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Are Empirically-Derived Subtypes of Mild Cognitive Impairment Consistent with Conventional Subtypes?

  • Lindsay R. Clark (a1), Lisa Delano-Wood (a2) (a3), David J. Libon (a4), Carrie R. McDonald (a3), Daniel A. Nation (a2), Katherine J. Bangen (a3), Amy J. Jak (a2) (a3), Rhoda Au (a5), David P. Salmon (a6) and Mark W. Bondi (a2) (a3)...

Abstract

Given the importance of identifying dementia prodromes for future treatment efforts, we examined two methods of diagnosing mild cognitive impairment (MCI) and determined whether empirically-derived MCI subtypes of these diagnostic methods were consistent with one another as well as with conventional MCI subtypes (i.e., amnestic, non-amnestic, single-domain, multi-domain). Participants were diagnosed with MCI using either conventional Petersen/Winblad criteria (n = 134; >1.5 SDs below normal on one test within a cognitive domain) or comprehensive neuropsychological criteria developed by Jak et al. (2009) (n = 80; >1 SD below normal on two tests within a domain), and the resulting samples were examined via hierarchical cluster and discriminant function analyses. Results showed that neuropsychological profiles varied depending on the criteria used to define MCI. Both criteria revealed an Amnestic subtype, consistent with prodromal Alzheimer's disease (AD), and a Mixed subtype that may capture individuals in advanced stages of MCI. The comprehensive criteria uniquely yielded Dysexecutive and Visuospatial subtypes, whereas the conventional criteria produced a subtype that performed within normal limits, suggesting its susceptibility to false positive diagnostic errors. Whether these empirically-derived MCI subtypes correspond to dissociable neuropathologic substrates and represent reliable prodromes of dementia will require additional follow-up. (JINS, 2013, 19, 1–11)

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Copyright

Corresponding author

Correspondence and reprint requests to: Mark W. Bondi, VA San Diego Healthcare System (116B), 3350 La Jolla Village Drive, San Diego, CA 92161. E-mail: mbondi@ucsd.edu

References

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Bartley, M., Bokde, A.L., Ewers, M., Faluyi, Y.O., Tobin, W.O., Snow, A., O'Neill, D. (2012). Subjective memory complaints in community dwelling health older people: The influence of brain and psychopathology. International Journal of Geriatric Psychiatry, 27, 836843.
Bickel, H., Mosch, E., Seigerschmidt, E., Siemen, M., Forstl, H. (2006). Prevalence and persistence of mild cognitive impairment among elderly patients in general hospitals. Dementia and Geriatric Cognitive Disorders, 21(4), 242250.
Binder, L.M., Iverson, G.L., Brooks, B.L. (2009). To err is human: “Abnormal” neuropsychological scores and variability are common in healthy adults. Archives of Clinical Neuropsychology, 24, 3146.
Busse, A., Hensel, A., Guhne, U., Angermeyer, M.C., Riedel-Heller, S.G. (2006). Mild cognitive impairment: Long-term course of four clinical subtypes. Neurology, 67, 21762185.
Calderon, J., Perry, R.J., Erzinclioglu, S.W., Berrios, G.E., Dening, T.R., Hodges, J.R. (2001). Perception, attention, and working memory are disproportionately impaired in dementia with Lewy bodies compared with Alzheimer's disease. Journal of Neurology, Neurosurgery, and Psychiatry, 70, 157164.
Chung, J.C., Man, D.W. (2009). Self-appraised, informant-reported, and objective memory and cognitive function in mild cognitive impairment. Dementia and Geriatric Cognitive Disorders, 27, 187193.
Collerton, D., Burn, D., McKeith, I., O'Brien, J. (2003). Systematic review and meta-analysis show that dementia with Lewy bodies is a visual-perceptual and attentional-executive dementia. Dementia & Geriatric Cognitive Disorders, 16, 229237.
Delano-Wood, L., Abeles, N., Sacco, J.M., Wierenga, C.E., Horne, N.R., Bozoki, A. (2008). Regional white matter pathology in mild cognitive impairment – Differential influence of lesion type on neuropsychological functioning. Stroke, 39, 794799.
Delano-Wood, L., Bondi, M.W., Sacco, J., Abeles, N., Jak, A.J., Libon, D.J., Bozoki, A. (2009). Heterogeneity in mild cognitive impairment: Differences in neuropsychological profile and associated white matter lesion pathology. Journal of the International Neuropsychological Society, 15, 906914.
Delis, D.C., Kramer, J.H., Kaplan, E., Ober, B.A. (1987). The California Verbal Learning Test. San Antonio, TX: The Psychological Corporation.
Delis, D.C., Kramer, J.H., Kaplan, E., Ober, B.A. (2000). California Verbal Learning Test: Second Edition. San Antonio, TX: The Psychological Corporation.
Delis, D.C., Kaplan, E., Kramer, J.H. (2001). Delis-Kaplan Executive Function System. San Antonio, TX: The Psychological Corporation.
Eppig, J., Wambach, D.M., Nieves, C., Price, C.C., Lamar, M., Delano-Wood, L., Libon, D.J. (2012). Dysexecutive functioning in mild cognitive impairment: Derailment in temporal gradients. Journal of the International Neuropsychological Society, 18, 2028.
Ganguli, M., Snitz, B.E., Saxton, J.A., Chang, C.-C.H., Lee, C.-W., Vander Bilt, J., Petersen, R.C. (2011). Outcomes of mild cognitive impairment by definition: A population study. Archives of Neurology, 68, 761767.
Geerlings M.I., Appelman A.P., Vincken K.L., Mali W.P., & van der Graaf Y., & SMART Study Group (2009). Association of white matter lesions and lacunar infarcts with executive functioning: The SMART-MR study. American Journal of Epidemiology, 170(9), 11471155.
Gorelick, P.B., Scuteri, A., Black, S.E., DeCarli, C., Greenberg, S.M., Iadecola, C., Seshadri, S. (2011). Vascular contributions to cognitive impairment and dementia: A statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke, 42, 26722713.
Grundman, M., Petersen, R.C., Ferris, S.H., Thomas, R.G., Aisen, P.S., Bennett, D.A., Thal, L.J. (2004). Mild cognitive impairment can be distinguished from Alzheimer disease and normal aging for clinical trials. Archives of Neurology, 61, 5966.
Harwood, D.G., Barker, W.W., Ownby, R.L., Mullan, M., Duara, R. (2004). No association between subjective memory complaints and apolipoprotein E genotype in cognitively intact elderly. International Journal of Geriatric Psychiatry, 19, 11311139.
Jak, A.J., Bondi, M.W., Delano-Wood, L., Wierenga, C., Corey-Bloom, J., Salmon, D.P., Delis, D.C. (2009). Quantification of five neuropsychological approaches to defining mild cognitive impairment. American Journal of Geriatric Psychiatry, 17(5), 368375.
Jellinger, K.A., Attems, J. (2010). Prevalence of dementia disorders in the oldest-old: An autopsy study. Acta Neuropathologica, 119, 421433.
Kaplan, E.F., Goodglass, H., Weintraub, S. (1983). The Boston Naming Test. Philadelphia: Lea & Febiger.
Lenehan, M.E., Klekociuk, S.Z., Summers, M.J. (2012). Absence of a relationship between subjective memory complaint and objective memory impairment in mild cognitive impairment (MCI): Is it time to abandon subjective memory complaint as an MCI diagnostic criterion? International Psychogeriatrics, 24, 15051514.
Libon, D.J., Bondi, M.W., Price, C.C., Lamar, M., Eppig, J., Wambach, D.M., Penney, D.L. (2011). Verbal serial list learning in mild cognitive impairment: A profile analysis of interference, forgetting, and errors. Journal of the International Neuropsychological Society, 17, 905914.
Libon, D.J., Xie, S.X., Eppig, J., Wicas, G., Lamar, M., Lippa, C., Wambach, D.M. (2010). The heterogeneity of mild cognitive impairment: A neuropsychological analysis. Journal of the International Neuropsychological Society, 16, 8493.
Lo, R.Y., Jagust, W.J., Alzheimer's Disease Neuroimaging Initiative. (2012). Vascular burden and Alzheimer disease pathologic progression. Neurology, 79(13), 13491355.
Loeb, P.A. (1996). Independent living scales. San Antonio, TX: The Psychological Corporation.
Loewenstein, D.A., Acevedo, A., Small, B.J., Agron, J., Crocco, E., Duara, R. (2009). Stability of different subtypes of mild cognitive impairment among the elderly over a 2- to 3- year follow-up period. Dementia and Geriatric Cognitive Disorders, 27, 418423.
Luck, T., Luppa, M., Briel, S., Riedel-Heller, S.G. (2010). Incidence of mild cognitive impairment: A systematic review. Dementia & Geriatric Cognitive Disorders, 29, 164175.
Manly, J.J., Tang, M.X., Schupf, N., Stern, Y., Vonsattel, J.P., Mayeux, R. (2008). Frequency and course of mild cognitive impairment in a multiethnic community. Annals of Neurology, 63, 494506.
McKeith, I.G., Dickson, D.W., Lowe, J., Ernre, M., O'Brien, J.T., Feldman, H.Consortium on DLB. Diagnosis and management of dementia with Lewy bodies: Third report of the DLB Consortium. Neurology, 65, 18631872.
Mitchell, A.J., Shiri-Feshki, M. (2009). Rate of progression of mild cognitive impairment to dementia – meta-analysis of 41 robust inception cohort studies. Acta Psychiatrica Scandinavica, 119, 252265.
Palmer, B.W., Boone, K.B., Lesser, I.M., Wohl, M.A. (1998). Base rates of “impaired” neuropsychological test performance among healthy older adults. Archives of Clinical Neuropsychology, 13, 503511.
Petersen, R.C. (2004). Mild cognitive impairment as a diagnostic entity. Journal of Internal Medicine, 256, 183194.
Petersen, R.C., Morris, J.C. (2005). Mild cognitive impairment as a clinical entity and treatment target. Archives of Neurology, 62, 11601163.
Reijmer, Y.D., van den Berg, E., Dekker, J.M., Niipels, G., Stehouwer, C.D., Kappelle, L.J., Biessels, G.J. (2012). Development of vascular risk factors over 15 years in relation to cognition: The Hoorn Study. Journal of the American Geriatric Society, 60(8), 14261433.
Reitan, R.M., Wolfson, D. (1985). The Halstead-Reitan Neuropsychological Test Battery. Tucson, AZ: Neuropsychology Press.
Roberts, R.O., Geda, Y.E., Knopman, D.S., Cha, R.H., Pankratz, V.S., Boeve, B.F., Petersen, R.C. (2012). The incidence of MCI differs by subtype and is higher in men: The Mayo Clinic Study of Aging. Neurology, 78, 342351.
Rountree, S.D., Waring, S.C., Chan, W.C., Lupo, P.J., Darby, E.J., Doody, R.S. (2007). Importance of subtle amnestic and nonamnestic deficits in mild cognitive impairments: Prognosis and conversion to dementia. Dementia & Geriatric Cognitive Disorders, 24, 476482.
Salmon, D.P., Bondi, M.W. (2009). Neuropsychological assessment of dementia. Annual Review of Psychology, 60, 257282.
Salmon, D.P., Butters, N.M. (1992). Neuropsychologic assessment of dementia in the elderly. In R. Katzman & J.W. Rowe (Eds.), Principles of geriatric neurology (pp. 144163). Philadelphia: F.A. Davis Company.
Savva, G.M., Wharton, S.B., Ince, P.G., Forster, G., Matthews, F.E., Brayne, C. (2009). Age, neuropathology, and dementia. New England Journal of Medicine, 360, 23022309.
Schneider, J.A., Arvanitakis, Z., Leurgans, S.E., Bennett, D.A. (2009). The neuropathology of probable Alzheimer disease and mild cognitive impairment. Annals of Neurology, 66, 200208.
Schretlen, D.J., Testa, S.M., Winicki, J.M., Pearlson, G.D., Gordon, B. (2008). Frequency and bases of abnormal performance by healthy adults on neuropsychological testing. Journal of the International Neuropsychological Society, 14, 436445.
Sinka, L., Kovari, E., Gold, G., Hof, P.R., Herrmann, F.R., Bouras, C., Giannakopoulos, P. (2010). Small vascular and Alzheimer disease-related pathologic determinants of dementia in the oldest-old. Journal of Neuropathology and Experimental Neurology, 69, 12471255.
Slavin, M.J., Brodaty, H., Kochan, N.A., Crawford, J.D., Trollor, J.N., Draper, B., Sachdev, P.S. (2010). Prevalence and predictors of “subjective cognitive complaints” in the Sydney Memory and Ageing Study. American Journal of Geriatric Psychiatry, 18, 701710.
Summers, M.J., Saunders, N.L. (2012). Neuropsychological measures predict decline to Alzheimer's dementia from mild cognitive impairment. Neuropsychology, 26, 498508.
Ward, A., Arrighi, H.M., Michels, S., Cedarbaum, J.M. (2012). Mild cognitive impairment: Disparity of incidence and prevalence estimates. Alzheimer's & Dementia, 8, 1421.
Wechsler, D. (1974). Wechsler Intelligence Scale for Children-Revised. New York: The Psychological Corporation.
Wechsler, D. (1981). Wechsler Adult Intelligence Scale-Revised Manual. San Antonio, TX: The Psychological Corporation.
Wechsler, D. (1987). Wechsler Memory Scale-Revised. New York: The Psychological Corporation.
Winblad, B., Palmer, K., Kivipelto, M., Jelic, V., Fratiglioni, L., Wahlund, L.O., Petersen, R.C. (2004). Mild cognitive impairment – beyond controversies, towards a consensus: Report of the International Working Group on Mild Cognitive Impairment. Journal of Internal Medicine, 256, 240246.
Yesavage, J.A., Brink, T.L., Rose, T.L., Lum, O., Huang, V., Adey, M.B., Leirer, V.O. (1983). Development and validation of a geriatric depression screening scale: A preliminary report. Journal of Psychiatric Research, 17, 3749.

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Are Empirically-Derived Subtypes of Mild Cognitive Impairment Consistent with Conventional Subtypes?

  • Lindsay R. Clark (a1), Lisa Delano-Wood (a2) (a3), David J. Libon (a4), Carrie R. McDonald (a3), Daniel A. Nation (a2), Katherine J. Bangen (a3), Amy J. Jak (a2) (a3), Rhoda Au (a5), David P. Salmon (a6) and Mark W. Bondi (a2) (a3)...

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