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New Intrusion Analyses on the CVLT-3: Utility in Distinguishing the Memory Disorders of Alzheimer’s versus Huntington’s Disease

Published online by Cambridge University Press:  07 May 2019

Lisa V. Graves ,
Heather M. Holden ,
Emily J. Van Etten ,
Lisa Delano-Wood ,
Mark W. Bondi ,
David P. Salmon ,
Jody Corey-Bloom ,
Paul E. Gilbert  and
Dean C. Delis
Lisa V. Graves
Affiliation:
San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, California, USA Department of Psychology, San Diego State University, San Diego, California, USA
Heather M. Holden
Affiliation:
San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, California, USA Department of Psychology, San Diego State University, San Diego, California, USA
Emily J. Van Etten
Affiliation:
Department of Psychology, University of Arizona, Tucson, Arizona, USA
Lisa Delano-Wood
Affiliation:
San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, California, USA Veterans Affairs Healthcare System, San Diego, California, USA Department of Psychiatry, University of California San Diego School of Medicine, La Jolla, California, USA
Mark W. Bondi
Affiliation:
San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, California, USA Veterans Affairs Healthcare System, San Diego, California, USA Department of Psychiatry, University of California San Diego School of Medicine, La Jolla, California, USA
David P. Salmon
Affiliation:
San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, California, USA Department of Neurosciences, University of California San Diego, La Jolla, California, USA
Jody Corey-Bloom
Affiliation:
San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, California, USA Department of Neurosciences, University of California San Diego, La Jolla, California, USA
Paul E. Gilbert*
Affiliation:
San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, California, USA Department of Psychology, San Diego State University, San Diego, California, USA
Dean C. Delis
Affiliation:
San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, California, USA Department of Psychiatry, University of California San Diego School of Medicine, La Jolla, California, USA
*
*Correspondence and reprint requests to: Dr. Paul E. Gilbert, SDSU/UC San Diego Joint Doctoral Program in Clinical Psychology, 6363 Alvarado Court, Suite 103, San Diego, CA, 92120. E-mail: pgilbert@sdsu.edu
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Abstract

Objectives: Research has shown that analyzing intrusion errors generated on verbal learning and memory measures is helpful for distinguishing between the memory disorders associated with Alzheimer’s disease (AD) and other neurological disorders, including Huntington’s disease (HD). Moreover, preliminary evidence suggests that certain clinical populations may be prone to exhibit different types of intrusion errors. Methods: We examined the prevalence of two new California Verbal Learning Test-3 (CVLT-3) intrusion subtypes – across-trial novel intrusions and across/within trial repeated intrusions – in individuals with AD or HD. We hypothesized that the encoding/storage impairment associated with medial-temporal involvement in AD would result in a greater number of novel intrusions on the delayed recall trials of the CVLT-3, whereas the executive dysfunction associated with subcortical-frontal involvement in HD would result in a greater number of repeated intrusions across trials. Results: The AD group generated significantly more across-trial novel intrusions than across/within trial repeated intrusions on the delayed cued-recall trials, whereas the HD group showed the opposite pattern on the delayed free-recall trials. Conclusions: These new intrusion subtypes, combined with traditional memory analyses (e.g., recall versus recognition performance), promise to enhance our ability to distinguish between the memory disorders associated with primarily medial-temporal versus subcortical-frontal involvement.

Keywords

Alzheimer’s diseaseHuntington diseaseMemory disordersVerbal learningMemoryMemory and learning testsNeuropsychological tests
Type
Brief Communication
Information
Journal of the International Neuropsychological Society , Volume 25 , Issue 8 , September 2019 , pp. 878 - 883
Copyright
Copyright © INS. Published by Cambridge University Press, 2019. 

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