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Nucleotide sequence analysis of class II genes borne by mouse t chromosomes

Published online by Cambridge University Press:  14 April 2009

M. Golubić ,
O. Budimir ,
R. Schoepfer ,
M. Kasahara ,
W. E. Mayer ,
F. Figueroa  and
J. Klein
M. Golubić
Affiliation:
Max-Planck-Institui für Biologie, Abteilung Immungenetik, Corrensstrasse 42, D-7400 Tübingen, F.R.G.
O. Budimir
Affiliation:
Max-Planck-Institui für Biologie, Abteilung Immungenetik, Corrensstrasse 42, D-7400 Tübingen, F.R.G.
R. Schoepfer
Affiliation:
Max-Planck-Institui für Biologie, Abteilung Immungenetik, Corrensstrasse 42, D-7400 Tübingen, F.R.G.
M. Kasahara
Affiliation:
Max-Planck-Institui für Biologie, Abteilung Immungenetik, Corrensstrasse 42, D-7400 Tübingen, F.R.G.
W. E. Mayer
Affiliation:
Max-Planck-Institui für Biologie, Abteilung Immungenetik, Corrensstrasse 42, D-7400 Tübingen, F.R.G.
F. Figueroa
Affiliation:
Max-Planck-Institui für Biologie, Abteilung Immungenetik, Corrensstrasse 42, D-7400 Tübingen, F.R.G.
J. Klein*
Affiliation:
Max-Planck-Institui für Biologie, Abteilung Immungenetik, Corrensstrasse 42, D-7400 Tübingen, F.R.G.
*
†Corresponding author.

Summary

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Five class II H-2 genes borne by t chromosomes were partially sequenced: borne by the tTuw10 chromosome of EDY589 (H-2w2); and borne by the tTuw8 chromosome of CR0437 (H-2w57), as well as and borne by the tTuw7 chromosome of CR0435 (H-2w37). These genes are representatives of the three major groups of alleles found associated with t chromosomes. The sequenced part consisted of almost the entire exon 2 and the entire exon 3 coding for the first and the second domain of the β polypeptide chains, respectively. The sequence was compared with the published sequences of Aβ and Eβ alleles borne, by non-t chromosomes. The comparison revealed that the t-associated alleles are no more similar to one another than they are to the corresponding genes present on non-t chromosomes in laboratory mice. This divergence in the nucleotide sequence among the class II genes is interpreted as evidence that the t complex is very old.

Type
Research Article
Information
Genetics Research , Volume 50 , Issue 2 , October 1987 , pp. 137 - 146
Copyright
Copyright © Cambridge University Press 1987

References

Artzt, K., Shin, H.-S. & Bennett, D. (1982). Gene mapping within the T/t complex of the mouse. II. Anomalous position of the H-2 complex. Cell 28, 471–476.CrossRefGoogle Scholar
Artzt, K., Shin, H.-S., Bennett, D. & Dimeo-Talento, A. (1985). Analysis of major histocompatibility complex haplotypes of t-chromosomes reveals that the majority of diversity is generated by recombination. Journal of Experimental Medicine 162, 93–104.CrossRefGoogle ScholarPubMed
Ayane, M., Klein, D., Margetić, E., Figueroa, F. & Klein, J. (1987). Neuraminidase-1 variation among mice carrying t chromosomes. Immunogenetics (in press).CrossRefGoogle Scholar
Choi, E., McIntyre, K., Germain, R. N. & Seidman, J. G. (1983). Murine I–Aβ chain polymorphism: Nucleotide sequences of three allelic I–Aβ genes. Science 221, 283–286.CrossRefGoogle Scholar
Dembić, Z., Singer, P. A. & Klein, J. (1984). E°: a history of mutation. The EMBO Journal 3, 1647–1654.CrossRefGoogle Scholar
Dunn, L. C. (1955). Widespread distribution of mutant alleles (t-alleles) in populations of wild house mice. Nature 176, 1275–1276.CrossRefGoogle ScholarPubMed
Dunn, L. C., Beasley, & Tinker, H. (1960). Polymorphism in populations of wild house mice. Journal of Mammalogy 41, 220–229.CrossRefGoogle Scholar
Estess, P., Begovich, A. B., Koo, M., Jones, P. P. & McDevitt, H. O. (1986). Sequence analysis and structure-function correlations of murine q, k, u, s, and f haplotype I–Aβ cDNA clones. Proceedings of the National Academy of Sciences USA 83, 3594–3598.CrossRefGoogle Scholar
Figueroa, F., Golubić, M., Nizetić, D. & Klein, J. (1985). Evolution of mouse major histocompatibility complex genes borne by t chromosomes. Proceedings of the National Academy of Sciences USA 82, 2819–2823.CrossRefGoogle ScholarPubMed
Fox, M., Martin, G., Lyon, M. F., Herrmann, B., Frischauf, A.-M., Lehrach, H. & Silver, L. M. (1985). Molecular probes define different regions of the mouse t complex. Cell 40, 63–69.CrossRefGoogle ScholarPubMed
Frischauf, A. M., Garroff, H., Lehrach, H. (1980). A subcloning strategy for DNA sequence analysis. Nucleic Acids Research 8, 5541–5549.CrossRefGoogle ScholarPubMed
Golubić, M., Figueroa, F., Tosi, M. & Klein, J. (1985). Restriction fragment length polymorphism of C4 genes in mice with t-chromosomes. Immunogenetics 21, 247–256.CrossRefGoogle ScholarPubMed
Hammerberg, C. & Klein, J. (1975). Linkage disequilibrium between H-2 and t complexes in chromosome 17 of the mouse. Nature 258, 296–299.CrossRefGoogle Scholar
Herrmann, B., Bućan, M., Mains, P. E., Frischauf, A.-M., Silver, L. M. & Lehrach, H. (1986). Genetic analysis of the proximal portion of the mouse t complex: evidence for a second inversion within t haplotypes. Cell 44, 469–476.CrossRefGoogle Scholar
Jones, P. P., Murphy, D. B. & McDevitt, H. O. (1978). Two-gene control of the expression of a murine la antigen. Journal of Experimental Medicine 148, 925–939.CrossRefGoogle Scholar
Klein, J. (1980). Generation of diversity at MHC loci: Implications for T cell receptor repertoires. In Immunology 80 (ed. Fougereau, M. and Dausset, J.), pp. 239–253. London: Academic Press.Google Scholar
Klein, J. (1986). Natural History of the Major Histocompatibility Complex, pp. 683–795. New York: Wiley.Google Scholar
Klein, J. & Figueroa, F. (1986). Evolution of the Major Histocompatibility Complex. CRC Immunology. 6, 295–386.Google ScholarPubMed
Klein, J. & Hammerberg, C. (1977). The control of differentiation by the T-complex. Immunological Reviews 33, 70–104.CrossRefGoogle ScholarPubMed
Klein, J., Sipos, P. & Figueroa, F. (1984). Polymorphism of t-complex genes in European wild mice. Genetical Research 44, 39–46.CrossRefGoogle Scholar
Klein, J., Nizetić, D., Golubić, M., Dembić, Z. & Figueroa, F. (1985). Evolution of H-2 genes on t chromosomes. In Cell Biology of the Major Histocompatibility Complex (ed. Pernis, B. and Vogel, H. J.), pp. 97–106. New York: Academic Press.CrossRefGoogle Scholar
Larhammar, D., Hämmerling, U., Denaro, M., Lund, T., Flavell, R. A., Rask, L. & Peterson, P. A. (1983). Structure of the murine immune response I–Aβ locus: Sequence of the I–Aβ gene and an adjacent β-chain second domain exon. Cell 34, 179–188.CrossRefGoogle Scholar
Lyon, M. F. (1981). The T-complex and the genetical control of development. Symposium of the Zoological Society, London 47, 71–104.Google Scholar
Lyon, M. F. & Phillips, R. J. S. (1959). Crossing-over in mice heterozygous for t-alleles. Heredity 13, 23–32.CrossRefGoogle Scholar
Malissen, M., Hunkapiller, T. & Hood, L. (1983). Nucleotide sequence of a light chain gene of the mouse I–A subregion: . Science 221, 750–754.CrossRefGoogle ScholarPubMed
Maxam, A. M. & Gilbert, W. (1977). A new method for sequencing DNA. Proceedings of the National Academy of Sciences USA 74, 560–564.CrossRefGoogle ScholarPubMed
Mengle-Gaw, L. & McDevitt, H. O. (1983). Isolation and characterization of a cDNA clone from the murine I–Eβ polypeptide chain. Proceedings of the National Academy of Sciences USA 80, 7621–7625.CrossRefGoogle Scholar
Mengle-Gaw, L. & McDevitt, H. O. (1985). Predicted protein sequence of the murine polypeptide chain from cDNA and genomic clones. Proceedings of the National Academy of Sciences USA 82, 2910–2914.CrossRefGoogle ScholarPubMed
Nadeau, J. (1983). Absence of detectable gametic disequilibrium between the t-complex and linked allozymeencoding loci in house mice. Genetical Research 42, 323–333.CrossRefGoogle ScholarPubMed
Nadeau, J. H. (1986). A glyoxalase-1 variant associated with the t-complex in house mice. Genetics 113, 91–99.CrossRefGoogle ScholarPubMed
Nizetić, D., Figueroa, F. & Klein, J. (1984). Evolutionary relationships between the t and H-2 haplotypes in the house mouse. Immunogenetics 19, 311–320.CrossRefGoogle Scholar
Röhme, D., Fox, H., Herrmann, B., Frischauf, A.-M., Edstrom, J. E., Mains, P., Silver, L. M. & Lehrach, H. (1984). Molecular clones of the mouse t complex derived from microdissected metaphase chromosomes. Cell 36, 783–788.CrossRefGoogle Scholar
Saito, H., Maki, R. A., Clayton, L. J. & Tonegawa, S. (1983). Complete primary structures of the Eβ chain and gene of the mouse major histocompatibility complex. Proceedings of the National Academy of Sciences USA 80, 5520–5524.CrossRefGoogle Scholar
Sanger, F., Nicklen, S. & Coulson, A. R. (1977). DNA sequencing with chain terminating inhibitors. Proceedings of the National Academy of Sciences USA 74, 5463–5467.CrossRefGoogle ScholarPubMed
Shin, H.-S., Starnezer, J., Artzt, K. & Bennett, D. (1982). The genetic structure and origin of t-haplotypes of mice, analysed with H-2 cDNA probes. Cell 29, 969–976.CrossRefGoogle Scholar
Silver, L. M. (1982). Genomic analysis of the H-2 complex region associated with mouse t haplotypes. Cell 29, 961–968.CrossRefGoogle ScholarPubMed
Silver, L. M. (1985). Mouse t haplotypes. Annual Reviews of Genetics 19, 179–208.CrossRefGoogle ScholarPubMed
Silver, L. M., Artzt, K. & Bennett, D. (1979). A major testicular cell protein specified by a mouse T/t complex gene. Cell 17, 275–284.CrossRefGoogle Scholar
Silver, L. M., Uman, J., Danska, J. & Garrels, J. (1983). A diversified set of testicular cell proteins specified by genes within the mouse t complex. Cell 35, 35–45.CrossRefGoogle ScholarPubMed
Silver, L. M., Hammer, M., Fox, H., Garrels, J., Bucan, M., Herrmann, B., Frischauf, A.-M., Lehrach, H., Winking, H., Figueroa, F. & Klein, J. (1986). Molecular evidence that all mouse t haplotypes are descended from a single ancestral chromosome. Molecular Biology and Evolution. (In the Press.)Google Scholar
Steinmetz, M., Minard, K., Horvath, S., McNicholas, J., Frelinger, J., Wake, C., Long, E., Mach, B. & Hood, L. (1982). A molecular map of the immune region from the najor histocompatibility complex of the mouse. Nature 300, 35–42.CrossRefGoogle Scholar
Sturm, S., Figueroa, F. & Klein, J. (1982). The relationship between t and H-2 complexes in wild mice. I. The H-2 haplotypes of 20 t-bearing strains. Genetical Research 40, 73–88.CrossRefGoogle ScholarPubMed
Viera, J. & Messing, J. (1982). The pUC plasmids and M13 mpt derived system for insertion mutagenesis and sequencing with synthetic universal primers. Gene 19, 259–268.CrossRefGoogle Scholar
Widera, G. & Flavell, R. A. (1984). The nucleotide sequence of the murine immune response gene: evidence for gene conversion events in class II genes of the major histocompatibility complex. The EMBO Journal 3, 1221–1225.CrossRefGoogle ScholarPubMed