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The “Alzheimer's Type” Profile of Semantic Clustering in Amnestic Mild Cognitive Impairment

  • Paula M. McLaughlin (a1) (a2), Matthew J. Wright (a2) (a3), Michael LaRocca (a4), Peter T. Nguyen (a5), Edmond Teng (a1) (a6), Liana G. Apostolova (a1), John M. Ringman (a1), Yan Zhou (a1), Jeffrey L. Cummings (a7) and Ellen Woo (a1)...

Abstract

Impairments in learning and recall have been well established in amnestic mild cognitive impairment (aMCI). However, a relative dearth of studies has examined the profiles of memory strategy use in persons with aMCI relative to those with Alzheimer's disease (AD). Participants with aMCI, nonamnestic MCI, AD, and healthy older adults were administered the California Verbal Learning Test-II (CVLT-II). Measures of semantic clustering and recall were obtained across learning and delayed recall trials. In addition, we investigated whether deficits in semantic clustering were related to progression from healthy aging to aMCI and from aMCI to AD. The aMCI group displayed similar semantic clustering performance as the AD participants, whereas the AD group showed greater impairments on recall relative to the aMCI participants. Control participants who progressed to aMCI showed reduced semantic clustering at the short delay at baseline compared to individuals who remained diagnostically stable across follow-up visits. These findings show that the ability to engage in an effective memory strategy is compromised in aMCI, before AD has developed, suggesting that disruptions in semantic networks are an early marker of the disease. (JINS, 2014, 20, 1–11)

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Corresponding author

Correspondence and reprint requests to: Ellen Woo, 10911 Weyburn Avenue, Ste. 200, Los Angeles, CA 90095-7226. E-mail: ewoo@mednet.ucla.edu

References

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Adlam, A.L., Bozeat, S., Arnold, R., Watson, P., Hodges, J.R. (2006). Semantic knowledge in mild cognitive impairment and mild Alzheimer's disease. Cortex, 42, 675684.
Albert, M.S., Moss, M.B., Tanzi, R., Jones, K. (2001). Preclinical prediction of AD using neuropsychological tests. Journal of the International Neuropsychological Society, 7, 631639.
Alexander, M.P., Stuss, D.T., Fansabedian, N. (2003). California Verbal Learning Test: Performance by patients with focal frontal and non-frontal lesions. Brain, 126, 14931503. doi:10.1093/brain/awg128
Apostolova, L.G., Morra, J.H., Green, A.E., Hwang, K.S., Avedissian, C., Woo, E. (2010). Alzheimer's Disease Neuroimaging Initiative. Automated 3D mapping of baseline and 12-month associations between three verbal memory measures and hippocampal atrophy in 490 ADNI subjects. Neuroimage, 51, 488499. doi:10.1016/j.neuroimage.2009.12.12
Baddeley, A.D. (2001). Is working memory still working? American Psychologist, 56, 851864.
Bayles, K.A., Tomoeda, C.K., Kaszniak, A.W., Trosset, M.W. (1991). Alzheimer's disease effects on semantic memory: Loss of structure or impaired processing. Journal of Cognitive Neuroscience, 3, 166182.
Becker, S., Lim, J. (2003). A computational model of prefrontal control in free recall: Strategic memory use in the California Verbal Learning Task. Journal of Cognitive Neuroscience, 15, 821832.
Braak, H., Braak, E. (1991). Neuropathological staging of Alzheimer-related changes. Acta Neuropathology, 82, 239259.
Brink, T.L., Yesavage, J.A., Lum, O., Heersema, P., Adey, M.B., Rose, T.L. (1982). Screening tests for geriatric depression. Clinical Gerontologist, 1, 3744.
Bröder, A., Herwig, A., Teipel, S., Fast, K. (2008). Different storage and retrieval deficits in normal aging and mild cognitive impairment: A mulinomial modeling analysis. Psychology and Aging, 23, 353365. doi:10.1037/0882-7974.23.2.353
Chan, A., Salmon, D.P., Butters, N. (1998). Semantic network abnormalities in patients with Alzheimer's disease. In R.W. Parks, D.S. Levine, & D.L. Long (Eds.), Fundamentals of neural network modeling: Neuropsychology and cognitive neuroscience (pp. 381393). Cambridge, MA: MIT Press.
Chertkow, H., Bub, D. (1990). Semantic memory loss in dementia of Alzheimer's type. Brain, 113, 397417.
Cinan, S. (2003). Executive processing in free recall of categorized lists. Learning and Motivation, 34, 240261. doi:10.1016/S0023-9690(03)00022-5
Collins, A.M., Loftus, E.F. (1975). A spreading-activation theory of semantic processing. Psychological Review, 82, 407428.
Crowell, T.A., Luis, C.A., Vanderploeg, R.D., Schinka, J.A., Mullan, M. (2002). Memory patterns and executive functioning in mild cognitive impairment and Alzheimer's disease. Aging Neuropsychology and Cognition, 9, 288297.
Delis, D.C., Kramer, J.H., Kaplan, E., Ober, B.A. (2000). California Verbal Learning Test-II (2nd ed). New York: The Psychological Corporation.
Demick, J., Harkins, D. (1997). Role of cognitive style in the driving skills of young, middle-aged and older adults. Washington, DC: AARP Andrus Foundation Final Report.
Folstein, M.F., Folstein, S.W., McHugh, P.R. (1975). “Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189198. doi:10.1016/0022-3956(75)90026-6
Fuster, J. (2003). Cortex and mind: Unifying cognition. New York, NY: Oxford University Press.
Gaines, J.J., Shapiro, A., Benedict, R.H. (2006). Semantic clustering indexes for the Hopkins Verbal Learning Test-Revised: Initial exploration in elder control and dementia groups. Applied Neuropsychology, 13, 213222.
Greenaway, M.C., Lacritz, L.H., Binegar, D., Weiner, M.F., Lipton, A., Cullum, C.M. (2006). Patterns of verbal memory performance in mild cognitive impairment, Alzheimer disease, and normal aging. Cognitive and Behavioral Neurology, 19, 7984.
Hodges, J.R., Salmon, D.P., Butters, N. (1992). Semantic memory impairment in Alzheimer's disease: Failure of access or degraded knowledge? Neuropsychologia, 30, 301314.
Hudon, C., Villeneuve, S., Belleville, S. (2011). The effect of semantic orientation at encoding on free-recall performance in amnestic mild cognitive impairment and probably Alzheimer's disease. Journal of Clinical and Experimental Neuropsychology, 33, 631638. doi:10.1080/13803395.2010.547663
Huff, F.J., Corkin, S., Growdon, J.H. (1986). Semantic impairment and anomia in Alzheimer's and Huntington's disease. Brain and Language, 28, 235249.
Jack, C.R., Petersen, R.C., Xu, Y.C., O'Brien, P.C., Smith, G.E., Ivnik, R.J., Kokmen, E. (1999). Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment. Neurology, 52, 13971403.
Joubert, S., Brambait, S.M., Ansado, J., Barbeau, E.J., Felician, O., Didic, M., Kergoat, M.J. (2010). The cognitive and neural expression of semantic memory impairment in mild cognitive impairment and early Alzheimer's disease. Neuropsychologia, 48, 978988. doi:10.1016/j.neuropsychologia.2009.11.019
Joubert, S., Felician, O., Barabeau, E.J., Didic, M., Poncet, M., Ceccaldi, M. (2008). Patterns of semantic memory impairment in mild cognitive impairment. Behavioral Neurology, 19, 3540.
Kaplan, E.F., Goodglass, H., Weintraub, S. (1983). The Boston Naming Test (2nd ed.). Philadelphia: Lea & Febiger.
Malek-Ahmadi, M., Raj, A., Small, B.J. (2011). Semantic clustering as a neuropsychological predictor for amnestic-MCI. Aging, Neuropsychology, and Cognition, 18, 280292. doi:10.1080/13825585.2010.540642
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., Stadlan, E.M. (1984). Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services taskforce on Alzheimer's disease. Neurology, 34, 939944.
Meyers, J.E., Meyers, K.R. (1995). Rey Complex Figure Test and Recognition Trial. Odessa, FL: Psychological Assessment Resources, Inc.
Mori, T. (1975). Processes underlying clustering in free recall. Hiroshima Forum for Psychology, 2, 2530.
Murphy, K.J., Rich, J.B., Troyer, A.K. (2006). Verbal fluency patterns in amnestic mild cognitive impairment are characteristic of Alzheimer's type dementia. Journal of the International Neuropsychological Society, 12, 570574.
Perri, R., Carlesimo, G.A., Serra, L., Caltagirone, C., & The Early Diagnosis Group of the Italian Interdisciplinary Network on Alzheimer's Disease (2005). Characterization of memory profile in subjects with amnestic mild cognitive impairment. Journal of Clinical and Experimental Neuropsychology, 27, 10331055. doi:10.1080/13803390490919317
Perry, R.J., Hodges, J.R. (1999). Attention and executive deficits in Alzheimer's disease: A critical review. Brain, 122, 383404.
Petersen, R.C. (2004). Mild cognitive impairment as a diagnostic entity. Journal of Internal Medicine, 256, 183194. doi:10.1111/j.1365-2796.2004.01388.x
Price, S.E., Kinsella, G.J., Ong, B., Mullaly, E., Phillips, M., Pangnadasa-Fox, L., Storey, E. (2010). Learning and memory in amnestic mild cognitive impairment: Contribution of working memory. Journal of the International Neuropsychological Society, 16, 342351. doi:10.1017/S1355617709991391
Ribeiro, F., Guerreiro, M., De Mendonça, A. (2007). Verbal learning and memory deficits in mild cognitive impairment. Journal of Clinical and Experimental Neuropsychology, 29, 187197.
Rosser, A., Hodges, J.R. (1994). Initial letter and semantic category fluency in Alzheimer's disease, Huntington's disease, and progressive supranuclear palsy. Journal of Neurology, Neurosurgery, and Psychiatry, 57, 13891394.
Salmon, D.P. (2012). Loss of semantic knowledge in mild cognitive impairment. American Journal of Psychiatry, 169, 12261229. doi:10.1176/appi.ajp.2012.12101262
Strauss, E., Sherman, E.M.S., Spreen, O. (2006). A compendium of neuropsychological tests: Administration, norms, and commentary (3rd ed.). New York: Oxford University Press.
Stricker, J.L., Brown, G.G., Wixted, J., Baldo, J.V., Delis, D.C. (2002). New semantic and serial clustering indices for the California Verbal Learning Test–Second Edition: Background, rationale, and formulae. Journal of the International Neuropsychological Society, 8, 425435.
Tombaugh, T.N. (2004). Trail making test A and B: Normative data stratified by age and education. Archives of Clinical Neuropsychology, 19, 203214. doi:10.1016/S0887-6177(03)00039-8
Tombaugh, T.N., Kozak, J., Rees, L. (1999). Normative data stratified by age and education for two measures of verbal fluency: FAS and animal naming. Archives of Clinical Neuropsychology, 14, 167177. doi:10.1016/S0887-6177(97)00095-4
Tremont, G., Halpert, S., Javorsky, D.J., Stern, R.A. (2000). Differential impact of executive dysfunction on verbal list learning and story recall. The Clinical Neurospychologist, 14, 295302.
Wechsler, D. (1997a). Wechsler Adult Intelligence Scale (3rd ed.). San Antonio, TX: The Psychological Corporation.
Wechsler, D. (1997b). Wechsler Memory Scale (3rd ed.). San Antonio, TX: The Psychological Corporation.

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