No CrossRef data available.
Article contents
Sex differences in diagnostic stability in first episode psychosis after 1-year follow-up
Published online by Cambridge University Press: 27 August 2024
Abstract
Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Introduction
Diagnostic stability is a controversial issue in first episode psychosis (FEP) due to heterogenous symptoms and unclear affective symptoms. Differencing affective and non-affective psychoses is important as treatment strategies are different. Initial affective symptomatology has low specificity for predicting the subsequent diagnosis of affective psychosis. Sex has proven to be relevant for clinical and functional outcomes but it remains unclear how sex may contribute to diagnosis switch of FEP.
Objectives
To determine the role of sex in diagnostic stability in a sample of FEP after 1-year follow-up.
Methods
Diagnoses of FEP patients from Hospital del Mar of Barcelona were assessed at baseline and 1 year after. Univariate analyses was perfomed for all diagnoses and dichotomic variable (affective/non-affective). Logistic regression model was perfomed to know which variables predict diagnosis switch.
Results
TABLE 2A and 2B.
256 patients were enrolled. No differences were found at baseline between completers and non-completers (Table 1). No significant differences between men and women at baseline diagnosis were found, neither all diagnoses (p=0.274) nor the dichotomic variable affective/non-affective (p=0.829) (Table 2AB). Significant differences were found at 1-year follow-up between men and women, for all diagnoses (p=0.043) and the dichotomic variable (p=0.039). Sex was the only variable that predicted diagnosis switch (Figure 1), PANSS, CDSS, YMRS, GAF and cannabis did not.Table 1.
Baseline characteristics of participants
| Completers (n=188) | Non-completers (n=68) | p | |
|---|---|---|---|
| Women (n, %) | 71 (37.8) | 30 (44.1) | 0.111 |
| Age (M, IQR) | 24 (20-28) | 22 (20-28) | 0.899 |
| Cannabis use (M, IQR) | 5.5 (0-18) | 7 (0-21) | 0.231 |
| DUP (M, IQR) | 45 (12.5-130) | 36 (11.25-115.75) | 0.213 |
| PANSS (m, sd) | 44.55 (10.17) | 40.93 (10.42) | 0.761 |
| CDSS (M, IQR) | 2 (0-7) | 3 (0-5.5) | 0.199 |
| YMRS (m, sd) | 19 (9.64) | 17.6 (9.15) | 0.845 |
| GAF (M, IQR) | 30 (25-50) | 30 (25-35) | 0.114 |
Diagnosis comparison (n, %)
| Baseline | 1-year follow-up | |||||
|---|---|---|---|---|---|---|
| Men | Women | Total | Men | Women | Total | |
| Psychosis NOS | 69 (59) | 39 (54.9) | 108 (57.4) | 28 (23.9) | 10 (14.1) | 38 (20.2) |
| Schizophreniform disorder | 22 (18.8) | 16 (22.5) | 38 (20.2) | 14 (12 | 9 (12.7) | 23 (12.2) |
| Induced psychosis | 4 (3.4) | 0 (0) | 4 (2.1) | 15 (12.8) | 4 (5.6) | 19 (10.1) |
| Affective psychosis | 17 (14.5) | 9 (12.7) | 26 (13.8) | 24 (20.5) | 25 (35.2) | 49 (26.1) |
| Schizophrenia | 0 (0) | 0 (0) | 1 (0.4) | 30 (25.6) | 14 (19.7) | 44 (23.4) |
| Brief psychotic disorder | 5 (4.3) | 7 (9.9) | 12 (6.4) | 6 (5.1) | 8 (11.3) | 14 (7.4) |
| Baseline | 1-year follow-up | |||||
|---|---|---|---|---|---|---|
| Men | Women | Total | Men | Women | Total | |
| Affective psychosis | 17 (14.5) | 9 (12.7) | 26 (13.8) | 24 (20.5) | 25 (35.2) | 49 (26.1) |
| Non-affective psychosis | 100 (85.5) | 62 (87.3) | 162 (86.2) | 93 (79.5) | 46 (64.8) | 139 (73.9) |
Image:
Conclusions
Sex has proven to be the main predictor of switching initial diagnosis of FEP.
Disclosure of Interest
None Declared
- Type
- Abstract
- Information
- European Psychiatry , Volume 67 , Special Issue S1: Abstracts of the 32nd European Congress of Psychiatry , April 2024 , pp. S470 - S471
- Creative Commons
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.- Copyright
- © The Author(s), 2024. Published by Cambridge University Press on behalf of European Psychiatric Association
You have
Access
Open access
Comments
No Comments have been published for this article.