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Variation in the BDNF Val66Met polymorphism and response to cognitive-behavior therapy in obsessive-compulsive disorder

Published online by Cambridge University Press:  15 April 2020

M.A. Fullana ,
P. Alonso ,
M. Gratacòs ,
N. Jaurrieta ,
S. Jiménez-Murcia ,
C. Segalàs ,
E. Real ,
X. Estivill  and
J.M. Menchón
M.A. Fullana*
Affiliation:
Department of Psychological Medicine, Institute of Psychiatry, King's College London, London, United Kingdom Department of Psychiatry, Autonomous University of Barcelona & Anxiety Unit, INAD, Parc de Salut Mar, Barcelona, Spain
P. Alonso
Affiliation:
OCD Clinical and Research Unit, Psychiatry Department, Hospital Universitari de Bellvitge, Barcelona, Spain CIBERSAM (Centro de Investigación en Red de Salud Mental), Instituto de Salud Carlos III., Spain Department of Clinical Sciences, Bellvitge Campus, University of Barcelona, Barcelona, Spain
M. Gratacòs
Affiliation:
CIBERESP en Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III., Spain Genes and Disease Program, Center for Genomic Regulation (CRG), Barcelona Biomedical Research Park, Barcelona, Spain
N. Jaurrieta
Affiliation:
OCD Clinical and Research Unit, Psychiatry Department, Hospital Universitari de Bellvitge, Barcelona, Spain
S. Jiménez-Murcia
Affiliation:
OCD Clinical and Research Unit, Psychiatry Department, Hospital Universitari de Bellvitge, Barcelona, Spain Department of Clinical Sciences, Bellvitge Campus, University of Barcelona, Barcelona, Spain
C. Segalàs
Affiliation:
OCD Clinical and Research Unit, Psychiatry Department, Hospital Universitari de Bellvitge, Barcelona, Spain
E. Real
Affiliation:
Institut d’Investigació Biomèdica de Bellvitge (IDIBELL), L’Hospitalet de Llobregat, Barcelona, Spain
X. Estivill
Affiliation:
CIBERESP en Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III., Spain Genes and Disease Program, Center for Genomic Regulation (CRG), Barcelona Biomedical Research Park, Barcelona, Spain Genomics Core Facility and Centro Nacional de Genotipado (CeGen), Center for Genomic Regulation (CRG), Barcelona, Spain Experimental and Health Sciences Department, Pompeu Fabra University, Barcelona, Spain
J.M. Menchón
Affiliation:
OCD Clinical and Research Unit, Psychiatry Department, Hospital Universitari de Bellvitge, Barcelona, Spain CIBERSAM (Centro de Investigación en Red de Salud Mental), Instituto de Salud Carlos III., Spain Department of Clinical Sciences, Bellvitge Campus, University of Barcelona, Barcelona, Spain
*
*Corresponding author. King's College London, Institute of Psychiatry, PO69 De Crespigny Park Road, SE5 8AF, London, United Kingdom. Tel.: +44 2078 480 543; fax: +44 2078 480 379. E-mail address: Miguel.Fullana@kcl.ac.uk (M.A. Fullana).
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Abstract

Background

Recent research suggests that the brain-derived neurotrophic factor (BDNF) may play a role in extinction learning. The goal of this study was to test whether variation in the BDNF Val66Met polymorphism is related to treatment response to exposure-based cognitive-behavior therapy (CBT), a form of extinction learning, in obsessive-compulsive disorder (OCD).

Methods

One hundred and six OCD patients from a specialized clinic, who underwent a standardized CBT treatment after partial or non-response to a 12-week pharmacological trial, were genotyped for the BDNF Val66Met and the relationship between genotype and treatment response was analyzed.

Results

Among 98 CBT completers, 36% of those carrying the BDNF Met allele were rated as CBT responders compared to 60% of nonMet allele carriers (P = 0.027). When analyzing the different obsessive-compulsive symptom dimensions, in patients with contamination/cleaning symptoms, the Met allele was associated with a significantly worse CBT response (P<0.0001) and a lower obsessions severity decrease from pre- to posttreatment (P = 0.046).

Conclusion

Genetic variation in BDNF may be associated with treatment response in exposure-based CBT in OCD, especially in those patients exhibiting contamination/cleaning symptoms.

Keywords

Obsessive-compulsive disorderExtinctionCognitive-behavior therapyGeneticsBDNFVal66Met
Type
Original articles
Information
European Psychiatry , Volume 27 , Issue 5 , July 2012 , pp. 386 - 390
Copyright
Copyright © Elsevier Masson SAS 2012

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