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A systematic review of the efficacy and safety of second generation antipsychotics in the treatment of mania

Published online by Cambridge University Press:  16 April 2020

R.M. Jones ,
C. Thompson  and
I. Bitter
R.M. Jones*
Affiliation:
Mental Health Group, University of Southampton, Southampton, UK
C. Thompson
Affiliation:
Mental Health Group, University of Southampton, Southampton, UK
I. Bitter
Affiliation:
E. Lilly Regional Operations, Vienna, Austria Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary
*
*Corresponding author. Present address. Department of Psychiatry, Royal South Hants Hospital, Brittons Terrace, Southampton, S014 OYD, UK. Tel.: +44 2380 79 6581. E-mail address:rolandmjones@yahoo.co.uk (R.M. Jones).
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Abstract

Second generation antipsychotic agents are increasingly used in the management of acute mania. A systematic review of the efficacy and safety of these agents, as both monotherapy and in combination with mood stabilisers, was performed to establish the evidence for their use. Randomised controlled trials (RCTs) were critically appraised in more detail than studies that presented lower levels of evidence such as case reports, case series and open label follow up studies. We found 11 RCTs reporting on patients treated with second generation antipsychotics for acute bipolar mania, of which three included randomisation between the second generation antipsychotic and placebo, and eight between a mood stabiliser combined with either the second generation antipsychotic or placebo. Data from non-randomised trials is also presented.

Keywords

ManiaBipolar disorderSecond generationAntipsychoticEfficacySafety
Type
Review
Information
European Psychiatry , Volume 21 , Issue 1 , January 2006 , pp. 1 - 9
Copyright
Copyright © Elsevier SAS 2006

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