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Cerebral Volume Loss, Cognitive Deficit, and Neuropsychological Performance: Comparative Measures of Brain Atrophy: II. Traumatic Brain Injury

Published online by Cambridge University Press:  28 February 2011

David F. Tate ,
Rola Khedraki ,
E. Shannon Neeley ,
David K. Ryser  and
Erin D. Bigler
David F. Tate*
Affiliation:
Center for Neurological Imaging, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts Alzheimer's Disease Center, Boston University Medical Center, Boston, Massachusetts Department of Statistics, Brigham Young University, Provo, Utah
Rola Khedraki
Affiliation:
Center for Neurological Imaging, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
E. Shannon Neeley
Affiliation:
Department of Statistics, Brigham Young University, Provo, Utah
David K. Ryser
Affiliation:
Department of Physical Medicine and Rehabilitation, Intermountain Medical Center, Murray, Utah
Erin D. Bigler
Affiliation:
Department of Psychology and Neuroscience, Brigham Young University, Provo, Utah Department of Psychiatry, University of Utah, Salt Lake City, Utah
*
Correspondence and reprint requests to: David F. Tate, Center for Neurological Imaging, 1249 Boylston Street, Room 345, Boston, MA 02115. E-mail: dftatephd@mac.com
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Abstract

Traumatic brain injury (TBI) results in a variable degree of cerebral atrophy that is not always related to cognitive measures across studies. However, the use of different methods for examining atrophy may be a reason why differences exist. The purpose of this manuscript was to examine the predictive utility of seven magnetic resonance imaging (MRI) -derived brain volume or indices of atrophy for a large cohort of TBI patients (n = 65). The seven quantitative MRI (qMRI) measures included uncorrected whole brain volume, brain volume corrected by total intracranial volume, brain volume corrected by the ratio of the individual TICV by group TICV, a ventricle to brain ratio, total ventricular volume, ventricular volume corrected by TICV, and a direct measure of parenchymal volume loss. Results demonstrated that the various qMRI measures were highly interrelated and that corrected measures proved to be the most robust measures related to neuropsychological performance. Similar to an earlier study that examined cerebral atrophy in aging and dementia, these results suggest that a single corrected brain volume measure is all that is necessary in studies examining global MRI indicators of cerebral atrophy in relationship to cognitive function making additional measures of global atrophy redundant and unnecessary. (JINS, 2011, 17, 308–316)

Keywords

MRITBICognitionAtrophyBrain/behavior relationshipsCNS
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 17 , Issue 2 , 28 February 2011 , pp. 308 - 316
Copyright
Copyright © The International Neuropsychological Society 2010

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