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Sex difference in counts of α4 and α7 nicotinic acetylcholine receptors in the nasal polyps of adults with or without exposure to tobacco smoke

  • B B Montaño-Velázquez (a1), D A Lara-Sánchez (a1), A Orozco-Sánchez (a1), F J García-Vázquez (a2), M R Mora-Campos (a3) and K Jáuregui-Renaud (a4)...



To assess counts of α4 and α7 nicotinic acetylcholine receptors in nasal polyps of adults with or without long-term exposure to cigarette tobacco smoke.


Twenty-two patients with and 22 patients without exposure to cigarette tobacco smoke participated in the study. After endoscopic polypectomy, the fragments of the nasal polyps were analysed by immunohistochemistry.


Compared to patients with no exposure, patients with exposure showed higher counts of α4 and α7 nicotinic acetylcholine receptors (t-test, p < 0.05). However, in patients with no exposure, multivariate analysis showed gender dimorphism, with lower counts in males than in females, and no influence from other variables (analysis of covariance, p > 0.05).


Exposure to cigarette tobacco smoke may induce increased counts of α4 and α7 nicotinic acetylcholine receptors in nasal polyps of adults, with lower counts in males than females without exposure to tobacco smoke.


Corresponding author

Address for correspondence: Dr Kathrine Jáuregui-Renaud, Unidad de Investigación Médica en Otoneurología, PB Edificio C Salud en el Trabajo, Centro Médico Nacional sXXI, IMSS, Av. Cuauhtémoc 330, Colonia Doctores, CP 06720, Ciudad de México, México E-mail:


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Dr K Jáuregui-Renaud takes responsibility for the integrity of the content of the paper



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Sex difference in counts of α4 and α7 nicotinic acetylcholine receptors in the nasal polyps of adults with or without exposure to tobacco smoke

  • B B Montaño-Velázquez (a1), D A Lara-Sánchez (a1), A Orozco-Sánchez (a1), F J García-Vázquez (a2), M R Mora-Campos (a3) and K Jáuregui-Renaud (a4)...


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