Objective of this investigation was distinguishing the totality of significant constitutional-biological factors for identification of the prognosis, course and development of methods of treatment of comorbid depressive and sexual disorders.

In clinics of Mental Health Research Institute 40 men with comorbid depressive and sexual disorders aged 25-55 years have been examined. Examination was conducted with psychopathological method, method of structural analysis of sexological disorders, statistic method. Three typological variants of depression have been distinguished: “vital depression”, characterized by anguish and apathy (25%), “reactive depression”, characterized by relevant psychogenic experiences (30%), “depression of exhaustion”, characterized by asthenic, psychosomatic manifestations (45%).

In mild (HDRS – 10 scores; 50%) and moderate (HDRS – 16 scores; 30%) depressive disorders sexual dysfunctions may be regarded as a general clinical radical in depressions in men and their prevalence rate constituted up to 80%.

They manifested themselves in decrease of libido (80%), erectile dysfunctions (58%), ejaculatory (26%) and orgasmic disturbances (10%).

In severe depressive states (HDRS – 25 scores; 20% of patients) sexological disturbances fade into the background, sexual life becomes irrelevant.

After restoration of mental state in depressive patients, sexual disturbances often remain. In this association program of treatment and rehabilitation of patients with comorbid depressive and sexual disorders with use of preparation LEVITRA (vardenafil) allowing realization of principle of complex biopsychosocial model.