Skip to main content Accessibility help
×
Home

Atypical Local Interference Affects Global Processing in Children with Neurofibromatosis Type 1

  • Jonathan M. Payne (a1) (a2), Melanie A. Porter (a3), Samantha Bzishvili (a3) and Kathryn N. North (a1) (a2)

Abstract

Objectives: To examine hierarchical visuospatial processing in children with neurofibromatosis type 1 (NF1), a single gene disorder associated with visuospatial impairments, attention deficits, and executive dysfunction. Methods: We used a modified Navon paradigm consisting of a large “global” shape composed of smaller “local” shapes that were either congruent (same) or incongruent (different) to the global shape. Participants were instructed to name either the global or local shape within a block. Reaction times, interference ratios, and error rates of children with NF1 (n=30) and typically developing controls (n=24) were compared. Results: Typically developing participants demonstrated the expected global processing bias evidenced by a vulnerability to global interference when naming local stimuli without a cost of congruence when naming global stimuli. NF1 participants, however, experienced significant interference from the unattended level when naming both local and global levels of the stimuli. Conclusions: Findings suggest that children with NF1 do not demonstrate the typical human bias of processing visual information from a global perspective. (JINS, 2017, 23, 446–450)

Copyright

Corresponding author

Correspondence and reprint requests to: Jonathan M. Payne. Murdoch Childrens Research Institute, Royal Children’s Hospital, Flemington Road, Parkville VIC 3052 Australia. E-mail: jonathan.payne@mcri.edu.au

References

Hide All
Bihrle, A.M., Bellugi, U., Delis, D., & Marks, S. (1989). Seeing either the forest or the trees: Dissociation in visuospatial processing. Brain and Cognition, 11, 3749.
Brosnan, M.J., Scott, F.J., Fox, S., & Pye, J. (2004). Gestalt processing in autism: Failure to process perceptual relationships and the implications for contextual understanding. Journal of Child Psychology and Psychiatry, 45, 459469.
Clements-Stephens, A.M., Rimrodt, S.L., Gaur, P., & Cutting, L.E. (2008). Visuospatial processing in children with neurofibromatosis type 1. Neuropsychologia, 46, 690697.
Ferner, R.E., Hughes, R.A.C., & Weinman, J. (1996). Intellectual impairment in neurofibromatosis 1. Journal of the Neurological Sciences, 138, 125133.
Fink, G.R., Halligan, P.W., Marshall, J.C., Frith, C.D., Frackowiak, R.S.J., & Dolan, R.J. (1996). Where in the brain does visual attention select the forest and the trees? Nature, 382, 626628.
Forster, K.I., & Forster, J.C. (2003). DMDX: A windows display program with millisecond accuracy. Behavior Research Methods, Instruments, & Computers, 35, 116124.
Frith, U. (1989). Autism: Explaining the enigma. Cambridge, UK: Blackwell.
Garg, S., Green, J., Leadbitter, K., Emsley, R., Lehtonen, A., Evans, D.G., & Huson, S.M. (2013). Neurofibromatosis type 1 and autism spectrum disorder. Pediatrics, 132, e1642e1648.
Hyman, S.L., Shores, E.A., & North, K.N. (2005). The nature and frequency of cognitive deficits in children with neurofibromatosis type 1. Neurology, 65, 10371044.
Jett, K., & Friedman, J.M. (2010). Clinical and genetic aspects of neurofibromatosis 1. Genetics in Medicine, 12, 111.
Lehtonen, A., Howie, E., Trump, D., & Huson, S.M. (2012). Behaviour in children with neurofibromatosis type 1: Cognition, executive function, attention, emotion, and social competence. Developmental Medicine and Child Neurology, 55, 111125.
Mondloch, C.J., Geldart, S., Maurer, D., & de Schonen, S. (2003). Developmental changes in the processing of hierarchical shapes continue into adolescence. Journal of Experimental Child Psychology, 84, 2040.
Navon, D. (1977). Forest before trees: The precedence of global features in visual perception. Cognitive Psychology, 9, 441474.
National Institutes of Health Conference Statement. (1988). Neurofibromatosis conference statement. National Institues of Health Consensus Development Conference. Archives of Neurology, 45, 575578.
Payne, J.M., Arnold, S.S., Pride, N.A., & North, K.N. (2012). Does attention-deficit–hyperactivity disorder exacerbate executive dysfunction in children with neurofibromatosis type 1? Developmental Medicine and Child Neurology, 34, 898904.
Payne, J.M., Hyman, S.L., Shores, E.A., & North, K.N. (2011). Assessment of executive function and attention in children with neurofibromatosis type 1: Relationships between cognitive measures and real-world behavior. Child Neuropsychology, 17, 313329.
Porter, M.A., & Coltheart, M. (2006). Global and local processing in Williams syndrome, autism, and Down syndrome: Perception, attention, and construction. Developmental Neuropsychology, 30, 771789.
Robertson, L.C., & Lamb, M.R. (1991). Neuropsychological contributions to theories of part/whole organization. Cognitive Psychology, 23, 299330.
Schrimsher, G.W., Billingsley, R.L., Slopis, J.M., & Moore, B.D. (2003). Visual-spatial performance deficits in children with neurofibromatosis type-1. American Journal of Medical Genetics . Part A, 120A, 326330.
Song, Y., & Hakoda, Y. (2015). Lack of global precedence and global-to-local interference without local processing deficit: A robust finding in children with attention-deficit/hyperactivity disorder under different visual angles of the Navon task. Neuropsychology, 29, 888894.
Wechsler, D. (2003). Wechsler Intelligence Scales for Children (4th ed.). San Antonio, TX: The Psychological Corporation.

Keywords

Type Description Title
WORD
Supplementary materials

Payne supplementary material
Payne supplementary material 1

 Word (26 KB)
26 KB

Atypical Local Interference Affects Global Processing in Children with Neurofibromatosis Type 1

  • Jonathan M. Payne (a1) (a2), Melanie A. Porter (a3), Samantha Bzishvili (a3) and Kathryn N. North (a1) (a2)

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed