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Aspiration pneumonia related deaths in head and neck cancer patients: a retrospective analysis of risk factors from a tertiary care centre in North India

  • R Madan (a1), A K Kairo (a2), A Sharma (a1), S Roy (a1), S Singh (a2), L Singh (a3), J Kaur (a1), B K Mohanti (a1), S Bhasker (a1), A D Upadhyay (a4) and G K Rath (a1)...

Abstract

Background:

Aspiration pneumonia is an important cause of death in head and neck cancer patients. This study therefore aimed to evaluate the risk factors associated with aspiration pneumonia in head and neck cancer patients.

Methods:

Hospital death records from 12 years (2000–2012) were reviewed to obtain the number of deaths. Treatment details and cause of death were analysed. Statistical analysis was performed to identify the risk factors for aspiration pneumonia.

Results:

The records revealed that aspiration pneumonia was the cause of death in 51 out of 85 patients. Primary tumour site (oropharynx and hypopharynx, odds ratio 3.3; 95 per cent confidence interval 1.17–9.4, p = 0.02) and advanced tumour stage (odds ratio 4.2, 95 per cent confidence interval 1.16–15.61, p = 0.02) had significant negative impacts on aspiration pneumonia related mortality.

Conclusion:

Advanced pharyngeal cancer patients are at an increased risk of aspiration pneumonia related death. Investigations for the early detection of this condition are recommended in these high-risk patients.

Copyright

Corresponding author

Address for correspondence: Dr R Madan, Department of Radiotherapy, R. No. 29, Ground floor, Dr BRA, IRCH, All India Institute of Medical Sciences, New Delhi-110029, India E-mail: renumadan10@yahoo.com

Footnotes

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Presented as an oral presentation at the 1st Indian Cancer Congress, 21–24 November 2013, New Delhi, India

Footnotes

References

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1Ferlay, J, Soerjomataram, I, Ervik, M, Dikshit, R, Eser, S, Mathers, C et al. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11. In: http://globocan.iarc.fr/Default.aspx [28 May 2015]
2Mohanti, BK, Nachiappan, P, Pandey, RM, Sharma, A, Bahadur, S, Thakar, A. Analysis of 2167 head and neck cancer patients' management, treatment compliance and outcomes from a regional cancer centre, Delhi, India. J Laryngol Otol 2007;121:4956
3Pignon, JP, le Maître, A, Maillard, E, Bourhis, J; MACH-NC Collaborative Group. Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients. Radiother Oncol 2009;92:414
4Batth, SS, Caudell, JJ, Chen, AM. Practical considerations in reducing swallowing dysfunction following concurrent chemo radiotherapy with intensity-modulated radiotherapy for head and neck cancer. Head Neck 2014;36:291–8
5Nguyen, NP, Frank, C, Moltz, CC, Vos, P, Smith, HJ, Bhamidipati, PV et al. Aspiration rate following chemoradiation for head and neck cancer: an underreported occurrence. Radiother Oncol 2006;80:302–6
6Stenson, KM, Mccracken, E, List, M, Haraf, DJ, Brockstein, B, Weichselbaum, R et al. Swallowing function in head and neck cancer patient prior to treatment. Arch Otolaryngol Head Neck Surg 2000;126:384–9
7Russi, EG, Corvò, R, Merlotti, A, Alterio, D, Franco, P, Pergolizzi, S et al. Swallowing dysfunction in head and neck cancer patients treated by radiotherapy: review and recommendations of the supportive task group of the Italian Association of Radiation Oncology. Cancer Treat Rev 2012;38:1033–49
8Marik, PE. Aspiration pneumonitis and aspiration pneumonia. N Engl J Med. 2001;344:665–71
9Langerman, A, Maccracken, E, Kasza, K, Haraf, DJ, Vokes, EE, Stenson, KM. Aspiration in chemoradiated patients with head and neck cancer. Arch Otolaryngol Head Neck Surg 2007;133:1289–95
10Mortensen, HR, Jensen, K, Grau, C. Aspiration pneumonia in patients treated with radiotherapy for head and neck cancer. Acta Oncol 2013;52:270–6
11Jung, SJ, Kim, DY, Joo, SY. Risk factors associated with aspiration in patients with head and neck cancer. Ann Rehabil Med 2011;35:781–90
12Kotz, T, Costello, R, Li, Y, Posner, MR. Swallowing dysfunction after chemo-radiation for advanced squamous cell carcinoma of the head and neck. Head Neck 2004;26:365–72
13Langmore, SE, Schatz, K, Olson, N. Endoscopic and video-fluoroscopic evaluations of swallowing and aspiration. Ann Otol Rhinol Laryngol 1991;100:678–81
14Smith, RV, Kotz, T, Beitler, JJ, Wadler, S. Long-term swallowing problems after organ preservation therapy with concomitant radiation therapy and intravenous hydroxyurea. Arch Otolaryngol Head Neck Surg 2000;126:384–9
15Nguyen, NP, Smith, HJ, Dutta, S, Alfieri, A, North, D, Nguyen, PD et al. Aspiration occurrence during chemoradiation for head and neck cancer. Anticancer Res 2007;27:1669–72
16Hunter, KU, Lee, OE, Lyden, TH, Haxer, MJ, Feng, FY, Schipper, M, Worden, F, Prince, ME, McLean, SA, Wolf, GT, Bradford, CR, Chepeha, DB, Eisbruch, A. Aspiration pneumonia after chemo-intensity-modulated radiation therapy of oropharyngeal carcinoma and its clinical and dysphagia-related predictors. Head Neck 2014;36:120–5

Keywords

Aspiration pneumonia related deaths in head and neck cancer patients: a retrospective analysis of risk factors from a tertiary care centre in North India

  • R Madan (a1), A K Kairo (a2), A Sharma (a1), S Roy (a1), S Singh (a2), L Singh (a3), J Kaur (a1), B K Mohanti (a1), S Bhasker (a1), A D Upadhyay (a4) and G K Rath (a1)...

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