The lower–upper Cenomanian boundaries interval of the Nouader site in the Aures Basin (NE Algeria) has been studied for the first time using the association of two particularly effective taxonomic groups, one macrofossil (ammonites), and the other microfossil (foraminifera). The study section is divided into two formations (Fahdene and Bahloul) and one member (Annaba). Biostratigraphicaly, six ammonite biozones and five foraminiferan biozones were identified and calibrated. The ammonite fauna allows recognition of the lower Cenomanian Mantelliceras mantelli Zone, the upper lower Cenomanian Mantelliceras dixoni Zone, the succeeding lower middle Cenomanian Cunningtoniceras inerme Zone, the Acanthoceras rhotomagense Zone and its subzones of Turrilites costatus and Turrilites acutus, followed by the upper middle Cenomanian Acanthoceras amphibolum Zone, the lower upper Cenomanian Eucalycoceras pentagonum Zone and finally the lower Turonian Pseudaspidoceras flexuosum Zone. The foraminiferan biozones are respectively: Thalmanninella brotzeni Zone, Thalmanninella reicheli Zone, Rotalipora cushmani Zone, Whiteinella archaeocretacea Zone and Helvetoglobotruncana helvetica Zone. Among 14 ammonite zones in the Tethyan domain versus 11 in the Boreal domain, seven are common to both domains. For the planktonic foraminifera the Tethyan domain has five zones, the Boreal domain also has five, with five in common. The succession of index species occurs in the same order in both Tethyan (NE Algeria and Central Tunisia) and Boreal realms (East and NW Europe). Furthermore, the supposed depositional setting is interpreted as a calm and relatively deep environment which can be located around the middle to the external platform.