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Which psychotherapy is effective in panic disorder? Findings and reflections from a systematic network meta-analysis

Published online by Cambridge University Press:  13 August 2021

D. Papola ,
G. Ostuzzi ,
C. Gastaldon ,
M. Purgato ,
C. Del Giovane ,
A. Pompoli ,
E. Karyotaki ,
M. Sijbrandij ,
T. Furukawa  and
P. Cuijpers
...Show all authors
D. Papola*
Affiliation:
Department Of Neuroscience, Biomedicine And Movement Sciences, University of Verona, Verona, Italy
G. Ostuzzi
Affiliation:
Department Of Neuroscience, Biomedicine And Movement Sciences, University of Verona, Verona, Italy
C. Gastaldon
Affiliation:
Neuroscience, Psychological And Psychiatric Science, Science Of Bio Movement, University of Verona, Verona, Italy
M. Purgato
Affiliation:
Department Of Neuroscience, Biomedicine And Movement Sciences, University of Verona, Verona, Italy
C. Del Giovane
Affiliation:
Institute Of Primary Health Care (biham), University of Bern, Bern, Switzerland
A. Pompoli
Affiliation:
-, Psychiatric Rehabilitation Clinic Villa San Pietro, Trento, Italy
E. Karyotaki
Affiliation:
Department Of Clinical, Neuro And Developmental Psychology, Vrije Universiteit, Amsterdam, Netherlands
M. Sijbrandij
Affiliation:
Department Of Clinical, Neuro And Developmental Psychology, Vrije Universiteit, Amsterdam, Netherlands
T. Furukawa
Affiliation:
Departments Of Health Promotion And Human Behavior, Kyoto University, Kyoto, Japan
P. Cuijpers
Affiliation:
Department Of Clinical, Neuro And Developmental Psychology, Vrije Universiteit, Amsterdam, Netherlands
C. Barbui
Affiliation:
Department Of Neuroscience, Biomedicine And Movement Sciences, University of Verona, Verona, Italy
*
*Corresponding author.

Abstract

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Introduction

Panic disorder is among the most prevalent anxiety diseases. Although psychotherapy is recommended as first-line treatment for panic disorder, little is known about the relative efficacy of different types of psychotherapies.

Objectives

To evaluate the effectiveness and acceptability of different types of psychotherapies for adults suffering from panic disorder, with or without agoraphobia.

Methods

We are conducting a systematic network meta-analysis of randomized controlled trials examining panic disorder. A comprehensive search was performed to identify relevant studies. The primary efficacy outcome is anxiety symptoms at study endpoint. The primary acceptability outcome is all-cause trial discontinuation at endpoint. Pairwise and network meta-analysis will be conducted. We are considering any kind of psychotherapy delivered by any therapist, as long as they were trained to deliver the therapy, or as self-help.

Results

To date we have identified 126 panic disorder and agoraphobia trials. The publication time span ranges from 1968 to 2020. We are now extracting data to provide an overview of the included study characteristics. The statistical analysis will be conducted between December 2020 and January 2021, and its results presented for the first time at the forthcoming 2021 EPA congress.

Conclusions

126 trials on psychotherapy for panic disorders in adults are available. Because of this huge body of knowledge, it is important that the results of these studies are summarized using network meta-analytic techniques. The findings of this study will guide future research as knowledge gaps will be easily identified. Moreover, policymakers will have the opportunity to use this summarized knowledge to inform evidence-based decision making.

Disclosure

No significant relationships.

Keywords

network meta-analysispanic disorderpsychotherapy
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S118
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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