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Alzheimer’s Disease: Past, Present, and Future

  • Mark W. Bondi (a1) (a2), Emily C. Edmonds (a1) (a2) and David P. Salmon (a3)

Abstract

Although dementia has been described in ancient texts over many centuries (e.g., “Be kind to your father, even if his mind fail him.” – Old Testament: Sirach 3:12), our knowledge of its underlying causes is little more than a century old. Alzheimer published his now famous case study only 110 years ago, and our modern understanding of the disease that bears his name, and its neuropsychological consequences, really only began to accelerate in the 1980s. Since then we have witnessed an explosion of basic and translational research into the causes, characterizations, and possible treatments for Alzheimer’s disease (AD) and other dementias. We review this lineage of work beginning with Alzheimer’s own writings and drawings, then jump to the modern era beginning in the 1970s and early 1980s and provide a sampling of neuropsychological and other contextual work from each ensuing decade. During the 1980s our field began its foundational studies of profiling the neuropsychological deficits associated with AD and its differentiation from other dementias (e.g., cortical vs. subcortical dementias). The 1990s continued these efforts and began to identify the specific cognitive mechanisms affected by various neuropathologic substrates. The 2000s ushered in a focus on the study of prodromal stages of neurodegenerative disease before the full-blown dementia syndrome (i.e., mild cognitive impairment). The current decade has seen the rise of imaging and other biomarkers to characterize preclinical disease before the development of significant cognitive decline. Finally, we suggest future directions and predictions for dementia-related research and potential therapeutic interventions. (JINS, 2017, 23, 818–831)

Copyright

Corresponding author

Correspondence and reprint requests to: Mark W. Bondi, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0603V. E-mail: mbondi@ucsd.edu

References

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Albert, M.L., Feldman, R.G., & Willis, A.L. (1974). The ‘subcortical dementia’ of progressive supranuclear palsy. Journal of Neurology, Neurosurgery, and Psychiatry, 37, 121130.
Albert, M.S., DeKosky, S.T., Dickson, D., Dubois, B., Feldman, H.H., Fox, N.C., & Phelps, C.H. (2011). The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimer’s & Dementia, 7, 270279.
Alzheimer, A. (1907). über eine eigenartige Erkankung der Hirnrinde. Allgemeine Zeitschrift fur Psychiatrie under Psychisch-Gerichtliche Medizin, 64, 146148.
Alzheimer, A. (1911). Über eigenartige Krankheitsfälle des späteren Alters. Zeitschrift für die Gesamte Neurologie und Psychiatrie, 4, 356385.
American Psychiatric Association. (1968). Diagnostic and Statistical Manual of Mental Disorders (2nd Ed). Washington, DC: American Psychiatric Association.
American Psychiatric Association. (1980). Task force on nomenclature and statistics. Diagnostic and statistical manual of mental disorders (DSM-III). Washington, DC: American Psychiatric Association.
Baddeley, A.D., Bressi, S., Della Sala, S., Logie, R., & Spinnler, H. (1991). The decline of working memory in Alzheimer’s disease: A longitudinal study. Brain, 114, 25212542.
Bateman, R.J., Xiong, C., Benzinger, T.L., Fagan, A.M., Goate, A., Fox, N.C., & Morris, J.C.; Dominantly Inherited Alzheimer Network. (2012). Clinical and biomarker changes in dominantly inherited Alzheimer’s disease. The New England Journal of Medicine, 367, 795804.
Bird, T.D. (1999). Clinical genetics of familial Alzheimer’s disease. In R.D. Terry, R. Katzman, K.L. Bick & S.S. Sisodia (Eds.), Alzheimer disease (pp. 5766). Philadelphia: Lippincott Williams & Wilkens.
Blessed, G., Tomlinson, B., & Roth, M. (1968). The association between quantitative measures of dementia and of senile changes in the cerebral grey matter of elderly subjects. British Journal of Psychiatry, 114, 797811.
Bondi, M.W., Edmonds, E.C., Jak, A.J., Clark, L.R., Delano-Wood, L., McDonald, C.R., & Salmon, D.P. (2014). Neuropsychological criteria for mild cognitive impairment improves diagnostic precision, biomarker associations, and prediction of progression. Journal of Alzheimer’s Disease, 42, 275289.
Bondi, M.W., Monsch, A.U., Butters, N., Salmon, D.P., & Paulsen, J.S. (1993). Utility of a modified version of the Wisconsin Card Sorting Test in the detection of dementia of the Alzheimer type. Clinical Neuropsychologist, 7, 161170.
Bondi, M.W., Monsch, A.U., Galasko, D., Butters, N., Salmon, D.P., & Delis, D.C. (1994). Preclinical cognitive markers of dementia of the Alzheimer’s type. Neuropsychology, 8, 374384.
Bondi, M.W., Salmon, D.P., Galasko, D., Thomas, R.G., & Thal, L.J. (1999). Neuropsychological function and apolipoprotein E qgenotype in the preclinical detection of Alzheimer’s disease. Psychology and Aging, 14, 295303.
Bondi, M.W., Salmon, D.P., Monsch, A.U., Galasko, D., Butters, N., Klauber, M.R., & Saitoh, T. (1995). Episodic memory changes are associated with the ApoE-ε4 allele in nondemented older adults. Neurology, 45, 22032206.
Braak, H., & Braak, E. (1991). Neuropathological staging of Alzheimer-related changes. Acta Neuropathologica, 82, 239259.
Braak, H., & Del Tredici, K. (2014). Are cases with tau pathology occurring in the absence of Aβ deposits part of the AD-related pathological process? Acta Neuropathologica, 128, 767772.
Braak, H., & Del Tredici, K. (2015). The preclinical phase of the pathological process underlying sporadic Alzheimer’s disease. Brain, 138, 28142833.
Braak, H., Thal, D.R., Ghebremedhin, E., & Del Tredici, K. (2011). Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years. Journal of Neuropathology & Experimental Neurology, 70, 960969.
Braak, H., Zetterberg, H., Del Tredici, K., & Blennow, K. (2013). Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-β changes occur before increases of tau in cerebrospinal fluid. Acta Neuropathologica, 126, 631641.
Brosch, J.R., Farlow, M.R., Risacher, S.L., & Apostolova, L.G. (2017). Tau imaging in Alzheimer’s disease diagnosis and clinical trials. Neurotherapeutics, 14, 6268.
Buschke, H., Sliwinski, M.J., Kuslansky, G., & Lipton, R.B. (1997). Diagnosis of early dementia by the double memory test. Neurology, 48, 989997.
Butters, N., Granholm, E., Salmon, D.P., Grant, I., & Wolfe, J. (1987). Episodic and semantic memory: A comparison of amnesic and demented patients. Journal of Clinical and Experimental Neuropsychology, 9, 479497.
Caine, D. (2004). Posterior cortical atrophy: a review of the literature. Neurocase, 10, 382385.
Chertkow, H., & Bub, D. (1990). Semantic memory loss in dementia of Alzheimer’s type. Brain, 113, 397417.
Clark, L.R., Delano-Wood, L., Libon, D.J., McDonald, C.R., Nation, D.A., Bangen, K.J., & Bondi, M.W. (2013). Are empirically derived subtypes of mild cognitive impairment consistent with conventional subtypes? Journal of the International Neuropsychological Society, 19, 635645.
Collette, F., Van der Linden, M., Bechet, S., & Salmon, E. (1999). Phonological loop and central executive functioning in Alzheimer’s disease. Neuropsychologia, 37, 905918.
Crary, J.F., Trojanowski, J.Q., Schneider, J.A., Abisambra, J.F., Abner, E.L., Alafuzoff, I., & Nelson, P.T. (2014). Primary age-related tauopathy (PART): A common pathology associated with human aging. Acta Neuropathologica, 128, 755766.
Cronin-Golomb, A., & Amick, M. (2001). Spatial abilities in aging, Alzheimer’s disease, and Parkinson’s disease. In F. Boller & S.F. Cappa (Eds.), Handbook of Neuropsychology. Aging and dementia (2nd, ed.), Vol. 6., pp. 119143). Amsterdam: Elsevier.
Cummings, J.L. (1990). Subcortical dementia. New York: Oxford University Press.
Cummings, J.L., & Benson, D.F. (1992). Dementia: A clinical approach. Boston: Butterworth-Heinemann.
Cummings, J.L., Morstorf, T., & Zhong, K. (2014). Alzheimer’s disease drug-development pipeline: few candidates, frequent failures. Alzheimer’s Research & Therapy, 6, 37.
Delis, D.C., Massman, P.J., Butters, N., Salmon, D.P., Cermak, L.S., & Kramer, J.H. (1991). Profiles of demented and amnesic patients on the California verbal learning test: Implications for the assessment of memory disorders. Psychological Assessment, 3, 1926.
Drachman, D.A. (2014). The amyloid hypothesis, time to move on: Amyloid is the downstream result, not cause, of Alzheimer’s disease. Alzheimer’s & Dementia, 10, 372380.
Edmonds, E.C., Delano-Wood, L., Clark, L.R., Jak, A.J., Nation, D.A., McDonald, C.R., & Bondi, M.W. (2015). Susceptibility of the conventional criteria for mild cognitive impairment to false-positive diagnostic errors. Alzheimer’s & Dementia, 11, 415424.
Edmonds, E.C., Delano-Wood, L., Galasko, D.R., Salmon, D.P., & Bondi, M.W. (2015). Subtle cognitive decline and biomarker staging in preclinical Alzheimer’s disease. Journal of Alzheimer’s Disease, 47, 231242.
Edmonds, E.C., Eppig, J., Bondi, M.W., Leyden, K.M., Goodwin, B., Delano-Wood, L., & McDonald, C.R. (2016). Heterogeneous cortical atrophy patterns not captured by conventional diagnostic criteria. Neurology, 87, 21082116.
Folstein, M.F., Folstein, S.E., & McHugh, P.R. (1975). “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189198.
Frisoni, G.B., Fox, N.C., Jack, C.R. Jr., Scheltens, P., & Thompson, P.M. (2010). The clinical use of structural MRI in Alzheimer’s disease. Nature Reviews Neurology, 6, 6777.
Gomar, J.J., Conejero-Goldberg, C., Davies, P., & Goldberg, T.E., Alzheimer’s Disease Neuroimaging Initiative. (2014). Extension and refinement of the predictive value of different classes of markers in ADNI: Four-year follow-up data. Alzheimer’s & Dementia, 10, 704712.
Gorno-Tempini, M.L., Dronkers, N.F., Rankin, K.P., Ogar, J.M., Phengrasamy, L., Rosen, H.J., & Miller, B.L. (2004). Cognition and anatomy in three variants of primary progressive aphasia. Annals of Neurology, 55, 335346.
Gorno-Tempini, M.L., Hillis, A.E., Weintraub, S., Kertesz, A., Mendez, M., Cappa, S.F., & Grossman, M. (2011). Classification of primary progressive aphasia and its variants. Neurology, 76, 10061014.
Gottesman, I.I. (2001). Psychopathology through a life span-genetic prism. American Psychologist, 56, 867878.
Heister, D., Brewer, J.B., Magda, S., Blennow, K., & McEvoy, L.K., Alzheimer’s Disease Neuroimaging Initiative. (2011). Predicting MCI outcome with clinically available MRI and CSF biomarkers. Neurology, 77, 16191628.
Hodges, J.R., & Patterson, K. (1995). Is semantic memory consistently impaired early in the course of Alzheimer’s disease? Neuroanatomical and diagnostic implications. Neuropsychologia, 33, 441459.
Hodges, J.R., Salmon, D.P., & Butters, N. (1992). Semantic memory impairment in Alzheimer’s disease: Failure of access or degraded knowledge? Neuropsychologia, 30, 301314.
Hof, P.R., Vogt, B.A., Bouras, C., & Morrison, J.H. (1997). Atypical form of Alzheimer’s disease with prominent posterior cortical atrophy: A review of lesion distribution and circuit disconnection in cortical visual pathways. Vision Research, 37, 36093625.
Huber, S.J., Shuttleworth, E.C., Paulson, G.W., Bellchambers, M.J., & Clapp, L.E. (1986). Cortical vs subcortical dementia. Neuropsychological differences. Archives of Neurology, 43, 392394.
Hyman, B.T., Damasio, A.R., Van Hoesen, G.W., & Barnes, C.L. (1984). Alzheimer’s disease: cell specific pathology isolates the hippocampal formation. Science, 225, 11681170.
Iba, M., McBride, J.D., Guo, J.L., Zhang, B., Trojanowski, J.Q., & Lee, V.M.Y. (2015). Tau pathology spread in PS19 tau transgenic mice following locus coeruleus (LC) injections of synthetic tau fibrils is determined by the LC’s afferent and efferent connections. Acta Neuropathologica, 130, 349362.
Jack, C.R. Jr., Bennett, D.A., Blennow, K., Carrillo, M.C., Feldman, H.H., Frisoni, G.B., & Dubois, B. (2016). A/T/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers. Neurology, 87, 539–347.
Jack, C.R. Jr., Knopman, D.S., Chetelat, G., Dickson, D., Fagan, A.M., Frisoni, G.B., & Vos, S.J.B. (2016). Suspected non-Alzheimer disease pathophysiology – Concept and controversy. Nature Reviews Neurology, 12, 117124.
Jack, C.R. Jr., Knopman, D.S., Jagust, W.J., Petersen, R.C., Weiner, M.W., Aisen, P.S., & Trojanowski, J.Q. (2013). Tracking pathophysiological processes in Alzheimer’s disease: an updated hypothetical model of dynamic biomarkers. Lancet Neurology, 12, 207216.
Jack, C.R. Jr., Knopman, D.S., Jagust, W.J., Shaw, L.M., Aisen, P.S., & Weiner, M.W. (2010). Hypothetical model of dynamic biomarkers of the Alzheimer’s pathological cascade. Lancet Neurology, 9, 119128.
Jacobs, D., Salmon, D.P., Tröster, A.I., & Butters, N. (1990). Intrusion errors in the figural memory of patients with Alzheimer’s and Huntington’s disease. Archives of Clinical Neuropsychology, 5, 4957.
Jak, A.J., Bondi, M.W., Delano-Wood, L., Wierenga, C., Corey-Bloom, J., Salmon, D.P., & Delis, D.C. (2009). Quantification of five neuropsychological approaches to defining mild cognitive impairment. American Journal of Geriatric Psychiatry, 17, 368375.
Jedynak, B.M., Lang, A., Liu, B., Katz, E., Zhang, Y., & Wyman, B.T., … Alzheimer’s Disease Neuroimaging Initiative. (2012). A computational neurodegenerative disease progression score: Method and results with the ADNI cohort. NeuroImage, 63, 14781486.
Jessen, F., Amariglio, R.E., van Boxtel, M., Breteler, M., Ceccaldi, M., & Chételat, G., . . . Subjective Cognitive Decline Initiative (SCD-I) Working Group. (2014). A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer’s disease. Alzheimer’s & Dementia, 10, 844852.
Johnson, J.K., Head, E., Kim, R., Starr, A., & Cotman, C.W. (1999). Clinical and pathological evidence for a frontal variant of Alzheimer disease. Archives of Neurology, 56, 12331239.
Katzman, R. (1976). The prevalence and malignancy of Alzheimer disease: A major killer. Archives of Neurology, 33, 217218.
Katzman, R., & Kawas, C. (1994). The epidemiology of dementia and Alzheimer disease. In R.D. Terry, R. Katzman & K.L. Bick (Eds.), Alzheimer disease (pp. 105122). New York: Raven Press.
Knopman, D.S., Jack, C.R. Jr., Wiste, H.J., Weigand, S.D., Vemuri, P., Lowe, V.J., & Petersen, R.C. (2013). Brain injury biomarkers are not dependent on β-amyloid in normal elderly. Annals of Neurology, 73, 472480.
Kraepelin, E. (1910). Psychiatrie: Ein Lehrbuch fur studierende und artzte. In Kraepelin E. (Ed), Handbook of psychiatry (8th ed., pp. 593632). Leipzig: Barth.
Lefleche, G., & Albert, M.S. (1995). Executive function deficits in mild Alzheimer’s disease. Neuropsychology, 9, 313320.
Landau, S.M., Harvey, D., Madison, C.M., Reiman, E.M., Foster, N.L., Aisen, P.S., … Alzheimer’s Disease Neuroimaging Initiative. (2010). Comparing predictors of conversion and decline in mild cognitive impairment. Neurology, 75, 230238.
La Rue, A., Matsuyama, S.S., McPherson, S., Sherman, J., & Jarvik, L.F. (1992). Cognitive performance in relatives of patients with probable Alzheimer disease: An age at onset effect? Journal of Clinical and Experimental Neuropsychology, 14, 533538.
Mahandra, B. (1984). Dementia: A survey of the syndrome of dementia. Lancaster, England: MTP.
Mathis, C.A., Wang, Y., Holt, D.P., Huang, G.-F., Debnath, M.L., & Klunk, W.E. (2003). Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents. Journal of Medicinal Chemistry, 46, 27402754.
Maurer, K., & Maurer, U. (2003). Alzheimer: The life of a physician and career of a disease. New York: Columbia University Press.
McHugh, P.R., & Folstein, M.F. (1975). Psychiatric symptoms of Huntington’s chorea: A clinical and phenomenologic study. In D.F. Benson & D. Blumer (Eds.), Psychiatric aspects of neurological disease (pp. 267285). New York: Raven Press.
McKeith, I.G., Boeve, B.F., Dickson, D.W., Halliday, G., Taylor, J.P., Weintraub, D., & Kosaka, K. (2017). Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium. Neurology, 89, 88100.
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, M. (1984). Clinical diagnosis of Alzheimer’s disease: report of the NINCD-ADRDA work group. Neurology, 34, 939944.
McKhann, G.M., Knopman, D.S., Chertkow, H., Hyman, B.T., Jack, C.R. Jr., Kawas, C.H., & Phelps, C.H. (2011). The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging – Alzheimer’s Association workgroup. Alzheimer’s & Dementia, 7, 263269.
Mendez, M.F., Ghajarania, M., & Perryman, K.M. (2002). Posterior cortical atrophy: Clinical characteristics and differences compared to Alzheimer’s disease. Dementia and Geriatric Cognitive Disorders, 14, 3340.
Mesulam, M., Wicklund, A., Johnson, N., Rogalski, E., Leger, G.C., Rademaker, A., & Bigio, E.H. (2008). Alzheimer and frontotemporal pathology in subsets of primary progressive aphasia. Annals of Neurology, 63, 709719.
Miller, E. (1971). On the nature of the memory disorder in presenile dementia. Neuropsychologia, 9, 7581.
Miller, E. (1973). Short- and long-term memory in patients with presenile dementia (Alzheimer’s disease). Psychological Medicine, 3, 221224.
Miller, E. (1975). Impaired recall and the memory disturbance in presenile dementia. British Journal of Social and Clinical Psychology, 14, 7379.
Miller, E. (1978). Retrieval from long-term memory in presenile dementia: two tests of an hypothesis. British Journal of Social and Clinical Psychology, 17, 143148.
Musiek, E.S., & Holtzman, D.M. (2015). Three dimensions of the amyloid hypothesis: Time, space and ‘wingmen’. Nature Neuroscience, 18, 800806.
Nebes, R. (1989). Semantic memory in Alzheimer’s disease. Psychological Bulletin, 106, 377394.
Nelson, P.T., Head, E., Schmitt, F.A., Davis, P.R., Neitner, J.H., Jicha, G.A., & Scheff, S.W. (2011). Alzheimer’s disease is not “brain aging”: Neuropathological, genetic, and epidemiological human studies. Acta Neuropathologica, 121, 571587.
Nestor, P.J., Caine, D., Fryer, T.D., Clarke, J., & Hodges, J.R. (2003). The topography of metabolic deficits in posterior cortical atrophy (the visual variant of Alzheimer’s disease) with FDG-PET. Journal of Neurology, Neurosurgery, and Psychiatry, 74, 15211529.
Norton, L.E., Bondi, M.W., Salmon, D.P., & Goodglass, H. (1997). Deterioration of generic knowledge in patients with Alzheimer’s disease: Evidence from the Number Information Test. Journal of Clinical and Experimental Neuropsychology, 19, 857866.
Parasuraman, R., & Haxby, J.V. (1993). Attention and brain function in Alzheimer’s disease. Neuropsychology, 7, 242272.
Perry, R.J., & Hodges, J.R. (1999). Attention and executive deficits in Alzheimer’s disease: A critical review. Brain, 122, 383404.
Petersen, R.C. (2009). Early diagnosis of Alzheimer disease: Is MCI too late? Current Alzheimer Research, 6, 324330.
Petersen, R.C. (2004). Mild cognitive impairment as a diagnostic entity. Journal of Internal Medicine, 256, 183194.
Petersen, R.C., Knopman, D.S., Boeve, B.F., Geda, Y.E., Ivnik, R.J., Smith, G.E., & Jack, C.R. Jr. (2009). Mild cognitive impairment: Ten years later. Archives of Neurology, 66, 14471455.
Petersen, R.C., & Morris, J.C. (2005). Mild cognitive impairment as a clinical entity and treatment target. Archives of Neurology, 62, 11601163.
Petersen, R.C., Smith, G.E., Ivnik, R.J., Tangalos, E.G., Schaid, D.J., Thibodeau, S.N., & Kurland, L.T. (1995). Apolipoprotein E status as a predictor of the development of Alzheimer’s disease in memory-impaired individuals. Journal of the American Medical Association, 273, 12741278.
Petersen, R.C., Smith, G.E., Waring, S.C., Ivnik, R.J., Tangalos, E.G., & Kokmen, E. (1999). Mild cognitive impairment: Clinical characterization and outcome. Archives of Neurology, 56, 303308.
Petersen, R.C., Thomas, R.G., Grundman, M., Bennett, D., Doody, R., Ferris, S., & Thal, L.J. (2005). Vitamin E and donepezil for the treatment of mild cognitive impairment. New England Journal of Medicine, 352, 23792388.
Rascovsky, K., Hodges, J.R., Knopman, D., Mendez, M.F., Kramer, J.H., Neuhaus, J., & Miller, B.L. (2011). Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain, 134, 24562477.
Rascovsky, K., Salmon, D.P., Hansen, L.A., Thal, L.J., & Galasko, D. (2007). Disparate phonemic and semantic fluency deficits in autopsy-confirmed frontotemporal dementia and Alzheimer’s disease. Neuropsychology, 21, 2030.
Rathore, S., Habes, M., Iftikhar, M.A., Shacklett, A., & Davatzikos, C. (2017). A review on neuroimaging-based classification studies and associated feature extraction methods for Alzheimer’s disease and its prodromal stages. NeuroImage, 155, 530548.
Reed, T., Carmelli, D., Swan, G.E., Breitner, J.C.S., Welsh, K.A., Jarvik, G.P., & Auwerx, J. (1994). Lower cognitive performance in normal older adult male twins carrying the apolipoprotein E ε4 allele. Archives of Neurology, 51, 11891192.
Renner, J.A., Burns, J.M., Hou, C.E., McKeel, D.W. Jr., Storandt, M., & Morris, J.C. (2004). Progressive posterior cortical dysfunction: a clinicopathologic series. Neurology, 63, 11751180.
Richard, E., Schmand, B.A., Eikelenboom, P., & Van Gool, W.A., Alzheimer’s Disease Neuroimaging Initiative. (2013). MRI and cerebrospinal fluid biomarkers for predicting progression to Alzheimer’s disease in patients with mild cognitive impairment: a diagnostic accuracy study. BMJ Open, 3, e002541.
Rosser, A., & Hodges, J.R. (1994). Initial letter and semantic category fluency in Alzheimer’s disease, Huntington’s disease, and progressive supranuclear palsy. Journal of Neurology, Neurosurgery, and Psychiatry, 57, 13891394.
Rouleau, I., Salmon, D.P., Butters, N., Kennedy, C., & McGuire, K. (1992). Quantitative and qualitative analyses of clock drawings in Alzheimer’s and Huntington’s disease. Brain and Cognition, 18, 7087.
Ryan, N.S., Keihaninejad, S., Shakespeare, T.J., Lehmann, M., Crutch, S.J., Malone, I.B., & Fox, N.C. (2013). Magnetic resonance imaging evidence for presymptomatic change in thalamus and caudate in familial Alzheimer’s disease. Brain, 136, 13991414.
Salmon, D.P., & Bondi, M.W. (2009). Neuropsychological assessment of dementia. Annual Review of Psychology, 60, 257282.
Salmon, D.P., Heindel, W.C., & Lange, K.L. (1999). Differential decline in word generation from phonemic and semantic categories during the course of Alzheimer’s disease: Implications for the integrity of semantic memory. Journal of the International Neuropsychological Society, 5, 692703.
Salmon, D.P., Kwo-on-Yuen, P.F., Heindel, W., Butters, N., & Thal, L.J. (1989). Differentiation of Alzheimer’s disease and Huntington’s disease with the Dementia Rating Scale. Archives of Neurology, 46, 12041208.
Salmon, D.P., Thomas, R.G., Pay, M.M., Booth, A., Hofstetter, C.R., Thal, L.J., & Kaltzman, R. (2002). Alzheimer’s disease can be accurately diagnosed in very mildly impaired individuals. Neurology, 59, 10221028.
Sheline, Y.I., Morris, J.C., Snyder, A.Z., Price, J.L., Yan, Z., D’Angelo, G., & Mintun, M.A. (2010). APOE4 allele disrupts resting state fMRI connectivity in the absence of amyloid plaques or decreased CSF Aβ42. Journal of Neuroscience, 30, 1703517040.
Sims, R., & Williams, J. (2016). Defining the genetic architecture of Alzheimer’s disease: Where next? Neurodegenerative Diseases, 16, 611.
Small, B.J., Fratiglioni, L., Viitanen, M., Winblad, B., & Bäckman, L. (2000). The course of cognitive impairment in preclinical Alzheimer disease: three- and six-year follow-up of a population based sample. Archives of Neurology, 57, 839844.
Smith, G.E., & Bondi, M.W. (2013). Mild cognitive impairment and dementia: Definitions, diagnosis, and treatment. New York: Oxford University Press.
Snowdon, D.A., Kemper, S.J., Mortimer, J.A., Greiner, L.H., Wekstein, D.R., & Markesbery, W.R. (1996). Linguistic ability in early life and cognitive function and Alzheimer’s disease in late life. Findings from the Nun Study. Journal of the American Medical Association, 275, 528532.
Sperling, R.A., Aisen, P.S., Beckett, L.A., Bennett, D.A., Craft, S., Fagan, A.M., & Phelps, C.H. (2011). Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimer’s & Dementia, 7, 280292.
Squire, L.R. (1987). Memory and brain. New York: Oxford University Press.
Stelzmann, R.A., Schnitzlein, N., & Murtagh, F.R. (1995). An English translation of Alzheimer’s paper, “über eine eigenartige Erkankung der Hirnrinde.”. Clinical Anatomy, 8, 429431.
Storandt, M., Botwinick, J., Danziger, W.L., Berg, L., & Hughes, C.P. (1984). Psychometric differentiation of mild senile dementia of the Alzheimer type. Archives of Neurology, 41, 497499.
Strittmatter, W.J., Saunders, A.M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G.S., & Roses, A.D. (1993). Apolipoprotein-E -- High-avidity binding to B-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America, 90, 96499653.
Tenovuo, O., Kemppainen, N., Aalto, S., Nagren, K., & Rinne, J.O. (2008). Posterior cortical atrophy: A rare form of dementia with in vivo evidence of amyloid-beta accumulation. Journal of Alzheimer’s Disease, 15, 351355.
Weiner, M.W., Veitch, D.P., Aisen, P.S., Beckett, L.A., Cairns, N.J., Green, R.C., & Trojanowski, J.Q. (2013). The Alzheimer’s Disease Neuroimaging Initiative: A review of papers published since its inception. Alzheimer’s & Dementia, 9, e111e194.
Winblad, B., Palmer, K., Kivipelto, M., Jelic, V., Fratiglioni, L., Wahlund, L.O., & Petersen, R.C. (2004). Mild cognitive impairment–beyond controversies, towards a consensus: Report of the Inter-national Working Group on Mild Cognitive Impairment. Journal of Internal Medicine, 256, 240246.
Wirth, M., Madison, C.M., Rabinovici, G.D., Oh, H., Landau, S.M., & Jagust, W.J. (2013). Alzheimer’s disease neurodegenerative biomarkers are associated with decreased cognitive function but not β-Amyloid in cognitively normal older individuals. Journal of Neuroscience, 33, 55535563.
World Health Organization. (1992). International Classification of Diseases (10th Edition, Geneva, Switzerland: WHO.

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