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Sociodemographic, lifestyle and clinical factors associated with good performance in paired associates learning (PAL) test in patients with schizophrenia

Published online by Cambridge University Press:  13 August 2021

M. Taivalantti ,
M. Kerkelä ,
A.-H. Halt ,
J. Barnett  and
J. Veijola
M. Taivalantti*
Affiliation:
Department Of Psychiatry, University of Oulu, Oulu, Finland
M. Kerkelä
Affiliation:
Department Of Psychiatry, University of Oulu, Oulu, Finland
A.-H. Halt
Affiliation:
Department Of Psychiatry, University of Oulu, Oulu, Finland
J. Barnett
Affiliation:
Department Of Psychiatry, Cambridge Cognition, UK, University of Cambridge, UK, Cambridge, United Kingdom
J. Veijola
Affiliation:
Department Of Psychiatry, University of Oulu, Oulu, Finland
*
*Corresponding author.

Abstract

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Introduction

Memory and learning deficits are central among cognitive deficits in schizophrenia. However, to a varying proportion ca. 20-25% of patients could not be considered deficit.

Objectives

Description of sociodemographic, lifestyle and clinical factors related to good performance in PAL-test in schizophrenia patients.

Methods

Participants (N=4500) were members of the Finnish SUPER study on the genetic mechanisms of psychotic disorders (SUPER). The database of the Northern Finland Birth Cohort 1966 (NFBC 1966) was utilized as a reference data. Visual memory and new learning were assessed using Cambridge Neuropsychological Test Automated Battery (CANTAB) Paired Associates Learning (PAL) test. The 50th percentile scores (10 error score or less) for outcome measure total errors adjusted (TEA) of NFBC 1966 was used as a cut-off for good performance in PAL test.

Results

The sociodemographic and lifestyle factors related good performance for both sexes were: younger age (p<.001), higher basic education (p <.001), independent form of dwelling (p<.001), hazardous drinking (p <.001), cannabis use (p <.001) and being married (females p = 0.009, males p = 0.049). The clinical factors related to good performance for both sexes were not using antipsychotic medication regularly (p <.001), not using all psychotropic medication (females p=0.05, males p <.001), less hospitalization times due to psychosis (p <.001), younger age at first hospitalization due to psychosis (p <.001), lower number of hospitalization days (p <.001) and lower percentage of time in hospital after first psychosis episode (p <.001).

Conclusions

Several factors related to good performance in the PAL–test in the crude analysis without any confounders.

Keywords

schizophréniavisual memory and new learning
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S543 - S544
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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