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Serum carotenoids and macular pigment optical density in patients with intestinal resections and healthy subjects: an exploratory study

  • Jane N. Eriksen (a1) (a2), August P. Prahm (a3), Mads Krüger Falk (a4), Eva Arrigoni (a2), Palle B. Jeppesen (a3), Michael Larsen (a4) and Lars O. Dragsted (a1)...

Abstract

Reduced absorption capacity in patients with intestinal resections (IR) could result in malabsorption of fat-soluble components like carotenoids, which are of clinical interest in relation to visual health. In this case cohort, we investigated the association between IR and serum lutein, zeaxanthin, β-carotene and macular pigment optical density, when compared with healthy controls. Ten patients with IR and twelve healthy controls were included in the study. Baseline characteristics were comparable between groups, except for higher serum TAG (P < 0·05) and shorter bowel length (P < 0·0001) in the group with IR. Serum lutein, zeaxanthin, β-carotene and macular pigment optical density were >15 % lower in the patient group compared with healthy controls (P < 0·05, adjusted for age) and, in the case of serum lutein and zeaxanthin, also for dietary intake of carotenoids. Results suggest that for a test of macular carotenoid supplementation, subjects with a potentially clinically significant carotenoid deficit could be recruited among patients with IR.

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Copyright

This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.

Corresponding author

* Corresponding author: J. N. Eriksen, email j-n-e@nexs.ku.dk

References

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1. Ma, L, Dou, HL, Wu, YQ, et al. (2012) Lutein and zeaxanthin intake and the risk of age-related macular degeneration: a systematic review and meta-analysis. Br J Nutr 107, 350359.
2. Schmidl, D, Garhofer, G & Schmetterer, L (2015) Nutritional supplements in age-related macular degeneration. Acta Ophthalmol 93, 105121.
3. del Rocío Gómez-García, M & Ochoa-Alejo, N (2013) Biochemistry and molecular biology of carotenoid biosynthesis in chili peppers (Capsicum spp.). Int J Molec Sci 14, 1902519053.
4. Bohn, T, Desmarchelier, C, Dragsted, LO, et al. (2017) Host-related factors explaining interindividual variability of carotenoid bioavailability and tissue concentrations in humans. Mol Nutr Food Res 61, 201600685.
5. Matarese, LE (2012) Nutrition and fluid optimization for patients with short bowel syndrome. J Parenter Enteral Nutr 37, 161170.
6. Moran, R, Johnson, EJ, Stack, E, et al. (2014) The relationship between dietary intake of lutein and zeaxanthin and their concentration in serum: introduction of a novel carotenoid dietary screener. International Carotenoid Symposium 2014, Park City, UT, USA.
7. Eriksen, JN, Madsen, PL, Dragsted, LO, et al. (2017) Optimized, fast-throughput UHPLC-DAD based method for carotenoid quantification in spinach, serum, chylomicrons, and feces. J Agric Food Chem 65, 973980.
8. Geerling, BJ, Badart-Smook, A, Stockbrugger, RW, et al. (2000) Comprehensive nutritional status in recently diagnosed patients with inflammatory bowel disease compared with population controls. Eur J Clin Nutr 54, 514521.
9. Drai, J, Borel, P, Faure, H, et al. (2009) Fasting plasma carotenoids concentrations in Crohn's and pancreatic cancer patients compared to control subjects. Int J Vitam Nutr Res 79, 8794.
10. Renner, AB, Dietrich-Ntoukas, T & Jagle, H (2015) Recurrent episodes of night blindness in a patient with short bowel syndrome. Doc Ophthalmol 131, 221230.
11. da Rocha Lima, B, Pichi, F & Lowder, CY (2014) Night blindness and Crohn's disease. Int Ophthalmol 34, 11411144.
12. Schupp, C, Olano-Martin, E, Gerth, C, et al. (2004) Lutein, zeaxanthin, macular pigment, and visual function in adult cystic fibrosis patients. Am J Clin Nutr 79, 10451052.
13. Shi, AJ, Morrissey, BM, Durbin-Johnson, B, et al. (2014) Macular pigment and macular volume in eyes of patients with cystic fibrosis. Free Radic Res 48, 740748.

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Serum carotenoids and macular pigment optical density in patients with intestinal resections and healthy subjects: an exploratory study

  • Jane N. Eriksen (a1) (a2), August P. Prahm (a3), Mads Krüger Falk (a4), Eva Arrigoni (a2), Palle B. Jeppesen (a3), Michael Larsen (a4) and Lars O. Dragsted (a1)...

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