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Tinnitus as a comorbidity to depression and transcranial magnetic stimulation as a treatment for both - case report

Published online by Cambridge University Press:  01 September 2022

P. Marinovic ,
M. Zivkovic ,
T. Bagaric ,
M. Skocic Hanzek  and
A. Mihaljevic-Peles
P. Marinovic*
Affiliation:
University Hospital Centre Zagreb, Psychiatry, Zagreb, Croatia
M. Zivkovic
Affiliation:
University Hospital Centre Zagreb, Psychiatry, Zagreb, Croatia
T. Bagaric
Affiliation:
University Hospital Centre Zagreb, Psychiatry, Zagreb, Croatia
M. Skocic Hanzek
Affiliation:
University Hospital Centre Zagreb, Psychiatry, Zagreb, Croatia
A. Mihaljevic-Peles
Affiliation:
University Hospital Centre Zagreb, Psychiatry, Zagreb, Croatia
*
*Corresponding author.

Abstract

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Introduction

Depressive symptoms are common in individuals with tinnitus, however, the mechanisms of their interaction are not fully understood. There is neurobiological evidence that might help understanding the interplay between tinnitus and depression which, in turn, helps in making the right choice for treating both conditions.

Objectives

This case report describes a 70-year old female patient that presented with tinnitus and depressive symptoms lasting for the past 5 years.

Methods

The patient showed limited treatment results with different antidepressants. The otorhinolaryngologist ruled out any possible somatic causes of her tinnitus. Tinnitus was causing her sleep disturbances, which worsened her everyday functioning that was already quite poor even further.

Results

After being administered with 30 rounds of TMS, her symptoms either completely resolved or at least reached a level that was adequate for her to start functioning normally on a day-to-day basis.

Conclusions

TMS is a technique that provides non-invasive cortical stimulation, more specifically, when used for depression treatment it stimulates the left dorsolateral prefrontal cortex, a brain region synaptically connected to the limbic system involved in mood regulation that is proven to be hypoactive in depression. The limbic system is where tinnitus-related brain networks and regions involved in the pathophysiology of depression overlap. Further research is needed to deepen the understanding of this topic.

Disclosure

No significant relationships.

Keywords

AntidepressantsDepressiontinnitusTMS
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S741
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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