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Suicidality in Treatment-Resistant Depression Patients

Published online by Cambridge University Press:  19 July 2023

E. B. Lyubov  and
N. D. Semenova
E. B. Lyubov
Affiliation:
1Suicidology
N. D. Semenova*
Affiliation:
2Psychological Counselling, Moscow Research Institute of Psychiatry, Moscow, Russian Federation
*
*Corresponding author.

Abstract

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Introduction

Depression and treatment-resistant depression (RD) are associated with suicidal behavior (SB) at a higher rate.

Objectives

1) determination prevalence of RD in district outpatient psychiatric сlinics (i.e., dispensaries) and the socio-demographic characteristics of RD patients with SB.

Methods

In this multicenter (3 sites), retrospective, observational epidemiological study, patients (n=148) with diagnoses F 30-39 (ICD-10) were recruited in 2020. Patients (n=22) were assessed for RD, defined as failure to respond to ≥ two antidepressant medications of adequate dose and duration for at least three months.

Results

The prevalence of depression is ≤ 2% of the outpatient population. RD prevalence ˜15%. SB (i.e., suicidal attempts) was noted in every fifth (n=5) for the index year. SB patients differed in the following typical features: a woman (82%) mean age, 46.8 years with long-term (≥ 10 years) depression and annual hospitalizations for three years (61.4 days per patient), and with suicidal attempts (repeated within the last two years) through (80%) self-poisoning with psychotropic drugs. Nobоdy worked, and everyone was divorced.

Conclusions

On the background of ubiquitous underdiagnosis of depressive disorders in routine practice, RD patients with SP represent a high-resource users group with combined clinical and social problems requiring pharmacotherapy and target psychosocial rehabilitation.

Disclosure of Interest

None Declared

Type
Abstract
Information
European Psychiatry , Volume 66 , Special Issue S1: Abstracts of the 31st European Congress of Psychiatry , March 2023 , pp. S317 - S318
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of the European Psychiatric Association
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