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Single-prolonged stress induced mitochondrial - dependent apoptosis in hippocampus in the rat model of post-traumatic stress disorder

Published online by Cambridge University Press:  16 April 2020

M.X. Li ,
F. Han ,
J.D. Liu  and
X.Y. Shi
M.X. Li
Affiliation:
China Medical University, Shenyang, China
F. Han
Affiliation:
China Medical University, Shenyang, China
J.D. Liu
Affiliation:
China Medical University, Shenyang, China
X.Y. Shi
Affiliation:
China Medical University, Shenyang, China

Abstract

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Objective

The aim of this study was to reveal the possible mechanisms involved in apoptosis induced by single prolonged stress (SPS) in hippocampus of post-traumatic stress disorder (PTSD) rats.

Methods

SPS is one of the animal models proposed for PTSD. Wistar rats were killed at 1, 4, 7, 14 and 28days after exposure to SPS. Expression of caspase-9, caspase-3, cytochrome c, Bcl-2 and Bax was detected by immunohistochemistry, immunofluorescence, western blotting and electron microscopy. Apoptotic cells were assessed by TUNEL method.

Results

Our results showed apoptotic cells were significantly increased in hippocampus of SPS rats, accompanied by release of cytochrome c from the mitochondria into the cytosol, increase of caspase-9 and caspase-3 expression and decrease of the Bcl-2 / Bax ratio.

Conclusion

The results indicate that SPS induced apoptosis in hippocampus of PTSD rats, and the mitochondrial pathway was involved in the process of SPS induced apoptosis. *National Natural Science Foundation of China

Type
P02-487
Information
European Psychiatry , Volume 26 , Issue S2: Abstracts of the 19th European Congress of Psychiatry , March 2011 , pp. 1083
Copyright
Copyright © European Psychiatric Association 2011
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