex, 23, 519524.
Bozoki, A., Giordani, B., Heidebrink, J.L., Berent, S., & Foster, N.L. (2001). Mild cognitive impairments predict dementia in nondemented elderly patients with memory loss. Archives of Neurology, 58, 411416.
Brookmeyer, R., Gray, S., & Kwas, C. (1998). Projections of Alzheimer's disease in the United Stated and the public health impact of delaying disease onset. American Journal of Public Health, 88, 13371342.
Cerhan, J.H., Ivnik, R.J., Smith, G.E., Tangalos, E.C., Petersen, R.C., & Boeve, B.F. (2002). Diagnostic utility of letter fluency, category fluency, and fluency difference scores in Alzheimer's disease. Clinical Neuropsychology, 16, 3542.
Collie, A. & Maruff, P. (2000). The neuropsychology of preclinical Alzheimer's disease and mild cognitive impairment. Neuroscience and Biobehavioral Reviews, 24, 365374.
Elias, M.F., Beiser, A., Wolf, P.A., Au, R., White, R.F., & D'Agostino, R.B. (2000). The preclinical phase of Alzheimer disease: A 22-year prospective study of the Framingham cohort. Archives of Neurology, 57, 808813.
Faber-Langendoen, K., Morris, J.C., Knesevich, J.W., LaBarge, E., Miller, J.P., & Berg, L. (1988). Aphasia in senile dementia of the Alzheimer type. Annals of Neurology, 23, 365370.
Fisher, N.J., Rourke, B.P., & Bieliauskas, L.A. (1999). Neuropsychological subgroups of patients with Alzheimer's disease: An examinations of the first 10 years of CERAD data. Journal of Clinical and Experimental Neuropsychology, 21, 488518.
Fletcher, R.H., Fletcher, S.W., & Wagner, E.H. (1996). Diagnosis. In Clinical epidemiology: The essentials (pp. 4275). Baltimore: Williams & Wilkins.
Hy, L.X. & Keller, D.M. (2000). Prevalence of AD among whites: A summary by levels of severity. Neurology, 55, 198204.
Ivnik, R.J., Malec, J.F., Smith, G.E., Tangalos, E.G., & Petersen, R.C. (1996). Neuropsychological tests' norms above age 55: COWAT, BNT, MAE Token, WRAT–R Reading, AMNART, STROOP, TMT, and JLO. Clinical Neuropsychologist, 10, 262278.
Ivnik, R.J., Malec, J.F., Smith., G.E., Tangalos, E.G., Petersen, R.C., Kokmen, E., & Kurland, L.T. (1992). Mayo's Older Americans Normative Studies: WMS–R norms for ages 56 to 94. Clinical Neuropsychologist, 6(Suppl.), 4881.
Ivnik, R.J., Smith, G.E., Cerhan, J.H., Boeve, B.F., Tangalos, E.G., & Petersen, R.C. (2001). Understanding the diagnostic capabilities of cognitive tests. Clinical Neuropsychologist, 15, 114124.
Ivnik, R.J., Smith, G.E., Petersen, R.C., Boeve, B.F., Kokmen, E., & Tangalos, E.G. (2000). Diagnostic accuracy of four approaches to interpreting neuropsychological test data. Neuropsychology, 14, 163177.
Jacobs, D.M., Sano, M., Dooneief, G., Marder, K., Bell, K.L., & Stern, Y. (1995). Neuropsychological detection and characterization of preclinical Alzheimer's disease. Neurology, 45, 957962.
Jacobson, M.W., Delis, D.C., Bondi, M.W., & Salmon, D.P. (2002). Do neuropsychological tests detect preclinical Alzheimer's disease: Individual-test versus cognitive-discrepancy score analyses. Neuropsychology, 16, 132139.
Kaplan, E., Goodglass, H., & Weintraub, S. (1983). Boston Naming Test. Philadelphia: Lea & Febiger.
Kaszniak, A.W., Wilson, R.S., Fox, J.H., & Stebbins, G.T. (1986). Cognitive assessment in Alzheimer's disease: Cross-sectional and longitudinal perspectives. Canadian Journal of Neurological Science, 13, 420423.
Katzman, R. & Fox, P.J. (1999). The worldwide impact of dementia: projections of prevalence and costs. In R. Mayeux & Y. Christen (Eds.), Epidemiology of Alzheimer's disease: From gene to prevention (pp. 117). Heidelberg, Germany: Springer-Verlag.
Kirshner, H.S., Webb, W.G., & Kelly, M.P. (1984). The naming disorder of dementia. Neuropsychologia, 22, 2330.
Locascio, J.J., Growdon, J.H., & Corkin, S. (1995). Cognitive test performance in detecting, staging, and tracking Alzheimer's disease. Archives of Neurology, 52, 10871099.
Lucas, J.A., Ivnik, R.J., Smith, G.E., Bohac, D.L., Tangalos, E.G., Graff-Radford, N.R., & Petersen, R.C. (1998). Mayo's older Americans normative studies: Category fluency norms. Journal of Clinical and Experimental Neuropsychology, 20, 194200.
Malec, J.F., Ivnik, R.J., & Smith, G.E. (1993). Neuropsychology and normal aging. In R.W. Parks, R.F. Zec, & R.S. Wilson (Eds.), Neuropsychology of Alzheimer's disease and other dementias (pp. 81111). New York: Oxford University Press.
Martin, A., Brouwers, P., Lalonde, F., Cox, C., Teleska, P., Fedio, P., Foster, N.L., & Chase, T.N. (1986). Towards a behavioral typology of Alzheimer's patients. Journal of Clinical and Experimental Neuropsychology, 5, 594610.
Masur, D.M., Fuld, P.A., Blau, A.D., Crystal, H., & Aronson, M.K. (1990). Predicting development of dementia in the elderly with the Selective Reminding Test. Journal of Clinical and Experimental Neuropsychology, 12, 529538.
Masur, D.M., Sliwinski, M., Lipton, R.B., Blau, A.D., & Crystal, H.A. (1994). Neuropsychological prediction of dementia and the absence of dementia in healthy elderly persons. Neurology, 44, 14271432.
Mattis, S. (1973). Mattis Dementia Rating Scale (MDRS). Odessa, Fl: Psychological Assessment Resources.
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E.M. (1984). Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology, 34, 939944.
Monsch, A.U., Bondi, M.W., Butters, N., Salmon, D.P., Katzman, R., & Thal, L.J. (1992). Archives of Neurology, 49, 12531258.
Morris, J.C. (1993). The Clinical Dementia Rating (CDR): Current version and scoring rules. Neurology, 43, 24122414.
Nielsen, H., Lolk, A., Andersen, K., Andersen, J., & Kragh-Sørensen, P. (1999). Characteristics of elderly who develop Alzheimer's disease during the next two years—A neuropsychological study using CAMCOG. The Odense Study. International Journal of Geriatric Psychiatry, 14, 957963.
Petersen, R., Kokmen, E., Tangalos, E.G., Ivnik, R.J., & Kurland, L.T. (1990). Mayo Clinic's Alzheimer's Disease Patient Registry. Aging, 2, 408415.
Petersen, R., Smith, G., Ivnik, R., Kokmen, E., & Tangalos, E. (1994). Memory function in very early Alzheimer's disease. Neurology, 44, 867872.
Petersen, R., Smith, G., Waring, S., Ivnik, R., Tangalos, E., & Kokmen, E. (1999). Mild cognitive impairment: clinical characterization and outcome. Archives of Neurology, 56, 303308.
Rey, A. (1964). L'examen clinique en psychologie [The clinical examination in psychology]. Paris: Presses Universitaires de France.
Rubin, E., Storandt, M., Miller, P., Kinscherf, D., Grant, E., Morris, J., & Berg, L. (1998). A prospective study of cognitive function and onset of dementia in cognitively healthy elders. Archives of Neurology, 55, 395401.
Sackett, D.L., Haynes, R.B., Guyatt, G.H., & Tugwell, P. (1991) The interpretation of diagnostic data. Clinical epidemiology: A basic science for clinical medicine (2nd ed.). Boston: Little, Brown & Company.
Salmon, D.P., Thomas, R.G., Pay, M.M., Booth, A., Hofstetter, C.R., Thal, L.J., & Katzman, R. (2002). Neurology, 7, 10221028.
Schenk, D. (2002). Amyloid-beta immunotherapy for Alzheimer's disease: The end of the beginning. National Review of Neuroscience, 3, 824828.
Small, B.J., Fratiglioni, L., Viitanen, M., Winblad, B., & Bäckman, L. (2000). The course of cognitive impairment in preclinical Alzheimer disease. Archives of Neurology, 57, 839844.
Smith, G.E., Cerhan, J.H., & Ivnik, R.J. (2003). Diagnostic validity. In D. Tulsky & D. Saaklofske (Eds.), Clinical interpretation of the WAIS–III and WMS–III. New York: Academic Press.
Soininen, H.S. & Scheltens, P. (1998). Early diagnostic indices for the prevention of Alzheimer's disease. Annals of Medicine, 30, 553559.
Tierney, M., Szalai, J., Snow, W., Fisher, R., Nores, A., Nadon, G., Dunn, E., & St. George-Hyslop, P. (1996). Prediction of probable Alzheimer's disease in memory-impaired patients: A prospective longitudinal study. Neurology, 46, 661665.
Wechsler, D. (1987). Wechsler Memory Scale–Revised. New York: The Psychological Corporation.
Williams, B.W., Mack, W., & Henderson, V.W. (1989). Boston Naming Test in Alzheimer's disease. Neuropsychologia, 27, 10731079.

Keywords

Confrontation naming does not add incremental diagnostic utility in MCI and Alzheimer's disease

  • JULIE A. TESTA (a1), ROBERT J. IVNIK (a1) (a2), BRADLEY BOEVE (a2) (a3), RONALD C. PETERSEN (a2) (a3), V. SHANE PANKRATZ (a4), DAVID KNOPMAN (a2) (a3), ERIC TANGALOS (a2) (a5) and GLENN E. SMITH (a1) (a2)...

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