Skip to main content Accessibility help

Cognitive asymmetries associated with apolipoprotein E genotype in patients with Alzheimer's disease

  • MICHAEL J. FINTON (a1), JOHN A. LUCAS (a1) (a2), JULIE D. RIPPETH (a1) (a3), DARYL L. BOHAC (a1) (a4), GLENN E. SMITH (a1) (a5), ROBERT J. IVNIK (a1) (a5), RONALD C. PETERSEN (a1) (a5) and NEILL R. GRAFF-RADFORD (a1) (a2)...


The relationship between apolipoprotein E (apoE) genotype and cognitive performance was examined in 200 patients with probable Alzheimer's disease (AD). Differences between composite measures of verbal and nonverbal functioning were used to define asymmetric patterns of cognition. Patients who were homozygous for apoE ε4 demonstrated relatively worse nonverbal as compared to verbal cognitive ability. In contrast, participants who were heterozygous for apoE ε4 or who possessed no ε4 allele demonstrated relatively equivalent verbal and nonverbal cognitive abilities. Although age and dementia severity also contributed to these patterns, apoE genotype appears to have a significant unique contribution to cognitive performance in these individuals. The ε4 allele may thus be associated with a specific neurocognitive phenotype among patients with AD, with the overall pattern of cognitive asymmetry dependent upon ε4 dose. (JINS, 2003, 9, 751–759.)


Corresponding author

Reprint requests to: John A. Lucas, PhD, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224. E-mail:



Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed