Skip to main content Accessibility help
×
Home

A Weak Association of the CLDN5 Locus with Schizophrenia in Chinese Case-control Samples

  • N. Wu (a1), X. Zhang (a1), L. Ye (a1), Q. Xu (a2), S. Jin (a1), Z. Wang (a1), S. Liu (a1), G. Ju (a1), Y. Shen (a2) and J. Wei (a3)...

Abstract

Background:

An increasing number of studies have described the relationship between velo-cardio-facial syndrome (VCFS) and schizophrenia. in a family-based study, we found that rs10314, a single nucleotide polymorphism (SNP) present in the 3’-flanking region of the CLDN5 gene, was associated with schizophrenia among a Chinese population. High false positive rate is a common problem with the association study of human diseases. It is very important to replicate an initial finding with different samples and experimental designs.

Methods:

A total of 749 patients with schizophrenia and 383 age and sex matched healthy control subjects in Chinese population were recruited. PCR-based RFLP protocol was applied to genotype rs10314 to see its disease association.

Results:

The χ2 goodness-of-fit test showed that the genotypic distributions of rs10314 were in Hardy-Weinberg equilibrium in both the patient group (χ2=1.12, P=0.289) and the control group (χ2=0.22, P=0.639). rs10314 was associated with schizophrenia with an odds ratio (OR) of 1.32 in the male subjects (χ2=5.45, P=0.02, 95% CI 1.05-1.67) but not in the female subjects (χ2=0.64, P=0.425, OR=1.14, 95% CI 0.83-1.57). the χ2 test showed a genotypic association only for combined samples (χ2=7.80, df=2, P=0.02). SNP rs10314 is a G to C base change. Frequency of the genotypes containing the C allele was significantly higher in the patient group than in the control group.

Conclusions:

The present work shows that the CLDN5 gene polymorphism is more likely to be involved in schizophrenic men than women, suggesting that this gene may contribute to the gender differences in schizophrenia.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      A Weak Association of the CLDN5 Locus with Schizophrenia in Chinese Case-control Samples
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      A Weak Association of the CLDN5 Locus with Schizophrenia in Chinese Case-control Samples
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      A Weak Association of the CLDN5 Locus with Schizophrenia in Chinese Case-control Samples
      Available formats
      ×

Copyright

A Weak Association of the CLDN5 Locus with Schizophrenia in Chinese Case-control Samples

  • N. Wu (a1), X. Zhang (a1), L. Ye (a1), Q. Xu (a2), S. Jin (a1), Z. Wang (a1), S. Liu (a1), G. Ju (a1), Y. Shen (a2) and J. Wei (a3)...

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed.

A Weak Association of the CLDN5 Locus with Schizophrenia in Chinese Case-control Samples

  • N. Wu (a1), X. Zhang (a1), L. Ye (a1), Q. Xu (a2), S. Jin (a1), Z. Wang (a1), S. Liu (a1), G. Ju (a1), Y. Shen (a2) and J. Wei (a3)...
Submit a response

Comments

No Comments have been published for this article.

×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *