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Thyrotropin and prolactin responses to TRH in delusional (psychotic) and nondelusional depressed patients

Published online by Cambridge University Press:  16 April 2020

L Lykouras ,
M Markianos ,
Y Papakostas  and
D Malliaras
L Lykouras
Affiliation:
Department of Psychiatry, Athens University Medical School, Eginition Hospital, 74, Voss Sophias Avenue, 11528Athens, Greece
M Markianos
Affiliation:
Department of Psychiatry, Athens University Medical School, Eginition Hospital, 74, Voss Sophias Avenue, 11528Athens, Greece
Y Papakostas
Affiliation:
Department of Psychiatry, Athens University Medical School, Eginition Hospital, 74, Voss Sophias Avenue, 11528Athens, Greece
D Malliaras
Affiliation:
Department of Psychiatry, Athens University Medical School, Eginition Hospital, 74, Voss Sophias Avenue, 11528Athens, Greece
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Summary

The thyrotropin (TSH) and prolactin (PRL) responses to protirelin (TRH) were studied in 62 female unipolar depressive patients, 24 delusional (psychotic) and 38 nondelusional (Diagnostic and Statistical Manual [DSM]-III-R criteria). The TSH response to TRH was blunted (≤6 μlU/mL) in ten of the 24 delusional (41.6%) and in 18 of the 38 nondelusional (47.4%) patients, the difference being not significant. The TSH and PRL responses to TRH, calculated as area under the curve, were not different between the two groups. Similar results were obtained when the response patterns were compared by repeated measure analysis of covariance.

Keywords

TRH testTSHprolactindelusiondepression
Type
Original articles
Information
European Psychiatry , Volume 12 , Issue 5 , 1997 , pp. 259 - 262
Copyright
Copyright © European Psychiatric Association 1997

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References

American Prychiatric Association, APA Diagnostic and Statistical Manual of Mental Disorders 3rd ed revisedWashington, DC: APA, 1987Google Scholar
American Psychiatric Association, APA Diagnostic and Statistical Manual of Mental Disorders 4th ed.Washington, DC: APA, 1994Google Scholar
Annunziato, L, Direnzo, G, Quattrone, A, Schettini, G, Preziosi, P. Brain neurotransmitters reguluting TRH producing neurons. Pharmacol Res Comm 1981; 13: 1–1010.1016/S0031-6989(81)80033-1CrossRefGoogle ScholarPubMed
Bennes, OS, Burrow, GN, Spaulding, SW, Donabedian, RK. Dopamine infusion acutely inhibits the TSH and prolactin response to TRH. J Clin Endocrinol Metah 1975; 41: 562–598Google Scholar
Burrow, GN, May, PB, Spaulding, SW, Donubedian, RK. TRH and dopamine interactions affecting pituitary hormone secretion. J Clin Endocrinol Metab 1977; 45: 65–7010.1210/jcem-45-1-65CrossRefGoogle Scholar
Charney, DS, Nelson, JC. Delusional and nondelusional unipolar depression: further evidence for distinct subtypes. Am J Prochtatry 1981; 138: 328–333Google ScholarPubMed
Classman, AH, Kantor, SJ, Shostak, M. Depressions, delusions, and drug response. Am J Psychiatry 1975; 132: 716–719Google Scholar
Hamilton, M. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960; 23: 56–6210.1136/jnnp.23.1.56CrossRefGoogle ScholarPubMed
Hershman, JM, Pekary, AERegulation of TSH secretion In: Immura, H eds. The Pituitary Gland New York: Raven Press, 1985; 149–188Google Scholar
Hubain, PP, Staner, L, Dramaix, M, Kerkhofs, M, et al.. TSH response to TRH and EEG sleep in non-bipolar major depression a multivariate approoch. Kur Neuropsychopharmacology 1994; 4: 517–525CrossRefGoogle Scholar
Kirkegaard, C, Erkiidsen, PC, Bjorum, N. Parallel changes of the response to thyrotropin, growth hormone and prolactin to thyrotropin-releasing hormone in endogenous depression. Psychoneuroendocrinology 1981; 6: 253–259CrossRefGoogle Scholar
Leong, DA, Frawley, LS, Neill, JO. Neuroendocrine control of prolactin secretion. Annu Rev Physiol 1983; 45: 109–12710.1146/annurev.ph.45.030183.000545CrossRefGoogle ScholarPubMed
Levy, AB, Stern, SL. DST and TRH stimulation test in mood disorders subtypes. Am J Psychiatry 1987; 144: 472–475Google Scholar
Lewis, BM, Diequez, C, Lewis, MD, Scanion, MF. Dopamine stimulates release of thyrotropin-releasing hormone from perfused intract hypothalamus via hypothalamic D2 receptors. J Endocrinol 1987; 115: 419–42410.1677/joe.0.1150419CrossRefGoogle Scholar
Loosen, PT. The TRH-induced TSH response in psychiatric patients: a possible neuroendocrine marker. Psychoneuroendocrinology 1985; 10: 237–260CrossRefGoogle ScholarPubMed
Lykouras, L, Markiunos, M, Hatzimanolis, J, Malliaras, D, Stefano, C. Biogenic amine metabolites in delusional (psychotic) depression and melancholia subtypes of major depression. Prog Neuropsychopharmacol Biol Psychiatry 1994; 18: 1261–1271CrossRefGoogle ScholarPubMed
Maes, MH, De Ruyter, M, Suy, E. Predict of subtype and severity of depression by means of dexamethasone supression test, L-tryptophan competing amino acid ratio and MHPC flow. Biol Psychiatr 1987; 22: 177–18810.1016/0006-3223(87)90228-9CrossRefGoogle Scholar
Markianos, M, Lykouras, L, Stefanis, C. Prolactin and TSH responses to TRH in pre- and post-menopausal women with major depression. Biol Psychiatry 1996; 40: 403–406CrossRefGoogle Scholar
Mason, GA, Garoutt, JC, Prange, AJ JrThyrotropin-releasing hormone. Focus on basic neurobiology In: Bloom, FEKupfer, DJ eds. Psychopharmacology: The Fourth Generation of Progress New York: Raven Press, 1995; 493–503Google Scholar
Minder, RE, Mandel, MR. The treatment of psychotic major depressive disorder, with drugs and electroconvulsive therapy. J Nerv Ment Dis 1979; 167: 726–73310.1097/00005053-197912000-00002CrossRefGoogle Scholar
Peters, JK, Foord, SM, Diegnez, C, Sconlon, MF, Hall, R. a1 Adrenoceptors on intact rat anterior pituitary cells in culture: correlation with thyrotropin release. Endocrinology 1983; 113: 133–140CrossRefGoogle Scholar
Reichlin, S, Jackson, I, Seiler, LRegulation of the secretion of TRH and LHRH In: Seeman, PBrown, G eds. Frontiers in Neurology and Neuroscience Research Toronto: University of Toronto Press, 1974; 48–59Google Scholar
Rihmer, Z, Arato, M, Szadoczky, E, Revai, K, et al.. The dexamethasone suppression test in psychotic versus nonpsychotic endogenous depression. Br J Psychiatry 1984; 145: 508–511CrossRefGoogle Scholar
Roose, SP, Glassman, AHDelusional depression In: Georgotas, AConcro, R eds. Depression and Mania New York: Elsevier, 1988; 76–85Google Scholar
Rudorfer, MV, Hwu, HG, Clayton, PJ. Dexamethasone suppression test in primary depression. Significance of family history and psychosis. Biol Psychiatry 1982; 17: 41–48Google ScholarPubMed
Schatzberg, AF, Rothshild, AJ. Psychotic (delusional) major depression: should it be included as a distinct syndrome in DSM-IV?. Am J Psychiatry 1992; 149: 733–745Google ScholarPubMed
Spiker, DG, Weiss, JC, Dealy, RS, Griffin, SJ, et al.. The pharmacological treatment of delusional depression. Am J Psychiatry 1985; 142: 430–436Google ScholarPubMed
Tabuchnick, BG, Fidell, LSUsing Multivariate Statistics New York: Harper and Row Publishers, 1989Google Scholar
World Health Organization, WHO The ICD-10 Classification of Mental and Behavioral Disorders. Clinical Descriptions and Diagnostic Guidelines Geneva: WHO, 1992Google Scholar
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