The general objective of the SUPREME project is to promote mental health in adolescents through the development and evaluation of an internet based, multi-language, culturally adapted, mental health promotion and suicide prevention intervention. The intervention will be designed building up on previous work done in the field. Existing interventions will be mapped and reviewed through a literature review and direct search on the Internet. A partnership of experts will be developed in order to ensure the highest quality scientific standards. The intervention will comprise a highly interactive website targeted at adolescents and young adults in the age group 14–24. The intervention will be translated and culturally adapted for all countries participating in the SUPREME project. On the basis of the results guidelines will be issued for best practices in the field of internet and media usage for mental health promotion interventions.