Skip to main content Accessibility help
×
Home

Sex difference in counts of α4 and α7 nicotinic acetylcholine receptors in the nasal polyps of adults with or without exposure to tobacco smoke

  • B B Montaño-Velázquez (a1), D A Lara-Sánchez (a1), A Orozco-Sánchez (a1), F J García-Vázquez (a2), M R Mora-Campos (a3) and K Jáuregui-Renaud (a4)...

Abstract

Objective

To assess counts of α4 and α7 nicotinic acetylcholine receptors in nasal polyps of adults with or without long-term exposure to cigarette tobacco smoke.

Methods

Twenty-two patients with and 22 patients without exposure to cigarette tobacco smoke participated in the study. After endoscopic polypectomy, the fragments of the nasal polyps were analysed by immunohistochemistry.

Results

Compared to patients with no exposure, patients with exposure showed higher counts of α4 and α7 nicotinic acetylcholine receptors (t-test, p < 0.05). However, in patients with no exposure, multivariate analysis showed gender dimorphism, with lower counts in males than in females, and no influence from other variables (analysis of covariance, p > 0.05).

Conclusion

Exposure to cigarette tobacco smoke may induce increased counts of α4 and α7 nicotinic acetylcholine receptors in nasal polyps of adults, with lower counts in males than females without exposure to tobacco smoke.

Copyright

Corresponding author

Address for correspondence: Dr Kathrine Jáuregui-Renaud, Unidad de Investigación Médica en Otoneurología, PB Edificio C Salud en el Trabajo, Centro Médico Nacional sXXI, IMSS, Av. Cuauhtémoc 330, Colonia Doctores, CP 06720, Ciudad de México, México E-mail: kathrine.jauregui@imss.gob.mx

Footnotes

Hide All

Dr K Jáuregui-Renaud takes responsibility for the integrity of the content of the paper

Footnotes

References

Hide All
1Hulse, KE, Stevens, WW, Tan, BK, Schleimer, RP. Pathogenesis of nasal polyposis. Clin Exp Allergy 2015;45:328–46
2Chen, Y, Dales, R, Lin, M. The epidemiology of chronic rhinosinusitis in Canadians. Laryngoscope 2003;113:1199–205
3Klein, JO. Current issues in upper respiratory tract infections in infants and children: rationale for antibacterial therapy. Pediatr Infect Dis J 1994;13:S59
4Pagliuca, G, Rosato, C, Martellucci, S, De Vincentiis, M, Greco, A, Fusconi, M et al. Cytologic and functional alterations of nasal mucosa in smokers: temporary or permanent damage? Otolaryngol Head Neck Surg 2015;152:740–5
5Sopori, M. Effects of cigarette smoke on the immune system. Nat Rev Immunol 2002;2:372–7
6Keiger, CJ, Case, LD, Kendal-Reed, M, Jones, KR, Drake, AF, Walker, JC. Nicotinic cholinergic receptor expression in the human nasal mucosa. Ann Otol Rhinol Laryngol 2003;112:7784
7Sharma, G, Vijayaraghavan, S. Nicotinic receptor signaling in nonexcitable cells. J Neurobiol 2002;53:524–34
8Wessler, I, Roth, E, Deutsch, C, Brockerhoff, P, Bittinger, F, Kirkpatrick, CJ et al. Release of non-neuronal acetylcholine from the isolated human placenta is mediated by organic cation transporters. Br J Pharmacol 2001;134:951–6
9Kummer, W, Lips, KS, Pfeil, U. The epithelial cholinergic system of the airways. Histochem Cell Biol 2008;130:219–34
10Grando, SA, Kawashima, K, Kirkpatrick, CJ, Wessler, I. Recent progress in understanding the non-neuronal cholinergic system in humans. Life Sci 2007;80:2181–5
11Albuquerque, EX, Pereira, EF, Alkondon, M, Rogers, SW. Mammalian nicotinic acetylcholine receptors: from structure to function. Physiol Rev 2009;89:73120
12Buisson, B, Bertrand, D. Chronic exposure to nicotine upregulates the human α4β2 nicotinic acetylcholine receptor function. J Neurosci 2001;21:1819–29
13Cosgrove, KP, Esterlis, I, McKee, SA, Bois, F, Seibyl, JP, Mazure, CM et al. Sex differences in availability of β2*-nicotinic acetylcholine receptors in recently abstinent tobacco smokers. Arch Gen Psychiatry 2012;69:418–27
14Wang, H, Yu, M, Ochani, M, Amella, CA, Tanovic, M, Susarla, S et al. Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature 2003;421:384–8
15Shin, VY, Wu, WK, Chu, KM, Wong, HP, Lam, EK, Tai, EK et al. Nicotine induces cyclooxygenase-2 and vascular endothelial growth factor receptor-2 in association with tumor-associated invasion and angiogenesis in gastric cancer. Mol Cancer Res 2005;3:607–15
16Maouche, K, Polette, M, Jolly, T, Medjber, K, Cloëz-Tayarani, I, Changeux, JP et al. α7 nicotinic acetylcholine receptor regulates airway epithelium differentiation by controlling basal cell proliferation. Am J Pathol 2009;175:1868–82
17Gahring, LC, Rogers, SW. Neuronal nicotinic acetylcholine receptor expression and function on nonneuronal cells. AAPS J 2006;7:E88594
18Zia, S, Ndoye, A, Nguyen, VT, Grando, SA. Nicotine enhances expression of the alpha 3, alpha 4, alpha 5, and alpha 7 nicotinic receptors modulating calcium metabolism and regulating adhesion and motility of respiratory epithelial cells. Res Commun Mol Pathol Pharmacol 1997;97:243–62
19Tapia-Conyer, R, Medina-Mora, ME, Sepúlveda, J, De la Fuente, R, Kumate, J. The national addictions survey of Mexico [in Spanish]. Salud Publica Mex 1990;32:507–22
20Lund, VJ, Kennedy, DW. Staging for rhinosinusitis. Otolaryngol Head Neck Surg 1997;117:S3540
21Kennedy, DW. Functional endoscopic sinus surgery. Technique. Arch Otolaryngol 1985;111:643–9
22Hosur, V, Leppanen, S, Abutaha, A, Loring, RH. Gene regulation of alpha4beta2 nicotinic receptors: microarray analysis of nicotine-induced receptor up-regulation and anti-inflammatory effects. J Neurochem 2009;111:848–58
23Ansar, AS, Penhale, WJ, Talal, N. Sex hormones, immune responses, and autoimmune diseases. Mechanisms of sex hormone action. Am J Pathol 1985;121:531–51
24Bouman, A, Heineman, MJ, Faas, MM. Sex hormones and the immune response in humans. Hum Reprod Update 2005;11:411–23
25Kanda, N, Tamaki, K. Estrogen enhances immunoglobulin production by human PBMCs. J Allergy Clin Immunol 1999;103:282–8
26Kanda, N, Tsuchida, T, Tamaki, K. Testosterone inhibits immunoglobulin production by human peripheral blood mononuclear cells. Clin Exp Immunol 1996;106:410–15
27Collins, MM, Pang, YT, Loughran, S, Wilson, JA. Environmental risk factors and gender in nasal polyposis. Clin Otolaryngol Allied Sci 2002;27:314–17
28Klein, SL. Hormonal and immunological mechanisms mediating sex differences in parasite infection. Parasite Immunol 2004;26:247–64

Keywords

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed